Journal
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volume 191, Issue -, Pages 36-43Publisher
ELSEVIER
DOI: 10.1016/j.vetimm.2017.07.012
Keywords
beta-Glucan; I-FABP2; IFN-gamma; NOx; Piglet; Rotavirus
Categories
Funding
- ICAR-IVRI
- All India Network Programme on Neonatal Mortality Project
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A non-blinded randomized clinical trial was conducted to assess the immunomodulatory potential of beta-glucan (BG) in piglet diarrhoea associated with type A rotavirus infection. A total of 12 rotavirus-infected diarrheic piglets were randomly divided into two groups: wherein six rotavirus-infected piglets were treated with supportive treatment (ST) and other six rotavirus-infected piglets were treated with BG along with ST (ST-BG). Simultaneously, six healthy piglets were also included in the study which served as control. In rotavirus-infected piglets, marked increase of Intestinal Fatty Acid Binding Protein-2 (I-FABP2), nitric oxide (NOx), Interferon-gamma (IFN-gamma) concentrations and decrease of immunoglobulin G (IgG) were noticed compared to healthy piglets. The faecal consistency and dehydration scores were significantly higher In rotavirus-Infected piglets than healthy piglets. The ST-BG treatment progressively reduced the I-FABP2 and increased the IgG concentrations over the time in rotavirus-infected piglets compared to piglets received only ST. A pronounced enhancement of NOx and IFN-gamma concentrations was observed initially on day 3 and thereafter the values reduced on day 5 in ST-BG treated piglets in comparison to piglets which received only ST. Additionally, ST-BG treatment significantly reduced faecal consistency and dehydration scores on day 3 compared to ST in rotavirus-infected piglets. These findings point that BG represents a potential additional therapeutic option to improve the health condition and reduce the piglet mortality from rotavirus associated diarrhoea where porcine rotavirus vaccine is not available.
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