Article
Engineering, Environmental
Jin-Ok Chu, Hye-Seon Jeong, Jong-Pil Park, Kyeongsoon Park, Sun-Ki Kim, Hyunmin Yi, Chang-Hyung Choi
Summary: A novel capsule-based colorimetric temperature monitoring system with precise and tunable temperature ranges is reported. It allows for customizable cold chain management and visual monitoring of temperature changes.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Shawn Jun, Youngbok Ko, Seung Hyun Lee
Summary: The cold chain of vaccine distribution is strictly regulated to avoid freeze damage. Supercooling technology can effectively inhibit ice crystal formation and protect the microscopic structure of vaccines. This technology is of great importance in storage and freeze protection.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Jiahuan Li, Ge Yu, Zhihui Liang, Min Li, Chen Chen, Xin Li, Yiyang Guo, Cheng Yang, Yang Liu, Caiqiao Zhang, Weiting Zhang, Jiaxu Liu, Xuehu Ma, Changying Xue, Bingbing Sun
Summary: This study revealed the impact of freezing on the functionality of aluminum-based adjuvants and the protective effect of a sugar-based surfactant on frozen aluminum oxyhydroxide nanoparticles. These findings provide insights into improving vaccine stability.
Article
Immunology
Varun Srivastava, Manish Ratna, Arindam Ray, Santosh Shukla, Vipin Shrivastava, Nitin Kothari, Amandeep Gupta, Meenal Kukreja, Harkabir Singh Jandu
Summary: The study conducted in Madhya Pradesh, India, focused on optimizing and expanding the cold chain network for immunization vaccines. By realigning health facilities and session sites, a significant reduction in remote sites beyond permissible travel time from CCPs was achieved, demonstrating a replicable approach for developing countries facing similar challenges.
Article
Environmental Sciences
Zening Wei, Wei Yang, Cheng Zhai, Yong Sun, Wei Tang, Aikun Chen, Hexiang Xu, Yu Wang
Summary: Granular materials in high-latitude cold and high-altitude areas can be damaged by freezing and thawing, due to changes in microscopic pore structure and moisture content. This study investigated the unfrozen water change and storage characteristics of granular materials under freeze-thaw cycles. The results showed that the freezing characteristic curve exhibited an exponential decrease and a left-bottom shift with an increasing number of cycles, indicating a more developed pore space. Freeze-thaw cycles intensified the hysteresis phenomenon and caused pore expansion in the early freeze-thaw period. The study also observed the destruction of weak surface structures through frost heave and water migration erosion, leading to granular accumulation instability.
ENVIRONMENTAL EARTH SCIENCES
(2023)
Article
Immunology
Michael Naor, Gavriel David Pinto, Pini Davidov, Lina Abdrbo
Summary: The research aimed to address the spread of coronaviruses by establishing an ultra-cold supply chain for vaccines. Utilizing publicly available dataset from the Israel Ministry of Health, linear regression was employed to analyze the daily rates of vaccination, testing, hospitalization, etc. The data provided statistical evidence of the effectiveness of Pfizer vaccines in reducing various disease factors and demonstrated the impact of different vaccine doses on controlling COVID-19 waves in Israel.
Review
Public, Environmental & Occupational Health
Bublu Thakur-Weigold, Pascal Buerki, Patrice Frei, Stephan M. Wagner
Summary: This study compares and analyzes the vaccine supply chain in Switzerland, finding that design flaws have led to a decrease in vaccination coverage. The results suggest that improving the segmentation of catchment populations, collaboration between administrative units, and better utilization of geolocation and material flow information can enhance the speed and reach of vaccinations during emergency response phases.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Food Science & Technology
Ulf Erikson, Solveig Uglem, Kirsti Greiff
Summary: The current review investigates the impact of various processing steps on whitefish quality, aiming to evaluate the freeze-chilling concept for year-round marketing in the fishing industry. It covers the effects of individual processing steps as well as the combined impact from sea to consumer.
Article
Engineering, Chemical
Julie Loisel, Antoine Cornuejols, Onrawee Laguerre, Margot Tardet, Dominique Cagnon, Olivier Duchesne de Lamotte, Steven Duret
Summary: Real-time prediction of product temperature is a challenge in cold chain monitoring, which can be addressed using machine learning methods like neural networks. Experimental data leads to better results compared to synthetic data, but requires material investment. Increasing the amount of synthetic data only decreases the variance, not the mean error. In experimental data, finding the optimal position of the sensor is more useful than using realistic scenarios.
JOURNAL OF FOOD ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Sobhi Mejjaouli
Summary: This study proposes an architecture for real-time monitoring and control system for a cold supply chain, which utilizes RFID-WSN-GPS technology to collect data and make decisions in order to reduce costs and mitigate risks. The results show cost reductions of up to 3.39% with the use of this system.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2022)
Article
Computer Science, Artificial Intelligence
Iurii Konovalenko, Andre Ludwig
Summary: Real-time temperature monitoring is crucial in cold pharmaceutical supply chains to prevent product quality deterioration from extreme temperature exposure. A new hybrid k-NN algorithm, based on principles of local similarity and neighborhood homogeneity, outperforms traditional k-NN in accuracy and precision for temperature alarms in pharmaceutical supply chains.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Article
Mathematics, Applied
Daoming Dai, Xuanyu Wu, Fengshan Si
Summary: The paper focuses on vaccine transportation in a COVID-19 supply chain model, examining the roles of distributor and retailer and how their decisions impact system stability. Results indicate that decision delay-time and adjustment speed significantly affect supply chain stability, with the stability domain of the system changing with customers' sensitivity to cold chain transportation and vaccine prices.
ADVANCES IN DIFFERENCE EQUATIONS
(2021)
Article
Computer Science, Artificial Intelligence
Iurii Konovalenko, Andre Ludwig, Henrik Leopold
Summary: Many goods, including pharmaceuticals, require close monitoring of temperature. Existing temperature prediction methods are focused on long-term forecasts, but there is a need for a method that can provide real-time predictions for unexpected ambient temperature changes.
DECISION SUPPORT SYSTEMS
(2021)
Article
Immunology
R. E. Guktur, E. Nep, O. Asala, P. O. Olorunfemi, N. C. Ngwuluka, N. A. Ochekpe, A. S. Sagay
Summary: Developing vaccines stabilized with modified local starches showed higher stability and immunogenicity compared to traditional stabilizers like peptone, as evidenced by hemagglutination inhibition test results. The use of different stabilizers also influenced the level of protective antibodies generated in vaccinated broilers.
Article
Immunology
James M. Azam, Barbara Saitta, Kimberly Bonner, Matthew J. Ferrari, Juliet R. C. Pulliam
Summary: The study investigated the strategy of rapid outbreak response vaccination for measles control and elimination, proposing the use of measles vaccines delivery outside cold chain. It suggests that this strategy presents improved operational and epidemiological outcomes relative to current practice and other options considered.