Journal
VACCINE
Volume 35, Issue 21, Pages 2855-2861Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2017.04.009
Keywords
Vaccine; Influenza; Dissolving microneedle; Transdermal vaccination; Whole virus particle; Split virion
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Funding
- FUJIFILM Corporation (Tokyo, Japan)
- Grants-in-Aid for Scientific Research [16H06597] Funding Source: KAKEN
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Transdermal vaccination using a microneedle (MN) confers enhanced immunity compared with subcutaneous (SC) vaccination. Here we developed a novel dissolving MN patch for the influenza vaccine. The potencies of split virion and whole virus particle (WVP) vaccines prepared from A/Puerto Rico/8/1934 (H1N1) and A/duck/Hokkaido/Vac-3/2007 (H5N1), respectively, were evaluated. MN vaccination induced higher neutralizing antibody responses than SC vaccination in mice. Moreover, MN vaccination with a lower dose of antigens conferred protective immunity against lethal challenges of influenza viruses than SC vaccination in mice. These results suggest that the WVP vaccines administered using MN are an effective combination for influenza vaccine to be further validated in humans. (C) 2017 Elsevier Ltd. All rights reserved.
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