Journal
UROLOGY
Volume 102, Issue -, Pages 138-142Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.urology.2016.11.032
Keywords
-
Categories
Funding
- The Danish Cancer Society [R134-A8271] Funding Source: researchfish
Ask authors/readers for more resources
OBJECTIVE To compare findings in NBI to findings in WL and PDD in a high-risk patient population. MATERIALS AND METHODS A total of 171 patients were included in the study from 4 different urology departments in Denmark and Norway. Patients were scheduled for a PDD-guided transurethral tumor resection or cystoscopyguided biopsy in accordance with Danish guidelines, on the suspicion of primary or concomitant CIS. All patients were examined with WL cystoscopy followed by both NBI and PDD before biopsy. RESULTS A total of 136 patients were biopsied due to findings with suspicion of CIS in at least 1 modality (482 biopsies with a mean of 3.5 biopsies per patient). Analysis at patient level showed that NBI and PDD had a significantly higher sensitivity regarding identification of CIS and dysplasia compared with WL (NBI: 95.7%, PDD: 95.7% vs WL: 65.2%, P < .05). Specificity was not significantly different between the 3 methods (NBI: 52.0%, PDD: 48.0%, and WL: 56.8%). When analyzed per biopsy, NBI and PDD had a significantly higher sensitivity than WL (NBI: 72.7% and PDD: 78.2% vs WL: 52.7%, P < .05), whereas the positive predictive values were not significantly different (NBI: 23.7%, PDD: 22.2%, and WL: 19.0%). CONCLUSION NBI was found to be a valid alternative to PDD regarding diagnosis of CIS and flat dysplasia. (C) 2016 Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available