Article
Materials Science, Multidisciplinary
Tun Naw Sut, Bo Kyeong Yoon, Won-Yong Jeon, Joshua A. Jackman, Nam-Joon Cho
Summary: Supported lipid bilayer (SLB) coatings, versatile cell-membrane-mimicking biointerfaces, have been expanded for medical and biotechnology applications, facilitating various studies and applications like biosensors, diagnostics, and antifouling surfaces.
APPLIED MATERIALS TODAY
(2021)
Article
Nanoscience & Nanotechnology
Guilherme B. Berselli, Aurelien Gimenez, Alexandra O'Connor, Tia E. Keyes
Summary: A biomolecular photoactive device based on light-activated proton pump bR reconstituted into highly fluidic microcavity-supported lipid bilayers (MSLBs) has been developed, demonstrating efficient photoelectrical properties. The optimal conditions for a self-sustaining photoelectrical switch were determined, showing significant increase in transient current for lipid bilayers containing approximately 0.3 mol % bR with a measured photo-current of 250 nA/cm(2).
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Sevde Puza, Shima Asfia, Ralf Seemann, Jean-Baptiste Fleury
Summary: Lipid droplets (LD) locate in the endoplasmic reticulum membrane and play important roles in biological functions. A protein called ADRP surrounds LDs along with phospholipid monolayers and is involved in storing neutral lipids. This article focuses on the influence of ADRP on the 3D shape of LDs embedded in bilayers and the diffusion of phospholipids on LD surfaces. The study shows that ADRP significantly affects the 3D structure of LDs. Rating: 9/10.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Rafael L. Schoch, Gilad Haran, Frank L. H. Brown
Summary: Recent single-molecule measurements have observed dynamic lipid-lipid correlations in membranes with high spatial and temporal resolution. Theoretical expressions are derived to infer experimentally measurable correlations from the diffusion matrix. The theoretical predictions match well with Brownian dynamics simulations of experimental measurements. Membrane protein diffusion measurement, along with lipid diffusion measurements, could help resolve experimental ambiguities in certain black lipid membranes.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Biochemical Research Methods
Siddhartha Banerjee, Yuri L. Lyubchenko
Summary: The article discusses the preparation of smooth, stable, and structurally homogeneous lipid bilayers without trapped vesicles, for probing the time-dependent early stages of aggregation of monomeric amyloid proteins. This methodology development allows for monitoring amyloid protein aggregation at low protein concentrations, and for studying the specific role of different lipids in aggregation kinetics and disease development mechanisms.
Article
Chemistry, Multidisciplinary
Yang Liu, Xu Zheng, Dongshi Guan, Xikai Jiang, Guoqing Hu
Summary: In this study, the impact of heterogeneous nanostructures on anomalous diffusion in dipalmitoylphosphatidylcholine (DPPC) monolayers is investigated. The existence of condensed nanodomains and their influence on diffusion are identified. The findings reveal a universal characteristic of multistage mean square displacement (MSD) and an anomalous double-peaked displacement probability distribution (DPD) phenomenon.
Article
Chemistry, Analytical
Karutha Pandian Divya, Shanmuganathan Keerthana, Chinnuswamy Viswanathan, Nagamony Ponpandian
Summary: This paper reports a biomimetic bilayer lipid membrane supported MXene based biosensor for electrochemical hybridization detection of the most prevalent and potential breast cancer biomarker BRCA1. A 2D MXene nanosheet-anchored gold nanoparticle-decorated biomimetic bilayer lipid membrane (AuNP@BLM) biosensor is used for the attachment of thiolated single-stranded DNA (HS-ssDNA) targeting hybridization detection. The synergistic combination of MXene and AuNP@BLM has proven to efficiently improve the detection signal to several folds.
Article
Nanoscience & Nanotechnology
Hyunhyuk Tae, Soohyun Park, Gamaliel Junren Ma, Nam-Joon Cho
Summary: In this study, an air-stable supported lipid bilayer (SLB) that is laterally mobile upon rehydration was fabricated using a sucrose-bicelle complex system. The sucrose fraction in the system was found to be an important factor, with 20 wt% sucrose yielding SLBs that fully recovered lateral mobility after the dehydration-rehydration process. This research provides potential for a wide range of biointerfacial science applications.
Article
Biophysics
Surajit Ghosh, Zeinab Mohamed, Jung-Ho Shin, Samavi Farnush Bint E. Naser, Karan Bali, Tobias Dorr, Roisin M. Owens, Alberto Salleo, Susan Daniel
Summary: Antibiotic resistance is a global health concern due to the decreasing number of available antibiotics and the development of drug-resistant bacteria. Understanding the interactions between the bacterial membrane and antibiotics is crucial for designing novel antimicrobial drugs. By creating a surface-supported planar bacterial outer membrane model, researchers can study these interactions and gain insights into membrane properties for drug design.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
One-Sun Lee, Mohamed E. Madjet, Khaled A. Mahmoud
Summary: The study conducted molecular dynamics simulations to investigate the interaction between MXene nanosheets and a model bacterial membrane, revealing that MXene adsorption could induce a local phase transition in the membrane and lead to cell lysis. This proposed bactericidal mechanism of MXenes provides a useful model for designing new antibacterial nanomaterials.
Article
Chemistry, Multidisciplinary
Rashad Kariuki, Rowan Penman, Saffron J. Bryant, Rebecca Orrell-Trigg, Nastaran Meftahi, Russell J. Crawford, Chris F. McConville, Gary Bryant, Kislon Voitchovsky, Charlotte E. Conn, Andrew J. Christofferson, Aaron Elbourne
Summary: Nanomaterials have the potential to revolutionize biological and biomedical research, and this study provides detailed insights into how gold nanoparticles interact with phospholipid membranes. The study shows that the nanoparticles can be absorbed and internalized by fluid-phase membranes, and partially embed into gel-phase membranes, causing perturbations throughout the bilayers.
Article
Biochemistry & Molecular Biology
Kathleen W. Swana, Terri A. Camesano, Ramanathan Nagarajan
Summary: Supported lipid bilayers (SLBs) on quartz crystals are versatile model systems for studying cell membrane behavior. This study successfully formed entirely anionic SLBs by treating the quartz crystal, which provides valuable model systems for studying interactions with Gram-positive bacterial membranes.
Article
Physics, Multidisciplinary
Eiji Yamamoto, Takuma Akimoto, Ayori Mitsutake, Ralf Metzler
Summary: The study demonstrates that protein conformational fluctuations directly affect the diffusion properties, showing synchronous fluctuations with diffusivity. The radius of gyration of proteins exhibits 1/f fluctuations. The validity of the Stokes-Einstein-type relation appears to be a general property based on analysis of different protein types.
PHYSICAL REVIEW LETTERS
(2021)
Article
Multidisciplinary Sciences
Joyce J. Wong, Zhongwen Chen, Jean K. Chung, Jay T. Groves, Theodore S. Jardetzky
Summary: Paramyxovirus membrane fusion requires an attachment protein binding to a host cell receptor and a fusion protein merging viral and host membranes. The dynamic events of NiV fusion activation involve G and ephrinB2 forming clusters, with ephrinB2 oligomerization being essential for F activation. Single-molecule tracking of F particles revealed an immobilized intermediate upon activation, and no stable F-G protein complexes were found.
Article
Materials Science, Multidisciplinary
Konstantinos Kallitsis, Anna-Maria Pappa, Zixuan Lu, Alberto Alvarez-Fernandez, Ioanna Charalambous, Sina Schack, Walther C. Traberg, Quentin Thiburce, Karan Bali, Graham Christie, Stefan Guldin, Susan Daniel, Alberto Salleo, Roisin M. Owens
Summary: This study presents a versatile method to modify the surface chemistry of conducting polymers, aiming to bridge the chemical gap between bioelectronic devices and biological systems. The surface of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) is modified to enhance the formation of cell-derived supported lipid bilayers (SLBs). The functionalized devices show improved electronic output and demonstrate the potential of this approach in membrane-on-a-chip systems.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Chemistry, Physical
Lech Gmachowski, Maciej Paczuski
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2015)
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Biophysics
Lech Gmachowski
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2018)
Article
Chemistry, Physical
Lech Gmachowski
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2008)
Article
Chemistry, Physical
Lech Gmachowski
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2008)
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Chemistry, Physical
Lech Gmachowski
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2009)
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Chemistry, Physical
Lech Gmachowski
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2010)
Article
Chemistry, Physical
Lech Gmachowski, Maciej Paczuski
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2011)
Article
Engineering, Chemical
Lech Gmachowski
JOURNAL OF AEROSOL SCIENCE
(2010)
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Engineering, Chemical
Lech Gmachowski
JOURNAL OF AEROSOL SCIENCE
(2013)
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Engineering, Chemical
Lech Gmachowski
JOURNAL OF AEROSOL SCIENCE
(2013)
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Biology
Lech Gmachowski
MATHEMATICAL BIOSCIENCES
(2014)
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Polymer Science
Lech Gmachowski
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Chemistry, Physical
Lech Gmachowski
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2019)
Article
Environmental Sciences
K. J. Rudzinski, L. Gmachowski, I. Kuznietsova
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2009)
