Article
Obstetrics & Gynecology
Frederikke Lihme, Saima Basit, Lisa G. Persson, Maria O. Larsen, Karin H. Lauridsen, Jacob A. Lykke, Anita S. Andersen, Karen Halse, Annette Thorsen-Meyer, Mads Melbye, Jan Wohlfahrt, Heather A. Boyd
Summary: This study aimed to establish reference ranges for maternal cardiac output, systemic vascular resistance, and stroke volume in the third trimester of pregnancy using the Ultrasound Cardiac Output Monitor 1A. The results showed that maximum cardiac output and stroke volume were measured in gestational weeks 30-32 and decreased over the third trimester, while systemic vascular resistance increased during the same period. The study not only provides reference ranges for clinicians to assess cardiac function during pregnancy, but also created a simple calculator for clinical practice.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Elisa Montaguti, Aly Youssef, Marta Cavalera, Maria Gaia Dodaro, Maria Cofano, Marta Fiorentini, Anita Pellegrino, Gianluigi Pilu
Summary: The study found an inverse correlation between pregnancy-associated plasma protein A (PAPP-A) and mean UTPI, indicating a relationship between placental function and maternal hemodynamics. Higher UTPI values were associated with lower cardiac output and higher peripheral resistances, with these women experiencing hypertensive disorders and fetal growth restriction postpartum. English summary
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Pediatrics
Karen Nora McCarthy, Andrea Pavel, Aisling A. Garvey, Ana-Louise Hawke, Criona Levins, Vicki Livingstone, Eugene M. Dempsey
Summary: This study aimed to measure cardiac output in term infants at delivery and in the first hours of life, finding that mean cardiac output measures using NICOM were lower than those found in studies using echocardiography.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Elisa Montaguti, Gaetana Di Donna, Aly Youssef, Gianluigi Pilu
Summary: Hypertensive disorders, including preeclampsia, are common in pregnancies and can have long-term cardiovascular consequences. Preeclampsia may not solely be caused by placental dysfunction, but also by maternal cardiovascular system failure to adapt to pregnancy. Evaluating maternal hemodynamic variables is important in identifying high-risk women and implementing appropriate prophylaxis.
JOURNAL OF MEDICAL ULTRASONICS
(2022)
Article
Biochemical Research Methods
Thien Nguyen, Kosar Khaksari, Siddharth M. Khare, Soongho Park, Afrouz A. Anderson, Janine Bieda, Eunjung Jung, Chaur-Dong Hsu, Roberto Romero, Amir H. Gandjbakhche
Summary: The study found a close relationship between placental oxygenation levels in pregnant women and pregnancy complications and placental pathology, with women with pregnancy complications having lower placental oxygenation levels. The wearable device designed in this study aims to continuously monitor placental oxygenation levels and assess maternal and fetal health.
BIOMEDICAL OPTICS EXPRESS
(2021)
Review
Pediatrics
Roisin O'Neill, Eugene M. Dempsey, Aisling A. Garvey, Christoph E. Schwarz
Summary: Circulatory monitoring in neonatal care is currently limited to heart rate and blood pressure assessment, but non-invasive cardiac output monitoring (NiCO) is gaining popularity in term and preterm neonates. This narrative review summarized 33 studies involving nearly 2,000 neonates and focused on the interchangeability with echocardiography. The review also discussed the application of NiCO in various clinical settings and highlighted the need for future research goals.
FRONTIERS IN PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Mullaly Rachel, Miletin Jan, Cary Heather, Semberova Jana
Summary: This study aims to determine the feasibility of measuring changes in cardiac output (CO) after elective extubation in neonates using transthoracic bioreactance (TBR). The results suggest that extubation significantly influences CO in neonatal patients, and the pattern of change appears to be related to the status of patent ductus arteriosus (PDA) prior to extubation.
EARLY HUMAN DEVELOPMENT
(2022)
Article
Medicine, General & Internal
Marije Wijnberge, Bjorn van der Ster, Alexander P. J. Vlaar, Markus W. Hollmann, Bart E. Geerts, Denise P. Veelo
Summary: Intraoperative hypotension is associated with postoperative complications, and the current intermittent cuff measurement method may result in missed events and delayed recognition of hypotensive events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Nnamdi I. Azih, Jacob M. Read, Gregory R. Jackson, Chak Inampudi, Lucas Witer, Arman Kilic, Nicholas H. Pope, Jennifer Hajj, Francois Haddad, Ryan J. Tedford, Brian A. Houston
Summary: There is ongoing debate on the best method to measure cardiac output (CO) in patients with left ventricular assist devices (LVAD). This study compared direct Fick CO with thermodilution (TD) and indirect Fick (iFick) CO in 61 LVAD patients. TD and LaFarge iFick showed moderate correlation with direct Fick, while Dehmer and Bergstra iFick showed poor correlation. All CO estimation techniques tended to overestimate CO compared to direct Fick, with the least bias and discrepancy observed using TD and Lafarge iFick methods.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Review
Critical Care Medicine
Virendra K. Arya, Waiel Al-Moustadi, Vikas Dutta
Summary: This article reviews various contemporary CO measurement technologies available and their utility in critically ill patients. Pulmonary artery catheter is the most accurate method, but its invasiveness may cause complications. Noninvasive devices predict CO via mathematical modeling, but are prone to errors in clinical situations. CCE provides CO and helps in differential diagnosis.
CURRENT OPINION IN CRITICAL CARE
(2022)
Article
Medicine, General & Internal
Lindsey A. Crowe, Leon Genecand, Anne-Lise Hachulla, Stephane Noble, Maurice Beghetti, Jean-Paul Vallee, Frederic Lador
Summary: The use of MRI to measure cardiac output is essential for pulmonary hypertension patients. The study found that SVMRI did not have interchangeability with SVTD, but showed better agreement when compared against each other.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Elisa Montaguti, Gaetana Di Donna, Gianluigi Pilu
Summary: Cardiovascular changes during pregnancy are debated, with complications like hypertension leading to poor changes in cardiovascular health. Monitoring high TVR in chronic hypertension patients can help identify those at risk for developing severe conditions.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Vinod Kumar, Shyamalima Buragohain, Parag Jyoti Deka, Goutam Narayan, Govindhaswamy Umapathy
Summary: The study on captive pygmy hogs revealed strong seasonality patterns in births from the breeding center, with successful detection of pregnancies in females. Fecal testosterone metabolite concentrations were significantly higher in males during the breeding season, while a significant difference in fecal progesterone metabolites concentration was observed between non-pregnant and pregnant females.
Article
Obstetrics & Gynecology
Ido Laskov, Sharon Alpern, Ilai Ronel, Roy Segal, Ofra Zindel, Ilanit Zoborovsky, Nadav Michaan, Dan Grisaru
Summary: This study assessed the effects of CO2 pneumoperitoneum and steep Trendelenburg position on cardiac function and hemodynamics in endometrial cancer patients undergoing minimally invasive surgery. Significant hemodynamic changes were observed during surgery, with CO2 insufflation causing the most dramatic deterioration. Knowledge of hemodynamic values in high-risk women during surgery may help ensure a safer procedure.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Biophysics
Shu Gong, Lim Wei Yap, Yuxin Zhang, Jinyuan He, Jialiang Yin, Faezeh Marzbanrad, David M. Kaye, Wenlong Cheng
Summary: This study reports a lightweight and user-friendly non-invasive wearable cardiac sensing system based on deformation-insensitive conductive gold nanowire foam and pressure-sensitive resistive gold nanowire electronic skin. The system enables real-time recording of electrocardiogram and artery pulses under dynamic real-world settings, and can also estimate blood pressure using machine learning algorithms.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Pediatrics
Christine E. Jones, Heather Bailey, Alasdair Bamford, Anna Calvert, Robert B. Dorey, Simon B. Drysdale, Asma Khalil, Paul T. Heath, Hermione Lyall, Kate Monica Isabel Ralph, Shari Sapuan, Tushna Vandrevala, Simone Walter, Elizabeth Whittaker, Sharon Wood
Summary: Congenital human cytomegalovirus (CMV) infection is a common condition with long-term consequences for children. However, it is not well-known among pregnant women, families, and healthcare providers. Timely diagnosis and treatment are important for reducing transmission and improving outcomes for infants. Further research is needed to inform screening, outcomes, and treatment decisions.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Nutrition & Dietetics
Pilar Palmrich, Alexandra Thajer, Nawa Schirwani, Christina Haberl, Harald Zeisler, Robin Ristl, Julia Binder
Summary: This study indicates that the majority of pregnant women are deficient in vitamin D during pregnancy, despite the intake of pregnancy vitamins containing vitamin D. Therefore, individualized vitamin D assessment should be considered to ensure adequate supplementation and prevention of hypovitaminosis D.
Review
Acoustics
F. D'Antonio, D. Marinceu, S. Prasad, N. Eltaweel, A. Khalil
Summary: This systematic review examines the outcomes of laser surgery for twin-twin transfusion syndrome (TTTS) in monochorionic diamniotic (MCDA) twin pregnancies complicated by selective fetal growth restriction (sFGR). The study finds that MCDA twin pregnancies with TTTS and sFGR have a higher risk of fetal loss after laser surgery, as well as a higher risk of neurological morbidity in the donor twin.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
S. Prasad, C. Di Fabrizio, N. Eltaweel, E. Kalafat, A. Khalil
Summary: The objective of this study was to assess the predictive accuracy of first-trimester choroid-plexus-to-lateral-ventricle/head ratios for development of ventriculomegaly at a later gestational age. The study found that first-trimester fetal choroid-plexus-to-lateral-ventricle/head ratios have good predictive accuracy for the development of ventriculomegaly.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
A. R. Anness, M. Nath, M. W. Osman, D. Webb, T. Robinson, A. Khalil, H. A. Mousa
Summary: This study aimed to investigate the difference in arterial stiffness (AS) between women with gestational diabetes mellitus (GDM) and healthy women, as well as the impact of different treatment modalities. The results showed that regardless of the treatment modality, pregnant women with GDM had significantly higher AS compared to low-risk pregnancies. The findings provide the basis for further research on the association between metformin therapy, changes in AS, and the risk of placenta-mediated diseases.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Multidisciplinary Sciences
Laura A. Magee, Erika Molteni, Vicky Bowyer, Jeffrey N. Bone, Harriet Boulding, Asma Khalil, Hiten D. Mistry, Lucilla Poston, Sergio A. Silverio, Ingrid Wolfe, Emma L. Duncan, Peter von Dadelszen
Summary: Among women of reproductive age, older age, White ethnicity, and being in the least-deprived index of multiple deprivation are independently associated with higher vaccine uptake. Ethnicity has the strongest influence, while multiple deprivation has the weakest. These findings are crucial for informing future vaccination policies and public messaging.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Samantha Knights, Smriti Prasad, Erkan Kalafat, Anahita Dadali, Pam Sizer, Francoise Harlow, Asma Khalil
Summary: This study demonstrates that routine third trimester ultrasound or point-of-care ultrasound (POCUS) is associated with a reduction in undiagnosed term breech presentations and improved neonatal outcomes.
Article
Cell Biology
Clara Apicella, Camino S. M. Ruano, Basky Thilaganathan, Asma Khalil, Veronica Giorgione, Geraldine Gascoin, Louis Marcellin, Cassandra Gaspar, Sebastien Jacques, Colin E. Murdoch, Francisco Miralles, Celine Mehats, Daniel Vaiman
Summary: In this study, we aimed to identify genetic variants affecting gene expression in the human placenta, specifically in normal and pathological situations. The analysis was constrained by the fact that placental tissue samples from diseased individuals are typically obtained at an earlier gestational age compared to control samples, leading to confounding factors in transcriptome regulation. To address this issue, we implemented a novel approach that accounted for gestational age and identified disease-specific cis-eQTLs. Through statistical correction and analysis, we identified a list of e-genes that significantly influenced expression levels, demonstrating the validity of our methodology for future research purposes.
Review
Genetics & Heredity
Hiba J. Mustafa, Faezeh Aghajani, Zinah A. Bairmani, Asma Khalil
Summary: This study is the first systematic review and meta-analysis comparing expectant management (EM) versus treatment with NSAIDs in fetuses with EA/TVD with a circular shunt. The results showed that the NSAID group had significantly higher rates of live birth and survival to hospital discharge compared with the EM group, but the number of cases treated with NSAIDs was small, with limited safety data.
PRENATAL DIAGNOSIS
(2023)
Review
Genetics & Heredity
Hiba J. Mustafa, Faezeh Aghajani, Mohammad Jawwad, Nensi Shah, Alfred Abuhamad, Asma Khalil
Summary: This study investigated the outcomes of fetuses with hypoplastic left heart syndrome (HLHS) and intact or restrictive atrial septum (I/RAS) managed expectantly or with fetal atrial septal intervention (FASI). The study found no differences in survival rates between the two groups, but FASI may lead to a less restrictive septum at birth. Future multicenter studies are needed for better identification of cases with improved outcomes and standardized techniques and definitions.
PRENATAL DIAGNOSIS
(2023)
Correction
Multidisciplinary Sciences
Laura A. Magee, Erika Molteni, Vicky Bowyer, Jeffrey N. Bone, Harriet Boulding, Asma Khalil, Hiten D. Mistry, Lucilla Poston, Sergio A. Silverio, Ingrid Wolfe, Emma L. Duncan, Peter von Dadelszen, Debra Bick
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Elisabeth Calek, Julia Binder, Pilar Palmrich, Felix Eibensteiner, Alexandra Thajer, Theresa Kainz, Karin Harreiter, Angelika Berger, Christoph Binder
Summary: Differentiating between IUGR and constitutionally small infants is essential for the nutritional management.
Review
Medicine, General & Internal
Francesco D'Antonio, Nashwa Eltaweel, Smriti C. Prasad, Maria Elena C. Flacco, Lamberto C. Manzoli, Asma C. Khalil
Summary: This systematic review and meta-analysis aimed to evaluate the role of cervical cerclage in preventing preterm birth and adverse outcomes in twin pregnancies. The findings suggest that cervical cerclage in twin pregnancies with short cervical length or cervical dilatation is associated with a reduced risk of preterm birth and improved neonatal outcomes. However, confirmation of these findings in large and well-designed randomized controlled trials is needed for stronger evidence.
Article
Medicine, General & Internal
Nawa Schirwani-Hartl, Pilar Palmrich, Christina Haberl, Nicole Perkmann-Nagele, Herbert Kiss, Angelika Berger, Judith Rittenschober-Bohm, Gregor Kasprian, Patric Kienast, Asma Khalil, Julia Binder
Summary: This retrospective analysis investigated the efficacy of administering hyperimmune globulin (HIG) therapy every 2 weeks compared to every 4 weeks in pregnant women with primary cytomegalovirus (CMV) infection. The study found no significant difference in congenital CMV rates or fetal ultrasound and magnetic resonance imaging (MRI) anomalies between the two groups. Larger studies are needed to evaluate the impact of administering HIG every 2 weeks on maternal-fetal transmission rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Pilar Palmrich, Nawa Schirwani-Hartl, Christina Haberl, Peter Haslinger, Florian Heinzl, Harald Zeisler, Julia Binder
Summary: Decreased serum catestatin levels are associated with the development of preeclampsia. Further research on the diagnostic and therapeutic role of catestatin in preeclampsia is necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)