Article
Biochemistry & Molecular Biology
Kainat Shafique, Aftab Farrukh, Tariq Mahmood Ali, Sumera Qasim, Laila Jafri, Hisham S. M. Abd-Rabboh, Murefah Mana AL-Anazy, Saima Kalsoom
Summary: A new series of 1,2,3-triazole derivatives were synthesized via a click one-pot reaction. These compounds showed activity against targeted protein 1T69 during molecular docking studies. The synthesized compounds were characterized and screened for their alpha-amylase and alpha-glucosidase inhibitory activities. Compound K-1 exhibited the highest antidiabetic activity and could be further developed as a promising molecule for antidiabetic compounds.
Article
Chemistry, Applied
Vighneshwar Shridhar Bhat, Anna Lee
Summary: A one-pot, three-component synthesis of 3-arylsulfonylated thioflavones has been developed, where the reactions were carried out without using any catalysts or additives, and the desired products were obtained through intramolecular radical cyclization. This method provides an alternative route for the synthesis of thioflavone derivatives, which have been found in various bioactive compounds.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Yupeng Cao, Haifeng Huang, Limin Wang, Xiangyang Lin, Jun Yang
Summary: In this study, the nitration of NH on the 1,2,3-triazole ring and the synthesis of nitrogen-rich energetic compounds were reported. A novel fused nitrogen-rich heterocycle was obtained, showing high nitrogen content and good thermal stability. The compounds synthesized exhibited high detonation velocity and detonation pressure.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Yupeng Cao, Haifeng Huang, Limin Wang, Xiangyang Lin, Jun Yang
Summary: In this study, the nitration of NH on the 1,2,3-triazole ring was reported, and several nitrogen-rich energetic compounds were synthesized based on the key intermediate 4-azido-5-(chlorodinitromethyl)-2-nitro-2H-1,2,3-triazole (5). Compound 5 was successfully constructed from 4-amino-1H-1,2,3-triazole-5-carbonitrile (1) through four steps. Furthermore, potassium 4-azido-5-(dinitromethyl)-2H-1,2,3-triazole (6), diammonium (8), and dihydrazinium (9) salts were synthesized and characterized. A novel fused nitrogen-rich heterocycle, 6H-[1,2,3]triazolo[4,5-d][1,2,3] triazine-6,7-diamine (10), with high nitrogen content and good thermal stability, as well as insensitivity to mechanical stimuli, was obtained.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Soheila Molaei, Ghazaleh Farhadi, Mina Talezari, Negin Gholizadeh, Karim Mahnam, Ali Keivanloo, Saghi Sepehri
Summary: Novel hybrids with 1,2,3-triazole and polyhydroquinoline scaffolds were successfully synthesized by multicomponent reaction followed through click reaction. Their anti-leishmanial activity was evaluated and three hybrids showed the highest activity with low cytotoxicity. Molecular docking and dynamics simulations were performed to explore possible mechanisms.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Organic
Hans-Ulrich Reissig, Fei Yu
Summary: In this study, the nucleophilic substitution of benzylic bromides with sodium azide and copper-catalyzed cycloaddition with terminal alkynes were combined to successfully synthesize complex alkynes bearing 1,2-oxazinyl substituents. The use of tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) as a ligand for the click step was found to be highly advantageous. However, the reductive cleavage of the 1,2-oxazine rings to aminopyran moieties did not proceed cleanly with these compounds.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Jianjing Yang, Ting Zeng, Kelu Yan, Zonghui Qin, Jiangwei Wen
Summary: This study successfully developed a one-pot three-component cross-coupling reaction mediated by electrolysis, which provides a straightforward method for the synthesis of alkylthioimidazoles without the need for metal catalysts and oxidants. Water is used as the co-solvent at room temperature.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Organic
Christopher A. Hughes-Whiffing, Alexis Perry
Summary: A rapid one-pot method for synthesizing 1,2,3-trisubstituted indoles has been developed, utilizing Fischer indolisation-indole N-alkylation sequence. The procedure is operationally straightforward, with high yields, using readily available building blocks to generate densely substituted indole products. This process has been successfully demonstrated in the synthesis of various indoles, benzoindoles, and tetrahydrocarbazoles with diverse and useful functionalities.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Ahmad Allahbakhsh, Zeinab Jarrahi, Gholamali Farzi, Amin Shavandi
Summary: Cu-based nanostructures with controlled morphological and structural properties were synthesized via a solvosonication process using graphene oxide nanosheets. The size range of Cu-BTC nanoparticles could be adjusted by varying the content of graphene oxide in the precursor solution. The antibacterial activity of Cu-BTC/graphene oxide nanocomposites is directly influenced by the structure and morphology of Cu-BTC nanoparticles, with the smallest nanoparticles showing the highest activity.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Medicinal
Tommaso Felicetti, Maria Sole Burali, Chin Piaw Gwee, Kitti Wing Ki Chan, Sylvie Alonso, Serena Massari, Stefano Sabatini, Oriana Tabarrini, Maria Letizia Barreca, Violetta Cecchetti, Subhash G. Vasudevan, Giuseppe Manfroni
Summary: A sustainable three-component reaction (3CR) was developed for synthesizing PBTZ analogues with broad-spectrum anti-flavivirus activity, with compound 22 identified as the best inhibitor in a new series. These results support PBTZ derivatives as promising anti-flavivirus agents for further development studies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Anisoara Oubraham, Daniela Ion-Ebrasu, Felicia Vasut, Amalia Soare, Ioan-Sorin Sorlei, Adriana Marinoiu
Summary: This paper presents the preparation of platinum on a reduced graphene oxide matrix (PtrGO) using the microwave-assisted method with three different pH solutions. The platinum concentration determined by energy-dispersive X-ray analysis (EDX) was 4.32 (weight%), 2.16 (weight %) and 5.70 (weight%), corresponding to pH 3.3, 11.7 and 7.2, respectively. Pt functionalization of reduced graphene oxide (rGO) decreased the rGO specific surface, as shown by Brunauer, Emmett and Teller (BET) analysis.
Article
Chemistry, Organic
Ting Zhou, Liangliang Yang, Ming Lang, Shiyong Peng
Summary: An efficient one-pot sequential annulation of 1,n-enynes with tosyl azide is reported, providing a series of novel N-alkyl 1,2,3-triazole-fused polycyclic scaffolds in moderate to excellent yields under mild reaction conditions.
SYNTHESIS-STUTTGART
(2022)
Article
Chemistry, Multidisciplinary
Gao He, Ziwei Zhang, Yanhui Zhu, Xiafei Yu, Fangze Qian, Xiaoqiang Zhang, Yu Luo, Xiang Li, Xiaoan Liu, Yong Hu
Summary: This study presents the design of high-performance cascade nanobioreactors using hierarchical porous DNA nanoflowers to convert gas donor into gas molecule in tumor microenvironment. The application of external ultrasound irradiation enhances the gas therapy effect.
Article
Chemistry, Medicinal
E. Ramya Sucharitha, Thupurani Murali Krishna, Ravinder Manchal, Gondru Ramesh, Sirassu Narsimha
Summary: This paper describes an efficient method for synthesizing new compounds through catalyzed reactions and investigates their antimicrobial activity and drug potency. The results show that some compounds exhibit good antimicrobial activity, inhibiting Bacillus subtilis and Staphylococcus epidermidis, as well as showing strong effects on biofilm growth.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Organic
Pavel S. Gribanov, Edita M. Atoian, Anna N. Philippova, Maxim A. Topchiy, Andrey F. Asachenko, Sergey N. Osipov
Summary: An efficient one-pot methodology has been developed for the synthesis of 5-amino-1,2,3-triazole derivatives under solvent-free conditions, using a combination of dipolar azide-nitrile cycloaddition and Dimroth rearrangement.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
