Journal
TURKISH JOURNAL OF CHEMISTRY
Volume 41, Issue 3, Pages 345-353Publisher
Tubitak Scientific & Technological Research Council Turkey
DOI: 10.3906/kim-1607-68
Keywords
Cephoside A; Dipsacaceae; triterpene saponin; iridoid glycoside; cytotoxic activity; Cephalaria; anemoclemoside A
Funding
- Office of Ege University, Izmir, Turkey [2013/Fen/035]
- Scientific Research Projects Coordination Unit of Istanbul University [29681]
- TUBITAK [BIDEB 2211-A]
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Investigation of the aerial parts of Cephalaria elazigensis var. purpurea afforded one new oleanane-type saponin, namely cephoside A (1), and five known natural compounds (2-6). Compound 2, named anemoclemoside A, which is an unusual triterpene glycoside, was identified in the family Dipsacaceae for the first time. Chemical structures of all compounds were determined on the basis of the HRESIMS and 1D and 2D NMR data. Cephoside A (1) and anemoclemoside A (2) were assessed for their cytotoxic activities against HeLa cells, having IC50 values of 495 and 135 mu g/mL, respectively.
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