Article
Biochemistry & Molecular Biology
Xiaoxiong Xiao, Lei Jiang, Huoli Hu, Yunhe Huang, Lun Yang, Yang Jiao, Guangxia Wei
Summary: UAP1L1 is overexpressed in esophageal squamous cell carcinoma (ESCC) and its increased expression correlates with disease progression. Knockdown of UAP1L1 inhibits ESCC development by inducing apoptosis through the regulation of apoptosis-related proteins. Additionally, UAP1L1 promotes ESCC progression by affecting the PI3K/Akt, CCND1, and MAPK pathways.
MOLECULAR CARCINOGENESIS
(2021)
Article
Neurosciences
Domantas Vaiciulis, Alvita Vilkeviciute, Greta Gedvilaite, Brigita Glebauskiene, Loresa Kriauciuniene, Rasa Liutkeviciene
Summary: The study revealed that SIRT1 rs7895833 G/G genotype is associated with about 13-fold increased odds of active PA development, and SIRT1 serum levels are significantly higher in women with PA compared to healthy women.
Article
Clinical Neurology
Dimin Zhu, Zheng Xiao, Zongming Wang, Bin Hu, Chengbin Duan, Ziyan Zhu, Nailin Gao, Yonghong Zhu, Haijun Wang
Summary: MEG3 and MIR-3768-3P expression levels were found to be decreased in patients with CNFPA, and their excessive expression inhibited tumorigenesis and promoted apoptosis in PDFS cells. MEG3 acted as an enhancer of MIR-3768-3P expression, while HMGA2 served as an oncogene in pituitary adenoma that could be negatively regulated by MEG3 via enriching MIR-3768-3P, revealing a novel regulatory network in CNFPAs.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Rongxin Geng, Xiaonan Zhu, Xiang Tao, Junhui Liu, Haitao Xu
Summary: This study found that EIF1A is upregulated in human pituitary adenoma cells and depletion of EIF1A can severely limit cell proliferation, weaken cell migration capacity, and increase apoptosis of tumor cells. The study demonstrates that EIF1A plays a prominent role in facilitating tumor cell proliferation and migration.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Petros Stefanidis, Georgios Kyriakopoulos, Andreas Miltiadis Seretis, Stefanos Korfias, Stamatios Theocharis, Anna Angelousi
Summary: This study evaluated the expression of Ki-67, CD-56, Cyclin-D1, and E-Cadherin in pituitary adenomas (PAs) and their association with clinical manifestation, tumor size, invasiveness, and risk of recurrence. Cyclin-D1 and Ki-67 were found to be positively correlated with tumor size, recurrence, extension beyond the sellar region, and invasion of the cavernous sinus. However, there was no correlation between CD-56 and E-Cadherin expression and the parameters mentioned above. Cyclin-D1 and Ki-67 may be promising markers in predicting the behavior and recurrence of PAs, but further studies are needed to confirm their role in routine evaluation of PAs.
Article
Biochemistry & Molecular Biology
Apor Veres-Szekely, Domonkos Pap, Beata Szebeni, Laszlo Orfi, Csenge Szasz, Csenge Pajtok, Eszter Levai, Attila J. Szabo, Adam Vannay
Summary: Fibroblasts play a central role in diseases such as idiopathic pulmonary fibrosis. This study developed a cost-effective method to examine fibroblast migration and discussed the advantages of combining different functional assays in drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hu Keqi, Liu Handong
Summary: The study revealed up-regulated CYTOR in IPA tissues and cell lines, which was associated with adenoma invasiveness and size. Down-regulation of CYTOR decreased the proliferation, migration, and invasion of HP75 cells, while up-regulation of miR-206 inhibited these processes.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Medicine, General & Internal
Liang Lu, Xueyan Wan, Yu Xu, Juan Chen, Kai Shu, Ting Lei
Summary: Invasiveness is an important predictor of surgical outcome and long-term prognosis in patients with pituitary adenomas (PAs). This study assessed PA invasiveness through radiological, surgical, and histological perspectives and established a classification scheme to predict invasive behavior and poor prognosis. The study found that radiological and surgical invasiveness were better predictors of complete resection and recurrence/progression-free survival rates than histological invasiveness. Knosp grades with surgical invasiveness were also better predictors of prognosis compared to Knosp grades without surgical invasiveness. The classification schemes developed based on invasiveness and Knosp classification were found to be clinically valuable in predicting prognosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Miho Takahashi, Yoshie Umehara, Hainan Yue, Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Risa Ikutama, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda, Francois Niyonsaba
Summary: hBD-3 promotes wound healing by enhancing fibroblast proliferation and migration, as well as increasing angiogenesis. It also stimulates the secretion of angiogenic growth factors in fibroblasts through the FGFR1/JAK2/STAT3 pathway activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chao-Yuan Chang, Yung-Chi Huang, Hung-Hsing Chiang, Yu-Yuan Wu, Kuan-Li Wu, Yung-Yun Chang, Lian-Xiu Liu, Ying-Ming Tsai, Ya-Ling Hsu
Summary: Lung cancer, especially in Taiwan, is a highly lethal type of cancer. Delayed diagnosis and lack of effective targets for drug treatment contribute to the poor prognosis of advanced lung cancer. These issues deserve more attention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Haitao Wen, Zhenwei Li, Sirong Song, Lixia Xu, Xiaoguang Tong, Hua Yan
Summary: This study demonstrated that LBX2-AS1 is significantly increased and negatively correlated with prognosis in glioma. Silencing LBX2-AS1 inhibited the proliferation, migration, and invasion of glioma cells and increased apoptosis. LBX2-AS1 was found to regulate the Akt/GSK3 beta pathway, making it a potential new target for glioma therapy.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Cell Biology
Jingdian Liu, Junwen Wang, Weidong Tian, Yu Xu, Ran Li, Kai Zhao, Chao You, Yuan Zhu, Joerg Walter Bartsch, Hongquan Niu, Huaqiu Zhang, Kai Shu, Ting Lei
Summary: This study demonstrates for the first time that PDCD10 can induce aggressive behaviors of pituitary adenomas by promoting cellular proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) through the CXCR2-AKT/ERK signaling axis.
Article
Biophysics
Maki Nakamura, Hiroko Araki, Hideo Tsurushima, Ayako Oyane
Summary: In this study, biocompatible calcium phosphate nanoparticles were successfully fabricated as a multifunctional delivery carrier of basic fibroblast growth factor (bFGF). These nanoparticles co-immobilized bFGF, heparin, and ferucarbotran, and showed stable dispersion in water. They released bFGF in a dose-dependent manner and promoted or inhibited cell proliferation depending on the cell type and dose.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Oncology
Roberto Campagna, Eleonora Salvolini, Veronica Pompei, Valentina Pozzi, Alessia Salvucci, Elisa Molinelli, Valerio Brisigotti, Davide Sartini, Anna Campanati, Annamaria Offidani, Monica Emanuelli
Summary: Melanoma, despite its small proportion of all skin tumors, is a major contributor to skin cancer-related deaths. This study identified NNMT enzyme as a potential therapeutic target for melanoma treatment, demonstrating that reducing NNMT levels can significantly inhibit cell proliferation and migration, as well as enhance sensitivity to chemotherapy drugs in melanoma cells.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Oncology
Cheng-Hsin Lu, Chun-Hsien Wu, Pei-Fang Hsieh, Chen-Yu Wu, Wade Wei-Ting Kuo, Chien-Hui Ou, Victor Chia Hsiang Lin
Summary: Enzalutamide is a treatment option for castration-resistant or metastatic prostate cancer. However, some patients develop resistance to enzalutamide after a period of treatment. This study investigated the role of N-cadherin in prostate cancer cells and found that downregulating its expression had a significant impact on cell physiology, suggesting it as a potential therapeutic option.