Article
Gastroenterology & Hepatology
Shu-Chi Wang, Chia-Yang Li, Wen-Tsan Chang, Wei-Chung Cheng, Chia-Hung Yen, Wen-Yu Tu, Zu-Yau Lin, Ching-Chih Lin, Ming-Lun Yeh, Chung-Feng Huang, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Yao-Li Chen, Ming-Lung Yu
Summary: Differentiation antagonizing non-protein coding RNA plays a crucial role in the progression of hepatitis C virus-related hepatocellular carcinoma. Circulating exosomal differentiation antagonizing non-protein coding RNA may serve as a non-invasive prognostic biomarker for predicting the outcome of hepatitis C virus-related hepatocellular carcinoma.
LIVER INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Hongwei Yan, Qi Liu, Jieming Jiang, Xufang Shen, Lei Zhang, Zhen Yuan, Yumeng Wu, Ying Liu
Summary: This study utilized high-throughput sequencing to analyze the transcriptome of tiger pufferfish gonads, identifying numerous miRNAs and lncRNAs potentially involved in regulating sex-related gene expression. Differential expression analysis revealed specific miRNAs and lncRNAs that were up-regulated or down-regulated in male gonads compared to female gonads. These findings could lead to further research on the function of miRNAs and lncRNAs in sex determination and differentiation.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Marianne C. Kramer, Hee Jong Kim, Kyle R. Palos, Benjamin A. Garcia, Eric Lyons, Mark A. Beilstein, Andrew D. L. Nelson, Brian D. Gregory
Summary: This article investigates a previously unstudied group of lncRNAs, lncCOBRA, and demonstrates that one member, lncCOBRA1, shows tissue and developmental specific expression in Arabidopsis thaliana. It is shown that plants lacking lncCOBRA1 exhibit delayed germination and stunted growth, indicating the important role of lncCOBRA1 in plant development.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Medicine, Research & Experimental
Lizhi Zhang, Mengfei Sheng, Huake Cao, Lei Zhang, Wei Shao
Summary: Periodontitis is an inflammatory disease that results in the loss of alveolar bone and periodontal ligament. Genetic factors contribute to roughly half of severe cases. Long non-coding RNAs (lncRNAs) have been found to play a crucial role in the pathogenesis of periodontitis, influencing processes such as osteogenic differentiation, inflammation, and apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemical Research Methods
Dongqing Zhao, Chunqing Wang, Shuai Yan, Ruibing Chen
Summary: Long non-coding RNAs (lncRNAs) play crucial regulatory roles in gene regulation, chromatin remodeling, and development. Understanding the protein interactions of lncRNAs is important for elucidating their functions and mechanisms. Mass spectrometry and other methods have identified many proteins that interact with lncRNAs.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xiaocong Lin, Guodan Li, Xiuwen Yan, Weiyu Fu, Jie Ruan, Hang Ding, Huajun Yu, Xiaoyi Chen, Liubo Lan, Yong Dai, Kai Pan, Xinguang Liu, Haitao Zhang
Summary: This study identifies lncRNA BC002811 as a critical regulator in the development and progression of gastric cancer. BC002811 is upregulated in GC tissues and cell lines and its high expression is associated with reduced overall survival in GC patients. BC002811 promotes GC cell proliferation, migration, invasion, and inhibits apoptosis in vitro, and accelerates tumor growth and metastasis in vivo. It upregulates MMP2 and MMP9 and promotes GC cell metastasis by downregulating PTEN expression and blocking SOX2 binding to the PTEN promoter.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Zihao Chen, Yong Li, Bibo Tan, Fang Li, Qun Zhao, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Yu Liu, Dong Wang
Summary: This study revealed that Lnc_ASNR is highly expressed in gastric cancer and promotes cell proliferation, migration, and invasion by regulating the miR-519e-5p/FGFR2 pathway. Lnc_ASNR functions as a ceRNA targeting miR-519e-5p, and its effects are closely related to epithelial-mesenchymal transition (EMT) in gastric cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pathology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Mohammad Taheri, Mohammadreza Hajiesmaeili
Summary: Long intergenic non-coding RNAs (lincRNAs) are a group of long non-coding RNAs that do not overlap with protein-coding genes, playing roles in chromatin configurations and cancer pathoetiology. LINC00460, a member of this group, acts as a sponge for tumor suppressor miRNAs, increasing oncogenic targets expression and affecting chemotherapeutic agents sensitivity of cancer cells.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Fadime Mutlu Icduygu, Egemen Akgun, Demet Sengul, Asuman Ozgoz, Ebru Alp
Summary: This study investigated the expression and clinical significance of SOX2OT, DANCR, and TINCR in papillary thyroid cancer. The results showed that the expression levels of SOX2OT and DANCR were increased in tumor samples, while TINCR expression did not show significant difference. Furthermore, the expression of SOX2OT and DANCR was associated with certain clinical characteristics. The findings suggest that DANCR may contribute to the development of papillary thyroid cancer, while SOX2OT may contribute to both the development and progression of the cancer.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Oncology
Zehang Zhuang, Jing Huang, Weiwang Wang, Cheng Wang, Pei Yu, Jing Hu, Haichao Liu, Hanqi Yin, Jinsong Hou, Xiqiang Liu
Summary: This study identified a differentiation-related lncRNA, TINCR, in oral squamous cell carcinoma (OSCC). TINCR was found to be downregulated in tumor tissues and correlated with pathological differentiation and lymph node metastasis. Function experiments showed that TINCR played a crucial role in cell differentiation and suppressed cell migration and invasion in OSCC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Ying Liu, Xiang Ao, Yu Wang, Xiaoge Li, Jianxun Wang
Summary: Gastric cancer is the third leading cause of cancer-related deaths worldwide, and chemotherapy is an important treatment method. However, most patients develop resistance to chemotherapy drugs. Recent studies have found that lncRNAs are involved in gastric cancer drug resistance and they regulate drug resistance through various mechanisms. Some lncRNAs have potential clinical applications.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yifan Li, Lan Lu, Xu Wu, Qianxiu Li, Yueshui Zhao, Fukuan Du, Yu Chen, Jing Shen, Zhangang Xiao, Zhigui Wu, Wei Hu, Chi Hin Cho, Mingxing Li
Summary: This review summarizes the research progress on the roles of long non-coding RNAs (lncRNAs) in gastric cancer (GC), focusing on their involvement in Helicobacter pylori infection, GC metastasis, tumor microenvironment regulation, drug resistance, and associated signaling pathways. LncRNAs may serve as novel biomarkers for diagnosis and prognosis of GC and potential therapeutic targets.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Cell Biology
Jihui Lee, Hara Kang
Summary: Sarcopenia is an age-related disease that can be regulated by alterations in the expression levels of non-coding RNAs, leading to muscle atrophy and dysfunction. Exercise can affect the expression patterns of non-coding RNAs involved in sarcopenia.
Review
Medicine, Research & Experimental
Bo Cao, Guoxiao Liu, Wang Zhang, Yajiao Shi, Bo Wei
Summary: Gastric cancer is a malignancy with high incidence and mortality rates globally, and non-coding RNAs, including circRNAs and lncRNAs, have been shown to play important roles in gastric carcinogenesis, serving as potential biomarkers for clinical diagnosis and prognosis. While significant progress has been made, there are still numerous issues to be addressed and further development is needed in this field.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Oncology
Gaurav Kumar Pandey, Chandrasekhar Kanduri
Summary: This article reviews the functional role and potential therapeutic applications of long non-coding RNA (lncRNA) in tumor development and discusses the extent of their decisive contribution to cancer development.
