Article
Biochemistry & Molecular Biology
Maria Panagopoulou, Andrianna Drosouni, Dionysios Fanidis, Makrina Karaglani, Ioanna Balgkouranidou, Nikolaos Xenidis, Vassilis Aidinis, Ekaterini Chatzaki
Summary: ENPP2 methylation profiles differ in breast cancer tissues compared to healthy tissues, impacting mRNA expression and related to metastasis and cancer stage. Methylation of the first exon in circulating cell-free DNA may serve as a potential biomarker for diagnosis and monitoring of breast cancer, with implications for liquid biopsy applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zelei Yang, Xiaoyun Tang, Todd P. W. McMullen, David N. Brindley, Denise G. Hemmings
Summary: The study found that HCMV infection in the tumor microenvironment preferentially targets tumor-associated fibroblasts and breast cancer cells expressing PDGFR alpha, and the infection rates in different cell lines are closely related to the expression level of PDGFRA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Andrianna Drosouni, Maria Panagopoulou, Vassilis Aidinis, Ekaterini Chatzaki
Summary: This review summarizes the role and regulation of Autotaxin (ATX) in breast cancer pathogenesis, highlighting its potential as a therapeutic target and biomarker. The article discusses the latest research on aberrant signaling through the ATX-LPA pathway in breast cancer and the role of ENPP2 expression and epigenetic modification.
Article
Biochemistry & Molecular Biology
Ganesh Venkatraman, Xiaoyun Tang, Guangwei Du, Amadeo M. Parisentti, Denise G. Hemmings, David N. Brindley
Summary: Lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) promote vasculogenesis, angiogenesis, and wound healing by activating overlapping signaling pathways that stimulate cell growth, survival, and migration. Maladaptive signaling by LPA and S1P can increase tumor progression and reduce patient outcomes post-chemotherapy and radiotherapy. The study found that LPA can impact S1P metabolism and signaling in breast cancer cells, potentially influencing tumor growth, metastasis, and response to treatment.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Biochemistry & Molecular Biology
Arturo Orlacchio, Pellegrino Mazzone
Summary: Pancreatic cancer is a lethal form of cancer characterized by its aggressiveness and metastatic potential. Toll-like receptors play a pivotal role in inflammation and immune response, and can be potential targets for cancer therapy. Studies have shown that TLRs play an important role in the progression of pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Naruomi Jinno, Michihiro Yoshida, Kazuki Hayashi, Itaru Naitoh, Yasuki Hori, Makoto Natsume, Akihisa Kato, Kenta Kachi, Go Asano, Naoki Atsuta, Hidenori Sahashi, Hiromi Kataoka
Summary: The study revealed the significance of ATX in malignant ascites of PDAC patients, demonstrating that ATX promotes peritoneal dissemination through the ATX-LPA axis and suggesting that ATX is a promising molecular target for treating peritoneal dissemination of PDAC.
Article
Biochemistry & Molecular Biology
Rikuhei Tsuchida, Daisuke Nishizawa, Ken-ichi Fukuda, Tatsuya Ichinohe, Kuniyuki Kano, Makoto Kurano, Kazutaka Ikeda, Masahiko Sumitani
Summary: A study on 362 healthy patients and 89 patients with cancer-related pain found that the ENPP2 gene polymorphisms rs7832704 and rs2249015 were significantly associated with opioid dose requirements, but not with postoperative pain intensity. This association was also validated in patients with cancer-related pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yang Long, Yuqin Wang, Mengxia Qu, Di Zhang, Xiaotian Zhang, Junjie Zhang
Summary: Autotaxin (ATX) is a key enzyme in lysophosphatidic acid (LPA) production, and the ATX-LPA axis plays a critical role in tumorigenesis. Clinical data analysis revealed a negative correlation between ATX and EZH2 expression in colon cancer. Our study identified ATX as a novel PRC2 target gene silenced by EZH2, and cotargeting EZH2 and the ATX-LPA-LPA2 axis may be a potential combination therapy strategy for colon cancer.
Article
Biochemistry & Molecular Biology
Maria Panagopoulou, Dionysios Fanidis, Vassilis Aidinis, Ekaterini Chatzaki
Summary: The study identified differential methylation patterns of the ENPP2 gene in healthy tissues and various cancers, with some methylation alterations correlated to aggressive phenotypes in cancer cell lines. Increased methylation of specific regions was also associated with decreased ENPP2 mRNA expression and poor prognosis parameters in prostate and lung adenocarcinomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Angela Gento-Caro, Esther Vilches-Herrando, Federico Portillo, David Gonzalez-Forero, Bernardo Moreno-Lopez
Summary: The study suggests that ATX regulates motor neuron excitability and ATX inhibitors can alleviate neuron loss and motor deterioration in ALS mice. The findings indicate that ATX may be a potential therapeutic target in ALS.
Article
Multidisciplinary Sciences
Joseph Tintelnot, Yang Xu, Till R. Lesker, Martin Schoenlein, Leonie Konczalla, Anastasios D. Giannou, Penelope Pelczar, Dominik Kylies, Victor G. G. Puelles, Agata A. A. Bielecka, Manuela Peschka, Filippo Cortesi, Kristoffer Riecken, Maximilian Jung, Lena Amend, Tobias S. S. Broering, Marija Trajkovic-Arsic, Jens T. T. Siveke, Thomas Renne, Danmei Zhang, Stefan Boeck, Till Strowig, Faik G. G. Uzunoglu, Cenap Gungoer, Alexander Stein, Jakob R. R. Izbicki, Carsten Bokemeyer, Marianne Sinn, Alec C. C. Kimmelman, Samuel Huber, Nicola Gagliani
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with limited response to chemotherapy. Researchers have found that the microbiota-derived metabolite, indole-3-acetic acid (3-IAA), is enriched in patients who respond to treatment. Using a combination of 3-IAA and chemotherapy can improve the efficacy of treatment, providing motivation for considering nutritional interventions in cancer patients.
Article
Oncology
Si Liu, Haiyan Jiang, Li Min, Tingting Ning, Junxuan Xu, Tiange Wang, Xingyu Wang, Qian Zhang, Ruizhen Cao, Shutian Zhang, Shengtao Zhu
Summary: The study revealed the close relationship between LPA and ESCC, with Lpar1 identified as a potential therapeutic target for ESCC. LPA was found to promote proliferation and migration of ESCC cells through the PI3K/Akt pathway.
Article
Biochemistry & Molecular Biology
Bo Young Jeong, Kyung Hwa Cho, Se-Hee Yoon, Chang Gyo Park, Hwan-Woo Park, Hoi Young Lee
Summary: LPA induces DDR2 expression through the activation of the PI3K/Akt/mTOR/HIF-1α/Twist1 signaling axes, aggravating ovarian cancer cell invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Tadashi Toyohara, Michihiro Yoshida, Katsuyuki Miyabe, Kazuki Hayashi, Itaru Naitoh, Hiromu Kondo, Yasuki Hori, Akihisa Kato, Kenta Kachi, Go Asano, Hidenori Sahashi, Akihisa Adachi, Kayoko Kuno, Yusuke Kito, Yoichi Matsuo, Hiromi Kataoka
Summary: This study demonstrates the significant elevation of autotaxin (ATX) expression in pancreatic neuroendocrine neoplasms (panNENs) and its association with panNEN progression. Through clinical data, cell lines, and a mouse model, the researchers confirm the involvement of the ATX-LPA axis in promoting cell proliferation and migration in panNENs. These findings suggest the potential of ATX as a novel biomarker and therapeutic target for panNENs.
Review
Chemistry, Multidisciplinary
Peipei Yang, Xin Zhi, Yunxue Xu, Linxue Qian, Zhifei Dai
Summary: Pancreatic carcinoma (PCa) is a highly lethal malignant tumor with limited treatment options. Nanoparticles have been introduced as a medium or carrier to focus energy at the tumor site and minimize side effects. The combination of nanomedicine and minimally invasive techniques provides a new opportunity for the treatment of PCa.