Journal
TUMOR BIOLOGY
Volume 39, Issue 6, Pages -Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1010428317706227
Keywords
Microenvironment; exosomes; B-cell lymphomas; lymphomagenesis; drug resistance; immunotherapy
Categories
Funding
- National Natural Science Foundation of China [81570177]
Ask authors/readers for more resources
B-cell lymphomas are composed of tumor cells and the tumor microenvironment, which is conventionally thought to be composed of a mixture of stromal cells, blood vessels, immune cells, and non-cell components, such as extracellular matrix, cytokines, and chemokines. Exosomes, small endocytically derived vesicles that have been proved to be present in a variety of tumor niches and involved in mediating cell signaling networks, are increasingly regarded as important components of tumor microenvironment. In this review, we first focus on the biogenesis, biodistribution, transportation, and other general characteristics of exosomes and then highlight the vital roles of exosomes in lymphomagenesis and disease progression, particularly from the perspective of immune dysfunction, virus infection, and therapeutic resistance mechanisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available