Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yudan Cui, Jingshan Cai, Wenxin Wang, Shengjun Wang
Summary: HDACIs are antitumor drugs that enhance gene transcription via epigenetic regulation, with cytotoxic properties against tumor cells. The effects of HDACIs on immunocytes in the tumor microenvironment, specifically MDSCs, are still not fully understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jingshan Cai, Yudan Cui, Jun Yang, Shengjun Wang
Summary: MDSCs play a crucial role in tumor immunity, closely linked to tumor EMT and possessing unique functions in an immunosuppressive environment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Immunology
Jie Shen, Mengyu Zhang, Ke Zhang, Yahan Qin, Meifang Liu, Shujuan Liang, Daquan Chen, Meiyu Peng
Summary: This study found that Angelica polysaccharide (APS) promoted the proliferation, differentiation, and immunosuppressive function of myeloid-derived suppressor cells (MDSC) through the STAT1 and STAT3 signaling pathways. In vivo, APS increased the proportion of MDSC in mice, suggesting that its clinical application should consider the possible side effects of increasing MDSC quantity and function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Suncica Kapor, Juan F. Santibanez
Summary: This review discusses the main features of MDSCs and MSCs in myeloid malignancies, revealing that MDSCs are elevated in numbers and exhibit strong immunosuppressive capabilities, while MSCs not only have immunosuppressive properties but also regulate the growth, apoptosis, and chemotherapy resistance of myeloid leukemia cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Guoqi Ya, Weihong Ren, Rui Qin, Jiao He, Shuo Zhao
Summary: Metastasis is a complex process that relies on the interaction between tumor cells and host organs, with the formation of a pre-metastasis niche being crucial. Myeloid-derived suppressor cells play a key role in this process, and targeting these cells as a therapeutic strategy may help inhibit the formation of the pre-metastasis niche and curb tumor metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Izabela Sieminska, Jarek Baran
Summary: Prostate cancer is the second most commonly diagnosed malignancy in men and a leading cause of cancer death worldwide. Environmental factors and immune cells, particularly MDSCs, play a significant role in the development and progression of prostate cancer. Clinical trials targeting MDSCs or affecting their function may hold promise as a new direction for anti-cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Maria Iglesias-Escudero, David San Segundo, David Merino-Fernandez, Victor M. Mora-Cuesta, Patricia Lamadrid, Marta Alonso-Pena, Sandra Raso, David Iturbe, Sonia Fernandez-Rozas, Jose Cifrian, Marcos Lopez-Hoyos
Summary: Lung transplantation is a primary treatment for end-stage lung diseases, but long-term survival is limited. The study explores the dysregulation of immune mechanisms and the role of myeloid-derived suppressor cells (MDSCs) in promoting graft tolerance. The results suggest that increased frequencies of Mo-MDSCs after acute cellular rejection may be associated with the development of chronic lung allograft dysfunction (CLAD).
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Norman Fultang, Xinyuan Li, Ting Li, Youhai H. Chen
Summary: MDSCs are a crucial sub-population of leukocytes in carcinogenesis and cancer immunotherapy. Despite the involvement of various transcription factors in regulating MDSC differentiation, none of them are specifically expressed in MDSCs. The recent discovery of the c-Rel-C/EBP beta enhanceosome in MDSCs may provide insights into how transcription factors regulate MDSC differentiation in a lineage-specific manner.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Hongchao Tang, Hao Li, Zhijun Sun
Summary: Immunotherapy is a promising breakthrough in cancer treatment, with immune checkpoint blockade showing positive clinical responses in different cancer types. However, the clinical efficacy of ICB is limited in some patients due to the immunosuppressive tumor microenvironment and the role of MDSCs. A combined treatment strategy using MDSC inhibitors and ICB is being proposed to enhance the antitumor efficacy.
CANCER BIOLOGY & MEDICINE
(2021)
Review
Cell Biology
Vaishali Bhardwaj, Stephen M. M. Ansell
Summary: Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells composed of pathologically activated neutrophils and monocytes that negatively regulate the immune response to cancer and chronic infections. They exhibit distinct characteristics and exert strong immunosuppressive effects on T-cells and other immune cells, making them a major obstacle to cancer immunotherapies. However, the clinical outcomes of targeting MDSCs in hematological malignancies, particularly B-cell malignancies, still require further exploration. This review provides a comprehensive summary of the complex biology and immunosuppressive pathways of MDSCs, with a focus on their role in modulating T-cell function in hematological malignancies, and discusses the challenges, therapeutic strategies, and clinical relevance of targeting MDSCs in these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Maria Luisa Sanchez-Leon, Carlos Jimenez-Cortegana, Gabriel Cabrera, Elba Monica Vermeulen, Luis de la Cruz-Merino, Victor Sanchez-Margalet
Summary: Dendritic cells (DCs) play a diminished role in various malignancies due to immunosuppressive conditions in the tumor microenvironment (TME). Myeloid-derived suppressor cells (MDSCs) accumulate in the TME and inhibit DC functions, maturation, and development. DC-based vaccines have been developed to improve antitumor immunity, and their effectiveness in murine models and cancer patients, alone or in combination with other treatments, has been explored.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Lei Wu, Yanquan Xu, Huakan Zhao, Yu Zhou, Yu Chen, Shuai Yang, Juan Lei, Jiangang Zhang, Jingchun Wang, Yongzhong Wu, Yongsheng Li
Summary: This study found that Fc gamma RIIB is upregulated in tumor-infiltrated MDSCs and identified its regulatory role in the differentiation and immunosuppressive activity of MDSCs. These findings suggest Fc gamma RIIB as a potential therapeutic target for anti-tumor therapy.
Article
Immunology
Ying He, Sze Wan Hung, Bo Liang, Ruizhe Zhang, Yating Gao, Ching Yan Chu, Tao Zhang, Hui Xu, Jacqueline Pui Wah Chung, Chi Chiu Wang
Summary: The study demonstrated that Sunitinib inhibited endometriotic lesions by promoting the maturation of MDSCs and inhibiting immunosuppressive functions, showing potential therapeutic effects for treating endometriosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Cheng Cui, Penglin Lan, Li Fu
Summary: Gastrointestinal cancer is the most common type of cancer worldwide, with increasing incidence and mortality rates. Myeloid-derived suppressor cells (MDSCs) play a key role in regulating the immune response to tumors and may serve as prognostic markers and therapeutic targets in cancer patients.
CANCER COMMUNICATIONS
(2021)
