Article
Oncology
Yuhan Yang, Lei Cao, Zengya Guo, Haitao Gu, Kundong Zhang, Zhengjun Qiu
Summary: This study uncovers the underlying mechanisms of the UCHL5/ELK3/Notch1 axis in the progression and stemness maintenance of Pancreatic Adenocarcinoma (PAAD). It provides insights for individualized treatment and risk stratification for PAAD patients.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Medicine, General & Internal
Abdessamad El Kaoutari, Nicolas A. Fraunhoffer, Luc Camoin, Yolande Berthois, Odile Gayet, Julie Roques, Martin Bigonnet, Claire Bongrain, Joseph Ciccolini, Juan L. Iovanna, Nelson J. Dusetti, Philippe Soubeyran
Summary: Through specific proteomic tools and bioinformatics analysis, we established the ubiquitin dependent proteome of 60 PDAC, identifying 38 ubiquitination site profiles correlated with tumor phenotype and having prognostic capabilities. These findings have potential application in predicting chemotherapy response and personalized treatment in clinical settings.
Article
Oncology
Tian-Jiao Li, Kai-Zhou Jin, Hong-Yu Zhou, Zhen-Yu Liao, Hui-Ru Zhang, Sai-Meng Shi, Meng-Xiong Lin, Shou-Jie Chai, Qing-Lin Fei, Long-Yun Ye, Xian-Jun Yu, Wei-Ding Wu
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with limited treatment options. In this study, we identified USP10 as a potential therapeutic target in PDAC. We found that USP10 promoted tumor growth and interacted with PABPC1, leading to decreased ubiquitination level and increased translation efficiency. Targeting USP10 significantly delayed the growth of PDAC tumors.
Review
Biochemistry & Molecular Biology
Anmol Sharma, Heena Khan, Thakur Gurjeet Singh, Amarjot Kaur Grewal, Agnieszka Najda, Malgorzata Kawecka-Radomska, Mohamed Kamel, Ahmed E. Altyar, Mohamed M. Abdel-Daim
Summary: The ubiquitin-proteasome pathway is crucial in regulating various biological functions and plays a significant role in tumor development. Inhibiting specific enzymes within this pathway can be an effective treatment for cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xiang Chen, Zaw Min Htet, Erika Lopez-Alfonzo, Andreas Martin, Kylie J. Walters
Summary: The 26S proteasome is responsible for regulated proteolysis in eukaryotic cells, with substrates targeted to it through post-translational modification with ubiquitin. Deubiquitinating enzymes (DUBs) play a crucial role in catalyzing ubiquitin chain hydrolysis, coupling deubiquitination to substrate unfolding and degradation. This intricate machinery of proteasomes and ubiquitin-modified substrates remains an active area of investigation, with potential for therapeutic targeting.
Article
Biochemistry & Molecular Biology
Wenyan Yang, Shiqun Wang, Shengqiang Tong, Wei-Dong Zhang, Jiang-Jiang Qin
Summary: This article provides an overview of the ubiquitin-proteasome system (UPS) and its role in pancreatic cancer. Studies indicate that mutations or aberrant expression of UPS members can lead to rewriting of the ubiquitination code, affecting tumor growth, metastasis, immune evasion, and drug resistance. The article also reviews current UPS modulators and analyzes their potential as cancer therapies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, T. Mamie Lih, Sara R. Savage, Karsten Krug, David J. Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A. Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M. Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D. Jewell, Galen Hostetter, Chelsea J. Newton, Qing Kay Li, Michael H. Roehr, David Fenyo, Pei Wang, Alexey Nesvizhskii, D. R. Mani, Gilbert S. Omenn, Emily S. Boja, Mehdi Mesri, Ana Robles, Henry Rodriguez, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang
Summary: This study conducted comprehensive proteogenomic analysis of PDAC to understand the molecular alterations that drive oncogenesis. Multiple analyses were performed on tissues from patients, providing valuable resources for early detection and identification of therapeutic targets.
Review
Biochemistry & Molecular Biology
Nausika Betriu, Juan Bertran-Mas, Anna Andreeva, Carlos E. Semino
Summary: Syndecans, a subfamily of proteoglycans, play critical roles in various physiological processes and have implications in disease progression. Their interactions with other macromolecules contribute to normal cellular functions and disease pathogenesis.
Article
Biochemistry & Molecular Biology
Sang -Soo Park, Hyeon-Ah Do, Hong-Beom Park, Hae-Seul Choi, Kwang-Hyun Baek
Summary: a-synuclein, a protein involved in neurodegenerative diseases like Parkinson's disease and Lewy body dementia, is regulated by the ubiquitin-proteasome system (UPS). In this study, researchers found that the deubiquitinating enzyme YOD1 interacts with a-synuclein and removes multiple types of ubiquitin chains from it. YOD1 also destabilizes a-synuclein by upregulating the E3 ligase NEDD4. These findings suggest that YOD1 may be a new regulator in the NEDD4-a-synuclein pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yuan Hu, Chenyang Qi, Jiaoyu Shi, Weiqiang Tan, Zhonghua Zhao, Yanyong Xu, Huijuan Wu, Zhigang Zhang
Summary: UCHL1 deficiency leads to severe kidney damage and proteinuria in podocytes, which is associated with ER stress, protein accumulation, and cell apoptosis. UCHL1 may be a potential target for preventing non-immune complex-mediated glomerulopathy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Oncology
Tomas Koltai, Stephan Joel Reshkin, Tiago M. A. Carvalho, Daria Di Molfetta, Maria Raffaella Greco, Khalid Omer Alfarouk, Rosa Angela Cardone
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor with a poor prognosis and inadequate response to treatment. Multiple factors contribute to therapeutic failure, including late diagnosis due to lack of symptoms, early spread, advanced age of patients, hyperfibrotic stroma, genetic heterogeneity, and early resistance to available treatments.
Review
Oncology
Eleonora Lai, Pina Ziranu, Dario Spanu, Marco Dubois, Andrea Pretta, Simona Tolu, Silvia Camera, Nicole Liscia, Stefano Mariani, Mara Persano, Marco Migliari, Clelia Donisi, Laura Demurtas, Valeria Pusceddu, Marco Puzzoni, Mario Scartozzi
Summary: Despite ongoing research, there is still insufficient data on BRCA1/2-mutant PDAC, and more understanding is needed on the specific landscape of PDAC with BRCA mutations.
BRITISH JOURNAL OF CANCER
(2021)
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Editorial Material
Biology
Jessica Castrillon Lal
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a low survival rate. Understanding the complexity of tumor architecture and identifying targetable cellular phenotypes are major challenges in PDAC. Recent research has found recurrent gene expression patterns in malignant and fibroblast cellular neighborhoods in PDAC tumors that are correlated with treatment outcomes.
COMMUNICATIONS BIOLOGY
(2022)
Review
Oncology
Kongyuan Wei, Thilo Hackert
Summary: Surgery is the main potential cure for pancreatic ductal adenocarcinoma, with advancements in surgical techniques and multimodal approaches. Despite low survival rates, combining surgery with adjuvant therapy can increase five-year survival to around 20%. However, pancreatic resection is complex and high-risk, with ongoing developments in minimally-invasive and robotic approaches.
Article
Medicine, Research & Experimental
Sanna Viitasalo, Taru Ilmarinen, Leena-Maija Aaltonen, Jaana Hagstrom, Maija Hytonen, Sari Hammaren-Malmi, Petra Pietarinen, Pia Jarvenpaa, Teemu Kinnari, Ahmed Geneid, Markus Lilja
Summary: This retrospective study assessed the epidemiological information of patients treated for sinonasal inverted papilloma (SNIP) at Helsinki University Hospital between 1984 and 2014, and found a very low malignant transformation rate of SNIP. The study also revealed that SNIP patients were not prone to HPV-associated non-sinonasal malignancies. Additionally, endoscopic resection and attachment-oriented surgery have become the predominant approaches in SNIP treatment, with a reduced recurrence rate.
Article
Multidisciplinary Sciences
Ines Beilmann-Lehtonen, Jussi Kasurinen, Jaana Hagstroem, Tuomas Kaprio, Camilla Boeckelman, Caj Haglund
Summary: This study aimed to investigate the relationship between Toll-like receptor (TLR) immunoexpressions and the infiltration densities of T-lymphocytes in colorectal cancer (CRC). The results showed significant associations between high tissue TLR2, TLR4, and TLR5 immunoexpressions and high densities of CD3- and CD8-positive cells. Combining these markers may improve the prognostic evaluation of CRC patients.
Article
Oncology
Rayan Mroueh, Elli Hirvonen, Janne Pitkaeniemi, Nea Malila, Jaana Hagstrom, Antti Makitie, Anni Virtanen
Summary: This study investigated the burden of head and neck cancer (HNC) among immigrants in Finland. The risk of HNC was not increased among first-generation male immigrants, but significantly elevated for cancer of the pharynx and larynx, and decreased for lip cancer. Female first-generation immigrants had a significantly reduced risk of HNC, while the children of first-generation immigrants did not have an increased risk of HNC.
Article
Oncology
Jussi Kasurinen, Ines Beilmann-Lehtonen, Tuomas Kaprio, Jaana Hagstrom, Caj Haglund, Camilla Bockelman
Summary: A study categorized colorectal cancer patients into four phenotypic subgroups using immunohistochemistry and found associations between these subgroups and patient prognosis and clinicopathological variables. The immune subgroup showed the best 5-year disease-specific survival rate, while the mesenchymal subgroup had the worst prognosis. These subgroups' associations and prognoses resemble the transcriptome-based consensus molecular subtypes (CMS) classification.
Article
Medicine, General & Internal
Karita Nylund, Jaana Helenius-Hietala, Fredrik Aberg, Jaana Hagstrom, Hellevi Ruokonen
Summary: Oral mucosal lesions can persist for years before symptoms or diagnosis of inflammatory bowel disease (IBD) and subsequent primary sclerosing cholangitis (PSC). Since a dental practitioner may be the first clinician to suspect IBD with extraintestinal manifestations (EIMs), early referral and close collaboration with a gastroenterologist are recommended.
CLINICAL CASE REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Piia Huopainen, Sirke Virkkunen, Johanna Snall, Arzu Tezvergil-Mutluay, Jaana Hagstrom, Satu Apajalahti
Summary: This study aimed to compare the detectability of periapical foreign materials in dentoalveolar imaging and histopathology. The results showed that histopathology was more accurate in diagnosing periapical foreign bodies or foreign body reactions. Clinicians should be aware of the limitations of imaging when diagnosing and planning treatment.
ACTA ODONTOLOGICA SCANDINAVICA
(2023)
Article
Gastroenterology & Hepatology
Mira Lanki, Harri Mustonen, Marko Salmi, Sirpa Jalkanen, Caj Haglund, Hanna Seppanen
Summary: This study found that inflammatory cytokines CTACK, GRO-a, and b-NGF, in addition to CA19-9 and CRP, may help distinguish between PDAC and CP.
Article
Oncology
Antti Silvoniemi, Jukka Laine, Katri Aro, Linda Nissi, Leif Back, Jukka Schildt, Jussi Hirvonen, Jaana Hagstrom, Heikki Irjala, Leena-Maija Aaltonen, Marko Seppanen, Heikki Minn
Summary: This study found an association between quantitative parameters in ctDNA and metabolic tumor burden measured with FDG-PET/CT in HNSCC. High maximum VAF correlated positively with TLG. The combination of ctDNA detection and FDG-PET/CT may provide additional value for the prognostic and predictive evaluation of HNSCC.
Article
Oncology
Jussi Herman Kasurinen, Jaana Hagstrom, Tuomas Kaprio, Sirpa Jalkanen, Marko Salmi, Camilla Bockelman, Caj Haglund
Summary: In this study, we found that the prognostic value of angiogenic growth factors VEGF, bFGF, and PDGF-bb varies according to the phenotypic subtype of the tumor. Patients were classified into immune, canonical, metabolic, and mesenchymal subgroups, and the serum concentrations and tissue expressions of these factors were determined. High expression and concentration of angiogenic growth factors were associated with improved prognosis in the metabolic subgroup, while a high VEGF serum concentration was associated with worse prognosis in the immune subgroup. Additionally, a high serum concentration of bFGF indicated improved prognosis in the canonical subgroup.
Article
Dentistry, Oral Surgery & Medicine
Orvokki Saraneva, Jussi Furuholm, Jaana Hagstrom, Timo Sorsa, Ville Rita, Taina Tervahartiala, Hannamari Valimaa, Hellevi Ruokonen
Summary: This retrospective study explored the role of oral potentially malignant disorders and the presence of intraepithelial Candida hyphae in the development of oral tongue squamous cell carcinoma. The results showed significant associations between histopathological diagnosis of oral lichen planus/lichenoid reaction and the presence of Candida hyphae with female gender. Patients with oral lichen planus/lichenoid reaction were less likely to be smokers, while Candida hyphae were more frequently observed in patients without alcohol use. Therefore, careful monitoring is necessary for these patients despite the absence of classical risk factors.
Article
Multidisciplinary Sciences
Heini Nieminen, Pirjo Nummela, Tero Satomaa, Annamari Heiskanen, Jukka O. O. Hiltunen, Tuomas Kaprio, Hanna Seppanen, Jaana Hagstrom, Harri Mustonen, Ari Ristimaki, Caj Haglund
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are potentially malignant cystic tumors of the pancreas. Diagnostic methods are needed to recognize IPMNs with malignant potential. Aberrantly expressed glycans offer interesting new options for diagnostics.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Sirke Virkkunen, Jaana Willberg, Caj Haglund, Malin Sund, Timo Sorsa, Jaana Hagstroem
Summary: The aim of this study was to investigate the immunexpression of bacterial lipopolysaccharide (LPS) in periapical lesions. Surprisingly, we found that Rushton bodies (RBs), whose origin has been debated, were positive for LPS. Staining of radicular cyst samples showed that all RBs (N=25) present in the tissue samples were positive for LPS, and calcification in the cyst capsule also showed immunopositivity. This study demonstrates for the first time that LPS is present in RBs, suggesting that the host response to bacteria may be the initial cause of RB formation and cyst capsule calcifications.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Letter
Oncology
Ella Brandt, Mutlu Keskin, Taina Tervahartiala, Mustafa Yilmaz, Ilknur Harmankaya, Didem Karacetin, Turgut Ipek, Ulvi Kahraman Gursoy, Shipra Gupta, Ismo T. Raisanen, Jaana Hagstrom, Jaana Rautava, Timo Sorsa
Article
Pathology
Anni Sjoblom, Henna Pehkonen, Lauri Jouhi, Outi Monni, Reija Randen-Brady, Piia-Riitta Karhemo, Jussi Tarkkanen, Caj Haglund, Petri Mattila, Antti Makitie, Jaana Hagstrom, Timo Carpen
Summary: Liprin-alpha 1 inhibits the expression of CD82 and its increased expression in tumor-infiltrating lymphocytes is associated with a favorable prognosis in HPV-positive patients with oropharyngeal squamous cell carcinoma.
HEAD & NECK PATHOLOGY
(2023)
Letter
Oncology
Shipra Gupta, Ismo T. Raisanen, Hanna Seppanen, Jaana Hagstrom, Andreas Grigoriadis, Kethe Hermunen, Dimitra Sakellari, Caj Haglund, Timo Sorsa