Article
Medicine, General & Internal
Tong Su, Jiejun Hou, Tonghua Liu, Pei Dai, LingLing Qin, Lei Ding, Yan Hu, Xiangyu Guo
Summary: This study identified miR-34a-5p and miR-452-5p as novel regulators of pancreatic endocrine dysfunction, with miR-34a-5p negatively regulating pancreatic β-cell proliferation through the Wnt signaling pathway, and miR-452-5p affecting mitochondrial function in pancreatic β-cells through the branched chain amino acid metabolism pathway. These miRNAs have the potential to be utilized as new predictive biomarkers for the diagnosis and treatment targets for Type 2 diabetes.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rahul D. Kamdar, Brittney S. Harrington, Emma Attar, Soumya Korrapati, Jyoti Shetty, Yongmei Zhao, Bao Tran, Nathan Wong, Carrie D. House, Christina M. Annunziata
Summary: Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer-related death in women worldwide, and chemoresistant, stem-like tumor-initiating cells (TICs) contribute to disease relapse. The NF-κB pathway and its transcription factors (RelA and RelB) have been found to promote TIC survival and chemoresistance. This study demonstrates that NF-κB signaling differentially regulates miRNA expression through RelA and RelB in EOC cells, and the miRNAs, hsa-miR-452-5p and hsa-miR-335-5p, play a role in TIC persistence. These findings provide new insights into preventing EOC recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yan Zhang, Xing Li, Jun Zhang, Lin Mao
Summary: The expression of circ-CCDC66 was upregulated in cervical cancer and correlated with later tumor stage and larger tumor size. Circ-CCDC66 can inhibit cervical cancer cell proliferation and migration through regulating the miR-452-5p/REXO1 axis. By modulating this axis, circ-CCDC66 may serve as a potential therapeutic target for cervical cancer intervention.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Xin Lin, Lu Han, Chuncai Gu, Yihong Lai, Qiuhua Lai, Qingyuan Li, Chengcheng He, Yan Meng, Lei Pan, Side Liu, Aimin Li
Summary: MiR-452-5p is up-regulated in CRC tissues, promoting cell proliferation, cycle transition, and chemoresistance while inhibiting apoptosis. It targets PKN2 and DUSP6, activating the ERK/MAPK signaling pathway, and is transcriptionally regulated by c-Jun. MiR-452-5p may serve as a potential therapeutic target and clinical response biomarker for CRC.
Article
Oncology
Jing Zhuang, Jianjun Fan, Lihuan Zhu, Lilan Zhao, Yangyun Huang, Xiaojie Pan, Tianxing Guo
Summary: This study found that miR-452-5p can regulate the cell proliferation, migration, and invasion ability of NSCLC through targeting MSN, and it also affects the EMT process. These findings might provide a novel prevention and treatment target for NSCLC.
Article
Genetics & Heredity
Jing Li, Zongren Zhao, Xiang Wang, Qiong Ma, Huanhuan Ji, Yan Wang, Rutong Yu
Summary: The study revealed that circTLK1 activates JAK/STAT signaling to promote glioma progression through the circTLK1/miR-452-5p/SSR1 axis. Additionally, the expression of circTLK1 in glioma cells is regulated by the transcription factor PBX2.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Maria Dobre, Radu Cristian Poenaru, Andrei Marian Niculae, Catalina Vladut, Vlad Herlea, Elena Milanesi, Mihail Eugen Hinescu
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal form of cancer. This study found 32 dysregulated miRNAs in PDAC tumoral tissues, with 19 upregulated and 13 downregulated. Additionally, miR-15b-5p and miR-20b-5p were identified as potential markers for hepatic metastasis in PDAC patients.
Article
Biochemistry & Molecular Biology
Huijie Guo, Mei Pu, Yusi Tai, Yuxiang Chen, Henglei Lu, Junwen Qiao, Guanghui Wang, Jing Chen, Xinming Qi, Ruimin Huang, Zhouteng Tao, Jin Ren
Summary: The study revealed that miR-30b-5p can inhibit TFEB-dependent gene transcription by binding to CLEAR elements in the nucleus, thus affecting lysosomal biogenesis and autophagy. Knocking out miR-30b-5p increases TFEB transactivation, leading to increased expression of autophagy and lysosomal biogenesis-related genes.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Oncology
Yongchun Zhou, Gaowei Wang, Jingjing Cai, Yaqian Du, Hongsheng Li, Lincan Duan, Guangqiang Zhao, Yunchao Huang
Summary: Exosomal transfer of miR-195-5p from normal bronchial epithelial cells inhibits tumor progression and angiogenesis in lung adenocarcinoma through suppression of the APLN/Wnt signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Laiwei Wu, Guoqiang Huang, Huifeng Hong, Xiangzhou Xu, Xiaohe Lu, Jing Li
Summary: This study investigated the function of miR-452-5p in retinoblastoma (RB) and found that it promoted cell proliferation and invasion through the SOCS3/JAK2/STAT3 signaling pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Oncology
Liyao Dong, Lin Zhang, Xinyun Zhao, Hongling Zou, Sisi Lin, Xinping Zhu, Jili Cao, Chun Zhou, Zhihong Yu, Yongqiang Zhu, Kequn Chai, Mingqian Li, Qun Li
Summary: This study elucidates the molecular mechanism whereby CYP4A22-AS1 overexpression promotes LUAD progression through the miR-205-5p/EREG and miR-34c-5p/BCL-2 axes.
CANCER CELL INTERNATIONAL
(2023)
Article
Allergy
Xiangzhi Wang, Chengyun Xu, Yuqing Cai, Xinyi Zou, Yunqi Chao, Ziyi Yan, Chaochun Zou, Ximei Wu, Lanfang Tang
Summary: This study revealed the high expression of circZNF652 in bronchoalveolar lavage fluid of allergic asthma patients and its role in promoting pathological goblet cell metaplasia through activation of the miR-452-5p/JAK2/STAT6 signaling pathway. These findings provide new strategies for the therapeutic intervention of epithelial remodeling in allergic airway inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biology
Cheng Zhang, Shasha Zhao, Huan Deng, Shihua Zhang, Juan Wang, Xiaoye Song, Deen Yu, Yue Zhang, Wensheng Deng, Michael R. Green
Summary: Deregulation of Pol III products leads to various diseases, including neural diseases and cancers. STAT3 positively regulates Pol III-mediated transcription and cancer cell growth. TP73 plays a crucial role in both STAT3-modulated Pol III transcription and independent suppression of Pol III product synthesis. MiR-106a-5p activates Pol III transcription by targeting TP73 mRNA, and STAT3 activates miR-106a-5p expression, connecting STAT3 with TP73 to regulate Pol III transcription.
Article
Cell Biology
Wei Jiang, Yaozhou He, Zijian Ma, Yu Zhang, Chengpeng Zhang, Nianpeng Zheng, Xing Tang
Summary: circ_0008234 in LUAC inhibits disease progression through a competitive endogenous RNA mechanism, potentially serving as a biomarker and therapeutic target for LUAC treatment.
CELL DEATH DISCOVERY
(2021)
Article
Biology
Sayed Haidar Abbas Raza, Ruimin Zhong, Shen Xing, Xiaoting Yu, Liang Chengcheng, Linsen Zan, Nicola M. Schreurs, Sameer D. Pant, Hongtao Lei
Summary: The purpose of this study was to identify potential RNA binding proteins associated with the survival of gastric adenocarcinoma and investigate their biological characteristics and signaling pathways. A total of 1495 RNA binding protein related genes were analyzed for differential expression, resulting in 296 differential RNA binding proteins. Cox regression analysis identified 20 prognosis-related RNA binding proteins, from which a new prognostic model was constructed. The model was validated using survival analysis, receiver operating characteristic curves, and prognosis analysis curves, and a prediction nomogram with good performance was developed.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)