Article
Food Science & Technology
Anne-Sophie Weyns, Annelies A. J. Verlaet, Maxim Van Herreweghe, Annelies Breynaert, Erik Fransen, Ingrid De Meester, Emilie Logie, Wim Vanden Berghe, Helene Verhelst, Dirk Van West, Ingrid Van Ingelghem, An I. Jonckheere, Diane Beysen, Sandra Kenis, Els Moens, Aalt P. J. van Roest, Huub F. J. Savelkoul, Tess De Bruyne, Luc Pieters, Berten Ceulemans, Nina Hermans
Summary: This study evaluated the effect of French Maritime Pine Bark Extract on paediatric ADHD, showing significant impact on oxidative stress pathways and significant influence of methylphenidate on immune biomarkers.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Raiyan Mahbub, Nidhish Francis, Christopher L. Blanchard, Abishek B. Santhakumar
Summary: The study found that chickpea hull phenolic extracts (CHPE) can alleviate oxidative stress and inflammation by increasing the activity of antioxidant enzymes and reducing the production of inflammatory markers. The results suggest that CHPE may have potential as a treatment for chronic inflammation.
Article
Food Science & Technology
Cristiane de Freitas Rodrigues, Jean Ramos Boldori, Marcell Valandro Soares, Sabrina Somacal, Tatiana Emanuelli, Aryele Izaguirry, Francielli Weber Santos Cibin, Paula Rossini Augusti, Cristiane Casagrande Denardin
Summary: Goji berry juice exerts toxic effects on Caenorhabditis elegans, promoting premature aging. Further studies in mammals are needed before its consumption can be recommended.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Plant Sciences
Yajie Wang, Yue Chen, Yanan Jia, Zihan Xue, Zhongqin Chen, Min Zhang, Pharkphoom Panichayupakaranant, Shuyu Yang, Haixia Chen
Summary: Chrysophyllum cainito leaves have promising antioxidant, hypoglycemic, and antiglycation activities, making them a potential candidate for treating diabetes and associated chronic diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Idolo Tedesco, Carmela Spagnuolo, Stefania Bilotto, Angelo A. Izzo, Francesca Borrelli, Daniela Rigano, Maria Russo, Fabrizio Tarricone, Gian Luigi Russo
Summary: Experimental and clinical studies have shown that moderate consumption of beer can have health benefits due to the presence of bioactive compounds such as polyphenols, vitamins, and fibers. A new beverage, Aliophen(R), based on barley malts and hops, has been designed with a high polyphenolic content. Research has demonstrated that Aliophen(R) has antioxidant properties and can potentially prevent colon cancer in animal models.
Article
Food Science & Technology
Anne-Sophie Weyns, Annelies A. J. Verlaet, Annelies Breynaert, Tania Naessens, Erik Fransen, Helene Verhelst, Dirk Van West, Ingrid Van Ingelghem, An I. Jonckheere, Diane Beysen, Sandra Kenis, Els Moens, Aalt P. J. van Roest, Huub F. J. Savelkoul, Tess De Bruyne, Luc Pieters, Berten Ceulemans, Nina Hermans
Summary: The study showed that French Maritime Pine Bark Extract has a significant impact on the behavior and co-morbid symptoms of pediatric ADHD, with a particularly good performance in reducing adverse effects. Teachers' observations indicated that both PBE and MPH had a noticeable improvement in ADHD symptoms compared to placebo.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nanoscience & Nanotechnology
Peng Yang, Jianhua Zhang, Siying Xiang, Zhekai Jin, Fang Zhu, Tianyou Wang, Gaigai Duan, Xianhu Liu, Zhipeng Gu, Yiwen Li
Summary: A novel strategy has been proposed to fabricate green nanoparticles using tea polyphenol extracts for efficiently modulating oxidative stress. These nanoparticles possess excellent radical scavenging properties and can effectively prevent oxidative damage-induced injuries.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Chouari Zhor, Lounis Wafaa, Imen Ghzaiel, Khadidja Kessas, Amira Zarrouk, Mohamed Ksila, Taoufik Ghrairi, Norbert Latruffe, Olfa Masmoudi-Kouki, Adil El Midaoui, Dominique Vervandier-Fasseur, Mohamed Hammami, Gerard Lizard, Anne Vejux, Omar Kharoubi
Summary: Aging leads to the deterioration of cellular functions and increases the risk of age-related diseases. Cardiovascular diseases, some neurological disorders, and cancers are among the diseases that affect lifespan and are associated with accumulated cellular damage and reduced stress response pathways. Inflammation and oxidative stress, key factors in the aging process, result from these processes. Edible plants have gained interest for their potential therapeutic effects in preventing age-related diseases. The beneficial effects of these foods are attributed, in part, to their high concentration of bioactive phenolic compounds, particularly antioxidants, which are associated with slower aging. Human dietary intervention studies strongly support the protective role of polyphenol supplementation in preventing age-related diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Janice Taile, Matthieu Bringart, Cynthia Planesse, Jessica Patche, Philippe Rondeau, Bryan Veeren, Patricia Clerc, Anne Gauvin-Bialecki, Steeve Bourane, Olivier Meilhac, David Couret, Marie-Paule Gonthier
Summary: This study evaluated the effects of polyphenols extracted from Antirhea borbonica on obesity and diabetes-related cerebrovascular damages during stroke. The results showed that polyphenols reduced insulin resistance, hyperglycemia, and dyslipidemia caused by obesity, and attenuated brain infarct, hemorrhagic transformation, and blood-brain barrier disruption. Polyphenols also exhibited anti-inflammatory and antioxidant properties, and decreased MMP-2 activity in hyperglycemic condition. Furthermore, the protective effects of polyphenols were associated with their circulating metabolites.
Article
Biochemistry & Molecular Biology
Pedro Ferreira-Santos, Antonio Nogueira, Cristina M. R. Rocha, Cristina Pereira Wilson, Jose A. Teixeira, Claudia Botelho
Summary: The bioavailability and toxicological effects of S. nigra extracts, specifically from flower and berry, were found to differ significantly, with the berry extract showing better antioxidative effects post-digestion and lower cytotoxicity. These findings suggest the potential of S. nigra by-product compounds as functional food ingredients or bio-therapeutic agents.
Article
Medicine, Research & Experimental
Karolina Jakubczyk, Aleksandra Tuchowska, Katarzyna Janda-Milczarek
Summary: Hydrolates, by-products of plant hydrodistillation, have high antioxidant potential depending on plant species, origin, plant part, and preservation method. The study demonstrates the wide application of hydrosols in cosmetics and their potential value in skincare and agri-food industry.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Hassan Barakat, Raghad I. Alkhurayji, Thamer Aljutaily
Summary: This study investigated the antioxidative and immune-boosting properties of the hydroalcoholic extract of Brassica nigra sprouts in rats with cyclophosphamide-induced immunosuppression. The results showed that the sprouts contained increasing levels of bioactive compounds and exhibited antioxidant activity during the sprouting period. In a rat model, dosing with the extract improved antioxidative stress and immune parameters in a dose-dependent manner. This suggests that mustard seed extracts have immunosuppressive properties against cyclophosphamide-induced immunosuppression.
Review
Food Science & Technology
Katarzyna Neffe-Skocinska, Marcelina Karbowiak, Danuta Kolozyn-Krajewska, Dorota Zielinska
Summary: This systematic review summarizes the effect of acetic acid bacteria (AAB) and oxidative fermentation on polyphenols and antioxidant activity in fermented foods of plant origin. The selected studies provide evidence that AAB activity contributes to the increase or stabilization of polyphenolic compounds and antioxidant activity in fermented foods, showing potential health-promoting effects on the human body. This article systematizes the knowledge about the impact of AAB on human health and its future application in food technology.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Glaucimeire R. Carvalho, Debora S. Braz, Talita C. O. Goncalves, Rafaela Aires, Larissa Z. Coco, Marcio Guidoni, Marcio Fronza, Denise C. Endringer, Antonio D. S. Junior, Manuel Campos-Toimil, Breno Nogueira, Elisardo C. Vasquez, Bianca P. Campagnaro, Thiago M. C. Pereira
Summary: The VO resin extract has shown promising effects in wound healing by promoting re-epithelialization through antioxidant mechanisms.
Article
Biochemistry & Molecular Biology
Grazia Pastorelli, Rachida Benamri, Massimo Faustini, Roberta De Bellis, Valentina Serra, Lauretta Turin, Marc Haumont, Philippe Durand, Laura Bianchessi, Emmanuelle Prost-Camus, Thomas Pecqueur, Michel Prost
Summary: This study investigated the effect of dietary inclusion of commercial polyphenol products (PPs) on the growth performance, antioxidant status, and immunity of post-weaning piglets. The results showed that replacing vitamin E with PPs can partially substitute vitamin E in post-weaning piglets.
Article
Biochemistry & Molecular Biology
Laura Peeters, Kenn Foubert, Mamadou Aliou Balde, Emmy Tuenter, An Matheeussen, Natascha Van Pelt, Guy Caljon, Nina Hermans, Luc Pieters
Summary: The traditional medicinal plant Nauclea pobeguinii is used for treating malaria. Research on the plant extract and strictosamide, a potential active compound, suggests that alkaloids in the extract undergo biotransformation to become active compounds after oral administration. The study found a diverse range of compounds in the extract, mainly saponins and alkaloids, contributing to its antiplasmodial activity.
Article
Plant Sciences
Yunita Eka Puspitasari, Tess De Bruyne, Kenn Foubert, Aulanni'am Aulanni'am, Luc Pieters, Nina Hermans, Emmy Tuenter
Summary: Sea cucumbers, belonging to the phylum Echinodermata, are used as food and traditional medicine in Asia, with triterpene glycosides being the most predominant secondary metabolites. The Holothuria genus, known for its high number and variety of triterpene glycosides, has had 63 saponins identified in the past decade, with LC-MS and NMR being common analytical techniques. However, inconsistencies in literature were noted, prompting a review to provide clarity on NMR and MS signals and interpretation for future research on Holothuria saponins.
PHYTOCHEMISTRY REVIEWS
(2022)
Letter
Public, Environmental & Occupational Health
Thomas Gestels, Berten Ceulemans
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Plant Sciences
Laura Peeters, Kenn Foubert, Annelies Breynaert, Gerd Schreurs, Anja Verhulst, Luc Pieters, Nina Hermans
Summary: The hepatic metabolites of medicagenic acid found in Hirsuta plant were evaluated for their in vitro activity against urinary stones. The results showed that these metabolites have the potential to inhibit crystal formation and reduce crystal retention in the urinary tract.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Cristian Diaz-Munoz, Dario Van de Voorde, Emmy Tuenter, Valerie Lemarcq, Davy Van de Walle, Jose Pedro Soares Maio, Alejandra Mencia, Carlos Eduardo Hernandez, Andrea Comasio, Eleni Sioriki, Stefan Weckx, Luc Pieters, Koen Dewettinck, Luc De Vuyst
Summary: This study examined the effects of Hanseniaspora opuntiae strain in cocoa fermentation. The results showed that the inoculated H. opuntiae strain was unable to dominate over other yeasts, resulting in under-fermented cocoa beans. However, cocoa fermentation processes inoculated with Saccharomyces cerevisiae strain produced richer and more reproducible aroma profiles.
Article
Biochemistry & Molecular Biology
Jesus Garcia Diaz, Rosalia Gonzalez Fernandez, Julio Cesar Escalona Arranz, Gabriel Llaurado Maury, Daniel Mendez Rodriguez, Linda De Vooght, Enrique Molina, Emmy Tuenter, Luc Pieters, Paul Cos
Summary: Oxidative stress is involved in many diseases, and natural antioxidants have shown potential in protecting against it. This study found that compounds in Croton linearis leaves can inhibit nitric oxide production and scavenge free radicals, making them a potential source of antioxidants for treating oxidative damage-related diseases.
Article
Biochemistry & Molecular Biology
Ngoc-Thao-Hien Le, Tom Vermeyen, Roy Aerts, Wouter A. Herrebout, Luc Pieters, Emmy Tuenter
Summary: Structural elucidation has always been challenging, and misassignment remains a stringent issue in the field of natural products. The combination of various spectroscopic methods with molecular modeling has gained popularity in recent years. In this work, the power of this combined approach was demonstrated for the first time in fully elucidating the 2-dimensional and 3-dimensional structures of two epimers in an epimeric mixture of 6-hydroxyhippeastidine. DFT calculation of chemical shifts and computer-assisted structure elucidation (CASE) coupled with ORD/ECD/VCD spectroscopies were used to establish the relative and absolute configurations.
Article
Clinical Neurology
Karen Verheyen, Lore Wyers, Eugenie Lambrecht, An-Sofie Schoonjans, Berten Ceulemans, Patricia van de Walle, Ann Hallemans
Summary: This cohort study aimed to describe functional mobility in individuals with Dravet syndrome. The results showed limitations in dual tasks and activities requiring stability, with limitations increasing from the age of 18 years. Age at independent walking, gait impairments, intellectual disability, and BMI can impact functional mobility in Dravet syndrome.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Chemistry, Applied
Qiqiong Li, Jan Stautemas, Stanley Omondi Onyango, Marjan De Mey, Dries Duchi, Emmy Tuenter, Nina Hermans, Patrick Calders, Tom Van de Wiele
Summary: Catechins have demonstrated various health benefits, but there is a significant variation between individuals. The ability of colonic microbiota to metabolize catechins plays a crucial role in this variability. In vitro experiments using microbiota from two donors - one fast converter and one slow converter - confirmed the robustness of the metabolic profiles observed. The patterns of metabolism and microbiota composition were consistent with the specific colon regions and individual donors. Upstream and downstream metabolites were detected predominantly in the proximal and distal colons, respectively, and were identified as important factors in microbiota clustering. Two specific bacteria, Eggerthella and Flavonifractor, involved in catechin metabolism were found to have higher abundances in the distal colon and in slow converters. These bacteria were also enriched in samples treated with catechins.
Article
Plant Sciences
Pathy Kibungu Kembelo, Emmy Tuenter, Wouter Vanhove, Honore Belesi Katulaa, Patrick Van Damme, Luc Pieters
Summary: This study conducted a phytochemical analysis of leaf extracts from Commelina africana and identified 22 compounds with antioxidant and anti-inflammatory properties, which may explain its traditional use for skin disorders.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Pharmacology & Pharmacy
Anastasia van der Auwera, Laura Peeters, Kenn Foubert, Stefano Piazza, Wim Vanden Berghe, Nina Hermans, Luc Pieters
Summary: This study investigated the active constituents or metabolites of Filipendula ulmaria and their anti-inflammatory activity. The results showed that after gastrointestinal biotransformation, the extract of F. ulmaria exhibited a better inhibition of COX-1 enzyme and contained aglycons such as quercetin, apigenin, naringenin, and kaempferol.
Article
Biochemistry & Molecular Biology
Pathy Kibungu Kembelo, Emmy Tuenter, Wouter Vanhove, Honore Belesi Katula, Patrick Van Damme, Luc Pieters
Summary: Kalaharia uncinata is a tropical plant widely used in Southern Africa for treating upper respiratory tract infections. This study aimed to identify and discuss the potential bioactivity of the phytochemical constituents in the plant. Results showed the presence of compounds with antiviral and anti-inflammatory properties, which may explain its efficacy against respiratory tract infections.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Applied
Lianny Perez-Gomez, Aurora T. T. Perez-Martinez, An Matheeussen, Luc Pieters, Daniel Mendez, Yemeys Quiros-Molina, Reinaldo Trujillo, Emmy Tuenter, Paul Cos
Summary: The investigation of natural alternatives to conventional fungicides is urgently needed. The extracts from Mosiera bullata leaves exhibited significant antifungal activity against various fungal plant pathogens, suggesting its potential as a natural antifungal product for disease control in agriculture.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Ngoc-Thao-Hien Le, Steven De Jonghe, Kristien Erven, Johan Neyts, Christophe Pannecouque, Tom Vermeyen, Wouter A. Herrebout, Luc Pieters, Emmy Tuenter
Summary: Scadoxus multiflorus is traditionally used for respiratory problems and this study investigated its alkaloidal composition. A previously undescribed alkaloid and fourteen known ones were identified. Some of the alkaloids exhibited weak antiviral activity against SARS-CoV-2, highlighting the potential of S. multiflorus as a source for anti-SARS-CoV-2 Amaryllidaceae alkaloid scaffolds.
PHYTOCHEMISTRY LETTERS
(2023)