Article
Endocrinology & Metabolism
Bishwajit Bhowmik, Tasnima Siddiquee, Ibrahimu Mdala, Liya Quamrun Nesa, Samsad Jahan Shelly, Zahid Hassan, Nayla Cristina do Moreira, Ishrat Jahan, A. K. Azad Khan, Graham A. Hitman, Akhtar Hussain
Summary: The study did not show the efficacy of vitamin D3 or B12 supplementation during pregnancy. Most pregnant women had normal levels of vitamin D and B12 at term, and there were no significant differences in pregnancy or birth outcomes among different supplementation groups.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Nutrition & Dietetics
Ye Ding, Ping Hu, Yue Yang, Fangping Xu, Fang Li, Xiaolong Lu, Zhencheng Xie, Zhixu Wang
Summary: The study suggests that daily oral low-dose vitamin A supplementation can improve maternal vitamin A levels, although it does not affect infant health status through breast milk.
Article
Nutrition & Dietetics
Raghad M. Alhomaid, Maria S. Mulhern, J. J. Strain, Eamon Laird, Martin Healy, Michael J. Parker, Mary T. McCann
Summary: Maternal supplementation of 20 μg vitamin D-3/d is more effective in achieving target 25(OH)D concentrations in pregnancy compared to 10 μg, especially for obese women. Low maternal 25(OH)D concentrations at baseline may lead to deficiencies in umbilical cord 25(OH)D, highlighting the importance of adequate vitamin D supplementation during pregnancy, especially for obese women.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Biology
Eva Dedeckova, Roman Vitak, Michal Jirasko, Marketa Kralova, Ondrej Topolcan, Ladislav Pecen, Tomas Furst, Pavel Broz, Radek Kucera
Summary: This study aimed to determine if doses of 1000 IU or 2000 IU of vitamin D-3 are sufficient to reach the reference values of [25(OH)D]. The results showed that a dose of 1000 IU taken daily for 60 days only slightly increased vitamin D levels, while taking 2000 IU daily led to a sharp increase and maintained desired levels even after 30 days of cessation. Therefore, a daily dose of 2000 IU can maintain vitamin D levels for a longer period.
Article
Microbiology
Renqiang Yu, Yizhe Ma, Zichen Luo, Ce Qi, Anni Xie, Yifan Jiang, Baoli Zhu, Jin Sun
Summary: This study aims to evaluate the efficacy of maternal consumption of L. reuteri FN041 during late pregnancy and lactation in preventing infantile atopic dermatitis (AD). Through a randomized, double-blind, placebo-controlled intervention study and a multicenter cohort study, the most efficient dosage of L. reuteri FN041 for preventing infantile AD will be determined.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Nutrition & Dietetics
Elham Kazemain, Samaneh Ansari, Sayed Hossein Davoodi, William B. Patterson, Pedram Shakerinava, Carol L. Wagner, Atieh Amouzegar
Summary: The study found that there is a relationship between vitamin D supplementation during lactation and vitamin D levels in mother-infant dyads. The dosage of maternal vitamin D supplementation is linearly related to the infants' circulating 25(OH)D concentrations, but nonlinearly related to the circulating 25(OH)D concentrations in breastfeeding women.
ADVANCES IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Hermann Brenner, Sabine Kuznia, Clarissa Laetsch, Tobias Niedermaier, Ben Schoettker
Summary: Meta-analyses have indicated a protective effect of vitamin D-3 supplementation against cancer mortality, but this effect may vary by body mass index. The VITAL study found that vitamin D-3 supplementation had protective effects on cancer incidence for normal-weight participants but not for overweight or obese participants. Further research is needed to explore the potential of adjuvant vitamin D therapy for cancer patients.
Article
Multidisciplinary Sciences
Valeria Garcia-Flores, Roberto Romero, Yi Xu, Kevin Theis, Marcia Arenas-Hernandez, Derek Miller, Azam Peyvandipour, Jose Galaz, Dustyn Levenson, Gaurav Bhatti, Meyer Gershater, Errile Pusod, David Kracht, Violetta Florova, Yaozhu Leng, Li Tao, Megan Faucett, Robert Para, Chaur-Dong Hsu, Gary Zhang, Adi Tarca, Roger Pique-Regi, Nardhy Gomez-Lopez
Summary: This study presents the maternal-fetal immune responses triggered by SARS-CoV-2 infection during pregnancy and highlights the rarity of placental infection. A T-cell dominant inflammatory response is observed at the maternal-fetal interface, but the virus remains undetectable in the placenta while triggering specific immune responses in the neonatal circulation.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Maria Elena Romero-Ibarguengoitia, Dalia Gutierrez-Gonzalez, Carlos Cantu-Lopez, Miguel Angel Sanz-Sanchez, Arnulfo Gonzalez-Cantu
Summary: This study aimed to evaluate the effect of vitamin D3 supplementation vs. dietary-hygienic measures on the SARS-CoV-2 infection rate in participants with serum 25(OH)D3 levels between 20-100 ng/mL. The results showed that participants who received vitamin D3 supplementation had a lower rate of SARS-CoV-2 infection compared to those who used dietary-hygienic measures during the 6-month follow-up.
Article
Infectious Diseases
Miao Hong, Ting Xiong, Junmei Huang, Yuanjue Wu, Lixia Lin, Zhen Zhang, Li Huang, Qin Gao, Huanzhuo Wang, Xuefeng Yang, Nianhong Yang, Liping Hao
Summary: This study aimed to assess the association between vitamin D supplementation and the risk of lower respiratory tract infection (LRTI) among infants. The study found that vitamin D supplementation was significantly associated with a reduced risk of LRTI in infants, and the risk reduction was linearly related to the supplementation dose.
Article
Biochemistry & Molecular Biology
Renata L. Goto, Mariana B. Tablas, Gabriel B. Prata, Sara G. Espirito Santo, Ana Angelica H. Fernandes, Bruno Cogliati, Luis F. Barbisan, Guilherme R. Romualdo
Summary: The study revealed that dietary VD3 supplementation can reduce inflammation and fibrosis in liver tissue, and help prevent the development of cirrhosis-associated hepatocellular carcinoma. The highest intervention of VD3 showed superior antioxidant and anti-neoplastic properties in the chemically-induced cirrhosis-associated hepatocarcinogenesis.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Majd Kittaneh, Moammal Qurt, Numan Malkieh, Hani Naseef, Ramzi Muqedi
Summary: This study prepared various film-forming solutions for transdermal delivery of vitamin D3. The release of vitamin D3 from the solution was greater compared to the dry film. In vitro permeation studies showed that after 24 hours, around 800 IU of vitamin D3 permeated through the artificial skin membrane.
Article
Nutrition & Dietetics
Fanny Loddo, Steve Nauleau, David Lapalus, Sophie Tardieu, Olivier Bernard, Farid Boubred
Summary: This population-based record-linkage study examined the association between maternal gestational Vitamin D3 supplementation and early respiratory health in offspring. The study found that infants prenatally exposed to maternal Vitamin D3 supplementation had a longer gestational age at birth and a lower risk of respiratory illness. This study provides evidence for the positive impact of maternal gestational Vitamin D3 supplementation on early respiratory outcomes in young children.
Article
Medicine, General & Internal
Martina Ferrillo, Mario Migliario, Andrea Roccuzzo, Pedro Molinero-Mourelle, Giovanni Falcicchio, Giuseppina Rosaria Umano, Federica Pezzotti, Pier Luigi Foglio Bonda, Dario Calafiore, Alessandro de Sire
Summary: The study found a correlation between periodontal disease, low vitamin D levels, preterm birth, and low birth weight in pregnant women. Poor oral health and vitamin D deficiency in pregnant women were significantly associated with higher rates of preterm birth and low birth weight.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Lise Sofie Bislev, Louise Wamberg, Lars Rolighed, Diana Grove-Laugesen, Lars Rejnmark
Summary: Supplementation of vitamin D did not have a significant impact on muscle health or quality of life overall. However, there was a potential beneficial effect on muscle strength in severely obese individuals and on quality of life in vitamin D deficient individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Infectious Diseases
Ajibola Ibraheem Abioye, Christopher R. Sudfeld, Michael D. Hughes, Said Aboud, Alfa Muhihi, Nzovu Ulenga, Tumaini J. Nagu, Molin Wang, Ferdinand Mugusi, Wafaie W. Fawzi
Summary: This study evaluated the trajectory of iron status among people living with HIV during the first year of highly active antiretroviral therapy (HAART) and analyzed the influence of inflammation correction methods on iron status research. The findings showed that elevated iron status was associated with HIV-1 viral load and underweight.
Article
Nutrition & Dietetics
Zhonghai Zhu, Yingze Zhu, Liang Wang, Qi Qi, Lin Huang, Amanuel Kidane Andegiorgish, Mohamed Elhoumed, Yue Cheng, Michael J. Dibley, Christopher R. Sudfeld, Lingxia Zeng
Summary: Antenatal micronutrient supplementation has been shown to improve birth outcomes and child development. However, its effect on offspring socioemotional outcomes remains unknown. This study found that iron supplementation during pregnancy reduced adolescent emotional and behavioral problem scores, providing support for expanding coverage of iron-containing prenatal supplements in resource-limited settings.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Ajibola Ibraheem Abioye, Michael D. Hughes, Christopher R. Sudfeld, Zulfiqarali Premji, Said Aboud, Davidson H. Hamer, Drucilla J. Roberts, Christopher P. Duggan, Wafaie W. Fawzi
Summary: The impact of iron deficiency anemia (IDA) and non-iron deficiency anemia (NIDA) on pregnancy and newborn outcomes, as well as the effectiveness of iron supplementation, remains uncertain. This study found that iron supplementation is effective even among pregnant women with NIDA.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Medicine, General & Internal
Lucy Lawrence Mpayo, Aslam Nkya, Shabani Mawalla, Karim Premji Manji
Summary: Teratomas in the neonatal age group, especially in the sacrococcygeal region, are mostly benign, but rarely associated with HIV infection. We present a case of an HIV-exposed newborn with a congenital teratoma in the post-auricular site, which resulted in an infection. Early total surgical resection is crucial to prevent complications and malignant transformation.
Article
Immunology
Ajibola Ibraheem Abioye, Michael D. D. Hughes, Christopher R. R. Sudfeld, Ramadhani Abdallah Noor, Sheila Isanaka, Zohra Lukmanji, Ferdinand Mugusi, Wafaie W. W. Fawzi
Summary: This study evaluated the relationship between dietary iron intake levels and sources with mortality and clinical outcomes among adults initiating HAART. The results showed that intake of red meat and legumes was associated with a lower risk of mortality and critical HIV-related outcomes.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Medicine, General & Internal
Linda Vesel, Roopa M. Bellad, Karim Manji, Friday Saidi, Esther Velasquez, Christopher R. Sudfeld, Katharine Miller, Mohamed Bakari, Kristina Lugangira, Rodrick Kisenge, Nahya Salim, Sarah Somji, Irving Hoffman, Kingsly Msimuko, Tisungane Mvalo, Fadire Nyirenda, Melda Phiri, Leena Das, Sangappa Dhaded, Shivaprasad S. Goudar, Veena Herekar, Yogesh Kumar, M. B. Koujalagi, Gowdar Guruprasad, Sanghamitra Panda, Latha G. Shamanur, Manjunath Somannavar, Sunil S. Vernekar, Sujata Misra, Linda Adair, Griffith Bell, Bethany A. Caruso, Christopher Duggan, Katelyn Fleming, Kiersten Israel-Ballard, Eliza Fishman, Anne C. C. Lee, Stuart Lipsitz, Kimberly L. Mansen, Stephanie L. Martin, Rana R. Mokhtar, Krysten North, Arthur Pote, Lauren Spigel, Danielle E. Tuller, Melissa Young, Katherine E. A. Semrau
Summary: This study aimed to describe the feeding profile of low birthweight infants in the first half of infancy and examine early risk factors and growth patterns of poor 6-month growth outcomes. The study found that preterm and small-for-gestational age infants had a higher risk of poor growth at 6 months, and infants who did not regain birthweight by 2 weeks also had a higher risk. Therefore, early interventions including optimal feeding support, action-oriented growth monitoring, and understanding the needs and growth patterns of small-for-gestational age infants are needed to promote appropriate weight gain and proactive management of vulnerable infants.
Article
Medicine, General & Internal
Naomi A. A. Mwamanenge, Fatima Mussa, Masawa K. K. Nyamuryekung'e, Martha Mkony, Yaser Abdallah, Karim Manji
Summary: This article presents a case report of a 6-week-old African male baby diagnosed with congenital diaphragmatic hernia after failing to respond to antibiotics for suspected pneumonia. Despite attempts at management, the baby died 5 weeks post-surgery. The case emphasizes the importance of early clinical suspicion and early detection of congenital diaphragmatic hernia in infants with respiratory symptoms, as well as the need for improved availability of imaging in primary care facilities for early diagnosis and management.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Article
Medicine, General & Internal
Naomi Mwamanenge, Haika Mariki, Martha Mkony, Karim Premji Manji
Summary: This is a case report of a preterm newborn baby with respiratory distress syndrome and bilateral knee contracture. Clinical examination and radiographic skeletal survey revealed a short spinal cord with complete agenesis of the lumbar, sacrum, and coccygeal spine, and hypoplastic iliac bones with bilateral knee contractures. The mother did not have diabetes. The long-term outcome is not well-known in our set-up.
Article
Medicine, General & Internal
Haika Mariki, Naomi Mwamanenge, Martha Mkony, Karim Premji Manji
Summary: We present a case of a newborn with neurocristic cutaneous hamartoma of the scalp, characterized by giant congenital nevi and disseminated melanocytic nevi. MRI scan revealed an occipital defect with herniation of the occipital lobes and ventricles, while the infratentorial brain parenchyma and cerebellum remained normal. Initial diagnosis was a ruptured giant haemangioma and possible cytomegalovirus infection, causing 'blueberry muffin' syndrome. Follow-up showed regression of the hamartoma/haemangioma-like mass and the presence of a well-demarcated melanotic patch on the scalp and encephalocele. Neurosurgical intervention is being scheduled for this infant.
Article
Medicine, General & Internal
Ernestina Mwipopo, Mariam Mngoya Massomo, Robert Moshiro, Karim Premji Manji
Summary: This is a case report of a male baby diagnosed with Manitoba oculo-tricho-anal syndrome and Fraser syndrome 2, as well as lissencephaly 10. The presence of overlapping genetic mutations highlights the importance of genetic testing, even in low-middle income countries (LMIC).
Article
Health Care Sciences & Services
Mathilda Regan, Chao Cheng, Eric Mboggo, Elysia Larson, Irene Andrew Lema, Lucy Magesa, Lameck Machumi, Nzovu Ulenga, David Sando, Mary Mwanyika-Sando, Dale A. Barnhart, Biling Hong, Ester Mungure, Nan Li, Hellen Siril, Phares Mujinja, Helga Naburi, Charles Kilewo, Anna Mia Ekstrom, Pascal Geldsetzer, Wafaie Fawzi, Till Barnighausen, Christopher R. Sudfeld, Donna Spiegelman
Summary: This study in Tanzania found that training community health workers (CHWs) in the public sector can significantly increase the likelihood of pregnant women attending antenatal care (ANC) visits and have a positive impact on the total number of ANC visits. However, additional interventions are needed to promote early initiation of ANC.
HEALTH POLICY AND PLANNING
(2023)
Article
Biotechnology & Applied Microbiology
Zainab Hassan Yussuph, Fadhlun M. Alwy Al-Beity, Furaha August, Amani Anaeli
Summary: A study conducted among pregnant women attending public antenatal clinics in Dar es Salaam aimed to determine the magnitude of hesitancy toward COVID-19 vaccines and the associated factors. The results showed that approximately 45% of pregnant women had vaccine hesitancy, which was higher among the unemployed and self-employed group. It was also higher among pregnant women with poor attitudes to COVID-19 vaccines and those who had low perceived benefits of the vaccines. The study highlights the importance of targeted interventions to address knowledge gaps and negative perceptions among pregnant women regarding COVID-19 vaccines.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Medicine, General & Internal
Ioannis Gallos, Adam Devall, James Martin, Lee Middleton, Leanne Beeson, Hadiza Galadanci, Fadhlun Alwy Al-beity, Zahida Qureshi, G. Justus Hofmeyr, Neil Moran, Sue Fawcus, Lumaan Sheikh, George Gwako, Alfred Osoti, Ashraf Aswat, Kristie-Marie Mammoliti, Kulandaipalayam N. Sindhu, Marcelina Podesek, Isobelle Horne, Rebecca Timms, Idnan Yunas, Jenipher Okore, Mandisa Singata-Madliki, Edna Arends, Aminu A. Wakili, Ard Mwampashi, Sidrah Nausheen, Shah Muhammad, Pallavi Latthe, Cherrie Evans, Shahinoor Akter, Gillian Forbes, David Lissauer, Shireen Meher, Andrew Weeks, Andrew Shennan, Anne Ammerdorffer, Eleanor Williams, Tracy Roberts, Mariana Widmer, Olufemi T. Oladapo, Fabiana Lorencatto, Meghan A. Bohren, Suellen Miller, Fernando Althabe, Metin Gulmezoglu, Jeffrey M. Smith, Karla Hemming, Arri Coomarasamy
Summary: Early detection and bundled treatment of postpartum hemorrhage led to a lower risk of severe complications or death compared to usual care among patients undergoing vaginal delivery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)