Journal
TRENDS IN MOLECULAR MEDICINE
Volume 23, Issue 8, Pages 721-736Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2017.06.001
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Funding
- Judith and Stewart Colton Center for Autoimmunity
- National Institutes of Health (NIH) [R01HL125816, 1R21AI110830]
- Ralph S. French Charitable Trust
- Beckman Foundation
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B lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies is of B cell origin, suggesting that the development and activation of B cells need to be tightly regulated. In recent years, increasing evidence has emerged demonstrating that microRNAs (miRNAs) - a class of non-coding RNAs that control gene expression - are involved in the regulation of B cell development and function. We provide here an overview of the current knowledge on the role of miRNAs and their relevant targets in B cell development, B cell activation, and B cell malignant transformation.
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