Journal
TRENDS IN CELL BIOLOGY
Volume 27, Issue 1, Pages 42-54Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2016.07.008
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The separation of chromosomes in anaphase is a precarious step in the cell cycle. The separation is irreversible, and any error can lead to cell death or genetic instability. Chromosome separation is controlled by the protease separase. Here we discuss recent work that has revealed additional layers of separase regulation and has deepened our understanding of how separase activation is coordinated with other events of mitotic exit.
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