Journal
TRENDS IN BIOTECHNOLOGY
Volume 35, Issue 1, Pages 43-54Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2016.10.003
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Funding
- National Research Foundation of Korea (NRF) grant - Korea government (MSIP) [2014R1A2A1A11050764]
- Bio & Medical Technology Development Program of the National Research Foundation (NRF) - Korean government (MSIP) [2012M3A9B4028738]
- National Research Foundation of Korea [2014R1A2A1A11050764] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Coral skeletons can regenerate replacement human bone in nonload-bearing excavated skeletal locations. A combination of multiscale, interconnected pores and channels and highly bioactive surface chemistry has established corals as an important alternative to using healthy host bone replacements. Here, we highlight how coral skeletal systems are being remolded into new calcified structures or synthetic corals by biomimetic processes, as places for the organized permeation of bone tissue cells and blood vessels. Progressive technologies in coral aquaculture and self-organization inorganic chemistry are helping to modify natural corals and create synthetic coral architectures able to accelerate bone regeneration with proper host integration at more skeletal locations, adapted to recent surgical techniques and used to treat intrinsic skeletal deformities and metabolic conditions.
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