Article
Oncology
Giancarlo Marra, Francesco Soria, Federica Peretti, Marco Oderda, Charles Dariane, Marc-Olivier Timsit, Julien Branchereau, Oussama Hedli, Benoit Mesnard, Derya Tilki, Jonathon Olsburgh, Meghana Kulkarni, Veeru Kasivisvanathan, Cedric Lebacle, Oscar Rodriguez-Faba, Alberto Breda, Timo Soeterik, Giorgio Gandaglia, Paola Todeschini, Luigi Biancone, Paolo Gontero
Summary: Currently, there is limited and conflicting evidence regarding the management of prostate cancer in renal transplant recipients. This study aimed to assess the differences in treatment and natural history of prostate cancer in renal transplant recipients. The study found that prostate cancer in renal transplant recipients is not aggressive and has similar outcomes to non-renal transplant recipients. However, renal transplant recipients have a significant risk of non-prostate cancer-related death. Therefore, aggressive upfront management of prostate cancer in most renal transplant recipients should be avoided.
Article
Urology & Nephrology
Giancarlo Marra, Marco Agnello, Andrea Giordano, Francesco Soria, Marco Oderda, Charles Dariane, Marc-Olivier Timsit, Julien Branchereau, Oussama Hedli, Benoit Mesnard, Derya Tilki, Jonathon Olsburgh, Meghana Kulkarni, Veeru Kasivisvanathan, Alberto Breda, Luigi Biancone, Paolo Gontero
Summary: This study describes the surgical technique and reports the outcomes of robot-assisted radical prostatectomy (RARP) in renal transplant recipients. The results suggest that RARP is safe and feasible in this patient population, with comparable operative, oncological, and functional outcomes to RARP in non-transplant patients. However, further research is needed to confirm these findings.
Review
Microbiology
Jesus E. Escamilla, Spenser E. January, Rodrigo Vazquez Guillamet
Summary: Fungal infections in lung transplant patients are a significant cause of morbidity, leading to allograft damage and chronic lung allograft dysfunction. Early diagnosis and treatment are crucial to prevent further damage. This review article discusses the incidence, risk factors, symptoms, diagnostic, and treatment strategies for various fungal infections in lung transplant recipients, including Aspergillus, Candida, Coccidioides, Histoplasma, Blastomyces, Scedosporium/Lomentospora, Fusarium, and Pneumocystis jirovecii. The use of newer triazole and inhaled antifungals for isolated pulmonary fungal infections in lung transplant recipients is also explored.
Article
Oncology
Eric A. Engels, Gregory Haber, Allyson Hart, Charles F. Lynch, Jie Li, Karen S. Pawlish, Baozhen Qiao, Kelly J. Yu, Ruth M. Pfeiffer
Summary: A previous cancer diagnosis is a negative factor in evaluating patients for solid organ transplantation. Statistical cure models were used to analyze cancer patients in the US general population. Patients with high cure probabilities at transplantation showed better outcomes, while those with low cure probabilities had increased cancer-specific mortality after transplantation.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Surgery
Pietro Spatafora, Francesco Sessa, Simone Caroassai Grisanti, Claudio Bisegna, Calogero Saieva, Giandomenico Roviello, Paolo Polverino, Anna Rivetti, Lorenzo Verdelli, Maria Zanazzi, Detti Beatrice, Graziano Vignolini, Gabriella Nesi, Giulio Nicita, Sergio Serni, Donata Villari
Summary: This study reviewed the 25-year experience in the management of prostate cancer after kidney transplantation at the Florence Transplant Centre. Standard treatments can be proposed to renal transplant recipients with satisfactory results on both post-operative and oncological outcomes. Further studies are needed to address the issue of prostate cancer screening based on PSA levels and the optimal management of prostate cancer in renal transplant recipients.
FRONTIERS IN SURGERY
(2021)
Article
Medicine, General & Internal
Nicholas C. Allen, Andrew J. Martin, Victoria A. Snaidr, Renee Eggins, Alvin H. Chong, Pablo Fernandez-Penas, Douglas Gin, Shireen Sidhu, Vanessa L. Paddon, Leith A. Banney, Adrian Lim, Edward Upjohn, Helmut Schaider, Aparna D. Ganhewa, Jennifer Nguyen, Catriona A. McKenzie, Saurabh Prakash, Catriona McLean, Alistair Lochhead, Jan Ibbetson, Andrew Dettrick, Anthony Landgren, Katherine J. Allnutt, Clare Allison, Rachael B. Davenport, Blake P. Mumford, Brittany Wong, Brendan Stagg, Alexander Tedman, Hannah Gribbin, Harrison A. Edwards, Nicholas De Rosa, Thomas Stewart, Brent J. Doolan, Yonatan Kok, Kate Simpson, Zhi M. Low, Tom Kovitwanichkanont, Richard A. Scolyer, Haryana M. Dhillon, Janette L. Vardy, Steven J. Chadban, David G. Bowen, Andrew C. Chen, Diona L. Damian
Summary: Immunosuppressed organ-transplant recipients have a higher incidence and mortality from skin cancer. Nicotinamide, a form of vitamin B3, has shown potential in preventing skin cancers. However, a placebo-controlled trial found that oral nicotinamide therapy did not reduce the number of keratinocyte cancers or actinic keratoses in immunosuppressed solid-organ transplant recipients.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Stergios Boussios, Perry Devo, Iain C. A. Goodall, Konstantinos Sirlantzis, Aruni Ghose, Sayali D. Shinde, Vasileios Papadopoulos, Elisabet Sanchez, Elie Rassy, Saak V. Ovsepian
Summary: This article reviews the characteristics and functions of extracellular vesicles (EVs), particularly exosomes, in renal cell carcinoma (RCC). It emphasizes the pivotal role of EVs in tumorigenesis, metastasis, immune evasion, and drug response, as well as their potential as biomarkers and therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Bradley Carthon, Hannah C. Sibold, Shannon Blee, Rebecca D. Pentz
Summary: Prostate cancer remains the leading diagnosed cancer among American men, with disparities existing among Black men. Despite lower rates of screening and diagnostic procedures, various therapies have shown effectiveness in Black populations. Increased inclusion in clinical trials, decentralized trial efforts, and successful models of patient navigation are vital to ensure progress in prostate cancer disparities.
Article
Surgery
Allyson Hart, Ruth M. Pfeiffer, Bozena M. Morawski, Charles F. Lynch, Yun Zeng, Karen Pawlish, Deborah Hurley, Kelly J. Yu, Eric A. Engels
Summary: This study examined the outcomes of solid organ transplant recipients with a pretransplant cancer diagnosis. It found that pretransplant cancer was associated with increased overall mortality, cancer-specific mortality, and risk of developing posttransplant cancer. Improved candidate selection and cancer screening and prevention may help reduce mortality in this population.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Biochemistry & Molecular Biology
Kathleen M. Job, Jessica K. Roberts, Elena Y. Enioutina, Silvia M. IIIamola, Shaun S. Kumar, Jahidur Rashid, Robert M. Ward, Tsuyoshi Fukuda, Joseph Sherbotie, Catherine M. Sherwin
Summary: This review examines the impact of pharmacokinetic variability on renal transplantation and its association with various factors. Pharmacodynamics are outlined for each immunosuppressant, along with potential adverse effects and the utility of pharmacodynamic biomarkers. Acquiring a better quantitative understanding of immunosuppressant pharmacokinetics and pharmacodynamics can help clinicians maintain the balance between therapeutic efficacy and drug-related toxicity.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Infectious Diseases
Feng Zhang, Jia Chen, He Huang, Xiaolong Deng, Wei Zhang, Min Zeng, Rangjiao Liu, Lizhong Dai, Qiquan Wan
Summary: This study demonstrated the value of mNGS in diagnosing PJP, highlighted the sensitivity of BDG assays, and found that cytomegalovirus and Torque teno virus infections often occur concurrently with PJP.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Piotr K. Krajewski, Piotr Olczyk, Magdalena Krajewska, Wojciech Krajewski, Jacek C. Szepietowski
Summary: This study analyzed data from 197 renal transplant patients and found that approximately one-third experienced itch during hemodialysis, but the majority saw complete resolution of itch after successful transplantation. Additionally, over half of the renal transplant recipients did not experience itch during dialysis.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Josephine L. C. Anderson, Markus van Der Giet, Antonio W. Gomes Neto, Stephan J. L. Bakker, Uwe J. F. Tietge
Summary: This study found that statin use does not significantly decrease cardiovascular events in renal transplant recipients overall. However, in patients using cyclosporine, statin use is independently associated with an increased risk of cardiovascular events and cardiovascular-specific mortality, possibly due to a pharmacological interaction.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Shoko Ishikawa, Masayuki Tasaki, Kazuhide Saito, Yuki Nakagawa, Masahiro Ikeda, Kota Takahashi, Yoshihiko Tomita
Summary: This study investigated the incidence of CMV infection in the chronic phase after kidney transplantation and found that 10-20% of patients had CMV infections in each year after transplantation. The study also showed that CMV viremia in the chronic phase was significantly associated with graft loss.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Food Science & Technology
Piotr K. Krajewski, Kinga Tyczynska, Klaudia Bardowska, Piotr Olczyk, Magdalena Krajewska, Jacek C. Szepietowski
Summary: Itch is a common symptom of chronic dermatoses and can be associated with systemic disorders. This study found that itch is a significant burden in renal transplant recipients (RTR), with higher prevalence of anxiety and depression among those experiencing itch. The severity of itch was positively correlated with anxiety, depression, and stigmatization. The results highlight the importance of addressing itch relief in a holistic approach to RTR patients.
Article
Urology & Nephrology
Jens Bedke, Laurence Albiges, Umberto Capitanio, Rachel H. Giles, Milan Hora, Thomas B. Lam, Borje Ljungberg, Lorenzo Marconi, Tobias Klatte, Alessandro Volpe, Yasmin Abu-Ghanem, Saeed Dabestani, Sergio Fernandez-Pello, Fabian Hofmann, Teele Kuusk, Rana Tahbaz, Thomas Powles, Axel Bex
Summary: Adjuvant pembrolizumab, an immune checkpoint inhibitor, showed significant improvement in disease-free survival (DFS) for high-risk clear cell renal cell carcinoma patients. However, the overall survival (OS) data are not yet available.
Review
Urology & Nephrology
Borje Ljungberg, Laurence Albiges, Yasmin Abu-Ghanem, Jens Bedke, Umberto Capitanio, Saeed Dabestani, Sergio Fernandez-Pello, Rachel H. Giles, Fabian Hofmann, Milan Hora, Tobias Klatte, Teele Kuusk, Thomas B. Lam, Lorenzo Marconi, Thomas Powles, Rana Tahbaz, Alessandro Volpe, Axel Bex
Summary: The European Association of Urology has prepared evidence-based guidelines for the management of RCC, which were updated in 2022 using a standardized methodology. The guidelines provide transparent and reliable evidence for the management of RCC, based on a thorough literature assessment and clinical practice recommendations.
Editorial Material
Urology & Nephrology
Umberto Capitanio, Jens Bedke, Laurence Albiges, Alessandro Volpe, Rachel H. Giles, Milan Hora, Lorenzo Marconi, Tobias Klatte, Yasmin Abu-Ghanem, Saeed Dabestani, Sergio Fernandez Pello, Fabian Hofmann, Teele Kuusk, Rana Tahbaz, Thomas Powles, Borje Ljungberg, Axel Bex
Article
Urology & Nephrology
Jens Bedke, Laurence Albiges, Umberto Capitanio, Rachel H. Giles, Milan Hora, Borje Ljungberg, Lorenzo Marconi, Tobias Klatte, Alessandro Volpe, Yasmin Abu-Ghanem, Saeed Dabestani, Sergio Fernandez-Pello, Fabian Hofmann, Teele Kuusk, Rana Tahbaz, Thomas Powles, Axel Bex
Summary: In the KEYNOTE-564 trial, adjuvant pembrolizumab showed significant improvement in disease-free survival (DFS) for localized clear-cell renal cell carcinoma (ccRCC) with a high risk of relapse. However, other immunotherapies, such as adjuvant atezolizumab, adjuvant nivolumab plus ipilimumab, and perioperative nivolumab did not meet the primary DFS endpoints. A meta-analysis is not recommended due to heterogeneity. Pembrolizumab remains the only recommended immune checkpoint inhibitor for this indication, but overall survival data are still immature and predictive biomarkers are lacking. Treatment decisions should be made cautiously and with patient involvement.
Article
Oncology
Giuseppe Fallara, Alessandro Larcher, Saeed Dabestani, Nicola Fossati, Petrus Jarvinen, Harry Nisen, Eirikur Gudmundsson, Thomas B. Lam, Lorenzo Marconi, Sergio Fernandez-Pello, Richard P. Meijer, Alessandro Volpe, Christian Beisland, Tobias Klatte, Grant D. Stewart, Karim Bensalah, Borje Ljungberg, Roberto Bertini, Francesco Montorsi, Axel Bex, Umberto Capitanio
Summary: The study found that minimally invasive surgery carries a higher risk of local recurrence and uncommon site metastases compared to open surgery, while no significant differences were observed in overall survival, cancer-specific survival, and disease-free survival. Main limitations include the retrospective nature of the study.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Editorial Material
Medicine, General & Internal
Vasco Quaresma, Lorenzo Marconi, Roberto Jarimba, Joao Lima, Arnaldo Figueiredo
ACTA MEDICA PORTUGUESA
(2023)
Letter
Urology & Nephrology
Umberto Capitanio, Jens Bedke, Laurence Albiges, Alessandro Volpe, Rachel H. Giles, Milan Hora, Lorenzo Marconi, Tobias Klatte, Yasmin Abu-Ghanem, Saeed Dabestani, Sergio Fernandez Pello, Fabian Hofmann, Teele Kuusk, Riccardo Campi, Rana Tahbaz, Thomas Powles, Boerje Ljungberg, Axel Bex
Editorial Material
Urology & Nephrology
Milan Hora, Laurence Albiges, Jens Bedke, Riccardo Campi, Umberto Capitanio, Rachel H. Giles, Borje Ljungberg, Lorenzo Marconi, Tobias Klatte, Alessandro Volpe, Yasmin Abu-Ghanem, Saeed Dabestani, Sergio Fernandez-Pello, Fabian Hofmann, Teele Kuusk, Rana Tahbaz, Thomas Powles, Axel Bex, Kiril Trpkov
Review
Urology & Nephrology
Francisco Javier Burgos Revilla, Alberto Artiles Medina, Ana Dominguez Gutierrez, Alfonso Muriel Garcia, Arnaldo Figueiredo, Victoria Gomez Dos Santos
Summary: This study assessed the safety of vascular closure devices in living-donor nephrectomy. The results showed that there were similar rates of device failure, severe hemorrhage, conversion to open surgery, and mortality between clips and staplers in non-comparative studies. In comparative studies, there were no significant differences in severe hemorrhage, conversion to open surgery, or death rates between the two groups. However, based on weak evidence, device failure was lower in the polymer clip group.
Article
Medicine, Research & Experimental
Andre Mansinho, Andreia Cruz, Lorenzo Marconi, Cidalia Pinto, Isabel Augusto
Summary: This work provides a summary of guideline recommendations and an expert position on the use of maintenance avelumab therapy for locally advanced or metastatic urothelial carcinoma (UC) based on a review of current international clinical practice guidelines. The expert panel recommends maintenance avelumab therapy in patients with response/stable disease following chemotherapy (regardless of PD-L1 status) for locally advanced or metastatic UC.
ADVANCES IN THERAPY
(2023)
Article
Urology & Nephrology
Joao Lorigo, Edgar Tavares Silva, Joao Pedroso Lima, Vasco Quaresma, Rui Pedrosa, Arnaldo Figueiredo
Summary: This study found that higher levels of C reactive protein/Albumin ratio (CAR) are associated with lower progression free survival (PFS) and overall survival (OS) in castration resistant metastatic prostate cancer (mCRPC) patients. A cut-off value of 0.22 for CAR was identified as the best predictor for prognosis. CAR is a valuable biomarker for prognosis, regardless of the timing of evaluation and treatment choice.
ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
(2023)
Article
Urology & Nephrology
Vasco Quaresma, Diogo Henriques, Lorenzo Marconi, Joao Lorigo, Ana-Marta Ferreira, Roberto Jarimba, Pedro Nunes, Arnaldo Figueiredo, Belmiro Parada
Summary: This study evaluated the clinical outcomes of 55 patients with stage I seminoma and analyzed the factors influencing treatment choice and oncological outcomes. The results showed that active surveillance is a safe modality, and adjuvant radiotherapy and adjuvant chemotherapy with carboplatin have similar results with fewer adverse effects in the chemotherapy group.
ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
(2023)
Article
Urology & Nephrology
Lorenzo Marconi, Teele Kuusk, Umberto Capitanio, Christian Beisland, Thomas Lam, Sergio Fernandez Pello, Grant D. Stewart, Tobias Klatte, Alessandro Volpe, Borje Ljungberg, Saeed Dabestani, Axel Bex
Summary: This study evaluated the effectiveness of local treatment for resectable recurrent renal cell carcinoma after surgical treatment of the primary kidney tumor. The results showed that local treatment could improve patients' survival, regardless of the risk of recurrence.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Review
Urology & Nephrology
Katharina Beyer, Christiaan Widdershoven, Lisa M. Wintner, Saeed Dabestani, Lorenzo Marconi, Charlotte Moss, Netty Kinsella, Yuhong Yuan, Rachel H. Giles, Ravi Barod, Mieke Van Hemelrijck, Axel Bex, Patricia Zondervan, Steven MacLennan
Summary: This study investigates the heterogeneity in outcome reporting in effectiveness trials and observational studies in localized renal cell carcinoma. The results show inconsistency in outcome reporting across studies and variability in definitions for conceptually similar outcomes.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Review
Urology & Nephrology
Michael M. E. L. Henderickx, Suraj V. Baldew, Lorenzo Marconi, Marcel D. van Dijk, Faridi S. van Etten-Jamaludin, Brunolf W. Lagerveld, Axel Bex, Patricia J. Zondervan
Summary: This study systematically reviewed the literature on surgical margins as a risk factor for LR in patients undergoing PN for pT1 RCC. The results showed a higher LR risk in PSM patients, but caution is needed in interpreting the data due to the overall low quality of evidence.
WORLD JOURNAL OF UROLOGY
(2022)