Article
Infectious Diseases
Hiroto Ishii, Tomohiko Sato, Miyuki Ishibashi, Hiroki Yokoyama, Takeshi Saito, Tetsunori Tasaki, Shingo Yano
Summary: The first case of immune complex type hemolytic anemia caused by initial micafungin administration is reported. The patient, a 42-year-old Japanese man receiving chemotherapy for primary amyloidosis, was given micafungin as prophylaxis. Previous cases in the literature were associated with secondary administration and immune hemolytic attacks. This rare case highlights the need for increased awareness of micafungin-induced hemolytic anemia upon initial administration.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Hongkai Lu, Na Wang, Peng Wang, Haolin Zhang, Ru Zhao, Hongju Liu, Xirong He, Zeya Liu, Yue Chang, Yongtong Cao, Shiyao Wang
Summary: This case report describes a patient with non-small cell lung cancer who developed severe immune hemolytic anemia after receiving pemetrexed plus cisplatin chemotherapy. Laboratory findings suggest the presence of complement-dependent pemetrexed antibodies and cisplatin-associated non-immunologic protein adsorption.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Anthie Damianaki, Marianna Tzanoudaki, Maria Kanariou, Emmanouil Liatsis, Alexandros Panos, Alexandra Soldatou, Lydia Kossiva
Summary: This is a case of a 3-year-old boy with severe and refractory warm antibody autoimmune hemolytic anemia. Despite B-cell recovery, the patient continued to have hypogammaglobulinemia 20 months after receiving rituximab therapy.
Review
Chemistry, Medicinal
Hsu-En Huang, Ko-Ming Lin, Jing-Chi Lin, Yu-Ting Lin, Hsiao-Ru He, Yu-Wei Wang, Shan-Fu Yu, Jia-Feng Chen, Tien-Tsai Cheng
Summary: Danazol therapy is an effective option for patients with refractory AIHA and ITP. In a 6-month observational study, 100% of AIHA patients and 75% of ITP patients achieved treatment response. Responders were able to reduce the dose of glucocorticoids and discontinue immunosuppressants.
Review
Medicine, General & Internal
Alexandra Esteves, Francisco Teixeira da Silva, Jose Carvalho, Ana Carvoeiro, Paula Felgueiras
Summary: This case demonstrates a rare but life-threatening drug side effect - diclofenac-induced immune hemolytic anemia. Timely diagnosis and treatment are crucial, and patients can fully recover after drug cessation.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Medicine, General & Internal
Marco Capecchi, Alessandro Ciavarella, Andrea Artoni, Maria Abbattista, Ida Martinelli
Summary: Autoimmune hemolytic anemias, including autoimmune hemolytic anemia and other immune-mediated anemias, are often associated with a high rate of thrombosis, but lack evidence-based guidance on prevention and management of thrombotic events. Pathophysiological mechanisms for thrombosis in these conditions may involve hemolysis itself and other effects of the immune system. Specific situations, like splenectomy and pregnancy, require particular attention for treatment and prevention of thrombotic complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Masafumi Fukuda, Masakazu Nabeta, Shuki Oya, Osamu Takasu
Summary: This article reports a case suspected to be drug-induced immune hemolytic anemia (DIIHA) caused by cefmetazole. The patient experienced rapid progression of anemia after receiving cefmetazole treatment. Despite treatment, the patient's condition further deteriorated and resulted in death. The diagnosis of DIIHA due to cefmetazole was confirmed through a drug-dependent antibody test.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Yuanjun Wu, Yong Wu, Yanli Ji, Yanhui Liu, Dongsheng Wu, Jiajie Liang, Ganping Guo, Baochan Chen
Summary: This study reported a case of a 44-year-old male patient who developed cimetidine-dependent antibodies and drug-independent non-specific antibodies leading to drug-induced immune hemolytic anemia after oral cimetidine administration. The pathogenic antibodies persisted in the patient's system for over 41 days, indicating the need for necessary medical monitoring within this time frame for patients with cimetidine-induced DIIHA.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Shengmei Chen, Ailing Fang, Yanfa Zhong, Jin Tang
Summary: In this study, iron nanoparticles were successfully biosynthesized using aqueous extracts from the leaf of Ziziphora clinopodioides, demonstrating a green, productive, and environmentally friendly method. The results of the study indicate that FeNPs have the potential to be used as a hematoprotective and anti-hemolytic anemia drug or supplement for the treatment of hemolytic anemia.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Immunology
Alexander Leonardo Silva-Junior, Nadja Pinto Garcia, Evilazio Cunha Cardoso, Stephanny Dias, Andrea Monteiro Tarrago, Nelson Abrahim Fraiji, Matheus Souza Gomes, Laurence Rodrigues Amaral, Andrea Teixeira-Carvalho, Olindo Assis Martins-Filho, Erich Vinicius De Paula, Allyson Guimaraes Costa, Adriana Malheiro
Summary: Sickle Cell Anemia (SCA) is characterized by genetic mutation in the beta-globin gene leading to increased hemolysis rate and involvement of immunological molecules. This study analyzed levels of various molecules in SCA patients in different clinical conditions, identifying a pro-inflammatory profile in steady-state patients and highlighting specific molecules in VOC patients. PDGF-BB and IL-1ra were important markers for transitioning from acute to chronic stage, showing significant decrease after crisis inflammation and statistical difference in different patient groups.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Urology & Nephrology
Yong Wu, Yuanjun Wu, Ganping Guo, Jiajun Zeng, Yan Liu, Yueqin Wu
Summary: This study provides a comprehensive description of the serological features and course of a patient with hypertensive nephropathy who developed drug-induced immune hemolytic anemia during repeated administration of piperacillin-tazobactam. The serological tests confirmed the diagnosis of piperacillin-induced immune hemolytic anemia. This study is important for deepening the understanding of drug-induced immune hemolytic anemia and learning from it.
Article
Medicine, General & Internal
Joe Okumoto, Shinjiro Sakamoto, Takeshi Masuda, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Hiroshi Iwamoto, Noriyasu Fukushima, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Summary: Drug-induced immune hemolytic anemia (DIIHA) is a rare condition with increasing incidence due to certain drugs. This case study reported a gradual improvement of anemia and hemolysis in a lung adenocarcinoma patient after discontinuation of alectinib, indicating a diagnosis of alectinib-induced IHA. The importance of correlating clinical laboratory findings in DIIHA was also emphasized.
Review
Medicine, General & Internal
Alessandro Noto, Ramona Cassin, Veronica Mattiello, Gianluigi Reda
Summary: Autoimmune cytopenias are common complications in chronic lymphocytic leukemia, with traditional chemo-immunotherapy employed for treatment. Ibrutinib has shown rapid and durable responses in treating AIHA arising in CLL, while controversy exists regarding the use of idelalisib in cases of AICs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Veterinary Sciences
Tomohiko Yoshida, Ahmed S. S. Mandour, Manami Sato, Miki Hirose, Rina Kikuchi, Norihiro Komiyama, Hanan A. A. Hendawy, Lina Hamabe, Ryou Tanaka, Katsuhiro Matsuura, Akiko Uemura
Summary: This article reports a clinical case of immune-mediated hemolytic anemia (IMHA) causing pulmonary thromboembolism (PTE) in a rare diagnosis in cats. The cat's anemia and cardiac function improved through antithrombotic and immunosuppressive therapy.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Hematology
Gabriella Gruden, Eloise Beggiato, Enrica Camerino, Serena Capriotti, Silvia Canepa, Michela Scandella, Maria Avolio, Fabrizia Pittalunga, Federica Barutta, Marilena Durazzo
Summary: A case of an 83-year-old woman with COVID-19 pneumonia associated with severe immune thrombocytopenia and hemolytic anemia is reported.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2021)
Article
Hematology
Anand Padmanabhan, Laura Connelly-Smith, Nicole Aqui, Rasheed A. Balogun, Reinhard Klingel, Erin Meyer, Huy P. Pham, Jennifer Schneiderman, Volker Witt, Yanyun Wu, Nicole D. Zantek, Nancy M. Dunbar, Joseph Schwartz
JOURNAL OF CLINICAL APHERESIS
(2019)
Article
Hematology
Yvette C. Tanhehco, Nicole D. Zantek, Mohamed Alsammak, Vishesh Chhibber, Yanhua Li, Joanne Becker, Ding W. Wu, Tisha Foster, Gay Wehrli
JOURNAL OF CLINICAL APHERESIS
(2019)
Article
Critical Care Medicine
Marianne E. Nellis, Marisa Tucci, Jacques Lacroix, Philip C. Spinella, Kelly D. Haque, Arabela Stock, Marie E. Steiner, E. Vincent S. Faustino, Nicole D. Zantek, Peter J. Davis, Simon J. Stanworth, Jill M. Cholette, Robert I. Parker, Pierre Demaret, Martin C. J. Kneyber, Robert T. Russell, Paul A. Stricker, Adam M. Vogel, Ariane Willems, Cassandra D. Josephson, Naomi L. C. Luban, Laura L. Loftis, Stephane Leteurtre, Christian F. Stocker, Susan M. Goobie, Oliver Karam
CRITICAL CARE MEDICINE
(2019)
Article
Hematology
Samuel J. Stellpflug, Michael E. Bond, Keith D. Henry, Kristin M. Engebretsen, Nicole D. Zantek
Summary: Dabigatran etexilate is an oral direct thrombin inhibitor used for patients with atrial fibrillation and prevention of thrombosis. Compared to warfarin, dabigatran offers advantages such as limited monitoring, but methods for reversal of anticoagulation are less well established.
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
(2021)
Editorial Material
Hematology
Rasheed A. Balogun, Amber P. Sanchez, Reinhard Klingel, Volker Witt, Nicole Aqui, Erin Meyer, Anand Padmanabhan, Huy P. Pham, Jennifer Schneiderman, Joseph Schwartz, Yanyun Wu, Nicole D. Zantek, Laura Connelly-Smith, Nancy M. Dunbar
JOURNAL OF CLINICAL APHERESIS
(2020)
Article
Hematology
Monica B. Pagano, Angela Treml, Laura D. Stephens, Sarita Joshi, Yanhua Li, Ileana Lopez-Plaza, Srivaths Poyyapakkam, Joseph Schwartz, Yvette Tanhehco, Nicole D. Zantek
Review
Hematology
Chinonso Onuoha, Karen D. Barton, Edward C. C. Wong, Jay S. Raval, Marian A. Rollins-Raval, Tina S. Ipe, Joseph E. Kiss, Leonard Boral, Jill Adamksi, Nicole D. Zantek, Oluwatoyosi A. Onwuemene
Article
Orthopedics
Edward Y. Cheng, David M. Matson, Kyle D. Morgenstern, Julie Agel, Paul Hoogervorst
Summary: This study developed and tested the reliability of a prioritization list for orthopaedic procedures during the COVID-19 pandemic and found it to be both adoptable and reliable. Further refinements may enhance its utility in the future.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2021)
Article
Hematology
Yvette C. Tanhehco, Yanhua Li, Nicole D. Zantek, Joanne Becker, Mohamed Alsammak, Kael Mikesell, Ding Wen Wu, Tisha Foster, Vishesh Chhibber, Marisa Saint Martin, Gay Wehrli
Summary: The study found that the COVID-19 pandemic negatively affected the well-being of some attending physicians, and measures taken by institutions or individuals were not able to completely resolve the decrease in well-being. Personal actions may be more effective in improving well-being during the pandemic.
Article
Hematology
Nicole D. Zantek, Ryan J. Martinez, Andrew D. Johnson, Anthony J. Tholkes, Surbhi Shah
Summary: This study analyzed the patterns and situations of apheresis procedures using health insurance claims data from large employers and health plans across the United States. A wide variety of diagnoses were treated through apheresis, but some procedure codes may not accurately reflect the nature of the procedures. The study highlights the need for direct measurement of apheresis procedures for future research studies.
JOURNAL OF CLINICAL APHERESIS
(2021)
Review
Hematology
Chisa Yamada, Jan C. Hofmann, Volker Witt, Gaurav K. Gupta, Jeffrey L. Winters
Summary: Vaccination efforts have helped reduce the number of infections, however, the emergence of SARS-CoV-2 variants has led to an increase in cases, indicating that the pandemic has not yet been resolved. Despite some relaxation of restrictions in certain regions, efforts to prevent virus transmission continue globally, with healthcare institutions and professional organizations implementing policies to address these challenges.
JOURNAL OF CLINICAL APHERESIS
(2021)
Review
Hematology
Ryan A. Metcalf, Claudia S. Cohn, Elizabeth S. Allen, Sara Bakhtary, Thomas Gniadek, Gaurav Gupta, Sarah Harm, Richard Haspel, Aaron Hess, Jessica Jacobson, Parvez M. Lokhandwala, Colin Murphy, Jacqueline Poston, Micah T. Prochaska, Jay S. Raval, Nabiha H. Saifee, Eric Salazar, Hua Shan, Nichole Zantek, Monica B. Pagano
Summary: This article presents an annual synopsis of the AABB Clinical Transfusion Medicine Committee (CTMC) in the field of transfusion medicine. It includes topics such as blood products, convalescent plasma, donor collections and testing, hemoglobinopathies, immunohematology and genomics, hemostasis, patient blood management, pediatrics, therapeutic apheresis, and cell therapy. The synopsis provides a useful resource for educational purposes.
Article
Medicine, Research & Experimental
Nicole D. Zantek, Marie E. Steiner, John M. VanBuren, Roger J. Lewis, Nicholas S. Berry, Kert Viele, Elizabeth Krachey, J. Michael Dean, Stacy Nelson, Philip C. Spinella
Summary: The CHIlled Platelet Study aims to compare the efficacy and safety of chilled platelets with room temperature-stored platelets in patients undergoing complex cardiac surgical procedures. The study will use a Bayesian adaptive design to determine the non-inferiority of chilled platelets at different storage durations. This study will provide valuable insights into the maximum duration of chilled platelet storage.
Editorial Material
Surgery
Andrew R. Leggett, Gregory J. Schneider, Yair D. Kissin, Edward Y. Cheng, Stephen R. Rossman
JBJS ESSENTIAL SURGICAL TECHNIQUES
(2023)
Review
Medicine, General & Internal
Jeremy T. Hines, Woo Lam Jo, Quanjun Cui, Michael A. Mont, Kyung Hoi Koo, Edward Y. Cheng, Stuart B. Goodman, Yong Chan Ha, Phillippe Hernigou, Lynne C. Jones, Shin Yoon Kim, Takashi Sakai, Nobuhiko Sugano, Takuaki Yamamoto, Mel S. Lee, Dewei Zhao, Wolf Drescher, Tae Young Kim, Young Kyun Lee, Byung Ho Yoon, Seung Hoon Baek, Wataru Ando, Hong Seok Kim, Jung Wee Park
Summary: Non-traumatic osteonecrosis of the femoral head (ONFH) predominantly affects adults younger than 50 years, leading to femoral head collapse and hip arthritis. The use of corticosteroids for leukemia and organ transplantation has contributed to the increasing prevalence of ONFH.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)