Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 95, Issue -, Pages 1-22Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2017.07.023
Keywords
Aptamer; Antibiotic; SELEX; Sensor; Purification; Detection; Environment; Food; Drinking water; Biological sample
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Antibiotic contamination and abuse are universal phenomena, accordingly antibiotic resistance has emerged as a serious issue globally in recent years. To detect antibiotics and their residues in the environment, foods, drugs and biological samples, numerous analytical techniques have been developed. Among them, aptamer-based methods are considered to be highly sensitive and selective and have been applied to the detection of various antibiotics in different samples. We present a systematical and critical review on the antibiotic-specific aptamers and their application in detection of antibiotics in different matrices, focusing on the recent advances in optical and electrochemical aptasensors, aptamer-affinity based sample purification, as well as the promising label-free and multiplex determination. (C) 2017 Elsevier B.V. All rights reserved.
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