Article
Biochemistry & Molecular Biology
Fatemeh Yarmohammadi, Samira Barangi, Seyed Hamid Aghaee-Bakhtiari, Hossein Hosseinzadeh, Zahra Moosavi, Russel J. J. Reiter, A. Wallace Hayes, Soghra Mehri, Gholamreza Karimi
Summary: Chronic arsenic exposure, mainly through contaminated water, is associated with cardiovascular diseases. Mitochondrial dysfunction, oxidative stress, inflammation, apoptosis, and autophagy are suggested as the molecular mechanisms of arsenic cardiotoxicity. Melatonin, as a powerful antioxidant, improves diabetic cardiomyopathy, cardiac remodeling, and heart failure. Pretreatment with melatonin can alleviate arsenic-induced prolongation of QT interval, oxidative stress, autophagy, and apoptosis, and modify the expression of Sirt1 and Nrf2. It also reverses the reduced expression of miR-34a and miR-144 caused by arsenic and moderates histopathological changes of cardiac injury.
Article
Environmental Sciences
Guanqun Cui, Ziyuan Li, Feifei Cao, Peng Li, Minghua Jin, Shanshan Hou, Xu Yang, Yingwen Mu, Cheng Peng, Hua Shao, Zhongjun Du
Summary: This study found that SiNPs induce cardiovascular toxicity through oxidative stress-mediated autophagy, and the Nrf2/HO-1 pathway negatively regulates autophagy.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Nadakuditi Venkata Raju, Palanisamy Prasanth, Thummala Harsha, Jalaja Naravula, Koigoora Srikanth, Venkatramaiah Nutalapati
Summary: This study investigated the toxicity of cobalt oxide nanoparticles on fresh water edible snails, revealing oxidative stress response in the snails exposed to Co(3)O(4)NPs. The findings are important for assessing the toxicity of Co(3)O(4)NPs in the environment.
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Suzan Attia Mawed, Carlotta Marini, Mahmoud Alagawany, Mayada R. Farag, Rasha M. Reda, Mohamed T. El-Saadony, Walaa M. Elhady, Gian E. Magi, Alessandro Di Cerbo, Wafaa G. El-Nagar
Summary: This study elucidated the ultrastructure changes in the ovary in response to exposure to zinc oxide nanoparticles (ZnO-NPs) and explored the role of autophagy and apoptosis in the fertility of female zebrafish. The results showed that ZnO-NPs induced cytotoxicity, oxidative stress, and necroptosis, leading to a reduction in the fecundity of female zebrafish.
Review
Biochemistry & Molecular Biology
Dong Qiao, Ting Zhang, Meng Tang
Summary: The rapid development of nanotechnology necessitates a deeper understanding of the potential health effects caused by nanoparticles (NPs). Autophagy, a programmed cell death, is induced by NPs and helps maintain intracellular homeostasis. Recent research has shown that NPs can regulate autophagy through both induction and blockade. This review examines the effects of different types of NPs on autophagy and highlights the potential mechanisms involved, as well as listing factors that influence NPs-regulated autophagy.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daolin Tang, Rui Kang
Summary: Over the past decade, research has focused on understanding oxidative cell death, particularly the transition from oxytosis to ferroptosis. Oxytosis, a form of nerve cell death induced by glutamate, was associated with intracellular glutathione depletion and inhibition of cystine uptake. The term ferroptosis was coined during a compound screening in 2012 and is induced by inhibitors of system xc(-) and GPX4. This article reviews the significant findings, models, and mechanisms of ferroptosis, and discusses its implications in various pathological conditions.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Neurosciences
Qisheng Tang, Tianwen Li, Kezhu Chen, Xiangyang Deng, Quan Zhang, Hailiang Tang, Zhifeng Shi, Tongming Zhu, Jianhong Zhu
Summary: Polystyrene nanoparticles (PS-NPs) are organic pollutants that pose potential threats to the environment and human health. This study investigates the neurotoxicity of PS-NPs and identifies the molecular mechanisms involving mitochondrial dysfunction and autophagy activation in human neuroblastoma SHSY-5Y cells.
Article
Chemistry, Multidisciplinary
Yen-Ling Lee, Yung-Sheng Shih, Zi-Yu Chen, Fong-Yu Cheng, Jing-Yu Lu, Yuan-Hua Wu, Ying-Jan Wang
Summary: This study investigated the effects of silver nanoparticles and zinc oxide nanoparticles on zebrafish embryos in aquatic environments. The research found that spiking these nanoparticles into natural water samples had a toxic effect on the embryos, with the level of toxicity influenced by complex components in the water. Additionally, zinc oxide nanoparticles caused a delay in embryo hatching. Measurement of reactive oxidative stress levels, apoptosis, and autophagy revealed the interaction and toxicity mechanisms of the nanoparticles with the embryos.
Article
Food Science & Technology
Zhanhang Wang, Shujuan Liu, Xiaolong Xu, Yuxuan Song, Lei Zhang, Xiaopeng An
Summary: This study used RNA-seq analysis to evaluate the potential toxicity of zinc oxide nanoparticles (ZnO NPs) on goat mammary epithelial cells (GMECs) in vitro. The results showed that ZnO NP treatment significantly reduced GMEC viability in a time- and dose-dependent manner. Additionally, ZnO NP exposure altered the expression levels of genes associated with mitochondrial dysfunction, oxidative stress, apoptosis pathways, endoplasmic reticulum stress, and autophagy. These findings highlight the significant toxic effects of ZnO NPs on GMECs and the need for cautious use in the feed and food industry. Furthermore, RNA-seq represents a promising method for assessing the toxicity mechanisms of nanomaterials.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Environmental Sciences
Yongyi Huang, Xiling Du, Te Liu, Qiang Liu
Summary: DEHP, a widely used plasticizer, has been found to cause cytotoxicity and various health issues. The exposure to DEHP affects the physiological functions and gene expression levels in Caenorhabditis elegans, while siRNA@SPION complexes are able to attenuate the toxic effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Oncology
Elisabeth Taucher, Iurii Mykoliuk, Melanie Fediuk, Freyja-Maria Smolle-Juettner
Summary: This article provides an overview of the connection between oxidative stress, autophagy, and cancer. Autophagy is a crucial cellular repair mechanism that is linked to various diseases, including cancer. Reactive oxygen and nitrogen species induce oxidative stress, which can trigger autophagy during nutrient deprivation. Researchers are increasingly focusing on identifying novel therapeutic targets in the autophagy process.
Article
Chemistry, Multidisciplinary
Songjing Zhong, Zeyu Zhang, Yunchao Zhao, Shaobo Wang, Quanhong Hu, Linlin Li
Summary: Researchers have fabricated bismuth nanoclusters as nanozymes that exhibit both catalytic and photothermal therapy effects. These nanozymes can generate toxic substances and deplete antioxidants in the tumor microenvironment, leading to remarkable antitumor effects.
Article
Chemistry, Multidisciplinary
Songjing Zhong, Zeyu Zhang, Yunchao Zhao, Shaobo Wang, Quanhong Hu, Linlin Li
Summary: We have designed a highly efficient bismuth nanocluster supported on nitrogen-doped porous carbon as a nanozyme (Bi-NC) for cancer therapy. At the same time, Bi-NC shows good photothermal conversion performance to generate heat for strengthening the therapy.
Article
Multidisciplinary Sciences
Yu-Hsuan Cheng, Hung-Keng Li, Chien-An Yao, Jing-Ying Huang, Yi-Ting Sung, Shiu-Dong Chung, Chiang-Ting Chien
Summary: Negative air ions have antioxidant and anti-inflammatory effects, protecting against lung injury and promoting wound healing in diabetic rats.
Article
Biochemistry & Molecular Biology
Xiao-Qing Li, Yi Wang, Shu-Jie Yang, Yu Liu, Xiang Ma, Lu Liu, Si-Hong Li, Dong Niu, Xing Duan
Summary: Maternal diabetes has negative effects on oocyte quality, but melatonin supplementation can protect oocytes from these damages and improve oocyte quality in assisted reproductive technologies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Allergy
A. Morotti, I. Sollaku, F. Franceschini, I. Cavazzana, M. Fredi, E. Sala, G. De Palma
Summary: Occupational exposure to free crystalline silica and tobacco smoking are associated with an increased risk of rheumatoid arthritis, especially with an interaction in seropositive subjects. Further studies are needed to support this association.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Environmental Sciences
Giuseppe De Palma, Gonzalo Carrasco-Avino, Enrica Gilberti, Moris Cadei, Tatiana Pedrazzi, Ivan M. Gallegos Mendez, Alejandra Roman, Nicolas Demartines, Paolo Boffetta, Ismail Labgaa
Summary: Gallbladder cancer (GBC) is a deadly malignancy with limited treatment options. The role of arsenic (As) in GBC carcinogenesis is debated, and there are no data on As measurement in GBC samples. This pilot study measured As concentrations in GBC tissue samples compared to non-cancerous gallbladder (NCGB) samples and found higher levels of arsenic in GBC samples, suggesting a potential impact of arsenic on GBC and the need for further studies.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sara Raia, Antonio Conti, Alan Zanardi, Barbara Ferrini, Giulia Maria Scotti, Enrica Gilberti, Giuseppe De Palma, Samuel David, Massimo Alessio
Summary: This study investigates the role of ceruloplasmin in iron and lipid metabolism. It reveals that deficiency of ceruloplasmin leads to obesity, adipose tissue accumulation, liver iron deposition, and steatosis. Ceruloplasmin replacement therapy is found to be effective in limiting liver iron accumulation and steatosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Toxicology
Elizabeth Leese, Kate Jones, Beatrice Bocca, Radia Bousoumah, Argelia Castano, Karen S. Galea, Ivo Iavicoli, Marta Esteban Lopez, Veruscka Leso, Sophie Ndaw, Simo P. Porras, Flavia Ruggieri, Paul T. J. Scheepers, Tiina Santonen
Summary: The aim of this study was to investigate the practicality of using exhaled breath condensate (EBC) as a biological matrix for detecting and measuring hexavalent chromium (Cr(VI)) and trivalent chromium (Cr(III)) in occupational workers. EBC samples were collected from workers in various countries and analyzed using hyphenated chromatography systems with inductively coupled plasma - mass spectrometry (ICP-MS). The results showed that occupationally exposed workers had significantly higher levels of Cr(VI) and Cr(III) compared to the control group. Chrome platers had the highest levels of Cr(VI) in their EBC samples, and both Cr(VI) and Cr(III) levels increased significantly after working. This study suggests that EBC can be a valid and non-invasive biological matrix for assessing occupational exposure to Cr(VI) and Cr(III).
TOXICOLOGY LETTERS
(2023)
Article
Immunology
Giulia Collatuzzo, Giuseppe De Palma, Francesco S. Violante, Stefano Porru, Francesca Larese Filon, Eleonora Fabianova, Concepcion Violan, Luigi Vimercati, Mihaela Leustean, Marta Maria Rodriguez-Suarez, Emanuele Sansone, Emma Sala, Carlotta Zunarelli, Vittorio Lodi, Maria Grazia Lourdes Monaco, Gianluca Spiteri, Corrado Negro, Jana Beresova, Lucia A. Carrasco-Ribelles, Silvio Tafuri, Shuffield S. Asafo, Giorgia Ditano, Mahsa Abedini, Paolo Boffetta
Summary: We investigated changes in serologic measurements after COVID-19 vaccination and found that age, infection, vaccine doses, time between doses and serologies, and vaccine type were associated with changes in serologic levels within 13 months.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Emanuele Sansone, Carlo Bonfanti, Emma Sala, Stefano Renzetti, Luigina Terlenghi, Alberto Matteelli, Mara Maria Tiraboschi, Tatiana Pedrazzi, Massimo Lombardo, Camillo Rossi, Anna Maria Indelicato, Arnaldo Caruso, Giuseppe De Palma
Summary: This study aims to assess the trends of anti-SARS-CoV-2 antibodies over a 9-month period after vaccination with an anti-SARS-CoV-2 vaccine in a COVID-19 hospital in Northern Italy. The results showed that vaccination significantly reduced the infection rate and elicited a specific humoral response that lasted throughout the observational period. Pre-vaccine infection, especially during the first wave of the pandemic, greatly enhanced the response to vaccination, which was also influenced by age.
Article
Biochemistry & Molecular Biology
Lucrezia Principi, Erica Ferrini, Roberta Ciccimarra, Lisa Pagani, Clizia Chinello, Paolo Previtali, Andrew Smith, Gino Villetti, Matteo Zoboli, Francesca Ravanetti, Franco Fabio Stellari, Fulvio Magni, Isabella Piga
Summary: This study investigated the molecular fingerprint of fibrosis progression and response to nintedanib treatment in mice with pulmonary fibrosis using mass spectrometry. The results showed that different stages of fibrosis have different protein expression patterns, and nintedanib treatment can alter the protein expression of fibrosis. These findings reveal the biological processes of pulmonary fibrosis and the mechanisms of fibrosis therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Amparo Guerrero Gerboles, Maricla Galetti, Stefano Rossi, Francesco Paolo lo Muzio, Silvana Pinelli, Nicola Delmonte, Cristina Caffarra Malvezzi, Claudio Macaluso, Michele Miragoli, Ruben Foresti
Summary: The toxicity of nanoparticles absorbed through contact or inhalation is a major concern for public health. In vitro nanotoxicological studies are conventionally limited, but the use of 3D bioprinting can provide a new perspective. In this study, 3D organoid-based scaffolds were developed to simulate lung cell exposure to nanoparticles, demonstrating toxicology responses that recapitulate in vivo experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Emanuele Sansone, Giulia Collatuzzo, Stefano Renzetti, Giorgia Ditano, Carlo Bonfanti, Emma Sala, Luigina Terlenghi, Alberto Matteelli, Mahsa Abedini, Shuffield Seyram Asafo, Paolo Boffetta, Giuseppe De Palma
Summary: Given their occupational risk profile, healthcare workers (HCWs) were prioritized for anti-SARS-CoV-2 vaccination. However, breakthrough infections remained common, especially with new SARS-CoV-2 variants of concern (VOCs) spreading rapidly in Italy. The level of anti-SARS-CoV-2 antibodies does not accurately predict protection from natural infection or vaccination, emphasizing the need for further research on susceptibility to SARS-CoV-2. This study aimed to characterize the risk profiles for SARS-CoV-2 infection in recently booster-dosed HCWs, finding that hybrid immunization (vaccine plus natural infection) elicited higher antibody levels. However, it did not always provide better protection against reinfection, highlighting the importance of the immunization profile as a virus-host interaction modifier. Despite high resistance to reinfection, there was a notable infection rate (5.6%) during the peri-booster period, reinforcing the importance of preventive measures.
Article
Biotechnology & Applied Microbiology
Giuseppe De Palma, Emma Sala, Sofia Rubino, Simone Dalola, Marco Ferrari, Daniele Marioli, Pietro Apostoli, Cesare Tomasi, Francesca Righetti, Flavia Mattioli, Vittorio Ferrari
Summary: This study evaluated the performance of an original and innovative system that can objectively assess the interactions between operators and display screen equipment (DSE). The system collects electrical impulses generated by mouse, keyboard, and camera to evaluate active operator-DSE interactions. The obtained results show that the system is effective in collecting activity data and can provide an objective evaluation of active time spent by DSE operators, facilitating more accurate occupational health risk assessment and management.
BIOENGINEERING-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Emma Sala, Lorenzo Cipriani, Andrea Bisioli, Emilio Paraggio, Cesare Tomasi, Pietro Apostoli, Giuseppe De Palma
Summary: This study retrospectively analyzed the risk assessment of biomechanical overload of the upper limb using multiple assessment methods, including the Washington State Standard, threshold limit values proposed by ACGIH, OCRA checklist, RULA, and INRS's Strain Index and Outil de Reperage et d'Evaluation des Gestes. The results showed differences in the assessment of action frequency and posture among the methods, while strength assessment was more consistent. Therefore, the use of multiple assessment methods ensures a more comprehensive analysis of biomechanical risk.
BIOENGINEERING-BASEL
(2023)
Article
Public, Environmental & Occupational Health
Emma Sala, Andrea Bisioli, Pietro Ponzoni, Alessandro De Bellis, Emilio Paraggio, Giuseppe De Palma
Summary: This study proposes a new methodology, named WB-RAMBO, to assess the risk in the activities performed by physiotherapists. By breaking down each type of intervention into elementary operations and integrating multiple ergonomic methods, the method provides a risk assessment for each operation. The results show that the risk assessment is acceptable from an ergonomic perspective, and the work plan can be redesigned and adapted based on the assessment.
MEDICINA DEL LAVORO
(2022)
Article
Immunology
Giulia Collatuzzo, Giovanni Visci, Francesco S. Violante, Stefano Porru, Gianluca Spiteri, Maria Grazia Lourdes Monaco, Francesca Larese Fillon, Corrado Negro, Christian Janke, Noemi Castelletti, Giuseppe De Palma, Emanuele Sansone, Dana Mates, Silvia Teodorescu, Eleonora Fabianova, Jana Beresova, Luigi Vimercati, Silvio Tafuri, Mahsa Abedini, Giorgia Ditano, Shuffield S. Asafo, Paolo Boffetta
Summary: This study analyzed the determinants of anti-SARS-CoV-2 IgG titer at 6 months after 2-dose COVID-19 vaccination in an international cohort of healthcare workers. The results showed that female sex, young age, past infection, two vaccine doses, and mRNA and heterologous vaccination predicted higher antibody levels. These findings provide valuable data for comparison with trends observed with longer follow-ups.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Giovanni Visci, Carlotta Zunarelli, Ihab Mansour, Stefano Porru, Giuseppe De Palma, Xavier Duval, Maria Grazia Lourdes Monaco, Gianluca Spiteri, Angela Carta, Giuseppe Lippi, Giuseppe Verlato, Emanuele Sansone, Emma Sala, Massimo Lombardo, Mahsa Abedini, Francesco Violante, Paolo Boffetta
Summary: Characterizing immunological response following COVID-19 vaccination is crucial for public health. This study investigated the proportion, level, and determinants of humoral response in vaccinated healthcare workers. Results showed that almost all vaccinated individuals developed a humoral response, with better antibody levels observed in female, younger, and previously infected individuals.
MEDICINA DEL LAVORO
(2022)
Article
Clinical Neurology
Flavia Mattioli, Simone Piva, Chiara Stampatori, Francesca Righetti, Ilaria Mega, Elena Peli, Emma Sala, Cesare Tomasi, Anna Maria Indelicato, Nicola Latronico, Giuseppe De Palma
Summary: This study investigates the types of neurological and cognitive impairment in COVID-19 cases of different severity. The results show that patients treated in ICU perform significantly worse in neuropsychological tests and have a higher level of cognitive impairment. These findings support the greater susceptibility of COVID-19 patients in ICU to develop neurological deficits and cognitive impairment at a four-month follow-up.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
