Article
Environmental Sciences
Shuang Ding, Wen Qi, Qi Xu, Tianyang Zhao, Xu Li, Jianli Yin, Ruxuan Zhang, Chuanyi Huo, Liting Zhou, Lin Ye
Summary: The study revealed that DEHP exposure may affect lipid metabolism in adolescents by regulating the expression of lipid metabolism-related genes, particularly showing significant associations with compounds like MECPP, MCMHP, and n-ary DEHP levels.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Monica Kam Draskau, Camilla Lindgren Schwartz, Bertrand Evrard, Aurelie Lardenois, Andrew Pask, Frederic Chalmel, Terje Svingen
Summary: Intrauterine exposure to endocrine disrupting chemicals can affect male reproductive development and lead to disorders. Predicting adverse effects in vivo based on in vitro effects is challenging. Understanding the underlying mechanisms of adverse effects is key to reducing animal testing for chemical safety assessments. This study analyzed the transcriptome of male fetal rats and the impact of an anti-androgenic fungicide, triticonazole, on the perineum and phallus. The findings highlight the importance of analyzing the correct tissue and provide valuable information for developing alternative test methods for assessing endocrine disrupting potential of chemicals.
Article
Pharmacology & Pharmacy
Rafael Chitolina, Patricia Nicola, Adrieli Sachett, Fernanda Bevilaqua, Lemen Cunico, Alissara Reginatto, Kanandra Bertoncello, Katiuska Marins, Ana Paula Zanatta, Marta Medeiros, Acauane S. Lima, Cristiane Parisotto, Jean Carlo O. Menegatt, Andre F. Goetten, Francielli C. Zimermann, Adriano T. Ramos, Valerio M. Portela, Marcos H. Barreta, Greicy Michelle M. Conterato, Leila Zanatta
Summary: Studies have shown that glyphosate can disrupt the endocrine system and have negative effects on male reproductive system. However, its effects on ovarian function are not well understood, calling for further studies on the toxicity of glyphosate in the female reproductive system.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Environmental Sciences
Martina Capriotti, Paolo Cocci, Luca Bracchetti, Erika Cottone, Rosaria Scandiffio, Giovanni Caprioli, Gianni Sagratini, Gilberto Mosconi, Patrizia Bovolin, Francesco Alessandro Palermo
Summary: This study presented environmental baseline data on floating microplastics in Italian coastal waters of the Central Adriatic Sea, revealing the presence of various organic pollutants on the surface of collected microplastics. Furthermore, the study indicated potential metabolic effects of microplastics on adipocytes, resulting in both adipogenesis and lipid uptake/storage.
Article
Environmental Sciences
Anna S. Young, Nicholas Herkert, Heather M. Stapleton, Brent A. Coull, Russ Hauser, Thomas Zoeller, Peter A. Behnisch, Emiel Felzel, Abraham Brouwer, Joseph G. Allen
Summary: Humans are exposed to complex mixtures of hormone-disrupting chemicals, and traditional research methods do not evaluate enough chemicals at once. This study used silicone wristbands to investigate exposures to chemical mixtures in office workers from different countries. The results revealed associations between chemical concentrations and hormonal activities, and identified several important chemicals contributing to the overall mixture effects. The study emphasized the role of personal care products and building microenvironments in hormone-disrupting exposures.
Article
Nutrition & Dietetics
Krystyna Makowska, Ewa Lepiarczyk, Slawomir Gonkowski
Summary: Bisphenol A (BPA), commonly used as a plasticizer, has a strong negative effect on living organisms and is being replaced by bisphenol S (BPS) in plastic production. This study compares the impact of BPA and BPS on enteric neurons for the first time using double immunofluorescence technique. Both BPA and BPS affect the number of enteric neurons containing various neuronal factors, with BPS showing a stronger impact on certain neuronal populations. The results indicate that long-term exposure to BPS, even in low doses, is not neutral for enteric neurons and may be more potent than BPA for certain neuronal populations.
Article
Toxicology
Indusha Kugathas, Hanna K. L. Johansson, Edith Chan Sock Peng, Maryne Toupin, Bertrand Evrard, Thomas A. A. Darde, Julie Boberg, Monica K. K. Draskau, Antoine D. D. Rolland, Severine Mazaud-Guittot, Frederic Chalmel, Terje Svingen
Summary: Exposure to endocrine-disrupting chemicals during development may cause reproductive disorders in women. This study characterized the transcriptional landscape of rat ovaries exposed to two well-known EDCs, diethylstilbestrol (DES) and ketoconazole (KTZ), and identified new candidate biomarkers for female reproductive toxicity induced by EDC.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Engineering, Environmental
Ioana Chelcea, Stefan Orn, Timo Hamers, Jacco Koekkoek, Jessica Legradi, Carolina Vogs, Patrik L. Andersson
Summary: This article presents a study on the distribution and kinetics of a new class of pollutants, bisphenol Z, in zebrafish. By establishing a physiologically based toxicokinetic model, researchers were able to predict the concentrations of bisphenols in different organs of the zebrafish and found that these bisphenols mainly distribute to the carcass and gonads.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Lorenzo Fabbri, Ronan Garlantezec, Karine Audouze, Mariona Bustamante, Angel Carracedo, Leda Chatzi, Juan Ramon Gonzalez, Regina Grazuleviciene, Hector Keun, Chung-Ho E. Lau, Eduard Sabido, Alexandros P. Siskos, Remy Slama, Cathrine Thomsen, John Wright, Wen Lun Yuan, Maribel Casas, Martin Vrijheid, Lea Maitre
Summary: This study aimed to identify multi-omic signatures associated with childhood exposure to non-persistent endocrine disrupting chemicals (EDCs). By using a repeated sampling strategy and integrating multiple omics data, a total of 950 reproducible associations were found, including 23 direct associations between EDCs and omics. These associations can help us understand the effects of EDCs on neurological and metabolic outcomes.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Rui Luo, Tao Zhang, Li Wang, Yong Feng
Summary: This report aims to assess the current state of understanding about endocrine disruptors in China, including their origins, impacts, and obstacles, and provide actionable recommendations for reducing exposure and mitigating negative effects. The study shows that land use and cover variables have significant impacts on agricultural nitrous oxide emissions and agricultural methane emissions. The study aims to increase knowledge of the potential advantages and disadvantages of endocrine disruptors in outdoor exercise, and aid in preventing and managing diseases and disorders caused by hormonal imbalances or disruptions.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Delnia Ahmadpour, Sakina Mhaouty-Kodja, Valerie Grange-Messent
Summary: Exposure to low doses of DEHP or an environmental phthalate mixture was found to increase BBB permeability, affect glial activation and neuroinflammation in specific brain regions. This suggests that exposure to endocrine disruptors like phthalates may pose a risk to cerebrovascular function.
Article
Environmental Sciences
Joseph M. Braun, George D. Papandonatos, Nan Li, Clara G. Sears, Jessie P. Buckley, Kim M. Cecil, Aimin Chen, Charles B. Eaton, Heidi J. Kalkwarf, Karl T. Kelsey, Bruce P. Lanphear, Kimberly Yolton
Summary: In this cohort, physical activity during adolescence modified the association between prenatal serum PFOA concentrations and cardiometabolic risk in children, suggesting that lifestyle interventions may alleviate the adverse effects of PFOA exposure. However, diet did not modify any associations.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Enrico Gugliandolo, Marika Cordaro, Roberta Fusco, Tiziana Genovese, Alessio Filippo Peritore, Rosalia Crupi, Livia Interdonato, Davide Di Paola, Salvatore Cuzzocrea, Daniela Impellizzeri, Rosalba Siracusa, Rosanna Di Paola
Summary: The exposure to endocrine disruptors (EDs) may worsen the progression of rheumatoid arthritis (RA), suggesting the need to limit exposure.
Article
Endocrinology & Metabolism
Luca De Toni, Andrea Di Nisio, Maria Santa Rocca, Federica Pedrucci, Andrea Garolla, Stefano Dall'Acqua, Diego Guidolin, Alberto Ferlin, Carlo Foresta
Summary: This study assessed the potential disrupting effect of PFOA, PFOS, and C6O4 on a murine thyroid cell model, and found that these substances may interfere with TSH-dependent signaling pathways to different extents through direct interaction with the TSH receptor.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Neena Roy, Elisa Mascolo, Clara Lazzaretti, Elia Paradiso, Sara D'Alessandro, Kornelia Zareba, Manuela Simoni, Livio Casarini
Summary: The accumulation of endocrine-disrupting pollutants in the environment poses an increasing exposure risk to humans, potentially impacting reproductive functions, particularly female fertility. Studies suggest that these chemicals may interfere with follicle-stimulating hormone-mediated signaling pathways, ultimately affecting the female reproductive system.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Aydilek Dagdeviren Cakir, Hande Turan, Tiraje Celkan, Nil Comunoglu, Oya Ercan, Olcay Evliyaoglu
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Ismet Cok, Ozlem Toprak Ikidag, Dilek Battal, Ayca Aktas
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2020)
Article
Pediatrics
Seha Saygili, Nur Canpolat, Aydilek Cakir, Dildar Konukoglu, Hande Turan, Salim Caliskan, Oya Ercan, Olcay Evliyaoglu, Lale Sever
PEDIATRIC NEPHROLOGY
(2020)
Article
Psychology, Developmental
Anna Dzielska, Colette Kelly, Kristiina Ojala, Emily Finne, Angela Spinelli, Jana Furstova, Anne-Siri Fismen, Oya Ercan, Riki Tesler, Marina Melkumova, Natale Canale, Paola Nardone, Jelena Gudelj Rakic, Paola Dalmasso
JOURNAL OF ADOLESCENT HEALTH
(2020)
Article
Biochemical Research Methods
Dilek Battal, Ayca Aktas Sukuroglu, Kumsal Kocadal, Ismet Cok, Irfan Unlusayin
Summary: A method for the trace analysis of endocrine disruptors such as Bisphenol A, 4-t-octylphenol, and 4-nonylphenol in human urine using liquid chromatography-mass spectrometry was developed and shown to be accurate and sensitive. The method was successfully applied for the determination of these compounds in 15 human urine samples, demonstrating its effectiveness in detecting these chemicals.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2021)
Article
Environmental Sciences
Ayca Aktas Sukuroglu, Dilek Battal, Kumsal Kocadal, Mehmet Ali Sungur, Ismet Cok, Irfan Unlusayin
Summary: This study conducted biomonitoring and risk assessment on the Turkish population for the first time, measuring urinary levels of Bisphenol A, 4-nonylphenol, and 4-t-octylphenol. While no potential health risk was observed from BPA and 4-NP exposure, there might be health risks associated with 4-t-OP exposure in the Turkish population.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Surgery
Onat Akyol, Serdar Demirgan, Aslihan Sengelen, Hasan Cem Guneyli, Duygu Sultan Oran, Funda Yildirim, Damla Haktanir, Mehmet Salih Sevdi, Kerem Erkalp, Aysin Selcan
Summary: Mild therapeutic hypothermia with external cooling can reduce lung inflammation and damage in a rabbit model of acute lung injury/acute respiratory distress syndrome (ALI/ARDS), while partially improving gas exchanges.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Medicine, General & Internal
Sinem Aslan, Ozlem Bostan Gayret, Meltem Erol, Selen Mandel Isikli, Ovgu Buke, Abdulrahman Ozel
Summary: This study found that passive smoking in households increases the frequency of respiratory tract infections in children. It is important to raise awareness about the harmful effects of passive smoking on children's health both at home and in society.
HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
(2022)
Review
Substance Abuse
Ismet Cok, Irem Iyigundogdu
Summary: This review evaluates the existing literature on how COVID-19 has affected people's alcohol consumption, smoking, and vaping use in different societies. It was found that the pandemic may result in no alterations in substance use or lead to a decrease or quit attempt due to health concerns, or an increase in alcohol or cigarette consumption. The aim is to provide detailed information on the impact of the pandemic on substance use from various studies conducted globally and highlight the importance of further research on this topic.
JOURNAL OF SUBSTANCE USE
(2023)
Article
Environmental Sciences
Ersin Göl, Ismet Cok, Dilek Battal, Ayca Aktas Süküroglu
Summary: Pesticides are products developed to prevent, destroy, repel or control certain forms of plant or animal life that are considered to be pests. However, now they are one of the critical risk factors threatening the environment, and they create a significant threat to the health of children.
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Beril Altun, Ismet Cok, Cemal Onur Noyan, Ela Kadioglu, Alptekin Cetin, Tijen Sengezer, Merih Altintas, Samet Kurnaz, Nesrin Dilbaz
Summary: This population-based case-control study evaluated the genetic susceptibility to synthetic cannabinoid use disorder in the Turkish population. The results indicate that the CNR1, FAAH, and MGLL gene polymorphisms are not associated with the risk of synthetic cannabinoid use disorder in this population.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)
Review
Pharmacology & Pharmacy
Ismet Cok, Irem Iyigundogdu, Mesut Yildirim
Summary: The use of electronic cigarettes may increase the risk for critical complications of COVID-19 by causing airway inflammation and affecting lung health. E-cigarette users have a five times higher risk of COVID-19 infection compared to non-smokers, and even higher risk compared to tobacco users.
JOURNAL OF RESEARCH IN PHARMACY
(2021)
Article
Urology & Nephrology
Abdullah Gul, Murat Gul, Sule Ozsoy, Tulin Sarac, Duygu S. Celik, Atilla Semercioz, Ege Can Serefoglu
ARCHIVOS ESPANOLES DE UROLOGIA
(2020)
Review
Pharmacology & Pharmacy
Beril Altun, Ismet Cok
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Correction
Endocrinology & Metabolism
Dagdeviren A. Cakir, H. Turan, A. Aykut, A. Durmaz, O. Ercan, O. Evliyaoglu
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2020)