Article
Nanoscience & Nanotechnology
Xiaorui Shi, Xinan Wang, Rong Huang, Chu Tang, Chong Hu, Pengbo Ning, Fu Wang
Summary: Micro- and nano-sized plastics (MPs and NPs) have become a global environmental concern. This study evaluated the cytotoxicity and genotoxicity of polystyrene (PS) MPs and NPs on human lung cells. The results showed that nano-level PS caused more serious cytotoxicity and genotoxicity compared to micro-level PS. Additionally, surface-modified PS-NPs were found to have stronger cell viability inhibitory ability and induced more micronuclei.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wenfeng Zhu, Yake Liu, Wei Wang, Zihua Zhou, Jin-hua Gu, Zexu Zhang, Huanjian Sun, Fan Liu
Summary: The study revealed that CoNPs exert toxicity on human vascular endothelial cells by depleting intracellular Fe2+ level, leading to activation of HIF-1 alpha. Supplementation of Fe2+, especially in the form of Fe(CH3CHOHCOO)(2) and Fe(CH2COO)(2), mitigates CoNP toxicity.
BIOSCIENCE REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Joelle Auclair, Patrice Turcotte, Christian Gagnon, Caroline Peyrot, Kevin James Wilkinson, Francois Gagne
Summary: The study examined the sub-lethal toxicity of low concentrations of selected nanoparticles alone and in mixtures in juvenile trout. The results showed that the nanoparticles were bioavailable for fish, with different levels of toxicity for different nanoparticles and antagonistic effects in the mixtures. In conclusion, the bioavailability and toxicity of these nanoparticles are influenced by mixtures of nanoparticles, which is likely to occur in contaminated environments.
Article
Environmental Sciences
Iteb Boughattas, Nesrine Zitouni, Marouane Mkhinini, Omayma Missawi, Sondes Helaoui, Sabrine Hattab, Moncef Mokni, Noureddine Bousserrhine, Mohamed Banni
Summary: This study investigated the effects of biochar on earthworms in soil remediation. The results showed that in the presence of biochar, the bioavailability of Cd and 2,4-D increased in earthworms, along with an increase in micronuclei frequency and a decrease in lysosomal membrane stability. Histopathological examination revealed numerous alterations in animals exposed to contaminants without any amelioration when biochar was added. The biochemical response of earthworms demonstrated that in the presence of biochar, animals tended to alleviate the toxicity of Cd and 2,4-D.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Environmental
Maria Rachele Guascito, Maria Giulia Lionetto, Franco Mazzotta, Marianna Conte, Maria Elena Giordano, Roberto Caricato, Anna Rita De Bartolomeo, Adelaide Dinoi, Daniela Cesari, Eva Merico, Laura Mazzotta, Daniele Contini
Summary: In this study, the toxicity of atmospheric particulate matter (PM) was investigated through in vitro experiments. The results showed correlations between extracellular and intracellular toxicity indicators, and significant effects of combustion sources on these toxicity indicators. Additionally, the advection of African dust resulted in lower intrinsic toxicity indicators.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Sara Gheraibia, Noureddine Belattar, Kawthar A. Diab, Marwa E. Hassan, Aziza A. El-Nekeety, Sekena H. Abdel-Aziem, Nabila S. Hassan, Mosaad A. Abdel-Wahhab
Summary: This study investigated the protective effects of Costus speciosus extract (CSE) against Zearalenone (ZEN)-induced oxidative damage, genotoxicity, and cytotoxicity. The results showed that CSE could alleviate ZEN toxicity through its antioxidant activity, modulation of iNOS, inflammatory related genes, and the Nrf2 pathway.
Article
Environmental Sciences
Sabrine Hattab, Iteb Boughattas, Tiziana Cappello, Nesrine Zitouni, Ghada Touil, Ilef Romdhani, Alexandre Livet, Nourreddine Bousserrhine, Mohamed Banni
Summary: Heavy metal pollution has harmful consequences on soil fertility, and earthworms are used as test organisms to evaluate the ecotoxicity of polluted soils. This study exposed Eisenia andrei to polymetallic contaminated soils for 7 and 14 days in southeastern Tunisia. The results showed increased heavy metal accumulation, genotoxicity, and cytotoxicity in earthworms after 14 days of exposure, as well as changes in biochemical and transcriptional responses. These findings support the use of earthworms as bioindicator species for pollution monitoring and provide valuable information about the harmful impact of biota exposure to contaminated soils.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Iftikhar Hussain Shah, Muhammad Aamir Manzoor, Irfan Ali Sabir, Muhammad Ashraf, Fiza Liaquat, Shazma Gulzar, Liying Chang, Yidong Zhang
Summary: This study aimed to investigate the toxic impact of copper oxide nanoparticles (CuONPs) on melon seedlings. The results showed that CuONPs significantly suppressed the growth rate and affected the physiological and biochemical activities of melon seedlings. CuONPs also caused phenotypical changes, reduced biomass and chlorophyll content, and accumulated in the shoot. Moreover, exposure to high concentrations of CuONPs increased reactive oxygen species accumulation, malondialdehyde and hydrogen peroxide levels, and induced toxicity in melon roots. The study highlights the toxic effects of CuONPs on melon seedlings and the potential threat to the ecological system.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Environmental Sciences
Ingra Tais Malacarne, Daniel Vitor De Souza, Barbara Dos Anjos Rosario, Milena De Barros Viana, Camilo Dias Seabra Pereira, Debora Estadella, Jean Nunes dos Santos, Daniel Araki Ribeiro
Summary: Crack-cocaine can induce genotoxicity and oxidative stress in mammalian cells, and studies have shown evidence supporting its role as a chemical carcinogen. However, the impact of inflammatory response after exposure to crack-cocaine remains inconclusive.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Joanna M. Goncalves, Vania Serrao Sousa, Margarida Ribau Teixeira, Maria Joao Bebianno
Summary: This study examined the effects of polystyrene nanoplastics on marine mussels and found that nanoplastics induce genotoxicity and oxidative damage in these organisms, overwhelming antioxidant enzymes and causing tissue-dependent toxicity over time. The results suggest that mussel tissues are incapable of coping with the adverse effects of nanoplastics.
Article
Biochemistry & Molecular Biology
Quaiser Saquib, Abdullah M. Al-Salem, Maqsood A. Siddiqui, Sabiha M. Ansari, Xiaowei Zhang, Abdulaziz A. Al-Khedhairy
Summary: This study found that Tris (2-ethylhexyl) phosphate (TEHP) has cytotoxic and genotoxic effects on HepG2 cells, possibly through inducing oxidative stress, causing mitochondrial dysfunction, and leading to DNA damage and cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Tugce Kalefetoglu Macar, Oksal Macar, Kultigin Cavusoglu, Emine Yalcin, Kursad Yapar
Summary: The present study evaluated the mitigative ability of turmeric against nickel chloride-related toxicity in the roots of Allium cepa. Turmeric showed remarkable protection potential against NiCl2 and improved various parameters in Allium cepa.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Toxicology
Nancy B. Andrioli, Gabriela Chaufan
Summary: The study evaluated the genotoxicity and oxidative stress in the A549 cell line exposed to sublethal concentrations of Iprodione. The increase in Iprodione concentrations slightly raised the probability of belonging to the genotoxic category, while oxidative stress analysis showed a significant linear increase in SOD and a significant linear decrease in GSH and GST.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Environmental Sciences
Eryka Costa Almeida, Larissa Souza Passos, Carlos Eduardo Delfino Vieira, Raphael Danna Acayaba, Cassiana Carolina Montagner, Ernani Pinto, Claudia Bueno dos Reis Martinez, Ana Lucia Fonseca
Summary: Female juveniles of the Neotropical fish Astyanax altiparanae exposed to Imidacloprid showed oxidative damage in different organs, neurotoxic effects in the muscle, and genotoxicity, indicating potential health risks in environmentally relevant concentrations.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Environmental Sciences
Hayal Cobanoglu, Murat Belivermis, Ercan Sikdokur, Onder Kilic, Akin Cayir
Summary: This study used the CBMN assay to determine the genotoxic and cytotoxic effects of microplastic on human peripheral lymphocytes, revealing both genomic instability and lack of cytotoxic potential in larger microplastic particles. Further investigation on smaller plastics and chronic effects on human population is recommended.
Article
Toxicology
Mahmoud Abudayyak, Ezgi Oztas, Gul Ozhan
Summary: The study suggests that PFOA may induce pancreatic toxicity through inflammation, leading to oxidative stress. In human pancreatic cells, PFOA causes cell death and apoptosis, with a significant increase in levels of trypsin and chymotrypsin. Oxidative stress and inflammation-related gene expression are altered significantly with PFOA exposure.
TOXICOLOGY IN VITRO
(2021)
Review
Environmental Sciences
Abbas Mohammadipour, Mahmoud Abudayyak
Summary: Metal base nanoparticles have the potential to induce harmful effects on the hippocampus, including oxidative stress, neuro-inflammation, mitochondrial dysfunction, gene expression alteration, and ultimately neuronal apoptosis. They also impact hippocampal neurogenesis and synaptic plasticity, affecting memory and learning processes.
REVIEWS ON ENVIRONMENTAL HEALTH
(2022)
Review
Nanoscience & Nanotechnology
Amir Mohammad Malvandi, Sara Shahba, Abbas Mohammadipour, Seyed Hamidreza Rastegar-Moghaddam, Mahmoud Abudayyak
Summary: Lanthanum nanoparticles, widely used in industry, pose potential risks to human health due to their large release into the environment. Research on the cellular and molecular interactions of lanthanum nanoparticles reveals their toxicity potential, especially on the nervous system and other tissues.
Article
Biology
Ezgi Oztas, Mehtap Kara, Tugce Boran, Enes Bisirir, Ecem Fatma Karaman, Engin Kaptan, Gul Ozhan
Summary: Acetamiprid, a widely used neonicotinoid insecticide, has been found to be associated with neurological symptoms and cell death in neural cells by increasing cellular stress and promoting apoptosis. Additional studies are needed to fully understand its molecular mechanisms and the potential harm it may cause to mammals.
Article
Toxicology
Muzeyyen Akar, Merve Ercin, Tugce Boran, Selda Gezginci-Oktayoglu, Gul Ozhan
Summary: This study evaluated the molecular mechanism of cytotoxic effects of UR-144 on a cardiomyoblastic cell line. The results showed that UR-144 may cause cardiovascular symptoms and induce cell death through apoptosis/necrosis and autophagy pathways. Elevated cytoplasmic Ca2+ levels and activation of DAPK1 may play important roles in UR-144-induced cardiotoxicity.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Chemistry, Multidisciplinary
Mahmoud Abudayyak, Ecem Fatma Karaman, Sibel Ozden
Summary: Citrinin (CIT), a mycotoxin produced by various strains of Aspergillus, Penicillium, Monascus, and other genera, has the potential to contaminate animal feed and human food. Its mechanisms of toxicity, particularly in relation to neurotoxicity, are not well understood. In this study, CIT was found to induce apoptosis and oxidative stress in human neuroblastoma cells, and upregulate the expression of genes related to these processes.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zeynep Rana Guler, Umran Yilmaz, Kubra Uzunosmanoglu, Busra Ozturk, Mahmoud Abudayyak, Sibel Ozden
Summary: Neonicotinoid insecticides, commonly used as alternatives to organophosphate insecticides, have been found to have harmful effects on human and environmental health. This study investigated the effects of imidacloprid and thiamethoxam on DNA methylation in human neuroblastoma cells, revealing significant increases in global DNA methylation after exposure to both chemicals.
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Dilara Sahin, Emre Sefik Caglar, Tugce Boran, Ayse Esra Karadag, Gul Ozhan, Neslihan Ustundag Okur
Summary: The aim of this study was to develop microemulsion formulations containing naringenin for anti-aging purposes. Different cosurfactants and surfactants were used to formulate topical microemulsions, and a triangle phase diagram was utilized to determine the optimal microemulsion system. The formulated microemulsions were characterized and tested for permeation, release, enzyme inhibition, antioxidant properties, cytotoxicity, gene expression, and cell culture. The results showed that the developed microemulsions had promising properties for anti-aging purposes.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Mycology
Ecem Fatma Karaman, Mahmoud Abudayyak, Sibel Ozden
Summary: This study investigated the effects of FB1 on global DNA methylation, chromatin-modifying enzymes, and histone modification levels of the p16 gene in human kidney cells. The results suggest that FB1 may play a role in carcinogenesis through DNA methylation, histone, and chromatin modifications.
MYCOTOXIN RESEARCH
(2023)
Article
Plant Sciences
Ebrar Tnal, Ebru Ozdemir Nath, Mahmoud Abudayyak, Seyma Ulusoy, Hatice Akbal Tnan, Mahmut Cicek, Murat Kartal
Summary: The essential oil compositions and chemotypes of Vitex agnus-castus L. flowers, leaves, and fruits from Turkiye were identified. The cytotoxic effects of the essential oils extracted from different parts of V. agnus-castus were analyzed on MCF-7 and A549 cell lines. The essential oils contained dominant monoterpene hydrocarbons and oxygenated monoterpene compounds, with sesquiterpene hydrocarbons being the major component in the flower oils.
RECORDS OF NATURAL PRODUCTS
(2023)
Article
Pharmacology & Pharmacy
Ozge Yazici, Mehtap Kara, Tugce Boran, Gul Ozhan
Summary: The study investigates the adverse effect of methimazole on pancreatic cell stress mechanism and apoptosis. It is found that methimazole may induce cellular stress conditions in pancreatic cells, but there is no significant difference in terms of apoptosis.
ADVANCED PHARMACEUTICAL BULLETIN
(2023)
Article
Agriculture, Multidisciplinary
Mahmoud Abudayyak, Seyda Kanbolat, Reyyan Ergene, Seyma Batur, Rezzan Aliyazicioglu
Summary: This study evaluated the antioxidant activity and cytotoxic potential of Alcea calvertii. The methanol extract of Alcea calvertii exhibited the highest antioxidant activity, and the antioxidant activity increased with increasing extract concentration. The IC50 values of DPPH in Alcea calvertii showed concentration-dependent cytotoxicity.
KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE
(2022)
Article
Chemistry, Multidisciplinary
Nurdan Yazici Bektas, Ezgi Ersoy, Mehmet Boga, Tugce Boran, Ercan Cinar, Gul Ozhan, Ahmet Ceyhan Goren, Esra Eroglu Ozkan
Summary: This study aimed to determine the secondary metabolites of Hypericum androsaemum L. extracts and investigate their antioxidant and cytotoxic activities. The results showed significant effects of different extracts on apoptosis induction and antioxidant activity in cancer cells.
TURKISH JOURNAL OF CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Mahmoud Abudayyak, E. Elif Guzel, Gul Ozhan
Summary: The study found that NiO-NPs caused morphological changes in cells, leading to cell death mainly through apoptosis. Genotoxicity and oxidative damage were observed to be dose-dependent.
ISTANBUL JOURNAL OF PHARMACY
(2021)
Article
Agriculture, Multidisciplinary
Mahmoud Abudayyak, Seyda Kanbolat, Seyma Batur, Reyyan Seda Ergene, Rezzan Aliyazicioglu
Summary: Jurinea brevicaulis, a perennial herbaceous plant, exhibits high antioxidant capacity and cytotoxic effects in cancerous cells, indicating its potential as an important herb for developing new drugs.
KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE
(2021)