Article
Environmental Sciences
Michael S. Bloom, Sarah Commodore, Pamela L. Ferguson, Brian Neelon, John L. Pearce, Anna Baumer, Roger B. Newman, William Grobman, Alan Tita, James Roberts, Daniel Skupski, Kristy Palomares, Michael Nageotte, Kurunthachalam Kannan, Cuilin Zhang, Ronald Wapner, John E. Vena, Kelly J. Hunt
Summary: The study found that specific PFAS may be developmental obesogens, with their effects varying by maternal race and obesity status.
ENVIRONMENTAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Nicole Mohajer, Erika M. Joloya, Jeongbin Seo, Toshi Shioda, Bruce Blumberg
Summary: Obesity and metabolic disorders are global pandemics, potentially linked to exposure to endocrine disrupting chemicals known as obesogens. Transgenerational inheritance of phenotypic traits and diseases, such as obesity, may be mediated by epigenetic mechanisms, highlighting the complexity of inherited susceptibility to environmental exposures.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Seungho Lee, Jin Hee Kim, Hyo-Bang Moon, Jeongim Park, Guyuyeon Choi, Sungkyoon Kim
Summary: This study estimated the fetal body burden of mercury in pregnant women and analyzed its effects on infant growth. Cord blood mercury levels were positively correlated with length at birth and the high cord blood group showed faster growth rates. Pregnant women are advised to mitigate mercury exposures, especially from diet. Further research is suggested to investigate the relationship between infant growth and mercury levels, considering fish consumption, diet information, and other environmental pollutants.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Mia Q. Peng, Carrie A. Karvonen-Gutierrez, William H. Herman, Bhramar Mukherjee, Sung Kyun Park
Summary: This study examined the association between phthalate exposure and body fat gain in midlife women. The results showed that higher levels of phthalate metabolites were associated with faster increases in body fat percentage, particularly in women who were normal/underweight at baseline. However, the estimates were attenuated in the sensitivity analyses, suggesting the need for further confirmation of the findings.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Axelle Brulport, Ludovic Le Corre, Guillaume Maquart, Virginie Barbet, Aurelie Dastugue, Isabelle Severin, Daniel Vaiman, Marie-Christine Chagnon
Summary: This study found that perinatal exposure to BPS can lead to sex-dependent obesogen effects in multiple generations of mice. In the F1 generation, male mice showed overweight while female mice exhibited dyslipidemia. In the F2 generation, BPS exposure was associated with increased body weight, fat, and visceral adipose tissue in both males and females.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Jiao Li, Yunping Li, Rui Sha, Liping Zheng, Li Xu, Heidi Qunhui Xie, Bin Zhao
Summary: Exposure to TCDD can impact the gut microbiota and metabolic pathways, both in mothers and their offspring. High dosage of TCDD leads to an increase in harmful bacteria and a decrease in beneficial bacteria, while low dosage has the opposite effect. Maternal exposure to TCDD causes noticeable changes in tryptophan metabolism in offspring, indicating a potential acceleration of dysregulation caused by pathogenic or opportunistic pathogens.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Carolina Martins Ribeiro, Fernanda Cerqueira Barroso de Oliveira, Sidney Alcantara Pereira, Ana Carolina Rocha Oliveira Moraes, Bruna Teles Soares Beserra, Jamison Cordeiro Dias, Nadyellem Graciano da Silva, Mariella Guimaraes Lacerda, Flora Aparecida Milton, Francisco de Assis Rocha Neves, Michella Soares Coelho, Angelica Amorim Amato
Summary: Exposure to the xenoestrogen nonylphenol (NP) outside critical developmental windows, even at environmentally relevant concentrations below the 'no observable adverse effects level', can negatively impact metabolic outcomes in adulthood. Prolonged exposure to NP reduced weight gain and hepatic fat content in male Swiss mice fed a normal-fat diet. NP exposure altered mRNA levels of estrogen receptor α (Esr1) and adipose lineage markers in a sexually dimorphic and adipose depot-dependent fashion in both male and female C57BL/6 mice fed a high-fat diet.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Layra G. Cintron-Rivera, Nicole Burns, Ratna Patel, Jessica S. Plavicki
Summary: Human exposure to environmental pollutants can negatively impact embryonic development and health outcomes. This study utilized zebrafish as a model to explore the cellular and transcriptional targets of TCDD-induced craniofacial malformations. The findings reveal a reduction in jaw and pharyngeal chondrocytes, decreased collagen deposition, and impaired development of tissues derived from specific progenitor cells.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Yanyuan Lu, Shiqi Liu, Yeqing Sun, Bin Zhao, Dan Xu
Summary: This study used weighted gene co-expression network analysis (WGCNA) to explore key genes involved in hepatocellular carcinoma (HCC) when exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and alpha-endosulfan. The results identified HK2, EXO1, and PFKP as key genes associated with HCC and exposure to TCDD and alpha-endosulfan mixture, and their aberrant expression was correlated with poor prognosis of HCC. Western blot analysis confirmed the elevated protein expression levels of PFKP and HK2 in exposed cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Maaike van Gerwen, Vikram Vasan, Eric Genden, Shira R. Saul
Summary: Thyroid cancer incidence has been steadily increasing since the 1970s, and exposure to environmental pollutants like TCDD and other dioxins may be a potential cause. This study reviewed available human studies on the association between TCDD exposure and thyroid cancer. Six studies were included, with results showing a non-significant increase in thyroid cancer risk from acute TCDD exposure in one case and a significant risk from Agent Orange exposure in two cases. One study evaluating TCDD exposure through herbicides found no association. More human studies are needed to further understand the potential link between TCDD exposure and thyroid cancer.
Article
Environmental Sciences
Rui Sha, Yangsheng Chen, Yijing Wang, Yali Luo, Yiyun Liu, Yongchao Ma, Yunping Li, Li Xu, Heidi Qunhui Xie, Bin Zhao
Summary: The study found that maternal exposure to TCDD, especially at a low dose, increased movement ability, novelty-exploration, and certain anxiety-related behaviors in the offspring. These hyperactivity-like behaviors were accompanied by the upregulation of certain genes associated with cholinergic neurotransmission or synaptogenesis in the offspring brain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Maggie R. Williams, Robert D. Stedtfeld, Tiffany M. Stedtfeld, Robert B. Crawford, Tomomi Kuwahara, Norbert E. Kaminski, James M. Tiedje, Syed A. Hashsham
Summary: SFB and B. fragilis colonization can impact miRNA expression in mice, with TCDD treatment exacerbating this effect. The miRNAs affected immune and inflammatory responses, as well as T-cell differentiation, highlighting the importance of gut microbiota in host response to toxicants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Medicinal
Victoria R. Stephens, Rebecca E. Moore, Sabrina K. Spicer, Julie A. Talbert, Jacky Lu, Riya Chinni, Schuyler A. Chambers, Steven D. Townsend, Shannon D. Manning, Lisa M. Rogers, David M. Aronoff, Zer Vue, Kit Neikirk, Antentor O. Hinton Jr, Steven M. Damo, Kristen N. Noble, Alison J. Eastman, Monique M. McCallister, Kevin G. Osteen, Jennifer A. Gaddy
Summary: Exposure to the environmental toxicant TCDD inhibits the response of placental macrophages to bacterial infection.
ACS INFECTIOUS DISEASES
(2023)
Article
Marine & Freshwater Biology
Layra G. Cintron-Rivera, Gabrielle Oulette, Aishwarya Prakki, Nicole M. Burns, Ratna Patel, Rachel Cyr, Jessica Plavicki
Summary: Dioxins are highly toxic and persistent environmental pollutants that have been shown to act as developmental teratogens. The most potent dioxin congener, TCDD, impairs nervous system, cardiac, and craniofacial development by activating the aryl hydrocarbon receptor (AHR). In zebrafish, TCDD exposure leads to craniofacial malformations through downregulation of sox9b, a member of the SoxE gene family. TCDD also affects the development of the zebrafish auditory system, specifically the otic vesicle, leading to structural deficits and altered collagen expression in the ears.
AQUATIC TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Han-Bi Kim, Ji-Young Um, Bo-Young Chung, Jin-Cheol Kim, Seok-Young Kang, Chun-Wook Park, Hye-One Kim
Summary: The aryl hydrocarbon receptor (AhR) is crucial for the metabolism of xenobiotics and has been found to be associated with various diseases in different organs. Recent studies have shed light on its functions in chronic inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis (PS), as well as its impact on the immune system of the skin. The therapeutic effects of AhR ligands have been demonstrated, but further research is needed to fully understand the roles of AhR in chronic inflammatory skin diseases.
Article
Biotechnology & Applied Microbiology
Axelle Brulport, Daniel Vaiman, Elias Bou-Maroun, Marie-Christine Chagnon, Ludovic Le Corre
Article
Environmental Sciences
Axelle Brulport, Corinne Lencina, Marie-Christine Chagnon, Ludovic Le Corre, Laurence Guzylack-Piriou
Summary: Increasing evidence shows the critical role of early life environment in shaping future health outcomes. BPS has been widely used as a substitute for BPA, but the lack of efficient evaluation of BPS raises doubts. The study found that exposure to BPS in early life can have transgenerational effects on intestinal inflammation and metabolism.
Article
Environmental Sciences
Axelle Brulport, Ludovic Le Corre, Guillaume Maquart, Virginie Barbet, Aurelie Dastugue, Isabelle Severin, Daniel Vaiman, Marie-Christine Chagnon
Summary: This study found that perinatal exposure to BPS can lead to sex-dependent obesogen effects in multiple generations of mice. In the F1 generation, male mice showed overweight while female mice exhibited dyslipidemia. In the F2 generation, BPS exposure was associated with increased body weight, fat, and visceral adipose tissue in both males and females.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Nicolas Kambia, Isabelle Severin, Amaury Farce, Laurence Dahbi, Thierry Dine, Emmanuel Moreau, Valerie Sautou, Marie-Christine Chagnon
Summary: DEHT, an alternative to DEHP, shows lower migration from PVC and lack of reprotoxicity. However, more data is needed to support the safety of its metabolites on thyroid system hormonal properties. Study findings suggest lack of interactions between DEHT metabolites and TRs, highlighting the potential benefits of DEHT.
Article
Nanoscience & Nanotechnology
Yann Pellequer, Gilbert Zanetta, Jean-Michel Rebibou, Isabelle Severin, Marie-Christine Chagnon, Gernot Zissel, Fabrice Neiers, Renaud Seigneuric
Summary: The current frontiers in Biology, Medicine, and Pharmacy are focused on the nanoscale, particularly in extracting, synthesizing, visualizing, and characterizing nanoparticles. Various instruments are being developed to quantify and compare nanoparticles sizes. This study introduces a statistical approach for comparing different groups of biological samples with potential applications in different fields such as determining the size differences in liposomes and extracellular vesicles.
APPLIED NANOSCIENCE
(2021)
Article
Toxicology
Laurence Dahbi, Amaury Farce, Nicolas Kambia, Isabelle Severin, Thierry Dine, Emmanuel Moreau, Valerie Sautou, Marie-Christine Chagnon
Summary: This study investigated the endocrine-disrupting effects of metabolites of the plasticizer TEHTM, commonly used in medical devices. The results showed that two of the metabolites (4-MEHTM and 2/1-MEHTM) had effects on hormone activity in vitro. However, the concentrations of these metabolites found in human urine were unlikely to have active effects on estrogen, androgen, thyroid receptors, and steroidogenesis-mediated effects.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ludovic Le Corre, Axelle Brulport, Daniel Vaiman, Marie-Christine Chagnon
Summary: Perinatal exposure to EPOX induces transgenerational effects on the liver, resulting in histological and transcriptomic changes that are dependent on the sex and generation of the animal.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Meeting Abstract
Toxicology
T. Lacour, R. Hayrapetyan, I. Severin, I. Mouche, F. Finot, M-C. Chagnon
TOXICOLOGY LETTERS
(2022)
Article
Nutrition & Dietetics
Isabelle Severin, Laurence Dahbi, Sandra Domenek, Phuong-Mai Nguyen, Anne Platel, Olivier Vitrac, Marie Christine Chagnon
Summary: Risk assessment of Non-Intentionally Added Substances (NIAS) in food contact packaging is a challenge. This article presents a strategy involving analytical tools, in silico and in vitro studies, to identify hazards in packaging extract/migrate and avoid undesirable substances in food. This approach is particularly important in the context of circular economy with increased use of bio-based and recycled materials. Traceability of these materials remains difficult.
CAHIERS DE NUTRITION ET DE DIETETIQUE
(2023)
Article
Biology
Colin Timaxian, Isabelle Raymond-Letron, Celine Bouclier, Linda Gulliver, Ludovic Le Corre, Karim Chebli, Anne Guillou, Patrice Mollard, Karl Balabanian, Gwendal Lazennec
LIFE SCIENCE ALLIANCE
(2020)