Article
Multidisciplinary Sciences
Arto Yuwono Soeroto, Raden Desy Nurhayati, Aga Purwiga, Bony Wiem Lestari, Chica Pratiwi, Prayudi Santoso, Iceu Dimas Kulsum, Hendarsyah Suryadinata, Ferdy Ferdian
Summary: This study investigated the success rate and factors associated with the treatment outcome of the shorter injectable-based regimen for MDR/RR-TB in West Java province, Indonesia. The study found that a history of previous TB treatment, time of culture conversion >2 months, and malnutrition were independent factors that decreased the chance for a successful outcome, while male gender increased the likelihood for a successful outcome.
Article
Infectious Diseases
Qi Nie, Lixuan Tao, Yingying Li, Nanshan Chen, Hua Chen, Yong Zhou, Yanqiu Wang, Huidong Chen, Qiuping Tang, Xianguang Wang, Chaolin Huang, Chengfeng Yang
Summary: The high-dose gatifloxacin-based shortened treatment regimen has shown successful outcomes in treating multidrug- or rifampicin-resistant tuberculosis in many countries. However, it is associated with significant adverse drug reactions, particularly hepatotoxicity and prolongation of the QT interval, which should not be disregarded.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Ilse Tack, Asnake Dumicho, Liesbet Ohler, Altynay Shigayeva, Abera Balcha Bulti, Kenneth White, Mduduzi Mbatha, Jennifer Furin, Petros Isaakidis
Summary: This study evaluated the safety and effectiveness of an all-oral treatment regimen containing BDQ and LZD for RR-TB patients in a rural setting in South Africa. The results showed good treatment outcomes but also common adverse events, especially for LZD, which could be managed in the program setting with support for staff training in monitoring, management, and reporting of adverse events.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
S. Kalai, P. Roychoudhury, T. K. Dutta, P. K. Subudhi, S. Chakraborty, N. N. Barman, A. Sen
Summary: An outbreak of exudative epidermatitis or greasy pig disease (GPD) was reported in Champhai district of Mizoram, India, with isolates of multidrug resistant Staphylococcus species belonging to four different species, including 66.67% MRSA. These pathogens were closely related to isolates from pigs in China, Germany, Japan, and the USA, suggesting potential transmission through illegal migration of pigs from Myanmar to India.
LETTERS IN APPLIED MICROBIOLOGY
(2021)
Article
Infectious Diseases
E. Lopez-Varela, A. J. Garcia-Prats, J. A. Seddon, H. R. Draper, J. Winckler, L. van der Laan, M. Palmer, W. A. Burger, H. S. Schaaf, A. C. Hesseling
Summary: This study observed the outcomes and safety of rifampicin-resistant TB treatment in children. The results showed that the treatment outcomes were excellent in this cohort, with few severe adverse events related to treatment, except for hearing loss.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2022)
Article
Agriculture, Dairy & Animal Science
Clara Marin, Laura Lorenzo-Rebenaque, Judith Moreno-Moliner, Sandra Sevilla-Navarro, Estefania Montero, Ma Carmen Chinillac, Jaume Jorda, Santiago Vega
Summary: This study assessed the epidemiology and antimicrobial resistance of Campylobacter jejuni in swine processing at a slaughterhouse in Eastern Spain. The results revealed high levels of multidrug-resistant C. jejuni swine batch contamination, indicating the need to include the swine sector in national control programs to reduce the bacterium and its resistance.
Article
Infectious Diseases
Simon Tiberi, Michael J. Vjecha, Adam Zumla, Jessica Galvin, Giovanni Battista Migliori, Alimuddin Zumla
Summary: The global report estimates a high number of MDR-TB cases, emphasizing the need for improving screening, diagnostic, treatment, and follow-up services; New TB drugs are showing promising results in improving cure rates, with a more tolerable six-month oral treatment regimen; The COVID-19 pandemic is negatively impacting TB services, requiring increased investment and expansion of TB treatment services.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Sanjay Singh, Tawanda Gumbo, Jan-Willem Alffenaar, Gunavanthi D. Boorgula, Prem Shankar, Tania A. Thomas, Keertan Dheda, Lesibana Malinga, Prithvi Raj, Santosh Aryal, Shashikant Srivastava
Summary: By testing and studying, it was found that the combination of meropenem with beta-lactamase inhibitors (BLIs) could potentially be an effective treatment regimen for multidrug-resistant tuberculosis (MDR-TB). The meropenem-vaborbactam-moxifloxacin backbone regimen has implications for creating a new effective MDR-TB regimen.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
H. Zhu, L. Xie, Z-Q Liu, B. Wang, M-Q Gao, Y. Lu
Summary: A population pharmacokinetic model for BDQ in Chinese patients with MDR-TB was developed, with no significant covariates found to have an impact on the model. The final model showed good simulation characteristics and stability, with accurate parameter estimation.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2021)
Article
Infectious Diseases
N. Nur, A. B. Sharif, D. K. Mitra
Summary: This study aimed to assess the stress resilience of drug-resistant pulmonary tuberculosis (DR-PTB) patients and its associated factors. The results showed that patients with multidrug-resistant (MDR) PTB had significantly higher stress resilience scores compared to those with pre-extensive drug-resistant (pre-XDR) PTB. Sex, level of education, employment status, and presence of asthma were significantly associated with stress resilience. These findings are important for improving the physical and mental health of patients.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2023)
Article
Infectious Diseases
L. Redwood, E. M. H. Mitchell, K. Viney, K. Snow, T. A. Nguyen, L. A. T. Dung, V. N. Nguyen, G. J. Fox
Summary: In Vietnam, depression and stigma are common among people with TB. Strategies to prevent and treat depressive symptoms and stigma in TB patients are critical for implementing a comprehensive, patient-centered care approach.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2021)
Article
Infectious Diseases
Malaisamy Muniyandi, Paranchi Murugesan Ramesh, William A. Wells, Umesh Alavadi, Suvanand Sahu, Chandrasekaran Padmapriyadarsini
Summary: This study evaluated the economic impacts of the 18-month pre-XDR-TB treatment regimen and the 6-9 month BEAT-TB India regimen using an economic model and decision tree analysis. Results showed that the BEAT-TB India regimen yielded higher life years and QALYs, and was cost-saving compared to the 18-month regimen for pre-XDR-TB patients. Therefore, the BEAT-TB India regimen is a dominant and cost-effective intervention.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Infectious Diseases
Y-S. Kwon, J. E. Shin, H. Kang, D. Jeon, J-J. Yim, T. S. Shim
Summary: This nationwide cohort study aimed to assess the treatment outcomes of multidrug-resistant TB (MDR-TB) patients in South Korea who underwent treatment guided by a national TB expert review committee. The study compared the final treatment outcomes between patients on new TB drugs and those not on new TB drugs and analyzed prognostic factors. Results showed that there was no difference in treatment success rate between patients on new TB drugs and those not on new TB drugs. The study concluded that the use of new drugs, as determined by an expert committee, did not compromise treatment success in mainly quinolone-susceptible MDR-TB.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2023)
Review
Public, Environmental & Occupational Health
Abudl Wahid, Nafees Ahmad, Abdul Ghafoor, Abdullah Latif, Fahad Saleem, Shereen Khan, Muhammad Atif, Qaiser Iqbal
Summary: The study showed that the shorter treatment regimen for multidrug-resistant tuberculosis in Pakistan achieved a high treatment success rate, but a portion of patients experienced death or loss to follow-up. Factors such as age, weight, and previous tuberculosis treatment history were found to have an impact on treatment outcomes.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Economics
Iro Chatzidaki, Tristan Curteis, Hannah Luedke, Dylan J. Mezzio, Martin S. Rhee, Eve McArthur, Lucy A. Eddowes
Summary: This study compared the efficacy of Lenacapavir plus an optimized background regimen (OBR) with other treatment options and found that Lenacapavir had significantly higher odds of virologic suppression in heavily treatment-experienced individuals with multidrug-resistant HIV. These findings suggest that Lenacapavir could be a novel treatment option for patients with drug-resistant HIV.
Article
Respiratory System
Elisa Tagliani, Richard Anthony, Thomas A. Kohl, Albert de Neeling, Vlad Nikolayevskyy, Csaba Kodmon, Florian P. Maurer, Stefan Niemann, Dick van Soolingen, Marieke J. van der Werf, Daniela Maria Cirillo
Summary: This study evaluated the systematic use of whole genome sequencing (WGS) for Mycobacterium tuberculosis complex (MTBC) surveillance in European Union/European Economic Area (EU/EEA) countries and highlighted challenges and lessons learnt for future development of a WGS-based surveillance system. The results showed that a WGS-based surveillance system is not only feasible but can efficiently elucidate the dynamics of in-country and cross-border rifampicin-resistant (RR) and multidrug-resistant (MDR) tuberculosis transmission across EU/EEA countries. Lessons learnt from this study emphasize the need for strengthening national integrated systems and developing clear procedures for international collaboration in investigating cross-border clusters.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Letter
Infectious Diseases
D. B. Folkvardsen, Y. Holicka, C. Kodmon, M. J. van der Were, T. Lillebaek, V. Nikolayevskyy
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2021)
Review
Infectious Diseases
Delia Goletti, Linda Petrone, Davide Manissero, Antonio Bertoletti, Sonia Rao, Nduku Ndunda, Alessandro Sette, Vladyslav Nikolayevskyy
Summary: T-cell responses play a crucial role in COVID-19, providing early detection of disease progression and predictive value for severity and survival rates. Vaccination stimulates robust T-cell responses, contributing significantly to protective immunity, although understanding of long-term T-cell responses remains limited.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Letter
Infectious Diseases
K. Klaos, Y. Holicka, R. Groenheit, C. Kodmon, M. J. van der Werf, V. Nikolayevskyy
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2022)
Review
Infectious Diseases
Maria Krutikov, Lena Faust, Vladyslav Nikolayevskyy, Yohhei Hamada, Rishi K. Gupta, Daniela Cirillo, Alberto Matteelli, Alexei Korobitsyn, Claudia M. Denkinger, Molebogeng X. Rangaka
Summary: This study systematically assessed the diagnostic performance of novel skin-based tests for tuberculosis infection compared to the TST and IGRA tests. The results showed that the novel skin-based tests performed similarly to IGRA or TST, but there were variations in study quality.
LANCET INFECTIOUS DISEASES
(2022)
Article
Immunology
Yen Holicka, Elisa Tagliani, Daniela Maria Cirillo, Vlad Nikolayevskyy
Summary: This study aims to gather observational evidence of the impact of Whole Genome Sequencing (WGS) in the pathogen identification, antimicrobial resistance profiling and transmission tracking of tuberculosis. The study found that WGS significantly improved TB drug resistance testing and reduced false clustering. Further research is needed to assess the financial impact of WGS.
Editorial Material
Respiratory System
Sophia B. Georghiou, Timothy C. Rodwell, Alexei Korobitsyn, Said H. Abbadi, Kanchan Ajbani, Jan-Willem Alffenaar, David Alland, Nataly Alvarez, Sonke Andres, Elisa Ardizzoni, Alexandra Aubry, Rossella Baldan, Marie Ballif, Ivan Barilar, Erik C. Bottger, Soumitesh Chakravorty, Pauline M. Claxton, Daniela M. Cirillo, Inaki Comas, Chris Coulter, Claudia M. Denkinger, Brigitta Derendinger, Edward P. Desmond, Jurriaan E. M. de Steenwinkel, Keertan Dheda, Andreas H. Diacon, David L. Dolinger, Kelly E. Dooley, Matthias Egger, Maha R. Farhat, Lanfranco Fattorini, Iris Finci, Laure Fournier Le Ray, Victoria Furio, Ramona Groenheit, Tawanda Gumbo, Scott K. Heysell, Doris Hillemann, Harald Hoffmann, Po-Ren Hsueh, Yi Hu, Hairong Huang, Alamdar Hussain, Farzana Ismail, Kiyohiko Izumi, Tomasz Jagielski, John L. Johnson, Priti Kambli, Kone Kaniga, G. H. R. Eranga Karunaratne, Meenu Kaushal Sharma, Peter M. Keller, Ellis C. Kelly, Margarita Kholina, Mikashmi Kohli, Katharina Kranzer, Ian F. Laurenson, Jason Limberis, S-Y Grace Lin, Yongge Liu, Alexandre Lopez-Gavin, Anna Lyander, Diana Machado, Elena Martinez, Faisal Masood, Satoshi Mitarai, Nomonde R. Mvelase, Stefan Niemann, Vladyslav Nikolayevskyy, Florian P. Maurer, Matthias Merker, Paolo Miotto, Shaheed Omar, Ralf Otto-Knapp, Moises Palaci, Juan Jose Palacios Gutierrez, Sharon J. Peacock, Charles A. Peloquin, Jennifer Perera, Catherine Pierre-Audigier, Suporn Pholwat, James E. Posey, Therdsak Prammananan, Leen Rigouts, Jaime Robledo, Neesha Rockwood, Camilla Rodrigues, Max Salfinger, Marcos C. Schechter, Marva Seifert, Sarah Sengstake, Thomas Shinnick, Natalia Shubladze, Vitali Sintchenko, Frederick Sirgel, Sulochana Somasundaram, Timothy R. Sterling, Andrea Spitaleri, Elizabeth Streicher, Philip Supply, Erik Svensson, Elisa Tagliani, Sabira Tahseen, Akiko Takaki, Grant Theron, Gabriela Torrea, Armand Van Deun, Annelies Van Rie, Dick van Soolingen, Roger Vargas, Amour Venter, Nicolas Veziris, Cristina Villellas, Miguel Viveiros, Robin Warren, Shu'an Wen, Jim Werngren, Robert J. Wilkinson, Caie Yang, Tingting Zhang, Danila Zimenkov, Nazir Ismail, Thomas Schon, Claudio U. Koser, Soudeh Ehsani, Jakko van Ingen, F. Ferda Yilmaz
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Infectious Diseases
David Wyllie, Trien Do, Richard Myers, Vlad Nikolayevskyy, Derrick Crook, Tim Peto, Eliza Alexander, Esther Robinson, A. Sarah Walker, Colin Campbell, E. Grace Smith
Summary: Mixtures of transmissible strains occur in at least 5% of tuberculosis infections in England, and when present in pulmonary disease, such mixtures are associated with an increased risk of tuberculosis transmission.
JOURNAL OF INFECTION
(2022)
Article
Biochemical Research Methods
Francis Stieber, Nadia Allen, Kara Carpenter, Jenny Howard, Riccardo Alagna, Davide Manissero, Vladyslav Nikolayevskyy
Summary: Emerging evidence suggests the significant role of T-cells in COVID-19 immunity, and IGRA assays are considered attractive alternatives for accurate assessment. Adhering to good laboratory practice principles is important.
JOURNAL OF VIROLOGICAL METHODS
(2022)
Review
Respiratory System
Elena Khimova, Ximena Gonzalo, Yulia Popova, Platon Eliseev, Maryandyshev Andrey, Vladyslav Nikolayevskyy, Agnieszka Broda, Francis Drobniewski
Summary: This review examines non-sputum diagnostic approaches for pulmonary tuberculosis based on urine samples, focusing on urine biomarkers. The analytical methods and designs vary among the studies, and only a few studies describe formal specificity and sensitivity analysis for diagnostic outcome prediction. Combining host and pathogen biomarkers may improve the sensitivity and specificity of tuberculosis diagnosis in the future.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Matthias Merker, Jean-Philippe Rasigade, Maxime Barbier, Helen Cox, Silke Feuerriegel, Thomas A. Kohl, Egor Shitikov, Kadri Klaos, Cyril Gaudin, Rudy Antoine, Roland Diel, Sonia Borrell, Sebastien Gagneux, Vladyslav Nikolayevskyy, Soenke Andres, Valeriu Crudu, Philip Supply, Stefan Niemann, Thierry Wirth
Summary: The research revealed that the W148 strain originated around 1963, and subsequently underwent two epidemic expansions in the late 20th century, developing resistance to multiple anti-TB drugs. The study also found that this strain carries a variety of drug resistance genes, posing a threat to the successful introduction of new anti-M/XDR-TB antibiotic regimens.
NATURE COMMUNICATIONS
(2022)
Review
Respiratory System
James Mahon, Sophie Beale, Hayden Holmes, Mick Arber, Vladyslav Nikolayevskyy, Riccardo Alagna, Davide Manissero, David Dowdy, Giovanni Battista Migliori, Giovanni Sotgiu, Raquel Duarte
Summary: This review examines the cost-effectiveness of testing and treatment for latent tuberculosis infection (LTBI) in high-risk groups using interferon gamma release assays (IGRAs) or a tuberculin skin test (TST). The results suggest that IGRAs are likely to be cost-effective in high-income countries for high-risk populations, although there is uncertainty in parameter values used in the studies. Further evidence is needed on the cost-effectiveness of different strategies in low to middle income countries and countries with high TB burden.
BMC PULMONARY MEDICINE
(2022)
Correction
Infectious Diseases
M. Krutikov, L. Faust, V Nikolayevskyy
LANCET INFECTIOUS DISEASES
(2022)
Correction
Infectious Diseases
M. Krutikov, L. Faust, V Nikolayevskyy
LANCET INFECTIOUS DISEASES
(2022)
Letter
Immunology
Hamzah Z. Farooq, Daniela M. Cirillo, Doris Hillemann, David Wyllie, Marieke J. van der Werf, Csaba Kodmon, Vlad Nikolayevskyy
Summary: In European laboratories, testing capacity for newer and repurposed tuberculosis drugs exists, but its availability is limited.
EMERGING INFECTIOUS DISEASES
(2021)
