Journal
THORAX
Volume 72, Issue 8, Pages 760-762Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/thoraxjnl-2016-208948
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Funding
- Cystic Fibrosis Trust
- National Institute of Health Research (NIHR)
- MRC [MR/M008894/1] Funding Source: UKRI
- National Institutes of Health Research (NIHR) [ICA-CDRF-2015-01-027] Funding Source: National Institutes of Health Research (NIHR)
- British Heart Foundation [SP/14/6/31350] Funding Source: researchfish
- Medical Research Council [MR/M008894/1, 1514448] Funding Source: researchfish
- National Institute for Health Research [ICA-CDRF-2015-01-027, NIHR-RP-R3-12-027, NIHR-CS-012-013] Funding Source: researchfish
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Hyperpolarised He-3 ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6-16 years) with clinically stable mild cystic fibrosis (CF) (FEV1> -1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure-function relationships.
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