Article
Critical Care Medicine
Janelle Vu Pugashetti, Ayodeji Adegunsoye, Zhe Wu, Cathryn T. Lee, Anand Srikrishnan, Sahand Ghodrati, Vivian Vo, Elisabetta A. Renzoni, Athol U. Wells, Christine Kim Garcia, Felix Chua, Chad A. Newton, Philip L. Molyneaux, Justin M. Oldham
Summary: This study found that a decline in FVC of >= 10% and six additional criteria can predict transplant-free survival in patients with non-IPF ILD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Carlo Albera, Giulia Verri, Federico Sciarrone, Elena Sitia, Mauro Mangiapia, Paolo Solidoro
Summary: Interstitial lung diseases (ILDs) encompass a diverse group of rare and chronic respiratory disorders, with idiopathic pulmonary fibrosis (IPF) being the most studied member. Recent development of antifibrotic drugs has shown benefits in ILDs characterized by progressive fibrosis, leading to significant changes in management.
Review
Medicine, General & Internal
Ahmad Abu Qubo, K. M. Capaccione, Elana J. Bernstein, Maria Padilla, Mary Salvatore
Summary: This article describes the role of radiology in the diagnosis and follow-up of PF-ILD. The manuscript reviews the radiographic diagnosis and unique CT characteristics associated with specific types of fibrosis. Radiology has the potential to make an important contribution to the multidisciplinary discussion for this important diagnosis.
FRONTIERS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Valentina Gonzalez-Jaramillo, Jelena Guyer, Nora Luethi, Piotr Sobanski, Rut Zbinden, Eveline Rodriguez, Lukas Hunziker, Steffen Eychmuller, Maud Maessen
Summary: This study translated and culturally adapted the NAT: PD-HF tool into German, and evaluated its internal consistency, inter-rater reliability, test-retest reliability, and validity. Results showed good internal consistency of the translated tool, substantial agreement among raters for most questions, and high face validity rating by health care personnel.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Review
Medicine, General & Internal
Carla R. Copeland, Lisa H. Lancaster
Summary: Progressive fibrosing interstitial lung diseases (PF-ILD) is a diverse group of interstitial lung diseases characterized by accelerated respiratory failure, frequent disease exacerbation, and earlier mortality. Available therapeutic approaches include antifibrotic therapy, immunosuppression, novel therapies, and lung transplantation.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
David Roofeh, Kevin K. Brown, Ella A. Kazerooni, Donald Tashkin, Shervin Assassi, Fernando Martinez, Athol U. Wells, Ganesh Raghu, Christopher P. Denton, Lorinda Chung, Anna-Maria Hoffmann-Vold, Oliver Distler, Kerri A. Johannson, Yannick Allanore, Eric L. Matteson, Leticia Kawano-Dourado, John D. Pauling, James R. Seibold, Elizabeth R. Volkmann, Simon L. F. Walsh, Chester Oddis, Eric S. White, Shaney L. Barratt, Elana J. Bernstein, Robyn T. Domsic, Paul F. Dellaripa, Richard Conway, Ivan Rosas, Nitin Bhatt, Vivien Hsu, Francesca Ingegnoli, Bashar Kahaleh, Puneet Garcha, Nishant Gupta, Surabhi Khanna, Peter Korsten, Celia Lin, Stephen C. Mathai, Vibeke Strand, Tracy J. Doyle, Virginia Steen, Donald F. Zoz, Juan Ovalles-Bonilla, Ignasi Rodriguez-Pinto, Padmanabha D. Shenoy, Andrew Lewandoski, Elizabeth Belloli, Alain Lescoat, Vivek Nagaraja, Wen Ye, Suiyuan Huang, Toby Maher, Dinesh Khanna
Summary: This study aimed to establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD). The results showed that using the proposed conceptual framework, international experts were able to achieve a consensus on classifying SSc-ILD patients along the dimensions of disease severity, risk of progression and progression over time.
Article
Pharmacology & Pharmacy
Alexandra Nagy, Tamas Nagy, Abigel Margit Kolonics-Farkas, Noemi Eszes, Krisztina Vincze, Eniko Barczi, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Gyorgy Nagy, Emese Kiss, Pal Maurovich-Horvat, Aniko Bohacs, Veronika Muller
Summary: This study evaluated the clinical characteristics and predictors of lung function changes in autoimmune PF-ILD patients. Older age and more severe clinical symptoms were observed in the IPAF group. Antifibrotic therapy had a positive impact on long-term lung function improvement in PF-ILD patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
John N. Shumar, Abhimanyu Chandel, Christopher S. King
Summary: Progressive fibrosing interstitial lung disease (PF-ILD) is a subset of interstitial lung diseases characterized by progressive and intractable lung fibrosis, with similarities to idiopathic pulmonary fibrosis. Recent studies have shown the clinical efficacy of antifibrotic therapy in PF-ILD, changing the treatment landscape for fibrotic lung diseases and opening the door for combined therapies targeting both fibrotic and inflammatory components.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Francesca Borgnis, Francesca Borghesi, Federica Rossetto, Elisa Pedroli, Mario Meloni, Giuseppe Riva, Francesca Baglio, Pietro Cipresso
Summary: The study aimed to test the diagnostic efficacy of EXIT 360 degrees in distinguishing executive functioning between healthy controls and patients with Parkinson's Disease (PwPD). The results showed that PwPD made more errors and took longer to complete EXIT 360 degrees. There was a significant correlation between neuropsychological tests and EXIT 360 degrees scores, indicating good convergent validity.
SCIENTIFIC REPORTS
(2023)
Article
Education, Scientific Disciplines
Satid Thammasitboon, Moushumi Sur, Joseph J. Rencic, Gurpreet Dhaliwal, Shelley Kumar, Suresh Sundaram, Parthasarathy Krishnamurthy
Summary: Assessing learners' competence in diagnostic reasoning is challenging in medical education. The ART-R tool, with five theoretical domains, was developed and validated through a psychometric evaluation. The internal consistency and association with global assessment provide evidence for its validity as an assessment tool.
Review
Medical Laboratory Technology
Xiaomeng Li, Yongmei Liu, Linlin Cheng, Yuan Huang, Songxin Yan, Haolong Li, Haoting Zhan, Yongzhe Li
Summary: Studies have shown that dysregulated expression of blood biomarkers related to ILD, such as ferritin, KL-6, SP-D, cytokines, and some tumor markers in MDA5(+)DM, may provide valuable information for disease presence, activity, treatment response, and prognosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Respiratory System
Byoung Soo Kwon, Jooae Choe, Eun Jin Chae, Hee Sang Hwang, Yong-Gil Kim, Jin Woo Song
Summary: Approximately 34% of non-IPF fibrosing ILD patients showed a progressive PF phenotype with poor prognosis, similar to that of IPF. The PF phenotype was identified as an independent prognostic factor in patients with fibrosing ILD.
RESPIRATORY RESEARCH
(2021)
Article
Critical Care Medicine
Simon L. F. Walsh, John A. Mackintosh, Lucio Calandriello, Mario Silva, Nicola Sverzellati, Anna Rita Larici, Stephen M. Humphries, David A. Lynch, Helen E. Jo, Ian Glaspole, Christopher Grainge, Nicole Goh, Peter M. A. Hopkins, Yuben Moodley, Paul N. Reynolds, Christopher Zappala, Gregory Keir, Wendy A. Cooper, Annabelle M. Mahar, Samantha Ellis, Athol U. Wells, Tamera J. Corte
Summary: This study evaluated the prognostic accuracy of a deep learning algorithm for predicting outcomes in patients with fibrotic lung disease using high-resolution computed tomography (HRCT) data. The results showed that this algorithm outperformed expert radiologist evaluation and guideline-based histologic pattern in predicting survival. It has the potential to be a useful tool in characterizing fibrotic lung disease in a multidisciplinary approach. Further research is needed to investigate its utility as a decision support system when interstitial lung disease expertise is unavailable.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
Willis S. Bowman, Gabrielle A. Echt, Justin M. Oldham
Summary: Interstitial lung disease (ILD) is a group of diverse lung disorders that can lead to irreversible pulmonary fibrosis. While idiopathic pulmonary fibrosis (IPF) is a common subtype, other ILD patients may develop a progressive fibrosing phenotype. Biomarker investigation has identified molecular markers that can predict disease endpoints, suggesting potential for biomarker implementation in ILD management.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Amy Hajari Case
Summary: Interstitial lung diseases (ILD) can have variable prognoses, but some exhibit fibrosis and progressive disease. Idiopathic pulmonary fibrosis is the most common type, but other ILDs, such as autoimmune ILD and chronic hypersensitivity pneumonitis, can also have a progressive fibrotic phenotype. The typical interstitial pneumonia pattern of lung involvement is a significant risk factor, suggesting shared fibrotic pathways that can be targeted by antifibrotic therapies. This review describes the most commonly fibrotic ILDs, shared risk factors for developing PF-ILD, and evidence for the use of antifibrotic therapies in their management.
FRONTIERS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Jonathan Koffman, Sabrina Bajwah, Joanna M. Davies, Jamilla Akhter Hussain
Summary: This article examines the position of minoritised communities in palliative care research and proposes recommendations to improve the precision and rigor of research and reporting of findings. The findings suggest the need for reflection and justification of the classification of minoritised communities, exploration of intersectionality, optimization of data quality, decolonization of research teams and methods, and focus on reducing inequities in end-of-life care experiences and outcomes.
PALLIATIVE MEDICINE
(2023)
Article
Health Care Sciences & Services
Diana H. Ferreira, Magnus Ekstrom, Belinda Fazekas, David C. Currow
Summary: This study aimed to investigate the effects of long-term low-dose sustained-release morphine on testosterone levels in patients with chronic obstructive pulmonary disease. The results showed that only 3 out of 20 participants experienced substantial declines in testosterone levels during the morphine treatment, and all three had worsening illness at the time of assessment. There was no apparent relationship between changes in testosterone, morphine dose, and breathlessness.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Article
Obstetrics & Gynecology
Penelope Fotheringham, Nadom Safi, Zhouyang Li, Antoinette Anazodo, Marc Remond, Andrew Hayen, David Currow, David Roder, Nada Hamad, Michael Nicholl, Adrienne Gordon, Jane Frawley, Elizabeth A. Sullivan
Summary: This study aimed to describe the incidence and perinatal outcomes of pregnancy-associated gynecological cancer (PAGC). The incidence of PAGC was 14.6 per 100,000 deliveries and did not change over time. Women with PAGC had increased odds of severe maternal morbidity and their babies had a higher rate of preterm birth and severe neonatal complications.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Oncology
David Banham, David Roder, Sandra Thompson, Anna Williamson, Freddie Bray, David Currow
Summary: This study examines the potential of more frequent contact with general practitioners (GPs) in ensuring early-stage cancer diagnosis among older Aboriginal Australians. The results show that frequent GP contact is associated with a higher likelihood of a local-stage diagnosis among Aboriginal people.
CANCER CAUSES & CONTROL
(2023)
Article
Respiratory System
Daisy J. A. Janssen, Sabrina Bajwah, Michele Hilton Boon, Courtney Coleman, David C. Currow, Albert Devillers, Chantal Vandendungen, Magnus Ekstrom, Ron Flewett, Sarah Greenley, Mai -Britt Guldin, Cristina Jacome, Miriam J. Johnson, Geana Paula Kurita, Matthew Maddocks, Alda Marques, Hilary Pinnock, Steffen T. Simon, Thomy Tonia, Kristoffer Marsaa
Summary: This study provides recommendations for the initiation and integration of palliative care in the respiratory care of patients with COPD or ILD, including considering palliative care during holistic needs assessment, providing palliative care interventions based on identified needs, offering advance care planning, and integrating palliative care into routine care for COPD and ILD.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Obstetrics & Gynecology
Nadom Safi, Zhuoyang Li, Antoinette Anazodo, Marc Remond, Andrew Hayen, David Currow, David Roder, Nada Hamad, Michael Nicholl, Adrienne Gordon, Jane Frawley, Penelope Fotheringham, Elizabeth Sullivan
Summary: This study investigated the obstetric management and outcomes of women with pregnancy-associated cancer (PAC) and their babies. The results showed that women with PAC are more likely to have serious maternal complications, and their babies are more likely to be born preterm and experience poorer perinatal outcomes.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Jessica Lee, David Currow, Melanie Lovell, Jane L. Phillips, Andrew McLachlan, Megan Ritchie, Linda Brown, Belinda Fazekas, Rajesh Aggarwal, Davinia Seah, Caitlin Sheehan, Richard Chye, Beverly Noble, Nikki McCaffrey, Ghauri Aggarwal, Rachel George, Marian Kow, Chadi Ayoub, Anthony Linton, Christine Sanderson, Dipti Mittal, Angela Rao, Grace Prael, Katalin Urban, Priyanka Vandersman, Meera Agar
Summary: This study aims to evaluate the safety and efficacy of lidocaine as a treatment for neuropathic cancer-related pain in patients. The study will involve a pilot trial, pharmacokinetic substudy, and qualitative substudy. The findings will inform the design of further clinical trials and provide important safety data.
Letter
Respiratory System
Diana H. Ferreira, Magnus Ekstrom, Sabrina Bajwah, Belinda Fazekas, David C. Currow
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Alison Bravington, George Obita, Elin Baddeley, Miriam J. Johnson, Fliss E. M. Murtagh, David C. Currow, Elaine G. Boland, Annmarie Nelson, Kathy Seddon, Alfred Oliver, Simon I. R. Noble, Jason W. Boland
Summary: This study aimed to develop a Core Outcome Set for the assessment of inoperable malignant bowel obstruction with the involvement of clinicians, patients, and caregivers, using the COMET methodology. Through a systematic review, a rapid review, and in-depth interviews, a comprehensive list of outcomes was identified and consolidated. In the Delphi process, 16 core outcomes were agreed upon by stakeholders in the areas of symptom control, life impact, treatment outcomes, and communication and patient preferences.
Article
Health Care Sciences & Services
Andrew Brew, Sarah O'Beirne, Miriam J. Johnson, Christina Ramsenthaler, Peter J. Watson, Philip A. Rubini, Michael J. Fagan, Flavia Swan, Andrew Simpson
Summary: The study found that using a fan to blow air towards the face can alleviate post-exercise breathlessness and speed up recovery. The airflow speed plays a crucial role in the recovery process, with speeds of 1.7 m/s or higher being most effective in reducing breathlessness and lowering facial temperature.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)
Meeting Abstract
Respiratory System
Stephen Morrell, Maija Kohonen-Corish, Robyn Ward, Tania Sorrell, David Roder, David Currow
Article
Oncology
Ming Li, Antoinette Anazodo, Luciano Dalla-Pozza, Paola Kabalan Baeza, David Roder, David Currow
Summary: This study investigated the impact of age on treatment and survival in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The results showed that children received shorter and less diverse treatments for ALL compared to adolescents and young adults. The 5-year disease-specific survival rate for ALL was 84%, and children had a lower risk of death from ALL. The 5-year survival rate for AML was 73%, with no age differences. Children receiving multiple treatments for ALL had a higher risk of mortality.
EUROPEAN JOURNAL OF CANCER CARE
(2023)
Article
Health Care Sciences & Services
Lisa Redwood, David Currow, Slavica Kochovska, Susan J. Thomas
Summary: This study applied EQ-5D-5L to measure HRQoL in a representative sample of the Australian population and established population norms for Australia. The findings highlight the heterogeneity of HRQoL between different sociodemographic variables.
QUALITY OF LIFE RESEARCH
(2023)
Article
Psychiatry
Michael Louis Impelido, Kate Brewer, Philip Burgess, Jackie Curtis, David Currow, Grant Sara
Summary: Women who use mental health services have lower cervical cancer screening rates, especially among older age groups. Intervention is needed to bridge this gap.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
