Journal
TETRAHEDRON LETTERS
Volume 58, Issue 5, Pages 445-448Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.12.053
Keywords
Copper-mediated; Intramolecular; Aza-Wacker-type cyclization; 3-Aryl indoles
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Funding
- National Natural Science Foundation of China [21272028, 21572025]
- Innovation & Entrepreneurship Talents Introduction Plan of Jiangsu Province
- Key University Science Research Project of Jiangsu Province [15KJA150001]
- Jiangsu Key Laboratory of Advanced Catalytic Materials Technology [BM2012110]
- Advanced Catalysis and Green Manufacturing Collaborative Innovation Center
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A copper-mediated intramolecular aza-Wacker-type cyclization was developed for the direct and efficient synthesis of 3-aryl indoles using 2-alkenylanilines in moderate to good yields with good functional group compatibility. This strategy shows the high efficiency, operational simplicity as well as broad substrate scope. (C) 2016 Elsevier Ltd. All rights reserved.
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