4.4 Article

Palladium-catalyzed synthesis of indole fused coumarins via cross-dehydrogenative coupling

Journal

TETRAHEDRON LETTERS
Volume 58, Issue 4, Pages 313-316

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.12.010

Keywords

C-H activation; Palladium; Oxygen; Coumarin; Indole

Funding

  1. SERB-DST, New Delhi
  2. CSIR
  3. UGC

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The present method describes a palladium-catalyzed cross-dehydrogenative coupling reaction of coumarin and aniline for the synthesis of indole fused coumarin derivatives. The one-pot method is operationally simple and molecular oxygen is used as sole oxidant. The target compounds are obtained in good yields from commercially available precursors. (C) 2016 Elsevier Ltd. All rights reserved.

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