Synthesis and Characterization of Novel BMI1 Inhibitors Targeting Cellular Self-Renewal in Hepatocellular Carcinoma

BMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer

(2016) N. Bansal et al.   CLINICAL CANCER RESEARCH

Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment

(2016) Arnold Bolomsky et al.   Journal of Hematology & Oncology

Liver cancer stem cell markers: Progression and therapeutic implications

(2016) Jing-Hui Sun et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Preclinical activity of the novel B-cell-specific Moloney murine leukemia virus integration site 1 inhibitor PTC-209 in acute myeloid leukemia: Implications for leukemia therapy

(2015) Yuki Nishida et al.   CANCER SCIENCE

Radiosensitization of Primary Human Glioblastoma Stem-like Cells with Low-Dose AKT Inhibition

(2015) M. Mehta et al.   MOLECULAR CANCER THERAPEUTICS

The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cells

(2015) Christian Mayr et al.   Oncotarget

Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

(2015) Juan Liu et al.   Oncotarget

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Investigation of diagnostic utility and expression profiles of stem cell markers (CD133 and CD90) in hepatocellular carcinoma, small cell dysplasia, and cirrhosis

(2014) Guldal Yilmaz et al.   PATHOLOGY RESEARCH AND PRACTICE

Evaluating human cancer cell metastasis in zebrafish

(2013) Yong Teng et al.   BMC CANCER

Self-renewal as a therapeutic target in human colorectal cancer

(2013) Antonija Kreso et al.   NATURE MEDICINE

Enrichment of human prostate cancer cells with tumor initiating properties in mouse and zebrafish xenografts by differential adhesion

(2013) Nitu Bansal et al.   PROSTATE

Novel therapeutic Strategies for Targeting Liver Cancer Stem Cells

(2012) Naoki Oishi et al.   International Journal of Biological Sciences

Residual dormant cancer stem-cell foci are responsible for tumor relapse after antiangiogenic metronomic therapy in hepatocellular carcinoma xenografts

(2012) Ines Martin-Padura et al.   LABORATORY INVESTIGATION

Bmi1 Is Required for Hepatic Progenitor Cell Expansion and Liver Tumor Development

(2012) Lingling Fan et al.   PLoS One

Role of BMI1, a Stem Cell Factor, in Cancer Recurrence and Chemoresistance: Preclinical and Clinical Evidences

(2012) Hifzur Rahman Siddique et al.   STEM CELLS

Functional Crosstalk between Bmi1 and MLL/Hoxa9 Axis in Establishment of Normal Hematopoietic and Leukemic Stem Cells

(2011) Lan-Lan Smith et al.   Cell Stem Cell

BMI1 as a novel target for drug discovery in cancer

(2011) Liangxian Cao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Cancer stem cells and hepatocellular carcinoma

(2010) Zhixing Yao et al.   CANCER BIOLOGY & THERAPY

Bmi-1 Is a Crucial Regulator of Prostate Stem Cell Self-Renewal and Malignant Transformation

(2010) Rita U. Lukacs et al.   Cell Stem Cell

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

(2010) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Bmi-1, stem cells and cancer

(2009) L. Jiang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Bmi-1gene is upregulated in early-stage hepatocellular carcinoma and correlates with ATP-binding cassette transporter B1 expression

(2009) Kathryn Effendi et al.   CANCER SCIENCE

Liver cancer stem cells: implications for a new therapeutic target

(2009) Terence Kin Wah Lee et al.   LIVER INTERNATIONAL

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

(2009) Bin-Bing S. Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma

(2008) T. Chiba et al.   CANCER RESEARCH

Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours

(2008) V. Häyry et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY