Article
Environmental Sciences
Miyuki Iwai-Shimada, Yayoi Kobayashi, Tomohiko Isobe, Shoji E. Nakayama, Makiko Sekiyama, Yu Taniguchi, Shin Yamazaki, Takehiro Michikawa, Masako Oda, Hiroshi Mitsubuchi, Masafumi Sanefuji, Shouichi Ohga, Nathan Mise, Akihiko Ikegami, Reiko Suga, Masayuki Shimono
Summary: Prenatal exposure to methylmercury can impact child development. This study compared two high-throughput methods for mercury speciation and found relatively good agreement between them. MeHg and IHg concentrations were determined in maternal and cord blood samples, highlighting the importance of analyzing different chemical forms for health effects.
Article
Chemistry, Analytical
Tamara Fernandez-Bautista, Beatriz Gomez-Gomez, Roberto Palacin-Garcia, Emma Gracia-Lor, Teresa Perez-Corona, Yolanda Madrid
Summary: The distribution of Se and Hg in different protein fractions extracted from muscle tissues of tuna, swordfish, and salmon (wild vs. farmed) was investigated for the first time. The study revealed that Se and Hg were associated with proteins of specific molecular weights, with differences observed between farmed and wild salmon. Additionally, Se speciation studies showed SeMeSeCys as the primary selenium species found in the proteins analyzed.
Article
Biochemistry & Molecular Biology
Derek D. Bussan, Chris Douvris, James Cizdziel
Summary: Wetlands are of great environmental value as they provide food and habitat for plants and animals. A study conducted in an old growth cypress wetland in the Mississippi Delta found that wetlands are hotspots for mercury (Hg) methylation and demethylation rates, with these rates influenced by temperature and other environmental factors. The study also provides baseline data for assessing the impacts of modifying water flow on Hg methylation and demethylation rates in wetlands.
Article
Biochemistry & Molecular Biology
Bin Li, Sew Lay Chua, Dingyi Yu, Sheot Harn Chan, Angela Li
Summary: This study established a reliable method for detecting silver nanoparticles (AgNPs) in food and evaluated their migration in milk and breast milk storage bags. The results showed no migration of AgNPs from the storage bags under various conditions.
Review
Chemistry, Multidisciplinary
Laura Favilli, Agnese Giacomino, Mery Malandrino, Paolo Inaudi, Aleandro Diana, Ornella Abollino
Summary: This review summarizes different approaches for the quantification of mercury species in different samples using HPLC-ICP-MS, and discusses the sampling and pretreatment steps prior to quantification.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Iman Al-Saleh
Summary: The levels of organic mercury, lead, and manganese in the breast milk of healthy Saudi mothers may pose potential risks to infant health. Despite some metals exceeding recommended values, breastfeeding is still considered beneficial overall.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Chemistry, Analytical
Davide Spanu, Laura Butti, Ginevra Boldrocchi, Roberta Bettinetti, Sandro Recchia, Damiano Monticelli
Summary: A fast and cost-effective procedure based on ICP-MS was proposed for the selective determination of methylmercury in fish tissue. The procedure achieved selectivity for methylmercury by inserting a strong anion exchange resin to block inorganic mercury. It featured a short extraction time and analysis time with a low limit of detection. The procedure was validated using standard reference materials and successfully applied to detecting methylmercury in the marine trophic web of Djibouti, revealing a high risk associated with biomagnification of methylmercury.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Tom Van Helden, Simone Braeuer, Thibaut Van Acker, Olivier Leroux, Dominique Van Der Straeten, Frank Vanhaecke
Summary: This study investigates the effects of instrumental setup on the response duration of elements, such as Hg and Se, in biological tissue. By optimizing the setup, significant improvement in the response duration is achieved. However, caution should be taken when selecting instrument settings and data acquisition conditions for accurate elemental mapping to avoid smearing effects.
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2022)
Article
Agronomy
Federica Carucci, Gustavo Moreno-Martin, Yolanda Madrid-Albarran, Giuseppe Gatta, Pasquale De Vita, Marcella Michela Giuliani
Summary: The study evaluated the effects of foliar application of selenate and organic nitrogen and sulfur sources on the selenium content and species in durum wheat grain. The results showed that foliar application of selenate led to increased selenium accumulation, particularly under conditions of lower rainfall. Organic foliar sulfur had a negative effect on selenium content, while organic foliar nitrogen increased it. Modern varieties generally had higher selenium content compared to old varieties.
Article
Chemistry, Analytical
Yihuan Song, Qingfang Ma, Heyong Cheng, Jinhua Liu, Yuanchao Wang
Summary: A method utilizing online solid-phase extraction coupled with high performance liquid chromatography and inductively coupled plasma mass spectrometry was developed for simultaneous enrichment and analysis of ultra-trace lead and mercury species in water. This method allows for efficient and accurate determination of lead and mercury species in water samples, with high enrichment factors and low LODs and LOQs. The method was successfully applied to analyze trace lead and mercury species in various types of water samples, showing promising results for unstable sample analysis.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Micheline Ghosn, Rachida Chekri, Celine Mahfouz, Gaby Khalaf, Thierry Guerin, Rachid Amara, Petru Jitaru
Summary: A simple, rapid, and robust method for speciation analysis of methylmercury (MeHg) was developed using reversed phase high-performance liquid chromatography coupled to inductively coupled plasma-mass spectrometry (RP HPLC-ICP-MS). The method successfully separated MeHg from its inorganic Hg precursor and was validated using the accuracy profile approach. The method showed good analytical performance in terms of repeatability and reproducibility, making it suitable for routine determination of MeHg in fishery products.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Lena Ruzik, Malgorzata Jakubowska
Summary: The popularity of plant-based food products has grown in response to the increasing demand for plant foods. This study analyzed the total arsenic content and its species in plant-based beverages purchased in Poland. The research validated a method for analyzing arsenic using high-performance liquid chromatography combined with inductively coupled plasma mass spectrometry.
Article
Chemistry, Applied
Semih Kara, Dotse Selali Chormey, Ahmet Saygilar, Sezgin Bakirdere
Summary: This study utilized a combination of high-performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS) to separate and quantify six arsenic species. The method demonstrated high sensitivity and accuracy, with limits of detection ranging between 0.14-0.29 ng/mL. Spike recovery experiments on rice samples validated the method's applicability to complex matrices, with recovery results ranging between 93 and 109%. Triplicate measurements on all spiked samples recorded percent relative standard deviation values below 10%, indicating the reliability and precision of the method.
Article
Environmental Sciences
Ersin Nazlican, Enes Arica, Ismail Ethem Goren, Betul Kilincli, Burak Mete, Nebile Daglioglu
Summary: The study aimed to assess the levels of heavy metals in breast milk samples of mothers in the Cukurova region, Turkey, showing high exposure levels for Cr and As. These metals can cross the placenta and accumulate in breast milk postnatally.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yahya R. Tahboub, Adnan M. Massadeh, Nihaya A. Al-sheyab, Diab El Shrafat, Israa A. Nsserat
Summary: This study aimed to compare levels of trace elements in human breast milk from Jordanian mothers and infant formula milk powder (IFMP) from the Jordanian market. Results showed that most elements, including toxic elements, had higher levels in human milk compared to IFMP, but were comparable to literature results. Positive correlations were observed between total toxic elements and Al, Cu, and Fe in human milk samples, indicating a possible coexistence of toxic elements with these elements.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Chemistry, Analytical
Micheline Ghosn, Rachida Chekri, Celine Mahfouz, Gaby Khalaf, Thierry Guerin, Rachid Amara, Petru Jitaru
Summary: A simple, rapid, and robust method for speciation analysis of methylmercury (MeHg) was developed using reversed phase high-performance liquid chromatography coupled to inductively coupled plasma-mass spectrometry (RP HPLC-ICP-MS). The method successfully separated MeHg from its inorganic Hg precursor and was validated using the accuracy profile approach. The method showed good analytical performance in terms of repeatability and reproducibility, making it suitable for routine determination of MeHg in fishery products.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Vincent Hort, Nathalie Arnich, Thierry Guerin, Gwenaelle Lavison-Bompard, Marina Nicolas
Article
Chemistry, Analytical
Lucas Givelet, Delphine Truffier-Boutry, Laurent Noel, Jean-Francois Damlencourt, Petru Jitaru, Thierry Guerin
Summary: This study optimized an analytical method for characterizing TiO2 nanoparticles in food additives and pharmaceuticals, finding that self-aspiration for sample intake and using the concentration-based method for transport efficiency were the most suitable. The Excel spreadsheet developed for this study provided results closer to the reference value than the ICP-MS software. Analysis of food samples and pharmaceuticals showed differences in the average diameter and nanoparticular fraction of TiO2 particles.
Article
Environmental Sciences
Veronique Sirot, Gilles Riviere, Stephane Leconte, Jean-Charles Leblanc, Martine Kolf-Clauw, Paule Vasseur, Jean-Pierre Cravedi, Marion Hulin
Summary: The TDS conducted in France assessed health risks related to chemicals in food of non-breastfed children under three years of age. Certain substances from food contact materials were targeted for the study, with generally tolerable levels found except for BPA in some children.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Gwenaelle Lavison-Bompard, Julien Parinet, Karelle Huby, Thierry Guerin, Chanthadary Inthavong, Marine Lambert
Summary: The study investigated the contamination levels of Chlordecone (CLD) in 200 bovines from Martinique and Guadeloupe, revealing a broader concentration range of CLD in the liver compared to fat and muscle. Statistical processing indicated correlations between CLD concentrations in the three studied tissues.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Virology
Nino Guy Cassuto, Anne Gravier, Mathilda Colin, Aurelie Theillay, Daniela Pires-Roteira, Sandra Pallay, Raphael Serreau, Laurent Hocqueloux, Thierry Prazuck
Summary: The study validates the high sensitivity and specificity of the COVID-VIRO (R) antigen test combined with nasal sampling method, as well as its usability in the general population.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Environmental Sciences
M. Ribeiro, N. Zephyr, J. A. L. Silva, M. Danion, T. Guerin, I Castanheira, A. Leufroy, P. Jitaru
Summary: The study found that MeHg bioaccumulates steadily in fish muscles when exposed individually, but the bioaccumulation is reduced when fish are first exposed to SeMet and then to MeHg, indicating a detoxifying effect of SeMet on MeHg.
Article
Chemistry, Applied
Geraldine Carne, David Makowski, Sandrine Carrillo, Thierry Guerin, Petru Jitaru, Jean-Cedric Reninger, Gilles Riviere, Nawel Bemrah
Summary: European and French populations are overexposed to cadmium through their foods. This study aimed to derive a low and protective cadmium concentration in edible seaweeds to limit overexposure. The research used a probabilistic approach considering other sources of cadmium exposure and identified a cadmium concentration that ensures the seaweed-consuming population does not exceed the tolerable daily intake of cadmium. This generic approach could be applied to other food/substance pairs in setting maximum limits, providing better protection for consumer health.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Article
Chemistry, Applied
Thierno Diallo, Yassine Makni, Adelaide Lerebours, Helene Thomas, Thierry Guerin, Julien Parinet
Summary: A qualitative screening high resolution mass spectrometry method was developed and validated according to EU guidelines for the analysis of pesticides in bivalve species. The optimized method allowed for quick screening and detection of pesticides in different bivalve samples, and successfully identified diuron and its metabolite.
Review
Food Science & Technology
Pierre Bouteiller, Emilie Lance, Thierry Guerin, Ronel Bire
Summary: This review summarizes the different methods of extraction and analysis for the total forms of microcystins. Four extraction methods were identified and it was found that the MMPB method remains the reference method, although deconjugation at basic pH showed promising results.
Article
Chemistry, Applied
Yassine Makni, Thierno Diallo, Thierry Gu, Julien Parinet
Summary: A screening method was developed for the analysis of pesticides in baby foods. Various sample preparation methods and MS/MS algorithms were studied to ensure accurate identification of pesticides. The method was validated according to guidelines and showed high accuracy and reliability.
Review
Chemistry, Medicinal
Raphael Serreau, Ammar Amirouche, Amine Benyamina, Sabine Berteina-Raboin
Summary: Psychedelics are being researched for their potential therapeutic applications in various central nervous system pathologies, particularly focusing on the compounds found in Psilocybe-type hallucinogenic mushrooms. However, obtaining and purifying sufficient quantities of these compounds from fungi poses challenges, thus necessitating the development of simple and efficient synthetic routes. This review explores different synthesis methods, including classical historical approaches, recent metallo-catalyzed couplings, and known biocatalytic methods. Further research should investigate alternative access routes given the therapeutic potential of these compounds.
Review
Biochemistry & Molecular Biology
Gatien Messire, Raphael Serreau, Sabine Berteina-Raboin
Summary: In this article, we highlight the main natural molecules extracted from Camellia sinensis, Andrographis paniculata, and Curcuma longa, which have antioxidant activities for skin protection. These molecules include catechins derivatives, especially EGCG, andrographolide, and curcuminoids. These plants are commonly used as beverages, dietary supplements, or spices. The molecules they contain have diverse therapeutic activities, including anti-inflammatory, antimicrobial, anti-cancer, antidiabetic, and dermatological treatment. While their antioxidant activities and therapeutic applications are well-documented, their use in cosmetics is relatively new.
Article
Multidisciplinary Sciences
Thierry Prazuck, Raphael Serreau, Aurelie Theillay, Sandra Pallay, Daniela Pires-Roteia, Fanny Prazuck, Fabien Lesne
Summary: Over the past two years, the SARS-CoV-2 virus has spread globally, resulting in the COVID-19 pandemic. To control the pandemic and develop efficient diagnostic tools, rapid antigen detection tests (RADT) for SARS-CoV-2 have been developed. A retrospective study compared the performance of different RADTs, with the AQ + InTec test showing better overall performance, including on the SARS-CoV-2 Omicron variant. A prospective study then evaluated the AQ + InTec test's sensitivity and specificity on nasal and nasopharyngeal samples, showing acceptable criteria and performance in symptomatic and asymptomatic patients. Overall, these studies confirm the value and effectiveness of the AQ + InTec test in testing during a pandemic, especially for detecting asymptomatic carriers of the SARS-CoV-2 virus, including the Omicron variant.
Article
Environmental Sciences
Deborah Martin, Fiona Lobo, Gwenaelle Lavison-Bompard, Thierry Guerin, Julien Parinet
ENVIRONMENT INTERNATIONAL
(2020)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).