Article
Chemistry, Analytical
Ruipeng Chen, Yunfeng Sun, Bingyang Huo, Zefeng Mao, Xiaojuan Wang, Shiyu Li, Ran Lu, Shuang Li, Jun Liang, Zhixian Gao
Summary: A universal surface-enhanced Raman scattering (SERS) aptasensor was developed for the detection of Zearalenone (ZEN) with a linear detection range from 0.005 to 500 ng mL(-1) and a detection limit of 0.001 ng mL(-1). The sensor showed excellent performance for analytical applications with real-world samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Applied
Saeid Aliakbarpour, Mohammad Amjadi, Tooba Hallaj
Summary: We introduced a sensitive colorimetric platform for hydrogen peroxide (H2O2) assay using gold/silver nanocages. The platform exhibits high sensitivity and low detection limit, and can be used for measurement using a smartphone.
Article
Chemistry, Analytical
Yong-Qiang He, Ying Chen, Xian-Zhu Meng, Hong -Chao Yi, Hui-Wen Gu, Xiao-Li Yin
Summary: A visual and smartphone-integrated aptasensor for rapid Staphylococcus aureus determination was developed using Exo III-assisted recycling and hemin/G-quadruplex DNAzymes for signal amplification. The assay quantified the released DNAzymes via Exo III-assisted recycling reaction and analyzed them with a smartphone and UV-Vis spectrophotometer. This method exhibited good analytical performance, low cost, and portability, making it a rapid point-of-care test method with great potential in food safety control.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Xiu Qin, Chunling Yuan, Rui Shi, Yilin Wang
Summary: Carbon quantum dots (CQDs) prepared from trifolium leaves were used to construct a double signal probe for the detection of ellagic acid (EA). The probe showed sensitive analysis, high selectivity, and feasibility in commercial cosmetics analysis.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Analytical
Jinhua Wang, Jiamin Wu, Yuping Zhang, Xia Zhou, Ziwei Hu, Xiaojian Liao, Bingbing Sheng, Kaisong Yuan, Xueqiang Wu, Huaihong Cai, Haibo Zhou, Pinghua Sun
Summary: A new strategy for colorimetric/SERS dual-mode determination of Hg2+ was proposed based on controllable etching Au@Ag NPs. The method showed excellent sensitivity and specificity, suitable for fast detecting of Hg2+.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Xiaoyu Qi, Yufei Ye, Hao Wang, Bianbian Zhao, Lixia Xu, Yuting Zhang, Xiaoli Wang, Nandi Zhou
Summary: An ultrasensitive and dual-recognition surface-enhanced Raman scattering (SERS) biosensor has been developed for the detection of Staphylococcus aureus (S. aureus). The biosensor utilizes teicoplanin (Tcp) functionalized gold-coated magnet nanoparticles (Fe3O4@Au-Tcp NPs) as the capture probe and S. aureus aptamer (Apt) functionalized silver coated gold nanoparticles (Au@Ag-DTNB-Apt NPs) as the signal probe. The biosensor demonstrates high sensitivity and specificity due to the SERS enhancement from the hot spot effect between Au NPs and Au@Ag NPs, as well as the dual-recognition ability based on Tcp and Apt. The biosensor is capable of detecting S. aureus in milk and orange juice samples.
Article
Chemistry, Analytical
Yaokun Xia, Tingting Chen, Wenqian Chen, Guanyu Chen, Lilan Xu, Li Zhang, Xiaoling Zhang, Weiming Sun, Jianming Lan, Xu Lin, Jinghua Chen
Summary: In this study, a dual-modal aptasensor based on a multifunctional signal probe was developed for the colorimetric and photoelectrochemical detection and quantitation of exosomes. The aptasensor showed the ability to perform rapid screening and quantitation, providing a valuable tool for exploring the biological roles of exosomes in specific diseases.
ANALYTICA CHIMICA ACTA
(2022)
Review
Substance Abuse
Camille Zolopa, Stine B. Hoj, Nanor Minoyan, Julie Bruneau, Iuliia Makarenko, Sarah Larney
Summary: This review provides an overview of research literature on ageing and older people who use illicit opioids and stimulants. It found that the literature in this area remains under-theorized, with low application of conceptual frameworks. Health status and health services are among the most frequently researched topics.
Article
Biochemical Research Methods
Fuming Sang, Suyao Yin, Jianxin Pan, Zhizhou Zhang
Summary: The novel aptasensor combines the plasmonic properties of gold nanoparticles (AuNPs) with exonuclease III (Exo III)-assisted target recycling for ultrasensitive detection of Hg2+, with a linear range from 5 pM to 0.6 nM and a detection limit of 0.2 pM. The sensor allows visual detection of Hg2+ as low as 50 pM by the naked eye and reliable determination of spiked Hg2+ in sea water samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jie Xiang, Junyi Zhang, Shunmei Li, Ruo Yuan, Yun Xiang
Summary: In this study, a new aptamer-based, sensitive and label-free colorimetric Phe detection strategy was developed by integrating catalytic hairpin assembly (CHA) and Mg2+-dependent DNAzyme amplification cascades. The strategy showed high affinity, selectivity and sensitivity towards Phe, and has the potential for simple diagnosis of Phe-related diseases.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biophysics
Dongdong Li, Jing Zhao, Jun Ma, Huiquan Yang, Xiaodong Zhang, Yuyu Cao, Peidang Liu
Summary: This study developed polyethylene glycol-coated Ag@Au core-shell nanoparticles (PSGNPs) modified with GMT8 aptamer (GSGNPs) and evaluated their radiosensitization effects on glioma cells through in vivo and in vitro experiments. The results demonstrated that GSGNPs showed good targeting ability, enhanced sensitization effect, and prolonged median survival time of mice bearing U87 glioma after intravenous administration combined with radiotherapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Analytical
Pian Wu, Ruixue Huang, Cuimei Chen, Jiecan Yi, Tianhan Kai, Yujuan Zhan, Xiaoqian Wei, Danqi Wang, Jingwen Zhang, Ping Ding
Summary: A novel probe, combining aptamer with gold nanoparticles, has been developed for the determination of Salmonella typhimurium. It allows the rapid and sensitive detection of S. typhimurium in milk samples within 40 minutes.
Article
Chemistry, Analytical
Sandip Kumar De, Sarmistha Ray, Yogita Rawat, Subrata Mondal, Arpita Nandy, Priya Verma, Anuradha Roy, Provash Sadhukhan, Chandrima Das, Sankar Bhattacharyya, Dulal Senapati
Summary: An efficient nanobioconjugate has been developed for specific detection and quantification of Dengue virus serotype 2 by self-assembling porous Au-seeded Ag nanorod networks with a thiol modified DNA aptamer. Characterization of the precursors and binding affinity between the bioconjugate and different serotypes were studied using various techniques, with the key achievement being the direct detection of DENV-2 without the need for an enzyme or antibody in dengue infected blood.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Applied
Zahra Khoshbin, Marzieh Moeenfard, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: A simple aptasensor embedded in a micropipette tip is developed for label-free monitoring of acrylamide. The aptasensor utilizes the formation of a triple-helix molecular switch structure to induce the aggregation of gold nanoparticles. A smartphone imaging readout strategy enables the quantification of acrylamide based on the color change of the solution inside the micropipette tip. This aptasensor shows good selectivity and can successfully quantify acrylamide in various food samples.
Article
Spectroscopy
Xiaoyuan Ma, Shan Xu, Liangyu Li, Zhouping Wang
Summary: In this study, an aptamer-based surface-enhanced Raman spectroscopy (SERS) method was developed for the detection of Staphylococcus aureus without immobilization. The method demonstrated high selectivity and sensitivity, with a low detection limit. It eliminated the need for bacterial immobilization, making it more convenient and efficient for detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Huaqiang Fu, Zhe Wang, Peng Li, Wei Qian, Zixin Zhang, Xin Zhao, Hao Feng, Zhugen Yang, Zongkui Kou, Daping He
Summary: This study demonstrates the positive role of well-structured three-dimensional channels in improving water permeance and purification performance for highly efficient wastewater treatment using graphene oxide-based membranes. The regular and negatively-charged three-dimensional channels significantly enhance water permeance and enable effective dye rejection.
Article
Chemistry, Analytical
Xiao-Meng Ma, Jian-Wei Wang, Li-Ting Zhao, Yafei Zhang, Jun-Ying Liu, Songmei Wang, Daochen Zhu, Zhugen Yang, Yang-Chun Yong
Summary: A novel microfiber-like biohydrogel was developed using electroactive bacteria-induced graphene oxide reduction and confined self-assembly in a capillary tube. This biohydrogel enabled efficient electron exchange between cells and the conductive graphene network, and was used to create a miniature whole-cell electrochemical biosensing system for fumarate detection. The system exhibited high sensitivity and a low limit of detection, offering new possibilities for bioelectrochemical detection in small volumes or at high spatial resolutions.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Carla Spatola Rossi, Frederic Coulon, Shaohua Ma, Yu Shrike Zhang, Zhugen Yang
Summary: Rapid, sensitive, and selective detection of live pathogens is crucial for quality control and risk assessment. Conventional methods are often complex, expensive, time-consuming, and not suitable for field testing or low-resource settings. Microfluidic devices that integrate laboratory functions in a miniaturized manner have emerged as a promising tool for rapid and sensitive pathogen detection.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Kai Yang, Zi-Jie Lu, Tian -Yu Zhu, Jing-Xian Wang, Fu-Qiao Yang, Syed Zaghum Abbas, Jun Zhou, Zhugen Yang, Jian-Li Mi, Sai Kishore Ravi, Yang-Chun Yong
Summary: A new approach to extend the cell sensing spectrum with bio-mineralized nanoparticles is developed, enabling whole-cell electrochemical detection of Vitamin B12. This nano-biohybrid design offers a new perspective on manipulating the microbial toolkit for an expanded sensing spectrum in whole-cell biosensors.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Jin Wang, Kaixuan Wang, Hanyong Peng, Zhen Zhang, Zhugen Yang, Maoyong Song, Guibin Jiang
Summary: Researchers have developed a stable and general method for real-time monitoring of microRNA-21 and telomerase in living cells using dual tetrahedral DNA nanostructures. The method enables remarkable signal amplification and has potential applications in biomedical imaging and early precise cancer diagnosis.
ANALYTICAL CHEMISTRY
(2023)
Review
Environmental Sciences
Jinze Wang, Wei Du, Yali Lei, Yuanchen Chen, Zhenglu Wang, Kang Mao, Shu Tao, Bo Pan
Summary: Indoor air quality is important for human health, but traditional filter-based monitoring cannot capture the large spatiotemporal heterogeneity of indoor air pollution. Real-time monitoring has made significant strides in indoor air evaluation by enabling dynamic and massive analysis. Real-time sensors used in indoor air evaluation have advantages in high spatiotemporal resolution, 3-dimensional monitoring, pollution peak and source identification, and short-term health effect evaluation. However, challenges remain in sensor selection, performance, stability, and calibration. Future developments include sensors with high performance and low energy consumption, as well as simultaneous detection of multiple target air pollutants in indoor air monitoring.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Chemistry, Physical
Xiaodong Ji, Xin Zhao, Zixin Zhang, Yunfa Si, Wei Qian, Huaqiang Fu, Zibo Chen, Zhe Wang, Huihui Jin, Zhugen Yang, Daping He
Summary: Conventional glassy carbon electrodes (GCE) cannot meet the requirements of future electrodes for wider use. Graphene, with its excellent physicochemical properties, is considered an ideal electrode. In this study, a graphene film with ultra-high conductivity was prepared and a three-electrode system was customized using laser engraving. The system exhibited excellent target detection capability for dopamine (DA) and glucose, without the need for further metal deposition. The high conductivity of the graphene film, combined with its ease of modification, mechanical properties, and mass production potential, makes it a promising alternative to GCE for electrochemical studies and wearable medical devices.
Review
Chemistry, Analytical
Wenliang Li, Xuanye Ma, Yang-Chun Yong, Guozhen Liu, Zhugen Yang
Summary: Detection of pathogens is crucial for global public health, and paper-based microfluidic analytical devices (mu PADs) offer a promising solution for rapid and on-site diagnosis.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Oluwasesan Adegoke, Kayode Oyinlola, Ojodomo J. Achadu, Zhugen Yang
Summary: In this study, a novel metal-enhanced fluorescence (MEF) and electrochemical biosensor was developed for the detection of SARS-CoV-2 spike (S) protein. The biosensor utilized SiO2-coated Si-doped ZnSeS quantum dots (QDs) and aptamer-molecular beacon (Apta-MB) as the sensing elements, and cationic gold nanoparticles (AuNPs) as the signal amplifiers. Under optimized experimental conditions, the biosensor demonstrated enhanced sensitivity in detecting the SARS-CoV-2 S protein. The detection was successfully performed in saliva samples.
ANALYTICA CHIMICA ACTA
(2023)
Article
Environmental Sciences
Da Lei, Haorui Cao, Kuankuan Zhang, Kang Mao, Yongkun Guo, Jen-How Huang, Guili Yang, Hua Zhang, Xinbin Feng
Summary: This study investigated the physiological responses of rice and the relationships between different antioxidant parameters under different levels of Se and Cd. The results revealed that the AsA-GSH cycle, GS-PCS coupling system, and GPX-SOD coupling system in aerial parts of rice contribute to the protection against Cd stress. However, in roots, the APX-GPX-CAT and PCS-GS-SOD systems play distinct roles.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Gui-Li Yang, Lei Huang, Xiao Yang, Zhu Li, Hai-Min Liao, Kang Mao, Zhao-Ju Liu, He-Yan Geng, Qin Cao, Ai-Juan Tan
Summary: In this study, the growth, Cd enrichment, and antioxidant enzyme activity of duckweed were investigated under Cd stress. The results showed that both high-Cd-tolerance duckweed (HCD) and low-Cd-tolerance duckweed (LCD) strains hyper-enriched with Cd. Transcriptome analysis revealed significant differences in gene expression between HCD and LCD, with antioxidant system being significantly expressed in HCD but not in LCD. Alpha-linolenic acid metabolism likely plays an important role in Cd detoxification in duckweed. These findings contribute to the understanding of Cd tolerance mechanisms in hyperaccumulator plants and lay the foundation for future phytoremediation studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Jinze Wang, Wei Du, Yali Lei, Wenyan Duan, Kang Mao, Zhenglu Wang, Bo Pan
Summary: This study aims to investigate the association between short-term PM2.5 exposure and blood pressure of rural residents and its variation between summer and winter. The results showed that mosquito coil users had 1.5 times higher PM2.5 exposure than non-mosquito coil users. Reducing PM2.5 exposure would have a positive effect on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Yu Jiang, Kang Mao, Jiabing Ran, Junxia Su, Guopei Huang, Xingli Zheng, Kuankuan Zhang, Hui Guan, Changying Yang, Hua Zhang
Summary: A novel heterogeneous Fenton system with carbon nitride-type polymers compounded with FeOCl as catalysts was constructed for the efficient removal of antibiotics. The system demonstrated a high efficiency in removing tetracycline hydrochloride within a short time and exhibited superior catalytic activity compared to FeOCl and CNPs alone. The degradation of antibiotics occurred through the production of ·OH radicals and eventually led to the formation of H2O and CO2. The electrons facilitated the cycling of Fe2+ and Fe3+ from FeOCl, enhancing the decomposition of H2O2 and improving the catalytic activity.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Environmental Sciences
Xiao Yang, Ai-Juan Tan, Meng-Meng Zheng, Dan Feng, Kang Mao, Gui-Li Yang
Summary: Through the study of duckweed (Lemna minor 0014), it was found that the physiological responses, enrichment characteristics, diversity of endophytic bacterial communities, and isolation of Cd-resistant endophytes were affected by cadmium (Cd) stress. The activities of peroxidase (POD) and catalase (CAT) decreased, while superoxide dismutase activity first increased and then decreased with increasing Cd stress duration. Malondialdehyde content and Cd accumulation in duckweed increased with increasing concentrations and time. The study also identified a highly diverse endophytic bacterial community in duckweed, with Paenibacillus sp. Y11 being isolated as a Cd-tolerant strain capable of promoting duckweed growth. This study provides a theoretical basis for the application of duckweed in water pollution treatment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Di Lv, Hongyun Liu, Qi An, Chengwei Lei, Yanxuan Wang, Jin Sun, Chuanhai Li, Yongfeng Lin, Qing Dong, Zhugen Yang, Kui Che, Wendong Liu, Wenchao Han
Summary: This study found that exposure to GenX in pregnant rats leads to developmental delays in their offspring and causes inflammation in the placenta. The results suggest that placental inflammation may play a key role in this process through the Rap1 signaling pathway.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
