Journal
SYNTHESIS-STUTTGART
Volume 49, Issue 12, Pages 2589-2604Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1589491
Keywords
piperazine; heterocycle; synthesis; cyclization; catalysis
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Funding
- Purdue University
- Purdue Center for Cancer Research
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Piperazine ranks as the third most common N-heterocycle appearing in small-molecule pharmaceuticals. This review highlights recent advances in methods development for the construction of the piperazine ring system with particular emphasis on preparing carbon-substituted piperazines.
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