Journal
SYNLETT
Volume 28, Issue 19, Pages 2581-2586Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1589126
Keywords
phenols; arylation; amides; ureas; nickel catalysis; photocatalysis
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Funding
- National Natural Science Foundation of China [21772129]
- 973 Project from of the MOST of China [2015CB856600]
- 1000-Youth Talents Plan
- Fundamental Research Funds for the Central Universities
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The arylation of amide and urea C(sp(3))-H bonds with aryl tosylates generated in situ from phenols has been realized at room temperature by combining visible-light-photoredox catalysis, hydrogen-atom-transfer catalysis, and nickel catalysis. This streamlined protocol permits rapid functionalization of phenols and direct transformation of -amino C(sp(3))-H bonds. The C(sp(3))-H arylation products are obtained in high yields with good functional-group tolerance at low catalyst loadings.
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