Journal
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
Volume 26, Issue 1, Pages 91-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.soc.2016.07.004
Keywords
Anal cancer; Chemoradiation; Radiotherapy; Chemotherapy; Toxicity; Intensity-modulated radiotherapy; Mitomycin-C; Cisplatin
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Over the past several decades, clinical trials have demonstrated improved disease-related outcomes in the definitive treatment of anal cancer. Although treatment with radiation and concurrent chemotherapy results in high rates of cure, significant acute and late toxicities are seen. This review focuses on the evolution of treatment-related toxicity for anal cancer. Management of these adverse effects is reviewed, as are future directions in anal cancer treatment and their impact on toxicity.
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