Article
Surgery
Jae Hun Chung, Dong Won Im, Cheol Woong Choi, Su Jin Kim, Sun-Hwi Hwang, Si-Hak Lee
Summary: The results of the study showed that uncut Roux-en-Y reconstruction can effectively reduce the incidence of bile reflux and gastritis in the remnant stomach after totally laparoscopic distal gastrectomy (TLDG).
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Chia-Hung Wu, Kuo-Hung Huang, Ming-Huang Chen, Wen-Liang Fang, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu, Yi-Ming Shyr
Summary: This study compared the long-term outcomes between Billroth-I and Roux-en-Y reconstruction after distal gastrectomy for gastric cancer, finding that Roux-en-Y reconstruction was associated with lower incidence of bile reflux and gastritis, but higher incidence of gallstone formation compared to Billroth-I reconstruction.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: Transoral gastric outlet reduction (TORe) is a safe and effective treatment for post-prandial hypoglycemia and weight regain after Roux-en-Y gastric bypass (RYGB) in patients with symptoms refractory to medications and dietary changes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: TORe is a safe and effective treatment for patients with refractory symptoms of post-prandial hypoglycemia and weight regain after RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Rocio Castillo-Larios, Naga Swati Gunturu, Jorge Cornejo, Spencer W. Trooboff, Abhishek Ramgir Giri, Steven P. Bowers, Enrique F. Elli
Summary: This study aimed to report and compare the outcomes of different revisional techniques for failed anti-reflux surgery. By retrospectively analyzing patients who underwent revisional surgery between 2016 and 2021, it was found that conversion to RYGB may offer better resolution of reflux than RF, especially for obese patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Endocrinology & Metabolism
Merel van den Broek, Loek J. M. de Heide, Fianne L. P. Sips, Martijn Koehorst, Tim van Zutphen, Marloes Emous, Martijn van Faassen, Albert K. Groen, Natal A. W. van Riel, Jan F. de Boer, Andre P. van Beek, Folkert Kuipers
Summary: Elevated plasma bile acids and FGF19 levels were observed in subjects post-RYGB, with postprandial hypoglycemia occurring in a subset of patients. Those who experienced hypoglycemia showed higher postprandial bile acid levels coinciding with increased GLP-1 and insulin responses during meal tests. Additionally, computer simulations suggested that altered intestinal transit may underlie exaggerated postprandial bile acid responses in hypoglycemic subjects.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Microbiology
Jia V. Li, Hutan Ashrafian, Magali Sarafian, Daniel Homola, Laura Rushton, Grace Barker, Paula Momo Cabrera, Matthew R. Lewis, Ara Darzi, Edward Lin, Nana Adwoa Gletsu-Miller, Stephen L. Atkin, Thozhukat Sathyapalan, Nigel J. Gooderham, Jeremy K. Nicholson, Julian R. Marchesi, Thanos Athanasiou, Elaine Holmes
Summary: Bariatric surgery, especially Roux-en-Y gastric bypass (RYGB), has a significant impact on the metabolism and gut microbiota of patients, leading to changes in metabolites and bacterial composition that are associated with successful weight loss and metabolic improvements. Further research is needed to understand the functional clinical outcomes of these metabolic changes.
Review
Health Care Sciences & Services
Maria Valeria Matteo, Camilla Gallo, Valerio Pontecorvi, Vincenzo Bove, Martina De Siena, Giorgio Carlino, Guido Costamagna, Ivo Boskoski
Summary: Obesity is a global epidemic, and bariatric surgery is currently the most effective long-term treatment. However, weight regain and dumping syndrome are common complications. This review focuses on transoral outlet reduction as a minimally invasive treatment option for patients who do not respond to conservative therapies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Antonella Santonicola, Luigi Ruggiero, Rossella Palma, Luigi Angrisani, Paola Iovino
Summary: Laparoscopic Roux-en-Y gastric bypass (RYGB) is the preferred surgical procedure for treating severe obesity and gastroesophageal reflux disease (GERD). It provides satisfactory weight loss and resolution of GERD symptoms in most patients, but about 24.4% of patients may experience GERD symptoms postoperatively.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Surgery
Jenny M. Shao, Sharbel A. Elhage, Tanu Prasad, Keith Gersin, Vedra A. Augenstein, Paul D. Colavita, B. Todd Heniford
Summary: The study found that redo fundoplication and conversion to Roux-en-Y anatomy with a gastric diversion are equally effective in resolving reflux symptoms in patients with failed fundoplications. Despite higher BMI, longer operative times, and greater blood loss in RYGD patients, they showed better resolution of other comorbidities and greater reduction in excess body weight.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Ping Li, Dianliang Zhang, Chao Zheng, Chunbao Guo
Summary: The study proposed a severity grading criterion for bile leakage in pediatric patients after Roux-en-Y hepaticojejunostomy, which can optimize objective diagnosis and therapeutic modalities.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Joost Maurissen, Nathalie Yercovich, Pieter Van Aelst, Bruno Dillemans
Summary: Postoperative dumping syndrome is a common complication after Roux-en-y gastric bypass for morbid obesity, typically managed with dietary or pharmacologic measures. In cases where conservative treatment is ineffective, surgical intervention may be considered. The use of a modified Nissen fundoplication for late dumping syndrome after RYGB shows promise as a surgical alternative.
Article
Surgery
U. G. Lange, Y. Moulla, M. Mehdorn, J. Tuennemann, A. Zabel-Langhennig, A. Ouaid, A. Dietrich
Summary: This article reports a case of bile reflux and development of Barrett's metaplasia after mini-gastric bypass surgery. The authors emphasize the potential significance of bile reflux in the development of Barrett's metaplasia and call for long-term prospective studies to further understand this issue.
Article
Oncology
Yan-xin Chen, Qiao-zhen Huang, Peng-cheng Wang, Yue-Jia Zhu, Li-quan Chen, Chu-ying Wu, Jin-tian Wang, Jun-xing Chen, Kai Ye
Summary: This study compared the short-term and long-term outcomes as well as the quality of life of patients undergoing Roux-en-Y (R-Y) or Billroth II with Braun (BII + B) reconstruction after distal gastrectomy. The results showed that R-Y reconstruction had a longer operative time but similar perioperative variables, complication rates, nutritional outcomes, and quality of life scores compared to BII + B reconstruction. However, R-Y reconstruction reduced the incidence of residual gastritis, bile reflux, and reflux esophagitis, and provided better postoperative quality of life for patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yudai Hojo, Tatsuro Nakamura, Tsutomu Kumamoto, Yasunori Kurahashi, Yoshinori Ishida, Yoshitaka Kitayama, Toshihiko Tomita, Hisashi Shinohara
Summary: Right gastroepiploic vessels-preserving antrectomy and Roux-en-Y biliary diversion are considered safe and feasible for medical treatment-resistant reflux esophagitis following proximal gastrectomy with esophagogastrostomy.
Article
Biochemical Research Methods
Andrea J. Radtke, Colin J. Chu, Ziv Yaniv, Li Yao, James Marr, Rebecca T. Beuschel, Hiroshi Ichise, Anita Gola, Juraj Kabat, Bradley Lowekamp, Emily Speranza, Joshua Croteau, Nishant Thakur, Danny Jonigk, Jeremy L. Davis, Jonathan M. Hernandez, Ronald N. Germain
Summary: IBEX is an iterative immunolabeling and chemical bleaching method that enables highly multiplexed imaging in diverse tissues.
Article
Surgery
Lauren A. Gamble, Alexander Rossi, Grace-Ann Fasaye, Chimene Kesserwan, Jonathan M. Hernandez, Andrew M. Blakely, Jeremy L. Davis
Summary: The study found high rates of occult signet ring cell gastric cancer among carriers of CDH1 P/LP variants with no family history of gastric cancer, suggesting that the germline CDH1 P/LP variants have a highly penetrant gastric phenotype regardless of family history. This data may be useful for counseling families with CDH1 variants presumed to have hereditary lobular breast cancer.
Meeting Abstract
Oncology
Lauren A. Gamble, Martha Teke, Jeremy Fridling, Sarah G. Samaranayake, Bernadette Redd, Andrew Blakely, Jeremy L. Davis
Meeting Abstract
Biochemistry & Molecular Biology
Steven D. Brooks, Xianke Zeng, Mary Jackson, Naomi Tesfuzigta, Kyeisha Laurence, Jessica Nino de Rivera, Jarrett Jackson, Robert Emeh, Rachel Smith, Olena Kamenyeva, Sundar Ganesan, Juraj Kabat, Phillip Cruz, Stacy Joyce, Jeremy Davis, A. Parker Ruhl, Hans Ackerman
Article
Multidisciplinary Sciences
Tahsin M. Khan, Emily A. Verbus, Alexander J. Rossi, Jonathan M. Hernandez, Jeremy L. Davis, Brian A. Coakley, Andrew M. Blakely
Summary: Wild-type KIT and PDGFRA gastrointestinal stromal tumors are rare and have limited treatment options. This study analyzed data from a large national database to identify factors influencing overall survival, finding that tumors in the small intestine and with high mitotic count were associated with decreased OS. Surgery remains the primary treatment modality for wild-type GIST.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Robert R. C. Grant, Tahsin M. Khan, Stephanie N. Gregory, Brian A. Coakley, Jonathan M. Hernandez, Jeremy L. Davis, Andrew M. Blakely
Summary: This study aimed to investigate the potential survival benefit of adjuvant chemotherapy (AC) in patients with stage II colon cancer. The results showed that patients who received AC had significantly increased overall survival (OS) across different numbers of high-risk features. Subgroup analysis revealed a reduced risk of death in patients receiving AC and an increased OS in patients with T4 tumors.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Genetics & Heredity
Benjamin L. Green, Grace-Ann Fasaye, Sarah G. Samaranayake, Anna Duemler, Lauren A. Gamble, Jeremy L. Davis
Summary: Pathogenic and likely pathogenic variants in the CDH1 gene are associated with increased risk of gastric and breast cancers, as well as hereditary cleft lip and palate (CLP). This study aimed to determine the prevalence of CLP in families with these variants. The results showed a high prevalence of CLP in families carrying CDH1 variants, with no clear genotype-phenotype pattern. Genetic testing for CDH1 should be considered in families with CLP and a history of gastric or lobular breast cancer.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Benjamin L. Green, Alisa N. Blumenthaler, Lauren A. Gamble, James D. McDonald, Kristen Robinson, Maureen Connolly, Monica Epstein, Jonathan M. Hernandez, Andrew M. Blakely, Brian D. Badgwell, Jeremy L. Davis
Summary: CRS-HIPEC treatment for gastric adenocarcinoma with peritoneal metastasis showed a 3-year survival rate of 22% and common complications. The number of lymph node metastases was inversely correlated with overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Benjamin L. Green, Alisa N. Blumenthaler, Lauren A. Gamble, James D. McDonald, Kristen Robinson, Maureen Connolly, Monica Epstein, Jonathan M. Hernandez, Andrew M. Blakely, Brian D. Badgwell, Jeremy L. Davis
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Xi Luo, Jamie L. Maciaszek, Bryony A. Thompson, Huei San Leong, Katherine Dixon, Sonia Sousa, Michael Anderson, Maegan E. Roberts, Kristy Lee, Amanda B. Spurdle, Arjen R. Mensenkamp, Terra Brannan, Carolina Pardo, Liying Zhang, Tina Pesaran, Sainan Wei, Grace-Ann Fasaye, Chimene Kesserwan, Brian H. Shirts, Jeremy L. Davis, Carla Oliveira, Sharon E. Plon, Kasmintan A. Schrader, Rachid Karam
Summary: Germline pathogenic variants in CDH1 are associated with increased risk of diffuse gastric cancer and lobular breast cancer. Accurate interpretation of these variants is critical for physicians deciding on risk reduction strategies, such as prophylactic surgery. The development of CDH1-specific interpretation guidelines by experts has led to improved clinical management recommendations.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Endocrinology & Metabolism
Lauren A. Gamble, Rachael Lopez, Suraj Rajasimhan, Sarah G. Samaranayake, Cassidy Bowden, Amber L. Famiglietti, Andrew M. Blakely, Smita Jha, Mark A. Ahlman, Jeremy L. Davis
Summary: Patients with CDH1 germline variants undergoing prophylactic TG are at risk of bone mineral density loss and micronutrient deficiencies. Serum biomarkers of mineral metabolism did not change significantly, but average BMD was decreased at 12 months post-TG. Adherence to calcium and multivitamin supplementation is associated with the preservation of BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Oncology
Stephanie N. Gregory, Jeremy L. Davis
Summary: Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome associated with a high risk of diffuse-type gastric cancer. Loss-of-function mutations in the CDH1 gene have been identified as the primary cause of HDGC. Prophylactic total gastrectomy (PTG) is recommended, but surveillance may also be an alternative for selected patients.
CHINESE CLINICAL ONCOLOGY
(2023)
Article
Oncology
Bilal Asif, Amber Leila Sarvestani, Lauren A. Gamble, Sarah G. Samaranayake, Amber L. Famiglietti, Grace -Ann Fasaye, Martha Quezado, Markku Miettinen, Louis Korman, Christopher Koh, Theo Heller, Jeremy L. Davis
Summary: This study aimed to evaluate the safety and effectiveness of endoscopy in individuals with CDH1 variants, particularly in those who declined prophylactic total gastrectomy. The study found that endoscopy had a certain level of safety and effectiveness in early detection and interception of gastric cancer.
Article
Oncology
Benjamin L. Green, Alisa N. Blumenthaler, Lauren A. Gamble, James D. McDonald, Kristen Robinson, Maureen Connolly, Monica Epstein, Jonathan M. Hernandez, Andrew M. Blakely, Brian D. Badgwell, Jeremy L. Davis
Summary: In patients with gastric adenocarcinoma and isolated peritoneal metastasis treated with CRS-HIPEC, the 3-year overall survival rate from CRS-HIPEC was 22%, and complications were common. The number of pathologic lymph node metastases was inversely correlated with overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Areeba Saif, Amber Leila Sarvestani, Carrie Ryan, Kirsten Remmert, Stephanie Lux, Martha Teke, Emily Verbus, Tahsin M. Khan, Jacob Lambdin, Allen Luna, Surajit Sinha, Andrew Blakely, Jeremy Davis, Jonathan Hernandez
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Angela Hill, Franklin Olumba, William Chapman
Summary: Transplantation for HCC is a complex topic, requiring considerations of multiple factors. Balancing tumor size with post-transplant outcome is still an ongoing challenge. Tumor downstaging and the use of new technologies have increased the number of HCC transplants, and these advances can also be applied to other liver tumors.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Olanrewaju A. Eletta, Guergana G. Panayotova, Keri E. Lunsford
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Brianna Ruch, Kayla Kumm, Sandra Arias, Nitin N. Katariya, Amit K. Mathur
Summary: DCD liver transplantation is an underutilized method that can increase access to liver transplantation. With proper donor and recipient selection, matching, surgical technique, and perioperative management, these transplants can achieve similar patient and graft survival rates as DBD liver transplantation. The main limitations in the further growth of DCD liver transplantation are driven by risk aversion, and the current experience is mainly concentrated in large centers. With the advancement of regional and machine perfusion techniques, the definition of a viable DCD liver allograft may be redefined, encouraging wider usage and acceptance.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Lauren Matevish, Madhukar S. Patel, Parsia A. Vagefi
Summary: Downstaging has been shown to be feasible within UNOS-DS criteria, with successful long-term outcomes. Interventional liver-directed therapies have been the standard, but systemic therapies are becoming more effective. Immunotherapy holds promise in downstaging, but further trials are needed to assess feasibility and safety. Individual expertise will continue to guide treatment until more data is available.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Hassan Aziz, Paramita Nayak, David C. Mulligan
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Catherine G. Pratt, Jenna N. Whitrock, Shimul A. Shah, Zhi Ven Fong
Summary: hCCA is a biologically aggressive disease and surgical resection is the only curative treatment. Factors such as patient's physical condition, tumor involvement, residual liver volume, and assessment of metastatic disease heavily influence the feasibility of surgical resection. A multidisciplinary, holistic, and individualized approach is critical for accurately determining resectability and optimizing clinical outcomes for patients with hCCA.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Sara-Catherine Whitney Zingg, Kristina Lemon
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Christopher J. Sonnenday
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Alban Longchamp, Tsukasa Nakamura, Korkut Uygun, James F. Markmann
SURGICAL CLINICS OF NORTH AMERICA
(2024)
