Article
Cell Biology
Li Chen, Ping Bai, Xiangyi Kong, Shaolong Huang, Zhongzhao Wang, Xiangyu Wang, Yi Fang, Jing Wang
Summary: The study showed that the PNI value can predict survival and disease progression in breast cancer patients receiving neoadjuvant chemotherapy, with patients having a higher PNI experiencing significantly better DFS and OS. Additionally, PNI has predictive value for both early-stage and advanced breast cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xuejun Gan, Shen Li, Yiding Wang, Hong Du, Ying Hu, Xiaofang Xing, Xiaojing Cheng, Yan Yan, Ziyu Li
Summary: The expression of ASPH was found to be higher in gastric cancer patients undergoing neoadjuvant chemotherapy (NACT), and was associated with prognosis. In vitro and in vivo experiments showed that ASPH knockout enhanced the inhibitory effects of chemotherapeutic drugs on cell proliferation, migration, and invasion. Therefore, ASPH may serve as a candidate biomarker to predict prognosis and a novel therapeutic target for gastric cancer patients treated with NACT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Li Chen, Xiangyi Kong, Shaolong Huang, Zhaohui Su, Mengliu Zhu, Yi Fang, Lin Zhang, Xingrui Li, Jing Wang
Summary: This study investigates the prognostic significance of the breast immune prognostic index (BIPI) in breast cancer patients who received neoadjuvant chemotherapy (NACT). The results suggest that patients with low BIPI score have better prognoses and longer disease-free survival (DFS) and overall survival (OS). The BIPI-based nomogram may serve as a convenient prognostic tool for breast cancer and help in clinical decision-making.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Li Chen, Yihang Qi, Xiangyi Kong, Zhaohui Su, Zhongzhao Wang, Xiangyu Wang, Yaying Du, Yi Fang, Xingrui Li, Jing Wang
Summary: The study found that NRI can independently predict disease-free survival (DFS) and overall survival (OS) in breast cancer patients, with high NRI value patients having significantly longer survival times. Patients with high NRI scores also had longer survival times in both early-stage and advanced breast cancer. Additionally, high NRI scores were associated with longer survival times in different molecular subtypes.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Li Chen, Yong Chen, Lele Zhang, Yingwei Xue, Shiwei Zhang, Xingrui Li, Hongjiang Song
Summary: The study demonstrated the prognostic significance of pre-treatment SIRI in gastric cancer patients receiving neoadjuvant chemotherapy, showing that the low SIRI group had better disease-free survival (DFS) and overall survival (OS) compared to the high SIRI group. SIRI may qualify as a useful prognostic indicator to provide personalized prognostication for gastric cancer patients treated with NACT.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Nutrition & Dietetics
Yuting Pan, Yue Ma, Guanghai Dai
Summary: Monoclonal antibodies against PD-1 have shown therapeutic effects in patients with advanced gastric or gastroesophageal junction cancer. Identifying new biomarker combinations based on tumor characteristics and microenvironment can help screen suitable patients for precise immunotherapy. The prognostic nutritional index (PNI) is a cost-effective and easily obtainable evaluation index for immunonutritional status, and it has been shown to be an independent prognostic factor for patients receiving immunotherapy.
Article
Oncology
Mizuki Tamai, Jun Kiuchi, Yoshiaki Kuriu, Tomohiro Arita, Hiroki Shimizu, Takuma Ohashi, Hirotaka Konishi, Yusuke Yamamoto, Ryo Morimura, Atsushi Shiozaki, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
Summary: Preoperative Prognostic Nutritional Index (PNI) is crucial for the prognosis of colorectal cancer (CRC). Postoperative PNI value can serve as a prognostic biomarker for CRC patients undergoing adjuvant chemotherapy (AC). Patients with low PNI value can improve prognosis by recovering PNI value through the introduction of AC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Tomoki Konishi, Toshiyuki Kosuga, Hiroyuki Inoue, Hirotaka Konishi, Atsushi Shiozaki, Takeshi Kubota, Kazuma Okamoto, Hitoshi Fujiwara, Eigo Otsuji
Summary: The study found that the preoperative Prognostic Nutritional Index (PNI) is an important predictor of postoperative survival outcomes in gastric cancer (GC) patients. Patients with PNI <48 showed poorer survival rates both before and immediately after surgery, necessitating appropriate preoperative interventions and postoperative monitoring.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Nutrition & Dietetics
Marta Correia, Ines Moreira, Sonia Cabral, Carolina Castro, Andreia Cruz, Bruno Magalhaes, Lucio Lara Santos, Susana Couto Irving
Summary: This systematic review identified three critical domains associated with nutritional status and clinical outcomes in gastric cancer patients undergoing neoadjuvant treatment. Body composition changes, particularly sarcopenia, were found to have a significant impact on treatment response and overall survival. However, the role of nutritional interventions during neoadjuvant chemotherapy has not been adequately explored.
Article
Oncology
Qi Jiang, Xiangyu Zeng, Chenggang Zhang, Ming Yang, Jun Fan, Gan Mao, Qian Shen, Yuping Yin, Weizhen Liu, Kaixiong Tao, Peng Zhang
Summary: The study found that lymph node ratio (LNR) has prognostic value in patients with locally advanced gastric cancer (LAGC) after neoadjuvant chemotherapy (NACT). Patients with low LNR had significantly better overall survival (OS) and progression-free survival (PFS) compared to those with high LNR.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Juan Sun, Xianze Wang, Zimu Zhang, Ziyang Zeng, Siwen Ouyang, Weiming Kang
Summary: Research on predicting the sensitivity of NACT for gastric cancer spans multiple aspects including biomarkers, inflammatory indicators, and imaging assessments. While numerous studies have been conducted on biomarkers, a unified conclusion has not yet been reached. Inflammatory indicators have been shown to be associated with the survival and prognosis of patients undergoing NACT, and imaging assessments such as CT, MRI, and PET may offer unique advantages in early screening for NACT-sensitive patients through careful integration and optimization.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Li-Wen Chang, Sheng-Chun Hung, Jian-Ri Li, Kun-Yuan Chiu, Cheng-Kuang Yang, Chuan-Shu Chen, Kevin Lu, Cheng-Che Chen, Shu-Chi Wang, Chia-Yen Lin, Chen-Li Cheng, Yen-Chuan Ou, Shun-Fa Yang, Chiann-Yi Hsu, Szu-Hang Ho, Shian-Shiang Wang
Summary: The study investigated the prognostic efficacy of the Geriatric Nutritional Risk Index (GNRI) in patients with metastatic Castration-resistant Prostate Cancer (mCRPC) receiving docetaxel as the first line of treatment. It was found that poor nutritional status, indicated by a GNRI <92, was associated with shorter progression free survival and overall survival. Additionally, metastatic volume and cumulative docetaxel dosage were identified as independent prognostic factors in overall survival.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Alina Desiree Sando, Reidun Fougner, Elin Synnove Royset, Hong Yan Dai, Jon Erik Gronbech, Erling Audun Bringeland
Summary: Evaluation of response following neoadjuvant chemotherapy (NAC) in gastric cancer has been widely debated. The aim of this study was to investigate downsizing and downstaging as methods of response evaluation. The findings suggest that comparing the baseline radiological CT stage to the pathological stage following NAC is a useful method for stratifying patients based on their long-term survival rates.
Article
Oncology
Haibin Song, Hongkai Sun, Laishou Yang, Hongyu Gao, Yongkang Cui, Chengping Yu, Haozhi Xu, Linqiang Li
Summary: This study aimed to determine the potential prognostic significance of nutritional risk index (NRI) in patients with stage III gastric cancer. The results showed that NRI was significantly associated with several clinicopathologic characteristics and identified as an independent factor to predict disease-free survival (DFS) and overall survival (OS). By establishing a diagnostic model, the survival probabilities of patients can be predicted, and the model showed good performance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Keishi Okubo, Takaaki Arigami, Daisuke Matsushita, Takako Tanaka, Yusuke Tsuruda, Masahiro Noda, Ken Sasaki, Shinichiro Mori, Hiroshi Kurahara, Takao Ohtsuka
Summary: The prognostic nutritional index (PNI) can serve as a useful tool in predicting the outcomes of patients with pathological stage II/III gastric cancer, and may aid in the selection of appropriate adjuvant chemotherapy regimens.