Article
Endocrinology & Metabolism
Rinki Murphy, Lindsay D. Plank, Michael G. Clarke, Nicholas J. Evennett, James Tan, David D. W. Kim, Richard Cutfield, Michael W. C. Booth
Summary: SR-LRYGB provided superior diabetes remission and weight loss compared with LSG at 5 years, with similar low risks of complications.
Article
Medicine, General & Internal
Brianna N. Lauren, Francesca Lim, Abraham Krikhely, Elsie M. Taveras, Jennifer A. Woo Baidal, Brandon K. Bellows, Chin Hur
Summary: This study evaluated the cost-effectiveness of medical therapy, sleeve gastrectomy (SG), and Roux-en-Y gastric bypass (RYGB) in patients with severe obesity and type 2 diabetes (T2D). The results showed that RYGB is the most cost-effective treatment strategy, resulting in the highest number of quality-adjusted life-years (QALYs) gained.
Article
Endocrinology & Metabolism
Marta Borges-Canha, Joao Sergio Neves, Fernando Mendonca, Maria Manuel Silva, Claudia Costa, Pedro M. Cabral, Vanessa Guerreiro, Rita Lourenco, Patricia Meira, Daniela Salazar, Maria Joao Ferreira, Jorge Pedro, Ebrahim Barkoudah, Ana Sande, Eva Lau, Selma B. Souto, John Preto, Paula Freitas, Davide Carvalho
Summary: This study aimed to evaluate the association between beta cell function and total body weight loss (TBWL%) 1 to 4 years after bariatric surgery in patients with morbid obesity. The results showed that baseline beta cell function was associated with long-term weight loss, especially after the first year post-surgery. This may be a helpful predictor of weight loss in clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Karolina Hoffmann, Anna Paczkowska, Wieslaw Bryl, Kinga Marzec, Jonas Raakow, Matthias Pross, Rafael Berghaus, Elzbieta Nowakowska, Krzysztof Kus, Michal Michalak
Summary: This study compares the level of discrimination among obese patients in Poland and Germany and finds that obesity significantly affects the social and economic well-being of patients. The study suggests the need to reduce weight stigma and alleviate the socioeconomic and psychological burden of obesity.
Article
Medicine, General & Internal
Regina Sierzantowicz, Jerzy R. Ladny, Krzysztof Kurek, Jolanta Lewko
Summary: This study aimed to analyze the pathologies on preoperative EGD in patients qualified for bariatric surgeries. The results showed that patients with obesity had a higher prevalence of esophageal pathologies compared to the control group, while the control group was more likely to have duodenal pathologies. Additionally, patient sex was a significant predictor of duodenal pathologies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Nesrin M. Hasan, Kelli F. Johnson, Jianyi Yin, Nicholas W. Baetz, Lea Fayad, Vadim Sherman, Sarah E. Blutt, Mary K. Estes, Vivek Kumbhari, Nicholas C. Zachos, Olga Kovbasnjuk
Summary: This study investigated the mechanisms underlying carbohydrate absorption and metabolism abnormalities in obese patients using human enteroids. Different phenotypes were found among obese patients, and elevated glucose absorption and gluconeogenesis in enteroids from obese patients were associated with specific transporter and enzyme expression. Human enteroids can be used as a preclinical platform to study obesity pathophysiology and identify novel therapeutics.
MOLECULAR METABOLISM
(2021)
Editorial Material
Endocrinology & Metabolism
Samuel Klein, Randy J. Seeley
Summary: Many individuals with obesity and type 2 diabetes experience diabetes remission after Roux-en-Y gastric bypass surgery, but there is disagreement regarding the underlying mechanisms. We present our perspective on conflicting datasets suggesting that the remission could be attributed solely to weight loss or weight loss-independent factors.
Letter
Surgery
A. Chierici, N. Chevalier, A. Iannelli
Summary: Revisional bariatric surgery is becoming more popular as long-term follow-up studies show a high failure rate of primary surgery. This study aimed to determine the best revisional procedure after failure of primary restrictive surgery. The results showed that biliopancreatic diversion with duodenal switch and single-anastomosis duodenoileal bypass were the most effective procedures in terms of weight loss.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Endocrinology & Metabolism
Ali Aminian, Rickesha Wilson, Alexander Zajichek, Chao Tu, Kathy E. Wolski, Philip R. Schauer, Michael W. Kattan, Steven E. Nissen, Stacy A. Brethauer
Summary: The study findings suggest that in patients with obesity and type 2 diabetes mellitus, Roux-en-Y gastric bypass (RYGB) surgery may be associated with greater weight loss, better diabetes control, and lower risk of major adverse cardiovascular events (MACE) and nephropathy compared with sleeve gastrectomy (SG) surgery.
Article
Medicine, General & Internal
Mengyi Li, Yang Liu, Wei-Jei Lee, Scott A. Shikora, Maud Robert, Weu Wang, Simon Kin Hung Wong, Yuanyuan Kong, Daniel King Hung Tong, Chun Hai Tan, Na Zeng, Shaihong Zhu, Cunchuan Wang, Pin Zhang, Yan Gu, Rixing Bai, Fanqiang Meng, Zhongqi Mao, Xiangwen Zhao, Liangping Wu, Yanjun Liu, Songhai Zhang, Peng Zhang, Zhongtao Zhang
Summary: This study aims to compare the efficacy and safety of OAGB and RYGB in the treatment of T2D. The study will last for 5 years and evaluate diabetes remission rate, complications, and weight loss. The study has received ethical approval, and the results are expected to be available in 2025.
Article
Endocrinology & Metabolism
Fahimeh Soheilipour, Mohammad Ebrahimian, Mohadeseh Pishgahroudsari, Maryam Hajian, Davoud Amirkashani, Mahtab Ordooei, Mohammad Radgoodarzi, Delaram Eskandari
Summary: The study aimed to evaluate zinc deficiency among morbidly obese patients before and after different types of bariatric surgeries, finding a high prevalence of preoperative zinc deficiency that increased postoperatively. It is recommended to assess zinc serum levels and prescribe zinc supplements before bariatric operations to reduce the incidence of zinc deficiency after surgery.
BMC ENDOCRINE DISORDERS
(2021)
Article
Medicine, General & Internal
Chia-Chen Lin, Keng-Hao Liu, Li-Ang Lee, Li-Pang Chuang, Yu-Sheng Lin, Li-Jen Hsin, Wan-Ni Lin, Yen-Ting Chiang, Wen-Nuan Cheng, Hsueh-Yu Li
Summary: This study proposes a comprehensive technique called combined airway and bariatric surgery (CABS) to improve both obesity and obstructive sleep apnea (OSA). The retrospective study showed that CABS can significantly improve AHI and BMI in morbidly obese OSA patients, with high success and cure rates for OSA, as well as improved quality of life and general health.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Andrea Herrera-Santelices, Andrea Tabach-Apraiz, Karen Andaur-Caceres, Antonio Roberto Zamuner
Summary: Bariatric surgery is an effective method for weight loss and long-term comorbidity resolution. This study aims to investigate the effects of two types of exercise, moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT), on body composition, cardiopulmonary function, and perceived quality of life in bariatric surgery patients. The study will be a randomized controlled exploratory pilot trial involving 75 adults scheduled for bariatric surgery, with outcomes assessed at various time points to evaluate the impact of exercise on the participants.
Article
Endocrinology & Metabolism
Kyuho Kim, Tae Jung Oh, Young Suk Park, Won Chang, Hyen Chung Cho, Jihye Lee, Yun Kyung Lee, Sung Hee Choi, Hak Chul Jang
Summary: This study found that obesity is independently associated with polyneuropathy in subjects without diabetes. However, in subjects with diabetes, although the association between obesity and polyneuropathy is not significant after adjusting for conventional risk factors, increased fibrotic gene expression in fat is associated with polyneuropathy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Federico Carbone, Elisa Nulli Migliola, Aldo Bonaventura, Alessandra Vecchie, Stefano De Vuono, Maria Anastasia Ricci, Gaetano Vaudo, Marcello Boni, Stefano Ministrini, Graziana Lupattelli, Fabrizio Montecucco
Summary: The study found that baseline serum levels of sclerostin are correlated with anthropometric measures of obesity and insulin resistance, particularly with peripheral insulin sensitivity. This suggests a close association between serum sclerostin and glycemic improvements after bariatric surgery.
Article
Nutrition & Dietetics
Maria Fontalba-Romero, Soledad Lopez-Enriquez, Ana Lago-Sampedro, Eva Garcia-Escobar, Ricardo L. Pastori, Juan Dominguez-Bendala, Silvia Alvarez-Cubela, Sergio Valdes, Gemma Rojo, Eduardo Garcia-Fuentes, Maria T. Labajos-Manzanares, Sara Garcia-Serrano
Summary: The study found that there is an association between specific serum levels of miRNAs and the amount and kind of food intake related to the Mediterranean diet. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile.
Article
Health Care Sciences & Services
Carolina Gutierrez-Repiso, Maria Molina-Vega, M. Rosa Bernal-Lopez, Lourdes Garrido-Sanchez, Jose M. Garcia-Almeida, Ignacio Sajoux, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: The study found that there is no specific pattern of gut microbiota changes associated with weight loss, but rather changes vary depending on the type of weight loss intervention.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Endocrinology & Metabolism
Carolina Gutierrez-Repiso, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: Evidence suggests that bariatric surgery alters gut microbiota, but its impact on host metabolism and microbiota-derived metabolites is not well understood. Future research should focus on analyzing gut microbiota functionality, the influence on bariatric surgery outcomes, and the predictive value in personalized medicine. The potential of using gut microbiota manipulation as a novel tool in post-surgery weight loss and metabolic profile improvement needs further investigation.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Medicine, Research & Experimental
Maria Molina-Vega, Maria J. Picon-Cesar, Carolina Gutierrez-Repiso, Andrea Fernandez-Valero, Fuensanta Lima-Rubio, Stella Gonzalez-Romero, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: In women with gestational diabetes mellitus, treatment with metformin led to lower postprandial glycemia and less weight gain compared to treatment with insulin. There were also changes in the composition of gut microbiota, with a decrease in Firmicutes and Peptostreptococcaceae abundance and an increase in Proteobacteria and Enterobacteriaceae abundance in the metformin group. Predicted metabolic pathways related to propionate degradation and ubiquinol biosynthesis were more prevalent in the metformin group. Further studies are needed to understand how these changes impact metabolic control during and after pregnancy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Carolina Gutierrez-Repiso, Teresa Maria Linares-Pineda, Andres Gonzalez-Jimenez, Francisca Aguilar-Lineros, Sergio Valdes, Federico Soriguer, Gemma Rojo-Martinez, Francisco J. Tinahones, Sonsoles Morcillo
Summary: This study found that DNA methylation status is associated with the stability/worsening of the MHO phenotype, identifying two potential biomarkers for transitioning to an unhealthy state and highlighting immune system-related pathways as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Teresa Maria Linares-Pineda, Hatim Boughanem, Carolina Gutierrez-Repiso, Manuel Macias-Gonzalez, Eduardo Andres-Leon, Gemma Rojo-Martinez, Sergio Valdes, Francisco J. Tinahones, Sonsoles Morcillo
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Surgery
Carolina Gutierrez-Repiso, Lourdes Garrido-Sanchez, Juan Alcaide-Torres, Isabel Cornejo-Pareja, Luis Ocana-Wilhelmi, Eduardo Garcia-Fuentes, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: This study found that the composition of the gut microbiota before surgery may impact the outcomes of bariatric surgery. The Prevotella-to-Bacteroides ratio could serve as a predictive tool for weight loss trajectory. Early after surgery, patients who experienced successful weight loss showed an enrichment in taxa related to beneficial effects on host metabolism.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Biochemistry & Molecular Biology
Jose Ignacio Martinez-Montoro, Mar Quesada-Molina, Carolina Gutierrez-Repiso, Patricia Ruiz-Limon, Alba Subiri-Verdugo, Francisco J. Tinahones, Isabel Moreno-Indias
Summary: The antioxidant capacity of beer polyphenols may induce positive shifts in gut microbiota composition, and some of the observed changes may be related to metabolic status.
Article
Nutrition & Dietetics
Concepcion Santiago-Fernandez, Cristina Rodriguez-Diaz, Ailec Ho-Plagaro, Carolina Gutierrez-Repiso, Wilfredo Oliva-Olivera, Flores Martin-Reyes, Virginia Mela, Rocio Bautista, Monicas Tome, Josefa Gomez-Maldonado, Francisco J. Tinahones, Eduardo Garcia-Fuentes, Lourdes Garrido-Sanchez
Summary: This study found that extra virgin olive oil (EVOO) and sunflower oil (SO) have different effects on the miRNA composition of endothelial cell-derived extracellular vesicles (EVs). These EVs can regulate the transcriptomic profile of smooth muscle cells (SMCs), which plays a role in the development of atherosclerosis.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Sergio Valdes, Viyey Doulatram-Gamgaram, Cristina Maldonado-Araque, Ana Lago-Sampedro, Eva Garcia-Escobar, Sara Garcia-Serrano, Marta Garcia-Vivanco, Luis Garrido Juan, Mark Richard Theobald, Victoria Gil, Fernando Martin-Llorente, Pilar Ocon, Alfonso Calle-Pascual, Luis Castano, Elias Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbes, F. Javier Chaves, Jose L. Galan-Garcia, Gabriel Aguilera-Venegas, Carolina Gutierrez-Repiso, Jose Carlos Fernandez-Garcia, Natalia Colomo, Federico Soriguer, Eduardo Garcia-Fuentes, Gemma Rojo-Martinez
Summary: This study evaluated the association between exposure to air pollutants and thyroid function parameters in a nationwide sample of Spanish adults. The results showed a significant negative correlation between PM2.5 concentrations and FT4 and FT3 levels, as well as a significant association between PM2.5 concentrations and the odds of presenting high TSH, lower FT4, and low FT3 levels. NO2 concentrations showed no association with thyroid hormone levels.
ENVIRONMENTAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Maria Molina-Vega, Maria Jose Picon-Cesar, Fuensanta Lima-Rubio, Carolina Gutierrez-Repiso, Teresa Maria Linares-Pineda, Maria Suarez-Arana, Ana Maria Fernandez-Ramos, Francisco J. Tinahones, Sonsoles Morcillo
Summary: Vitamin D deficiency is common in pregnant women and is associated with a higher risk of gestational diabetes mellitus (GDM). In this study, it was found that pregnant women who required insulin for GDM had higher levels of vitamin D compared to those who did not require insulin and healthy controls at postpartum and 1 year after birth.
Article
Endocrinology & Metabolism
Jose Ignacio Martinez-Montoro, Marta Generoso-Pinar, Luis Ocana-Wilhelmi, Carolina Gutierrez-Repiso, Ana Sanchez-Garcia, Rocio Soler-Humanes, Jose Luis Fernandez-Serrano, Pilar Sanchez-Gallego, Jose M. Martinez-Moreno, Eduardo Garcia-Fuentes, Francisco J. Tinahones, Lourdes Garrido-Sanchez
Summary: This study investigated the impact of preoperative clinical and biochemical parameters on the remission of Type 2 diabetes (T2DM) after metabolic surgery. The results showed that patients who did not experience T2DM remission after surgery had longer diabetes duration, higher levels of glycated hemoglobin (HbA1c), and were more likely to use insulin, antihypertensive drugs, and lipid-lowering therapies. Additionally, preexisting hypertension, hypercholesterolemia, and longer diabetes duration were independent predictors of T2DM persistence after metabolic surgery.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Teresa Maria Linares-Pineda, Nerea Pena-Montero, Carolina Gutierrez-Repiso, Fuensanta Lima-Rubio, Antonio Sanchez-Pozo, Francisco J. Tinahones, Maria Molina-Vega, Maria Jose Picon-Cesar, Sonsoles Morcillo
Summary: Gestational diabetes mellitus (GDM) increases the risk of metabolic disorders in pregnant women and their offspring. This study aims to identify epigenetic marks related to the development of GDM. DNA methylation patterns from 32 pregnant women, 16 with GDM and 16 without GDM, were analyzed. Differential methylated positions and annotated genes were identified, with a significant relationship found between certain genes and carbohydrate metabolism. Furthermore, a correlation was observed between specific methylation positions and biochemical variables during pregnancy and postpartum. These findings suggest a potential role of epigenetic mechanisms in GDM and related metabolic changes.
Article
Endocrinology & Metabolism
Teresa Maria Linares-Pineda, Carolina Gutierrez-Repiso, Nerea Pena-Montero, Maria Molina-Vega, Fuensanta Lima Rubio, Maria Suarez Arana, Francisco J. Tinahones, Maria Jose Picon-Cesar, Sonsoles Morcillo
Summary: There is increasing interest in developing markers for detecting pancreatic beta cell death to improve early diagnosis and treatment response in diabetes, particularly in type 1 diabetes. Early detection of beta cell death would also benefit other types of diabetes.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Biochemistry & Molecular Biology
Rocio Mateo-Gallego, Isabel Moreno-Indias, Ana M. Bea, Lidia Sanchez-Alcoholado, Antonio J. Fumanal, Mar Quesada-Molina, Ascension Prieto-Martin, Carolina Gutierrez-Repiso, Fernando Civeira, Francisco J. Tinahones
Summary: The study investigated the impact of consuming modified alcohol-free beer on the gut microbiome of diabetic subjects, showing a reduction in blood glucose and HOMA-IR after intake, along with an improvement in BMI. The most significant feature was found to be Parabacteroides from the Porphyromonadaceae family.
