Article
Endocrinology & Metabolism
Henri Honka, Janet Chuang, David D'Alessio, Marzieh Salehi
Summary: Patients after gastric bypass surgery exhibit greater variability in postprandial glucose levels, and a mixed meal test is more effective than continuous glucose monitoring system in diagnosing hypoglycemia related to gastric bypass surgery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Myat Win, Rowan Beckett, Lynn Thomson, Ajay Thankamony, Kathryn Beardsall
Summary: This retrospective study introduces the use of real-time CGM in monitoring persistent neonatal hypoglycemia. The study found significant fluctuations in glucose levels in babies with congenital hyperinsulinism, highlighting the challenges of preventing hypoglycemia. The results also suggest the potential application of CGM as an adjunct to clinical care in managing neonatal hypoglycemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Ana M. Ramos-Levi, Miguel A. Rubio-Herrera, Pilar Matia-Martin, Natalia Perez-Ferre, Clara Marcuello, Andres Sanchez-Pernaute, Antonio J. Torres-Garcia, Alfonso L. Calle-Pascual
Summary: Gastric bypass surgery can lead to increased incretin secretion and glucose excursions, potentially causing post-bariatric hypoglycemia (PBH). This study evaluated the effectiveness of mixed meal tolerance tests (MMTT) and continuous glucose monitoring (CGM) for diagnosing PBH. The MMTT confirmed PBH diagnosis in a large percentage of patients, especially those with longer postsurgical duration, while CGM identified both nocturnal asymptomatic and daytime postprandial hypoglycemia. The results highlight the importance of both tests in diagnosing and monitoring PBH after gastric bypass.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Michael A. Rotondi, Octavia Wong, Michael Riddell, Bruce Perkins
Summary: Universal use of CGM or isCGM in the Canadian T1D population is expected to reduce diabetes-related complications and mortality at an acceptable cost-effectiveness threshold.
Article
Chemistry, Analytical
Soo Yeun Sim, Moon Bae Ahn
Summary: The combined pituitary function test evaluates the anterior pituitary gland and the insulin tolerance test evaluates growth hormone deficiencies. Close medical supervision and glucose monitoring are required during hypoglycemia induction, making the test tedious. Continuous glucose monitoring can be used as a safe aid for clinicians during insulin tolerance tests where critical hypoglycemia is induced.
Article
Endocrinology & Metabolism
Diana Isaacs, Natalie J. Bellini, Ursula Biba, Albert Cai, Kelly L. Close
Summary: Continuous glucose monitoring is effective in improving glycemic control in individuals with diabetes, but there are disparities in its utilization among racially diverse and lower socio-economic populations. Addressing these disparities is crucial in optimizing the benefits of CGM for all individuals with diabetes.
DIABETES TECHNOLOGY & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Lucia Giordano, Alessandro Perri, Eloisa Tiberi, Annamaria Sbordone, Maria Letizia Patti, Vito D'Andrea, Giovanni Vento
Summary: This study assessed the feasibility and reliability of a continuous glucose monitoring system (CGMS) in asphyxiated neonates during therapeutic hypothermia. The CGMS detected more episodes of disglycemia than standard care, but showed poor accuracy in this particular setting.
Review
Cardiac & Cardiovascular Systems
Roberta Lupoli, Erminia Lembo, Carmen Rainone, Luigi Schiavo, Antonio Iannelli, Matteo N. D. Di Minno, Brunella Capaldo
Summary: Post-bariatric hypoglycemia (PBH) is more common than previously thought, with rates increasing over time following surgery. The occurrence of PBH is similar after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), but there is higher glycemic variability after RYGB. The study highlights the importance of continuous glucose monitoring (CGM) data to evaluate and manage PBH in bariatric surgery patients.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Endocrinology & Metabolism
Marzieh Salehi, Amalia Gastaldelli, Ralph DeFronzo
Summary: Roux-en Y gastric bypass surgery and sleeve gastrectomy alter postprandial glucose metabolism, increasing the risk of hypoglycemia. After surgery, there is a reduced hepatic glucose production response during insulin-induced hypoglycemia. However, the counterregulatory response to hypoglycemia is similar among individuals with surgery and without surgery.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Review
Chemistry, Analytical
Hima Zafar, Asma Channa, Varun Jeoti, Goran M. Stojanovic
Summary: This study summarizes recent developments in non-invasive continuous glucose monitoring using sweat sensors, with a focus on potential integration into wearable platforms.
Article
Endocrinology & Metabolism
Pauline Legris, Benjamin Bouillet, Justine Paris, Pauline Pistre, Madeline Devaux, Stephanie Bost, Isabelle Simoneau, Sylvain Manfredi, Antoine Drouillard, Jean-Noel Bastie, Marie Chaix, Pamela Massoud, Alexia Rouland, Serge Aho, Mathieu Boulin, Jean-Michel Petit
Summary: The aim of the study was to assess the glucose profile in people with diabetes starting chemotherapy using Continuous Glucose Monitoring (CGM). The results showed that CGM could reduce the risk of hypoglycemia in these patients, supporting the recommendation of assessing hypoglycemia risk before starting chemotherapy.
ACTA DIABETOLOGICA
(2023)
Article
Oncology
Motonari Ri, Souya Nunobe, Satoshi Ida, Naoki Ishizuka, Shinichiro Atsumi, Masaru Hayami, Rie Makuuchi, Koshi Kumagai, Manabu Ohashi, Takeshi Sano
Summary: This study aimed to investigate postprandial glycemic variability in patients undergoing different surgical procedures for gastric cancer. The findings suggest that pylorus preserving gastrectomy (PPG) leads to the most stable postprandial glucose profiles, while total gastrectomy with RY (TG-RY) and distal gastrectomy with RY (DG-RY) show spike-like glycemic variability. Continuous interstitial tissue glycemic monitoring can provide insights into postprandial glycemic changes after gastrectomy.
JOURNAL OF GASTRIC CANCER
(2021)
Article
Endocrinology & Metabolism
Bingkun Huang, Qiuhui Jiang, Ting Wu, Qingbao Shen, Wengui Wang, Shoubi Wang, Yinxiang Huang, Shunhua Wang, Peiying Huang, Mingzhu Lin, Xiulin Shi, Xuejun Li
Summary: This study investigated the prevalence and influencing factors of asymptomatic hypoglycemia in outpatients with type 2 diabetes. The results showed that younger age, lower hemoglobin A1c levels, and higher systolic blood pressure levels were associated with an increased risk of asymptomatic hypoglycemia. The study also found that male sex and Dipeptidylpeptidase-4 inhibitors treatment were associated with a lower risk of more severe asymptomatic hypoglycemia.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Endocrinology & Metabolism
Akemi Tokutsu, Yosuke Okada, Keiichi Torimoto, Yoshiya Tanaka
Summary: The study found that HbA1c variability is associated with hypoglycemia, suggesting the need to evaluate low blood sugar in patients with high HbA1c variability and reconsider their treatment regimen.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
Roy W. Beck, Dan Raghinaru, Peter Calhoun, Richard M. Bergenstal
Summary: This study investigated the relationship between the time spent with glucose levels below 70 mg/dL and below 54 mg/dL in patients with diabetes. The results showed that as the time below 70 mg/dL increased, the time below 54 mg/dL also increased. Furthermore, it was found that patients who monitored their glucose levels blindly had more time below 54 mg/dL compared to those who did not, and their data was similar to that of patients using an automated insulin delivery system.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Caroline Christfort Ohrstrom, Dorte Worm, Anna Hojager, Ditte Andersen, Jens Juul Holst, Urd Lynge Kielgast, Dorte Lindqvist Hansen
DIABETES OBESITY & METABOLISM
(2019)
Article
Endocrinology & Metabolism
C. C. Ohrstrem, F. K. Knop
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Surgery
Caroline C. Ohrstrom, Dorte L. Hansen, Urd Lynge Kielgast, Bolette Hartmann, Jens Juul Holst, Dorte Worm
Article
Surgery
Caroline C. Ohrstrom, Dorte Worm, Urd Lynge Kielgast, Jens Juul Holst, Dorte L. Hansen
Article
Surgery
Caroline C. Ohrstrom, Dorte L. Hansen, Urd Lynge Kielgast, Marianne Lerbok Bergmann, Simon Veedfald, Jens Juul Holst, Dorte Worm
Summary: This study evaluated counterregulatory responses during postprandial hypoglycemia in patients with postbariatric hypoglycemia who underwent Rouxen-Y gastric bypass surgery. The findings showed that individuals with postbariatric hypoglycemia had minor increases in counterregulatory hormones during postprandial hypoglycemia, but larger hormone responses occurred when glucose levels were lowered during treatment with sitagliptin.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Gastroenterology & Hepatology
Maria S. Svane, Caroline C. Ohrstrom, Astrid Plamboeck, Nils B. Jorgensen, Kirstine N. Bojsen-Moller, Carsten Dirksen, Christoffer Martinussen, Tina Vilsboll, Bolette Hartmann, Carolyn F. Deacon, Viggo B. Kristiansen, Filip K. Knop, Lars B. Svendsen, Sten Madsbad, Jens J. Holst, Simon Veedfald
Summary: NT secretion is increased after surgeries associated with accelerated gastric emptying and lowered by pasireotide.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Endocrinology & Metabolism
Casper K. Nielsen, Caroline C. Ohrstrom, Urd L. Kielgast, Dorte L. Hansen, Bolette Hartmann, Jens J. Holst, Asger Lund, Tina Vilsboll, Filip K. Knop
Summary: This study investigated the efficacy and safety of a novel stable glucagon analog, dasiglucagon, in individuals who had undergone Roux-en-Y gastric bypass (RYGB) and suffered from postbariatric hypoglycemia (PBH). The results demonstrated that a single-dose administration of dasiglucagon effectively mitigated postprandial hypoglycemia.