Journal
SURGERY
Volume 161, Issue 2, Pages 373-384Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.surg.2016.08.005
Keywords
-
Categories
Funding
- National Science Foundation for Distinguished Young Scholars of China [81625016]
- National Natural Science Foundation of China [81472670, 81172005, 81402397, 81402398, 81172276]
- National Natural Science Foundation of Shanghai [14ZR1407600]
- Yang-Fan Plan for Young Scientists of Shanghai [14YF1401100]
Ask authors/readers for more resources
Background. Carbohydrate antigen (CA19-9) is a well-established marker to monitor disease status after resection of pancreatic cancer. However, few serum markers have been reported to improve the prognostic ability of postoperative CA19-9, especially in patients with normal postoperative CA19-9. Methods. A total of 353 patients with pancreatic ductal adenocarcinoma treated by radical resection were reviewed retrospectively, and a prospective cohort including 142 patients with resectable pancreatic head carcinoma was analyzed as a validation cohort. Perioperative CA19-9 and postoperative serum markers (CEA, CA242, CA72-4, CA50, CA125, CA153, and AFP) were investigated. Results. Patients with postoperative normalization of CA19-9 had improved survival times (recurrence free survival: 11.9 months; overall survival: 22.5 months) compared with those with decreased but still elevated postoperative CA19-9 (recurrence-free survival: 6.8 months, P < .001; overall survival: 13.5 months, P < .001) or those with increased postoperative CA19-9 (recurrence-free survival: 3.5 months, P < .001; overall survival: 7.9 months, P < .001), which was similar to those with consistently normal CA19-9 during perioperative periods (recurrence-free survival: 10.6 months, P = . 799; overall survival: 24.1 months, P = . 756). Normal postoperative CA19-9 levels were an independent indicator for a positive outcome after operation, regardless of preoperative CA19-9 levels. Elevated postoperative CEA and CA125 were identified further as independent risk factors for patients with normal postoperative CA19-9, while elevated postoperative CA125 and nondecreased postoperative CA19-9 were independent prognostic markers for patients with elevated postoperative CA19-9. Conclusion. The postoperative monitoring of CEA and CA125 provided prognostic significance to the measurement of CA19-9 in pancreatic cancer after resection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available