Article
Multidisciplinary Sciences
Amir Shamloo, Amin Naghdloo, Mohsen Besanjideh
Summary: The study focused on isolating rare cancer cells using two centrifugal microfluidic devices. The passive design isolates cells through inertial effects and bifurcation law, while the hybrid design captures magnetically labeled cells using permanent magnets at the end of the microchannel. The hybrid design offers better separation efficiency and purity, while the passive one is simpler and cost-effective without the need for cell labeling.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Zhenglin Li, Chao Liu, Yangchang Cheng, Yike Li, Jinqi Deng, Lixiao Bai, Lili Qin, Huili Mei, Min Zeng, Fei Tian, Shaohua Zhang, Jiashu Sun
Summary: Tumor-derived extracellular vesicles (EVs) have the potential to improve noninvasive early cancer diagnosis. However, the lack of effective methods for isolating and detecting nanosized EVs in blood samples has been a challenge. To address this, researchers designed cascaded microfluidic circuits to filter EVs using a pneumatic clock pulse generator. This device allows for rapid and high-purity isolation of EVs from blood within 30 minutes and has shown 91% accuracy in diagnosing early-stage breast cancer.
Editorial Material
Multidisciplinary Sciences
Kassandra Kisler, Angeliki Maria Nikolakopoulou, Berislav V. Zlokovic
Summary: Microglia play a crucial role in regulating capillary vascular tone and blood flow, with a recently identified signaling mechanism attracting and maintaining them at the capillary wall.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Mechanical
Writtick Pakhira, R. Kumar, Khalid Mohd Ibrahimi, Rituraj Bhattacharjee
Summary: In recent years, microfluidic lab-on-chip devices have gained popularity in point-of-care medical diagnosis and liquid biopsy analyses. A new device utilizing negative dielectrophoresis (DEP) mechanism has been developed to separate distinct blood cells and plasma. The device has demonstrated efficient separation performance and eliminates the need for external sample preparation.
JOURNAL OF THE BRAZILIAN SOCIETY OF MECHANICAL SCIENCES AND ENGINEERING
(2022)
Retraction
Biochemical Research Methods
T. U. Vinitha, Sthitodhi Ghosh, Alexander Milleman, Thinh Nguyen, Chong H. Ahn
Summary: This retraction notice withdraws a study on the detection of unbound cortisol in saliva using a microfluidic capillary flow assay (MCFA) based polymer lab-on-a-chip (LOC). The study was conducted by Vinitha T.U. et al. and published in Lab Chip in 2020.
Article
Biochemical Research Methods
Andrew S. Clark, Adriana San-Miguel
Summary: We have developed two microfluidic lobe filters inspired by the filtration mechanism of manta rays to address clogging issues. These filters can efficiently filtrate particles around 10-30 μm with high throughput and precise control, showing increased filtration efficiency with fluid flow rate.
Article
Mechanics
Sen Xue, Xiwen Zhang, Feng He, Zhaomiao Liu, Pengfei Hao
Summary: The study investigates the effects of the tilted angle of the acoustic field and microchannel aspect ratios on particle manipulation, proposing an optimal tilt angle for efficient separation of particles. It also identifies two typical particle migration states and observes multi-layer particle focus in the vertical direction of microchannels for the first time, providing new insights for the development of high-throughput microfluidic devices.
Review
Nanoscience & Nanotechnology
Jens Ducree
Summary: This review discusses the challenges and current trends in larger-scale integration of microfluidic systems, highlighting the advantages of centrifugal systems for sample preparation. It also introduces a method using simulation tools for virtual prototyping and design optimization.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Matteo Agostini, Francesco Lunardelli, Mariacristina Gagliardi, Alessio Miranda, Leonardo Lamanna, Antonella Giuliana Luminare, Francesca Gambineri, Michele Lai, Mauro Pistello, Marco Cecchini
Summary: Measles is highly infectious, and despite the availability of a vaccine, it remains common in developing countries and sporadic outbreaks occur in developed countries. This study presents a point-of-care biosensing device capable of detecting measles virus in human saliva, with promising results for measles diagnosis and guidance for designing new biosensing systems.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemical Research Methods
Sujit S. Datta, Ilenia Battiato, Martin A. Ferno, Ruben Juanes, Shima Parsa, Valentina Prigiobbe, Enric Santanach-Carreras, Wen Song, Sibani Lisa Biswal, David Sinton
Summary: Transitioning to a sustainable future requires a transformation of energy and environmental technologies. Lab-on-a-chip (LoC) systems can contribute to this transition by studying and developing new processes and materials in areas such as carbon sequestration, hydrogen storage, geothermal energy extraction, bioenergy, critical materials recovery, and water filtration. It is important to engage the LoC community and raise awareness among researchers, industry experts, and policy makers about the potential of LoC approaches in achieving a low-carbon future.
Article
Engineering, Electrical & Electronic
Evangelos Skotadis, Evangelos Aslanidis, George Kokkoris, Emmanouil Artouro Vargkas Kousoulas, Angeliki Tserepi, Dimitris Tsoukalas
Summary: In this paper, a strain-sensing module is used to determine the flow in a microfluidic chip. The module is based on platinum nanoparticle networks and changes its resistance by introducing varying flow rates. The research shows that the module has a competitive limit of detection, low cost, low power requirements, and easy integration with existing microfluidic systems.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Chemistry, Analytical
Abdallah M. Alkhaiyat, Mohamed Badran
Summary: This study proposes a lab-on-chip design that efficiently separates circulating tumor cells (CTCs) from white blood cells (WBCs) and blood platelets (PLTs). Numerical simulations are used to optimize the design parameters, and the effects of applied voltage values and buffer inlet velocity are investigated. The proposed design achieves 100% separation efficiency in simulation and shows potential for early detection of CTCs and personalized cancer treatment.
Article
Endocrinology & Metabolism
Ana R. Santa-Maria, Fruzsina R. Walter, Ricardo Figueiredo, Andras Kincses, Judit P. Vigh, Marjolein Heymans, Maxime Culot, Peter Winter, Fabien Gosselet, Andras Der, Maria A. Deli
Summary: This study investigated the properties of the blood-brain barrier and glycocalyx in human-like brain endothelial cells (BLECs) using a microfluidic lab-on-a-chip device under dynamic conditions. The results showed that fluid flow regulated the expression of endothelial, BBB, and glycocalyx genes, leading to increased barrier properties and a more negative surface charge of BLECs. The study highlights the importance of fluid flow in maintaining the physiological functions of the BBB in culture models.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Amina Farooq, Fezan Hayat, Sobia Zafar, Nauman Zafar Butt
Summary: This study explores the design of an impedimetric microfluidic cytometer on a flexible substrate and compares two microfluidic geometries for their sensitivity. The results show that the microelectrode surface area and the geometry of the sensing volume significantly affect the sensor's output response. Reducing the sensing volume improves pulse amplitude and signal-to-noise ratio. The proposed design demonstrates good detection and differentiation of polystyrene beads and leukemia cells. Additionally, the study presents a feasible approach to achieve irreversible and strong bond strength between thin flexible surfaces in a biochip.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Ruonan Peng, Xinye Chen, Fengjun Xu, Richard Hailstone, Yujie Men, Ke Du
Summary: This study developed a miniaturized nano-sieve device that, when coupled with a CRISPR assay, allows for sensitive, accurate, and specific detection of drug-resistant bacteria in biofluids. This method has the potential to rapidly and accurately diagnose antibiotic-resistant bacterial infections in a point-of-care setting, improving patient outcomes in resource-limited medical conditions.
NANOSCALE HORIZONS
(2023)
