Article
Multidisciplinary Sciences
Randi von Wrede, Thorsten Rings, Sophia Schach, Christoph Helmstaedter, Klaus Lehnertz
Summary: The study found that short-term taVNS has an immediate effect on the topology, robustness, and stability of large-scale epileptic brain networks, enhancing the resilience of these networks without negatively impacting cognition, behavior, or mood.Further studies are needed to understand the exact mechanisms by which taVNS prevents or inhibits seizures for translation into clinical practice.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Roberta Coa, Simone Maurizio La Cava, Giulia Baldazzi, Lorenzo Polizzi, Giovanni Pinna, Carlo Conti, Giovanni Defazio, Danilo Pani, Monica Puligheddu
Summary: This study evaluated the effect of VNS on PLI and aperiodic parameters in subjects with DRE and found that PLI decreased in responders and remained unchanged in non-responders, while aperiodic parameters decreased in responders and increased in non-responders. Changes in aperiodic parameters were correlated with clinical response.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Sakar Rijal, Ludovica Corona, M. Scott Perry, Eleonora Tamilia, Joseph R. Madsen, Scellig S. D. Stone, Jeffrey Bolton, Phillip L. Pearl, Christos Papadelis
Summary: Normal brain functioning relies on complex interactions among different regions forming networks. This study investigates the use of functional connectivity in quantifying epileptogenicity and predicting surgical outcome in children with drug resistant epilepsy (DRE). The findings suggest that functional connectivity can distinguish epileptogenic states and predict outcome in patients with DRE.
SCIENTIFIC REPORTS
(2023)
Article
Computer Science, Information Systems
Junfeng Gao, Lingyun Gu, Xiangde Min, Pan Lin, Chenhong Li, Quan Zhang, Nini Rao
Summary: This study investigated the brain functional connectivity patterns related to lie detection tasks using EEG signals. The results showed that deceptive responses elicited greater oscillatory synchronization than truthful responses between different brain regions. The findings suggest that these functional connections play a crucial role in executing lying tasks, involving visuo-spatial imagery, attention and memory systems, and attention and inhibition processing. The proposed method, FTRPS, demonstrated high classification accuracy for identifying deception behavior.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Engineering, Biomedical
Ali Kareem Abbas, Ghasem Azemi, Samin Ravanshadi, Amir Omidvarnia
Summary: This study introduces a new methodology for extracting functional brain networks from multichannel scalp EEG recordings, focusing on investigating functional integration and segregation in brain networks. Statistical analysis reveals that frequency-specific graph measures have high discriminative ability between seizure and non-seizure intervals. The results show that during seizure activities, brain networks become more segregated and less aggregated compared to non-seizure intervals.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Multidisciplinary Sciences
Angela Yun Kim, Anna Marduy, Paulo S. de Melo, Anna Carolyna Gianlorenco, Chi Kyung Kim, Hyuk Choi, Jae-Jun Song, Felipe Fregni
Summary: This systematic review and meta-analysis provides evidence that transcutaneous auricular vagus nerve stimulation (taVNS) is a safe and feasible option for clinical intervention. The overall incidence of adverse events was low, with ear pain, headache, and tingling being the most frequently reported. No causal relationship was found between taVNS and severe adverse events.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Min-Lan Tsai, Chuang-Chin Wang, Feng-Chin Lee, Syu-Jyun Peng, Hsi Chang, Sung-Hui Tseng
Summary: This study analyzed EEG functional connectivity in children with rolandic spikes and found a relationship between connectivity strength and clinical parameters. Children with rolandic spikes without seizures showed similar connectivity enhancements as BECTS patients with seizures, while decreased connectivity function was only present in BECTS patients with seizures. Age at seizure onset was significantly positively associated with connectivity strength.
Review
Neurosciences
Stanislas Lagarde, Christian-G Benar, Fabrice Wendling, Fabrice Bartolomei
Summary: This article reviews the concept of the epileptogenic network, explains the basic notions of functional connectivity, and reports the current body of published data using intracranial EEG. The data show that there are differential changes in functional connectivity between epileptic and non-epileptic areas even at temporal distance from seizures. These findings may help locate epileptic areas and predict surgical outcomes.
BRAIN CONNECTIVITY
(2022)
Article
Mathematics, Applied
Ralph G. Andrzejak, Anais Espinoso, Eduardo Garcia-Portugues, Arthur Pewsey, Jacopo Epifanio, Marc G. Leguia, Kaspar Schindler
Summary: The article introduces how to quantify the concentration of unimodal circular data around the mean direction using the mean resultant length, and proposes a re-normalized version as an improvement. The relevance and effectiveness of the proposed method are illustrated through examples.
Article
Clinical Neurology
Graham W. Johnson, Derek J. Doss, Victoria L. Morgan, Danika L. Paulo, Leon Y. Cai, Jared S. Shless, Aarushi S. Negi, Abhijeet Gummadavelli, Hakmook Kang, Shilpa B. Reddy, Robert P. Naftel, Sarah K. Bick, Shawniqua Williams Roberson, Benoit M. Dawant, Mark T. Wallace, Dario J. Englot
Summary: Why are people with epilepsy not continuously having seizures? Johnson et al. use intracranial electrical recordings to analyse brain network interactions in people with epilepsy, and provide evidence that the seizure-onset network is actively suppressed by the rest of the brain during interictal states.
Article
Clinical Neurology
John M. Bernabei, Nishant Sinha, T. Campbell Arnold, Erin Conrad, Ian Ong, Akash R. Pattnaik, Joel M. Stein, Russell T. Shinohara, Timothy H. Lucas, Dani S. Bassett, Kathryn A. Davis, Brian Litt
Summary: Bernabei et al. constructed an atlas of normative interictal intracranial EEG recordings and found that brain regions generating spikes and seizures have different patterns of activity and connectivity compared to the atlas. Comparing EEG recordings to the atlas can reliably identify abnormal regions and guide invasive treatment for epilepsy.
Article
Clinical Neurology
Christoffer Hatlestad-Hall, Ricardo Bruna, Marte Roa Syvertsen, Aksel Erichsen, Vebjorn Andersson, Fabrizio Vecchio, Francesca Miraglia, Paolo M. Rossini, Hanna Renvall, Erik Tauboll, Fernando Maestu, Ira H. Haraldsen
Summary: This study investigated functional network alterations in focal epilepsy patients with good seizure control and high quality of life. Results showed significantly increased small world index in patients compared to controls, along with a shift towards greater alpha band hubness in two left-hemisphere regions. These findings suggest that functional network analysis could be clinically relevant for epilepsy.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Biodiversity Conservation
Lisbeth A. Hordley, Gary D. Powney, Tom Brereton, Simon Gillings, Owen L. Petchey, David B. Roy, Joseph A. Tobias, James Williams, Tom H. Oliver
Summary: Habitat loss leads to biodiversity loss and reduces the connectivity of landscapes for species movement. Quantifying functional connectivity is important for conservation management, and a technique based on population synchrony has been suggested. This study uses species survey data to investigate population synchrony for British birds and butterflies over time. Results show that butterfly synchrony has declined but recently increased, while bird synchrony has shown some decline followed by recovery. Developing indicators of functional connectivity using abundance data is crucial for effective land management strategies.
ECOLOGICAL INDICATORS
(2022)
Article
Clinical Neurology
Lucas E. Sainburg, Andrew P. Janson, Graham W. Johnson, Jasmine W. Jiang, Baxter P. Rogers, Catie Chang, Dario J. Englot, Victoria L. Morgan
Summary: Epilepsy surgery involves the resection of the epileptic focus and is used to treat drug-resistant focal epilepsy. However, focal brain lesions can have effects in distant brain regions. This study investigates the effects of focal disconnections in the brain network on function in distant brain regions using epilepsy surgery.
Article
Clinical Neurology
Tianhua Yang, Yingying Zhang, Tianyu Zhang, Huanyu Zhou, Menghan Yang, Jiechuan Ren, Lei Li, Du Lei, Qiyong Gong, Dong Zhou
Summary: The objective of this study was to investigate the changes in dynamic functional connectivity (dFC) of striatal-cortical circuits in juvenile myoclonic epilepsy (JME). The results showed increased dFC variability in fronto-striatal and striatal-thalamic networks and decreased dFC variability between striatum subdivisions and the default mode network (DMN) in JME patients compared with healthy controls. Furthermore, the hypervariability between specific regions of the striatum and cortex was positively correlated with the frequency of myoclonic seizures in JME patients.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Article
Clinical Neurology
Christophe Gauld, Regis Lopez, Charles Morin, Pierre A. Geoffroy, Julien Maquet, Pierre Desvergnes, Aileen McGonigal, Yves Dauvilliers, Pierre Philip, Guillaume Dumas, Jean-Arthur Micoulaud-Franchi
Summary: The study utilized symptom network analysis to explore diagnostic criteria in the ICSD-3 manual, revealing strong interconnections between sleep symptoms. Central roles were found for daytime sleepiness, insomnia, and behavior during sleep symptoms in the network, suggesting potential implications for better systematizing and organizing symptomatology in sleep medicine.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Clinical Neurology
Julia Makhalova, Arnaud Le Troter, Sandrine Aubert-Conil, Bernard Giusiano, Aileen McGonigal, Agnes Trebuchon, Romain Carron, Samuel Medina Villalon, Christian G. Benar, Jean-Philippe Ranjeva, Maxime Guye, Fabrice Bartolomei
Summary: This study assessed the epileptogenic networks underlying drug-resistant epilepsy with amygdala enlargement and found that most cases involved a combination of temporal and other networks. Amygdala enlargement could reflect an interaction between stress-mediated limbic network alterations and mechanisms of epileptogenesis.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Marie Arthuis, Stanislas Lagarde, Aileen Mcgonigal, Fabrice Bartolomei
Summary: Forced normalization refers to the appearance of psychiatric disturbance following control of previously uncontrolled epileptic seizures. This case report discusses the occurrence of acute psychosis after epilepsy surgery and raises questions about the relationship between forced normalization and the effect of surgery itself.
EPILEPTIC DISORDERS
(2022)
Article
Clinical Neurology
Aileen McGonigal
Summary: Frontal lobe seizures are debilitating and diverse, making them challenging to evaluate. Research has shown that motor symptoms reflect the hierarchical organization of the frontal lobe, aiding in presurgical localization. Distinguishing between different frontal sublobar regions is possible based on motor and emotional signs. The semiology of frontal lobe seizures also provides valuable in vivo human behavioral data for neuroscience.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
I Kotwas, M. Arthuis, M. Cermolacce, F. Bartolomei, A. McGonigal
Summary: This article reviews the guidelines for the diagnosis and management of psychogenic non-epileptic seizures (PNES) and discusses the team's experience in managing patients. The article emphasizes the importance of a multidisciplinary team approach in optimizing patient care.
REVUE NEUROLOGIQUE
(2022)
Article
Clinical Neurology
Lisa-Dounia Soncin, Sylvane Faure, Aileen McGonigal, Tatiana Horowitz, Sara Belquaid, Fabrice Bartolomei, Eric Guedj
Summary: The study suggests that there are specific brain changes in patients with temporal lobe epilepsy and PTSD, with hypometabolism in certain areas correlating with PTSD symptoms. This indicates a close relationship between epileptogenic and psychogenic processes in these individuals.
Article
Behavioral Sciences
Jean-Arthur Micoulaud-Franchi, Iliana Kotwas, Marie Arthuis, Lisa Soncin, Pauline Rontani, Geraldine Daquin, Michel Cermolacce, Fabrice Bartolomei, Aileen McGonigal
Summary: The study aimed to translate and validate the Epilepsy Anxiety Survey Instrument (EASI) in French people with epilepsy, and further investigate the screening properties of each dimension of the EASI in terms of Diagnostic and Statistical Manual of Mental Disorders (DSM) anxiety disorders and epilepsy specific anxiety disorders. The results showed that a significant proportion of epilepsy patients had anxiety disorders, but the screening performance for epilepsy specific anxiety symptoms was less satisfactory. The study proposed the Epilepsy-Specific Anxiety (ESA) 10-item screening instrument as a complementary tool.
EPILEPSY & BEHAVIOR
(2022)
Review
Clinical Neurology
Gerald A. Dienel, Lisa Gillinder, Aileen McGonigal, Karin Borges
Summary: Seizures often originate in epileptogenic foci. Between seizures (interictally), the foci and surrounding tissue often have low signals in FDG-PET, indicating glucose hypometabolism. Normal glucose but high glycogen levels have been found in epileptogenic brain areas during the interictal period. Glycogenolysis may lead to low FDG signals and contribute to seizure generation.
Article
Clinical Neurology
Baotian Zhao, Aileen McGonigal, Wenhan Hu, Chao Zhang, Xiu Wang, Jiajie Mo, Xiaobin Zhao, Lin Ai, Xiaoqiu Shao, Kai Zhang, Jianguo Zhang
Summary: This study investigated the quantitative relationship between interictal FDG- PET and HFOs in patients with refractory epilepsy. The results showed a negative correlation between interictal FDG-PET and HFOs. The concordance between FRs and hypometabolism inside the resection volume could provide prognostic information regarding surgical outcome.
Editorial Material
Clinical Neurology
Lorryn Delle Baite, Evelyn E. Harvey, Michael W. K. Fong, Aileen McGonigal, Sarah J. Wilson
Editorial Material
Clinical Neurology
Aileen McGonigal
Article
Behavioral Sciences
Lisa-Dounia Soncin, Sara Belquaid, Aileen Mcgonigal, Bernard Giusiano, Fabrice Bartolomei, Sylvane Faure
Summary: Epilepsy patients with PTSD experience cognitive changes such as heightened executive attentional control, weakened emotional inhibition, and improved seizure control perception. The study found a positive correlation between PTSD scores and performance at the executive control task. In the emotional inhibition task, behavioral inhibition errors were positively correlated with PTSD scores, specifically with hypervigilance symptoms in PTSD+ patients.
EPILEPSY & BEHAVIOR
(2023)
Article
Clinical Neurology
Aileen McGonigal, Christel Becker, Julia Fath, Kahina Hammam, Karine Baumstarck, Sara Fernandes, Bernard Giusiano, Stephane Dufau, Sylvain Rheims, Louis Maillard, Arnaud Biraben, Jean-Jacques Benoliel, Christophe Bernard, Fabrice Bartolomei
Summary: This study found that the use of anti-seizure medications affects serum BDNF levels in patients with epilepsy. However, the correlation between BDNF and epilepsy severity or psychiatric comorbidities is still unclear and requires further research.
Review
Neurosciences
Dhanisha J. Jhaveri, Aileen McGonigal, Christel Becker, Jean-Jacques Benoliel, L. Sanjay Nandam, Lisa Soncin, Iliana Kotwas, Christophe Bernard, Fabrice Bartolomei
Summary: Stress is identified as a major contributor to human disease, including epilepsy. This review explores the complex relationship between stress and epilepsy, highlighting key neurobiological mechanisms. It discusses current clinical management approaches and proposes the development of new treatments that target shared mechanisms of stress and epilepsy. The integration of data from genetics to systems biology is emphasized, with the potential for personalized interventions using machine learning and neuromodulation strategies.
Proceedings Paper
Acoustics
Jen-Cheng Hou, Aileen McGonigal, Fabrice Bartolomei, Monique Thonnat
Summary: This study proposes a method to classify epileptic seizures and psychogenic non-epileptic seizures based on clinical signs in seizure videos. By pre-training a Transformer-based framework on large unlabeled clinical videos and fine-tuning it with minimal modification, the study achieves good classification performance.
2022 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH AND SIGNAL PROCESSING (ICASSP)
(2022)
