Article
Oncology
Crystal J. Hare, Cassandra Crangle, Kaitlin McGarragle, Sarah E. Ferguson, Tae L. Hart
Summary: This study examines the impact of change in cancer-related fatigue (CRF) over time on health-related quality of life (HRQOL) in ovarian cancer patients. The results suggest that CRF negatively affects all domains of HRQOL except for social wellbeing. Improvement in CRF is associated with recovery in HRQOL domains, while development of CRF leads to a decline in HRQOL domains over time.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Adriaan Penson, Iris Walraven, Ewald Bronkhorst, Heleen Maurice-Stam, Martha A. Grootenhuis, Margriet Van der Heiden-van der Loo, Wim J. E. Tissing, Helena J. H. Van der Pal, Andrica C. H. De Vries, Dorine Bresters, Cecile Ronckers, Marry M. Van den Heuvel, Sebastian J. C. M. M. Neggers, Birgitta A. B. Versluys, Marloes Louwerens, Saskia M. F. Pluijm, Leontien C. M. Kremer, Nicole Blijlevens, Eline Van Dulmen-den Broeder, Hans Knoop, Jacqueline Loonen
Summary: The study found that fatigue in childhood cancer survivors can negatively impact vitality, general health, and role limitations. Therefore, timely treatment of fatigue is crucial for the quality of life of survivors.
Review
Public, Environmental & Occupational Health
Shirin Jalili, Ramin Ghasemi Shayan
Summary: Health assessment data is crucial for developing care plans and understanding patient needs. The Quality of Life of cancer patients is significantly impacted by the disease, with symptoms such as pain having a negative effect.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Ying-Wen Wang, Yu-Che Ou, Hao Lin, Kun-Siang Huang, Hung-Chun Fu, Chen-Hsuan Wu, Ying-Yi Chen, Szu-Wei Huang, Hung-Pin Tu, Ching-Chou Tsai
Summary: Cancer-related fatigue (CRF) is common in gynecological cancer patients and often goes unnoticed. This study aimed to explore the prevalence and clinical characteristics of CRF in these patients. The results showed that 77.9% of patients had received fatigue management, and a predictive model was developed to help identify high-risk patients.
Review
Oncology
Liu Dun, Wu Xian-Yi, Huang Si-Ting, Yu Xin-Yuan
Summary: Sleep interventions have a positive impact on the overall quality of life and physical fatigue of cancer patients, but do not significantly affect emotional fatigue, emotional function, perpetual fatigue, depression, or sleep quality. Comprehensive interventions focusing on sleep are beneficial in alleviating cancer-related fatigue.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Wei Dai, Wenhong Feng, Yuanqiang Zhang, Xin Shelley Wang, Yangjun Liu, Cecilia Pompili, Wei Xu, Shaohua Xie, Yaqin Wang, Jia Liao, Xing Wei, Run Xiang, Bin Hu, Bo Tian, Xiaozun Yang, Xiang Wang, Ping Xiao, Qi Lai, Xin Wang, Bangrong Cao, Qifeng Wang, Fang Liu, Xiaoqin Liu, Tianpeng Xie, Xiaojun Yang, Xiang Zhuang, Zhong Wu, Guowei Che, Qiang Li, Qiuling Shi
Summary: The study evaluated the efficacy and feasibility of patient-reported outcome (PRO)-based symptom management in the early period after lung cancer surgery. Results showed that PRO-based symptom management reduced symptom burden and complications compared to usual care.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Oncology
Tae-Young Choi, Lin Ang, Ji Hee Jun, Terje Alraek, Stephen Birch, Weidong Lu, Myeong Soo Lee
Summary: This study aimed to evaluate the efficacy and safety of acupuncture (AT) in the management of breast cancer-related fatigue (CRF). The results showed that AT had a beneficial effect compared with sham acupuncture and usual care on fatigue scores, and had a long-term effect on fatigue score. However, the methodological quality of the included studies was low and the sample sizes were small.
Article
Endocrinology & Metabolism
Zhuan Lv, Ruidong Liu, Kaiqi Su, Yiming Gu, Lu Fang, Yongfu Fan, Jing Gao, Xiaodi Ruan, Xiaodong Feng
Summary: This study investigated the effects of acupuncture treatment on cancer-related fatigue (CRF) and gut microbiota in mice with breast cancer (BC) undergoing chemotherapy. The results showed that acupuncture treatment had an anti-fatigue effect and improved gut barrier, gut inflammation, neuroinflammation, and dysfunction of the HPA axis. Furthermore, acupuncture treatment modulated the abundance of specific gut microbiota and altered serum metabolites. These findings suggest that the anti-fatigue mechanism of acupuncture treatment may be closely related to the gut microbiota-gut-brain axis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Tae-Young Choi, Lin Ang, Ji Hee Jun, Terje Alraek, Myeong Soo Lee
Summary: Acupuncture and moxibustion are commonly used for the management of cancer-related fatigue (CRF), but the methodological quality of most studies is low, limiting the ability to draw definitive conclusions. Further high-quality research is needed to confirm the findings.
Article
Oncology
Sarah N. Price, Amanda M. Palmer, Lisa M. Fucito, Evan M. Graboyes, Nathaniel L. Baker, Alana M. Rojewski, Benjamin A. Toll
Summary: This study examined the relationship between tobacco use and symptom burden in cancer survivors. The results showed that both smoking and vaping were associated with increased fatigue, pain, and emotional problems. However, the symptom burden did not affect the survivors' interest in quitting smoking. Future research should focus on the role of tobacco cessation in improving symptom burden and quality of life.
Article
Nursing
Xiaoli Chen, Juejin Li, Chongcheng Chen, Yalin Zhang, Shu Zhang, Yun Zhang, Lin Zhou, Xiaolin Hu
Summary: Exercise interventions have been found to significantly improve cancer-related fatigue and quality of life among cancer patients, based on a meta-analysis of randomized controlled trials. Particularly, aerobic exercise interventions of less than 12 weeks and at a frequency of three times per week have been shown to have the most positive effects. These interventions are especially effective for female cancer patients.
Article
Oncology
Martina E. Schmidt, Susanne Bergbold, Silke Hermann, Karen Steindorf
Summary: The study found that most cancer patients have inadequate knowledge about fatigue, healthcare professionals rarely ask patients about their fatigue, and there are deficiencies in fatigue management that need targeted improvements based on patients' needs.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Anne Katrine G. Levinsen, Susanne O. Dalton, Ingelise Andersen, Anders Mellemgaard, Marianne S. Oksen, Lena Saltbaek, Nina H. G. Hansen, Signe Carlsen, Trille K. Kjaer
Summary: This study aimed to investigate the association between health-related quality of life (HRQOL) at the time of diagnosis and the completion of planned first-line oncological treatment for lung cancer patients. The study found that patient with reduced function and patients reporting symptoms such as fatigue, pain, appetite loss, and financial difficulties were more likely to not complete the planned treatment. Assessing HRQOL may contribute to optimizing the treatment plan for lung cancer patients.
Review
Oncology
Alexander Haussmann, Martina E. Schmidt, Mona L. Illmann, Marleen Schroter, Thomas Hielscher, Holger Cramer, Imad Maatouk, Markus Horneber, Karen Steindorf
Summary: This meta-analysis aimed to identify intervention characteristics associated with greater reductions in cancer-related fatigue (CRF). The results showed that yoga, psychosocial, and mindfulness-based interventions all had a positive effect on CRF, but there were significant differences in the effects of different intervention types. In psychosocial interventions, using a group setting and working on cognition were related to higher efficacy. No specific intervention characteristics emerged as more favorable than others for yoga and mindfulness-based interventions. This study suggests opportunities to optimize psychosocial interventions for CRF, while the design of yoga and mindfulness-based interventions seems to allow for variation.
Article
Oncology
Hilde Van Parijs, Vincent Vinh-Hung, Christel Fontaine, Guy Storme, Claire Verschraegen, Dung M. Nguyen, Nele Adriaenssens, Nam P. Nguyen, Olena Gorobets, Mark De Ridder
Summary: Comparison between conventional radiotherapy and tomotherapy on long-term patient-reported outcomes (PRO) after breast cancer adjuvant radiotherapy showed that modern radiation therapy can significantly improve long-term PRO for patients.
Review
Oncology
Jiaqiang Wang, Chien-shan Cheng, Yan Lu, Shen Sun, Shaoqiang Huang
Summary: Volatile anesthetics are widely used in clinical anesthesia and have drawn attention for their potential anti-cancer signaling regulation. Research progress on this topic, including in vitro, in vivo, and clinical studies, aims to uncover underlying molecular mechanisms and provide insights for guiding clinical anesthesia procedures and enhancing postoperative recovery.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fengjiao Wang, Lai Wang, Chao Qu, Lianyu Chen, Yawen Geng, Chienshan Cheng, Shulin Yu, Dan Wang, Lina Yang, Zhiqiang Meng, Zhen Chen
Summary: Kaempferol effectively suppresses pancreatic cancer by upregulating ROS levels and inducing apoptosis via TGM2-mediated Akt/mTOR signaling pathway. High TGM2 expression is correlated with poor prognosis in pancreatic cancer patients, and TGM2 may serve as a promising prognostic biomarker for pancreatic cancer.
Review
Pharmacology & Pharmacy
Sha Li, Chien-Shan Cheng, Cheng Zhang, Guo-Yi Tang, Hor-Yue Tan, Hai-Yong Chen, Ning Wang, Agnes Yuen-Kwan Lai, Yibin Feng
Summary: The study examines the potential of edible plants and compounds in preventing and managing COVID-19, focusing on analyzing their underlying mechanisms to identify dietary supplements and functional foods that may help manage this epidemic.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Yuanyuan Chen, Chien-shan Cheng, Hor-Yue Tan, Chi Wing Tam, Ning Wang, Yibin Feng
Summary: This review evaluates the efficacy of traditional herbal medicines in alleviating chemotherapy-induced gastrointestinal toxicity and suggests that herbal medicines combined with chemotherapy can significantly reduce symptoms of CIGI toxicity, although no significant effects were seen in studies with a double-blind design. Further research and well-designed trials are needed to evaluate treatment efficacy comprehensively.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pang Haopeng, Dang Xuefei, Chen Zengai, Yao Zhenwei, Cheng Chien-shan, Meng Zhiqiang
Summary: This study aimed to determine the association between the apparent diffusion coefficient (ADC) and cellularity, as well as the nuclear-to-cytoplasmic (N/C) ratio, in C6 glioma. Through magnetic resonance scanning and immunostaining, it was found that the minimal ADC correlated well with cellularity and N/C ratios, and may serve as a biomarker for these pathological features.
ACADEMIC RADIOLOGY
(2022)
Article
Mathematical & Computational Biology
Soutik Ghosal, Zhen Chen
Summary: The study used longitudinal ultrasound examination data to estimate diagnostic accuracy parameters for predicting large fetuses at birth. The integration of placement value and Bayesian regression model proved to be more effective in simulations and application to real data. The diagnostic accuracy of estimated fetal weight was found to improve by about 65% from week 17 to 37 of gestation according to the Scandinavian Study data.
STATISTICS IN BIOSCIENCES
(2022)
Article
Plant Sciences
Pan-ling Xu, Chien-shan Cheng, Ju-ying Jiao, Hao Chen, Zhen Chen, Ping Li
Summary: This study explores the potential mechanism of matrine injection on pancreatic cancer through network pharmacology technique and in vitro experimental validation. The results show that matrine injection inhibited proliferation, arrested the cell cycle, and induced apoptosis of pancreatic cancer cells. The mechanism may be related to the induction of CA12 over-expression, and CA9 reduced expression. Carbonic anhydrases are identified as novel targets for pancreatic cancer treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Jiao Ju-ying, Cheng Chien-snan, Cao Zhang-qi, Chen Lian-Yu, Chen Zhen
Summary: Cancer, a deadly disease, has limited therapeutic options. Complementary and alternative medicine, particularly Chinese medicine, has been widely used in cancer management. However, there is a lack of understanding about the molecular characteristics of dampness-heat syndrome and a standardized animal model for studying this core syndrome in vivo.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Nutrition & Dietetics
Ling-Jun Li, Ruochen Du, Marion Ouidir, Ruijin Lu, Zhen Chen, Natalie L. Weir, Michael Y. Tsai, Paul S. Albert, Cuilin Zhang
Summary: Saturated fatty acids (SFAs) during pregnancy have an impact on metabolic programming and fetal growth. In this study, plasma phospholipid SFAs were measured in early pregnancy and fetal growth was monitored. It was found that even-chain and very long even-chain SFAs were negatively associated, while odd-chain SFAs were positively associated with fetal weight and size. Pentadecanoic acid (15:0) in the highest tertile showed a greater fetal weight and size compared to the lowest tertile. These findings suggest the potential use of an alternative high-fat diet rich in odd-chain SFAs for optimal fetal growth.
Article
Cardiac & Cardiovascular Systems
Lai Wang, Fengjiao Wang, Lianyu Chen, Yawen Geng, Shulin Yu, Zhen Chen
Summary: The study found that long-term adolescent and young adult cancer survivors have a higher risk of cardiovascular disease mortality compared to the general population and childhood cancer survivors, especially those with Hodgkin's lymphoma and central nervous system tumors who require continued close monitoring for cardiovascular conditions.
EUROPEAN HEART JOURNAL
(2021)
Article
Oncology
Yawen Geng, Jie Fan, Lianyu Chen, Chenyue Zhang, Chao Qu, Ling Qian, Kun Chen, Zhiqiang Meng, Zhen Chen, Peng Wang
Summary: This study uncovered a Notch-dependent feedback circuit between pancreatic cancer cells and macrophages, which promotes PDAC metastasis through miR-124, IL6, and STAT3 signaling pathways. Disrupting this circuit could potentially be a therapeutic approach for treating PDAC metastasis.