Review
Nutrition & Dietetics
Megan Crichton, Patsy M. Yates, Oluwaseyifunmi Andi Agbejule, Amy Spooner, Raymond J. Chan, Nicolas H. Hart
Summary: This study reviewed the effects of non-pharmacological self-management interventions on chemotherapy-induced peripheral neurotherapy in people with advanced cancer. The study found that physical exercise had a certain effect in reducing the severity of peripheral neurotherapy and improving physical function, while the evidence for other interventions was limited. More well-designed studies are needed to explore the effects of these interventions.
Review
Oncology
Manaal Siddiqui, Basma Abdellatif, Kevin Zhai, Alena Liskova, Peter Kubatka, Dietrich Busselberg
Summary: Flavonoids show promising potential in treating CIPN by reducing oxidative stress, inflammation, and neuronal damage. Further research is needed to evaluate the efficacy and side effects of flavonoids in human models before clinical benefits can be realized.
Article
Oncology
A. Lemanska, A. Harkin, T. Iveson, C. Kelly, M. Saunders, S. Faithfull
Summary: This study investigates the association of chemotherapy-induced peripheral neuropathy (CIPN) with age, sex, body mass index, baseline neuropathy, and chemotherapy regimen in patients treated with adjuvant oxaliplatin-containing chemotherapy for colorectal cancer. The findings suggest that the chemotherapy regimen and baseline neuropathy scores are associated with CIPN. Pre-treatment neuropathy assessment may help identify individuals at risk of developing CIPN.
Review
Medicine, General & Internal
Cindy Tofthagen, Mary Tanay, Adam Perlman, Jason Starr, Pooja Advani, Katharine Sheffield, Tara Brigham
Summary: This study evaluated the relationship between laboratory measures of nutrition and chemotherapy induced peripheral neuropathy (CIPN). It found that hemoglobin/hematocrit, vitamin D, albumin, and magnesium were associated with CIPN. Further research is needed to confirm these associations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Florent Bienfait, Arthur Julienne, Sabrina Jubier-Hamon, Valerie Seegers, Thierry Delorme, Virginie Jaoul, Yves-Marie Pluchon, Nathalie Lebrec, Denis Dupoiron
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and painful condition that can occur during or after cancer treatment. The high-concentration capsaicin patch (HCCP) is recommended as a second-line treatment, but there is limited evidence supporting its efficacy. This retrospective study aimed to evaluate the effectiveness and tolerability of HCCP in CIPN. The results showed that HCCP provided important or complete pain relief in 33.2% of the applications, corresponding to 43.9% of the patients. The effectiveness of HCCP varied depending on the type of chemotherapy and the line of analgesic treatment. The study also found that HCCP became more effective with repeated applications, starting from the third application. Local adverse events were the main side effects associated with HCCP. Overall, HCCP applications in painful CIPN were effective in relieving pain and generally well-tolerated.
Article
Oncology
Ian R. Kleckner, Todd A. Jusko, Eva Culakova, Kaitlin Chung, Amber S. Kleckner, Matthew Asare, Julia E. Inglis, Kah Poh Loh, Luke J. Peppone, Jessica Miller, Marianne Melnik, Samer Kasbari, Deborah Ossip, Karen M. Mustian
Summary: This study identified that fatigue, anxiety, depression, and baseline neuropathy were the strongest predictors of chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer patients before receiving taxane or platinum-based chemotherapy. Inflammation, as indicated by specific cytokine levels, also played a role in predicting CIPN severity.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Oncology
Diana Molinares, Sara Kurtevski, Yingrong Zhu
Summary: This review focuses on the pathophysiology, diagnosis, clinical presentation, and treatment of chemotherapy-induced peripheral neuropathy. It also discusses the agent-specific presentation and pathophysiology. Understanding the intricacies of this condition can provide physicians with better treatment tools and research opportunities to develop or identify new therapeutic agents.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Oncology
Ya-Jung Wang, Ya-Ning Chan, You-Wun Jheng, Chih-Jung Wu, Ming-Wei Lin, Ling-Ming Tseng, Yi-Fang Tsai, Liang-Chih Liu
Summary: This study aimed to explore the severity and prevalence of chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer survivors receiving taxane treatment. The results showed that both clinician-assessed and patient-reported CIPN increased over time, with the highest prevalence at chemotherapy completion. There were mild to moderate correlations between subjective and objective assessments of CIPN.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Environmental Sciences
Ines Klein, Helmar C. Lehmann
Summary: Peripheral neuropathy is a common side effect of chemotherapy, affecting up to 60% of cancer patients. Paclitaxel induces neuropathy in gynecological and urological cancer patients, leading to cell death and affecting both central and peripheral nervous system cells. Symptoms include pain and numbness in hands and feet, with pathomechanisms involving axonal damage and disrupted axonal transport.
Article
Oncology
Maryam Lustberg, Xuan Wu, Juan Luis Fernandez-Martinez, Enrique J. de Andres-Galiana, Santosh Philips, Jeffrey Leibowitz, Bryan Schneider, Stephen Sonis
Summary: The study assessed the utility of a collective SNP cluster identified using novel analytics for describing taxane-associated CIPN risk. A cluster of 267 SNPs was found to be associated with a CIPN+ phenotype with an accuracy of 96.1%.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Costantine Albany, Travis Dockter, Eric Wolfe, Jennifer Le-Rademacher, Nina Wagner-Johnston, Lawrence Einhorn, Jacqueline M. Lafky, Ellen Smith, Deirdre Pachman, Nathan Staff, Cynthia Ma, Charles L. Loprinzi, Brian A. Costello
Summary: The study aimed to compare cisplatin-induced peripheral neuropathy with neuropathy induced by other chemotherapy drugs, showing that cisplatin-induced neuropathy was more similar to oxaliplatin-induced neuropathy compared to paclitaxel-induced neuropathy, potentially due to the younger age of cisplatin recipients. Understanding the similarities and differences in neuropathy caused by different chemotherapy agents may help in elucidating CIPN processes and in developing strategies to prevent and/or treat established CIPN.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Multidisciplinary Sciences
Grace Ji-eun Shin, Maria Elena Pero, Luke A. Hammond, Anita Burgos, Atul Kumar, Samantha E. Galindo, Tanguy Lucas, Francesca Bartolini, Wesley B. Grueber
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect from cancer treatment with no known prevention or cure. Studying a genetically tractable Drosophila model and mouse sensory neurons, researchers have identified potential protective pathways against CIPN, shedding light on the mechanisms underlying this condition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Mary Anne Lagmay Tanay, Glenn Robert, Anne Marie Rafferty, Rona Moss-Morris, Jo Armes
Summary: The study highlights the lack of overall familiarity with CIPN among patients and limited knowledge and understanding about CIPN among clinicians, emphasizing the need for improvement. Patients and clinicians expect more transparency in reporting, providing information, and managing CIPN symptoms. Insights from patient and clinicians' CIPN experiences can inform future interventions to meet patients' genuine needs and enhance CIPN support.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Review
Oncology
Alisha Joan Leen, Dominic Wei Ting Yap, Chong Boon Teo, Benjamin Kye Jyn Tan, Alex Molassiotis, Hiroshi Ishiguro, Sarah Wei Xian Fan, Raghav Sundar, Yu Yang Soon, Aishwarya Bandla
Summary: The study found that non-pharmacological neuroprotective interventions are more effective than pharmacological methods in preventing PIPN, leading to a significant reduction in the incidence of PIPN.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Minjee Kim, Hyeyoung Kim, Bu-Gyeong Kang, Jooyoung Lee, Taegun Kim, Hwanho Lee, Jane Jung, Myung Joon Oh, Seungyoon Seo, Myung-Jeom Ryu, Yeojin Sung, Yunji Lee, Jeonghun Yeom, Gyoonhee Han, Sun-Shin Cha, Hosung Jung, Hyun Seok Kim
Summary: This study identifies a novel NAMPT inhibitor, A4276, that selectively targets NAPRT-deficient EMT-subtype cancer cells and prevents chemotherapy-induced peripheral neuropathy. It highlights the potential of A4276 as a promising anti-cancer agent for use in cancer monotherapy or combination therapy with conventional chemotherapeutics.
Article
Chemistry, Medicinal
Chien-Ming Huang, Ping-Jyun Sung, Yueh-Hsiung Kuo, Tsung-Hsien Chang, Chun-Lin Chen, Ming-Jen Cheng, Jih-Jung Chen
CHEMISTRY OF NATURAL COMPOUNDS
(2020)
Article
Biochemistry & Molecular Biology
Fu-Kai Chuang, Ching-Len Liao, Ming-Kuan Hu, Yi-Lin Chiu, An-Rong Lee, Shih-Ming Huang, Yu-Lung Chiu, Pei-Ling Tsai, Bo-Cyuan Su, Tsung-Hsien Chang, Chang-Chi Lin, Chih-Chin Shih, Li-Chen Yen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
An-Jen Chiang, Chia-Jung Li, Kuan-Hao Tsui, Chung Chang, Yuan-chin Ivan Chang, Li-Wen Chen, Tsung-Hsien Chang, Jim Jinn-Chyuan Sheu
Summary: The study found that UBE2C is highly expressed in human cervical squamous cell carcinoma (CESC) tissues and is related to clinical characteristics. In vitro experiments demonstrated that overexpression and knockdown of UBE2C respectively enhanced and reduced proliferation of cervical cancer cells. In vivo experiments showed that UBE2C regulates the expression and activity of the mTOR/PI3K/AKT pathway.
Article
Microbiology
Ming-Hsiang Kung, Ming-Wei Jan, Jih-Jung Chen, Yi-Chien Shieh, Tsung-Hsien Chang
Article
Microbiology
Bao-Chen Chen, Tsi-Shu Huang, Nuan-Ya Huang, Chiao-Shan Chen, Yao-Shen Chen, Tsung-Hsien Chang
Summary: This study described the first two cases of Aichi virus infection in Taiwan and analyzed the seroprevalence of Aichi virus in the region, with results indicating a relatively low seroprevalence compared to other countries.
Article
Chemistry, Medicinal
I-Chou Wang, Li-Chai Chen, Tsung-Hsien Chang, Chun-Lin Chen, Ping-Jyun Sung, Rong-An Lin, Ming-Jen Cheng, Jen-Wen Hsiao, Jih-Jung Chen
Summary: A new coumarin derivative, 7-O-methylparamicoumarin A, was isolated from Chionanthus retusus roots along with seven known compounds. Luteolin, quercetin, and apigenin exhibited cytotoxicity against different cancer cell lines, suggesting potential anticancer properties.
CHEMISTRY OF NATURAL COMPOUNDS
(2021)
Article
Chemistry, Medicinal
Fu-Sen Wu, Ching-Ju Hung, Chien-Liang Lin, Hsueh-Yang Huang, Yueh-Hsiung Kuo, Tsung-Hsien Chang, Chun-Lin Chen, Ping-Jyun Sung, Ming-Jen Cheng, Chu-Wen Kuo, Jih-Jung Chen
Summary: A new benzophenone derivative, hyperinokone, along with six known compounds, was isolated from the aerial part of Hypericum nokoense. Compound 1 and some other known compounds exhibited good activity in terms of cytotoxicity and inhibition of NO production.
CHEMISTRY OF NATURAL COMPOUNDS
(2021)
Article
Chemistry, Medicinal
Chien-Ming Huang, Chun-Hao Chang, Chang-Syun Yang, Chien-Liang Lin, Tsung-Hsien Chang, Chun-Lin Chen, Ping-Jyun Sung, Ming-Jen Cheng, Chieh-Yang Cheng, Jih-Jung Chen
Summary: A new acenaphthylene derivative, salviarisanal (1), was isolated from Salvia arisanensis, along with six known compounds. Among these isolates, certain compounds exhibited cytotoxicity against various cancer cell lines, indicating potential anti-tumor activity.
CHEMISTRY OF NATURAL COMPOUNDS
(2021)
Article
Genetics & Heredity
Kai-Che Wei, Shih-Fan Lai, Wei-Lun Huang, Kuo-Chung Yang, Ping-Chin Lai, Wan-Ju Wei, Tsung-Hsien Chang, Yun-Chen Huang, Ya-Chuan Tsai, Shin-Chih Lin, Sun-Jang Lin, Shih-Chieh Lin
Summary: YAP1 overexpression in skin specimens from FICRD patients plays a protective role by promoting DNA damage repair and inhibiting fibrosis. Targeting YAP1 downstream genes like NR3C1, which encodes glucocorticoid receptor, has therapeutic potential for FICRD patients. Investigating the underlying mechanism of FICRD is crucial for developing effective treatments.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Immunology
Ming-Wei Jan, Hong-Lin Su, Tsung-Hsien Chang, Kuen-Jer Tsai
Summary: Human parechovirus type 3 (PeV-A3) infection is identified as a cause of severe nerve disease or sepsis in infants and young children, with neuropathogenic mechanisms involving interferon and inflammatory cytokine expression, activation of death signaling pathways, and establishment of an experimental disease model of parechovirus encephalitis. In vivo studies in neonatal mice showed weight loss, paralysis, and mortality, with evidence of PeV-A3 infection, inflammatory cytokine expression, and death signaling transduction in the brain tissues. These findings suggest that PeV-A3-mediated neurological disorders involve activation of death signaling and inflammation responses, which may contribute to clinical manifestations associated with PeV-A3 infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Hsiao-Ting Chen, Chi-Wen Chuang, Ju-Chien Cheng, Yung-Ju Yeh, Tsung-Hsien Chang, Yu-Ting Shi, Chih-Hua Chao
Summary: Two rearranged terpenoids with a rare moiety and a megastigmane were isolated from the leaves of Euphorbia leucocephala. In addition, three known compounds were also identified. These compounds showed potent anti-influenza A virus activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Virology
Ming-Wei Jan, Chih-Yun Chiu, Jih-Jung Chen, Tsung-Hsien Chang, Kuen-Jer Tsai
Summary: This study found that the infection of Parechovirus type-A3 (PeV-A3) was reduced in human platelet lysate (hPL)-cultured cells compared to fetal bovine serum (FBS)-cultured cells. Mechanistic analysis revealed that hPL stimulates the type I interferon (IFN) antiviral pathway, resulting in the activation of related transcription factors and the expression of antiviral genes. Enhanced PeV-A3 replication was observed in hPL-cultured cells treated with STAT-1 inhibitor and STAT1 shRNA. These findings suggest that hPL may have potential antiviral effects.
Article
Chemistry, Medicinal
Hui-Ming Chen, Chien-Ming Huang, Li-Chai Chen, Chang-Syun Yang, Tsung-Hsien Chang, Chun-Lin Chen, Ping-Jyun Sung, Wen-Lung Kuo, Ming-Jen Cheng, Jen-Wen Hsiao, Jih-Jung Chen
Summary: A new triterpenoid compound was isolated from the leaves of Eriobotrya deflexa f. deflexa, and its structure was determined. This compound, along with other known compounds, exhibited inhibitory effects on LPS-induced NO generation.
CHEMISTRY OF NATURAL COMPOUNDS
(2022)
Article
Chemistry, Medicinal
Fu-Sen Wu, Ching-Ju Hung, Chien-Liang Lin, Tsung-Hsien Chang, Chun-Lin Chen, Ping-Jyun Sung, Ming-Jen Cheng, Hsueh-Yang Huang, Jih-Jung Chen
CHEMISTRY OF NATURAL COMPOUNDS
(2020)
Article
Chemistry, Medicinal
Jen-Wen Hsiao, Li-Chai Chen, Chien-Liang Lin, Tsung-Hsien Chang, Chun-Lin Chen, Ping-Jyun Sung, Ming-Jen Cheng, Ching-Ju Hung, Jih-Jung Chen
CHEMISTRY OF NATURAL COMPOUNDS
(2020)