Article
Medicine, Research & Experimental
Kewei Liu, Juan Zhu, Yuan Chang, Zhenzhou Lin, Zhu Shi, Xing Li, Xing Chen, Chuman Lin, Suyue Pan, Kaibin Huang
Summary: The study suggests that post-seizure cerebral edema may impair glymphatic system function, making the brain vulnerable to p-tau aggregation and neurocognitive impairment.
Review
Immunology
Yan-mei Qiu, Chun-lin Zhang, An-qi Chen, Hai-ling Wang, Yi-fan Zhou, Ya-nan Li, Bo Hu
Summary: Blood-Brain Barrier (BBB) disruption is a crucial pathophysiological process in acute ischemic stroke, where the rapid activation of immune cells plays a critical role. Infiltrating immune cells increase BBB permeability, causing microvascular disorder, but also promote BBB repair and angiogenesis. Understanding the inflammatory mechanisms behind BBB disruption can lead to the development of more effective therapeutics for acute ischemic stroke.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Nicholas H. Varvel, Claudia Espinosa-Garcia, Sarah Hunter-Chang, Di Chen, Ariel Biegel, Allison Hsieh, Lisa Blackmer-Raynolds, Thota Ganesh, Raymond Dingledine
Summary: The study shows that blocking the activation of EP2 receptors on immune myeloid cells plays a role in alleviating post-seizure inflammatory responses and BBB breakdown, but does not significantly affect neurodegeneration.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Marco de Curtis, Andrea O. Rossetti, Diogo Vila Verde, Erwin A. van Vliet, Christine T. Ekdahl
Summary: Status Epilepticus (SE) is a neurological emergency characterized by abnormally sustained seizures, which can result in long-term consequences for the brain. However, the specific effects of different types of SE on brain pathology and long-term deficits in patients are still not clearly understood.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Alejandra Palomino-Antolin, Paloma Narros-Fernandez, Victor Farre-Alins, Javier Sevilla-Montero, Celine Decouty-Perez, Ana Belen Lopez-Rodriguez, Nuria Fernandez, Luis Monge, Ana Casas, Maria Jose Calzada, Javier Egea
Summary: This study investigates the role and mechanism of NLRP3 inflammasome in ischemic stroke. The findings suggest that post-reperfusion inhibition of NLRP3 may be an effective therapy for protecting the blood-brain barrier and improving neuro-motor function in cerebral ischemia.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
David Martin-Hernandez, Marina Munoz-Lopez, Hiram Tendilla-Beltran, Javier R. Caso, Borja Garcia-Bueno, Luis Menchen, Juan C. Leza
Summary: Extensive research has shown the importance of immune alterations and dysfunctional biological barriers in psychiatric disorders. The leaky gut phenomenon, closely related to the brain and intestinal barriers, may contribute to inflammation in these conditions. Drugs based on sphingosine-1-phosphate (S1P), such as fingolimod and ozanimod, have been approved for multiple sclerosis and ulcerative colitis treatment, sparking a debate for their use in psychiatry. This review focuses on the molecular mechanisms of S1P in modulating the immune system and brain/intestinal barriers, aiming to uncover innovative therapies for psychiatric diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Assaf Zinger, Sirena Soriano, Gherardo Baudo, Enrica De Rosa, Francesca Taraballi, Sonia Villapol
Summary: The study developed leukocyte-based biomimetic nanoparticles for direct treatment of traumatic brain injury, achieving selective targeting of the damaged brain and accumulation in peripheral organs. The therapeutic approach showed potential efficacy in reducing brain damage.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Geetika Nehra, Bjoern Bauer, Anika M. S. Hartz
Summary: This review summarizes the extent and clinical relevance of barrier leakage in Alzheimer's disease (AD). By examining animal models, clinical and postmortem studies, signaling mechanisms, and potential therapeutic strategies, the review provides insights into the relationship between barrier leakage and neurodegeneration, cognitive decline, and the development of novel therapeutic targets for AD.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Harrison Rudd, Michal Toborek
Summary: HIV can cross the blood-brain barrier through a Trojan horse-like mechanism, leading to central nervous system infection. Latent HIV can evade detection by the immune system and antiretroviral therapy (ART), and work synergistically with ART to promote neuroinflammatory pathophysiology. Therefore, further research into novel therapeutic approaches is needed.
Article
Multidisciplinary Sciences
Danylo Batulin, Fereshteh Lagzi, Annamaria Vezzani, Peter Jedlicka, Jochen Triesch
Summary: The study presents a mathematical model to understand the complex processes involved in the development of epilepsy. The model successfully describes the characteristics of epileptogenesis and can be used to predict therapeutic strategies.
Review
Pediatrics
T. Foiadelli, A. Santangelo, G. Costagliola, E. Costa, M. Scacciati, A. Riva, G. Volpedo, M. Smaldone, A. Bonuccelli, A. M. Clemente, A. Ferretti, S. Savasta, P. Striano, A. Orsini
Summary: Status epilepticus (SE) is a medical emergency that can lead to long-term consequences such as neuronal death and impaired neuronal networks. Inflammation has been shown to contribute to seizure onset and recurrence in SE. Understanding the molecular mechanisms of neuroinflammation is crucial for improving SE treatment. Currently, the main approach to SE treatment is the use of medication for symptom control.
FRONTIERS IN PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Jing Lu, Xiaobing Fan, Lei Lu, Yueyue Yu, Erica Markiewicz, Jessica C. Little, Ashley M. Sidebottom, Erika C. Claud
Summary: Maternal immune activation (MIA) derived from late gestational infection increases the risk of neurodevelopmental deficits in offspring. This study shows that MIA induced underdevelopment and dysfunction of the blood-brain barrier (BBB) in prewean mice, leading to impaired spatial learning later in life. Maternal supplementation of Limosilactobacillus reuteri (L. reuteri) rescued BBB development and cognitive function associated with BBB dysfunction.
Article
Biochemistry & Molecular Biology
Alex M. Dickens, Tory P. Johnson, Santosh Lamichhane, Anupama Kumar, Carlos A. Pardo, Erie G. Gutierrez, Norman Haughey, Mackenzie C. Cervenka
Summary: This study investigates the clinical outcomes and related factors in patients with super-refractory status epilepticus (SRSE) treated with a ketogenic diet. The results show a significant reduction in pro-inflammatory mediators IL-6 and CXCL13 after 1 and 2 weeks of ketogenic diet treatment, while higher levels of β-hydroxybutyrate in the blood are associated with better clinical outcomes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Immunology
Josephine A. Mapunda, Houyam Tibar, Wafa Regragui, Britta Engelhardt
Summary: Multiple Sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS), with varying prevalence worldwide. Understanding how immune cells enter the CNS and the effects of immunomodulatory treatments on neuroinflammation is crucial. The brain barriers play a key role in regulating immune cell entry into the CNS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Pedro N. Bernardino, Brad A. Hobson, Sydney L. Huddleston, Peter M. Andrew, Jeremy A. Macmahon, Naomi H. Saito, Valerie A. Porter, Donald A. Bruun, Danielle J. Harvey, Joel R. Garbow, Angie Gelli, Abhijit J. Chaudhari, Pamela J. Lein
Summary: Acute organophosphate intoxication can lead to seizures and chronic morbidities. This study used MRI and immunohistochemistry to investigate the spatiotemporal progression of blood-brain barrier (BBB) impairment following diisopropylfluorophosphate-induced status epilepticus in rats. The results showed increased BBB permeability starting at 6 hours post-exposure and persisting for 7 days, with the most severe and persistent impairment observed in the piriform cortex and amygdala. The extent of BBB leakage was correlated with the severity of behavioral seizures.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Cato M. Drion, Lieneke Kooijman, Derek Chan, Janna Berkhout, Erwin A. van Vliet, Wytse J. Wadman, Jan A. Gorter
Summary: The study found that curcumin can delay the development of epilepsy, but cannot prevent full kindling. The effects of curcumin on neuropathology were not significant, highlighting the need for further research into its potential as an anti-epileptic agent.
Article
Cell Biology
Frances S. Cho, Ilia D. Vainchtein, Yuliya Voskobiynyk, Allison R. Morningstar, Francisco Aparicio, Bryan Higashikubo, Agnieszka Ciesielska, Diede W. M. Broekaart, Jasper J. Anink, Erwin A. van Vliet, Xinzhu Yu, Baljit S. Khakh, Eleonora Aronica, Anna Molofsky, Jeanne T. Paz
Summary: Inflammatory processes induced by brain injury are important for recovery, but uncontrolled inflammation can be harmful. Chronic activation of glial cells in the thalamus has been suggested as an indicator of increased seizure risk and cognitive deficits after cortical injury. This study found that thalamic inflammation was sufficient to cause cellular and circuit hyperexcitability, enhanced seizure risk, and disruptions in cortical rhythms. Down-regulation of GAT-3 in thalamic astrocytes mediated this neurological dysfunction.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mirte Scheper, Alessia Romagnolo, Zein Mersini Besharat, Anand M. Iyer, Romina Moavero, Christoph Hertzberg, Bernhard Weschke, Kate Riney, Martha Feucht, Theresa Scholl, Borivoj Petrak, Alice Maulisova, Rima Nabbout, Anna C. Jansen, Floor E. Jansen, Lieven Lagae, Malgorzata Urbanska, Elisabetta Ferretti, Aleksandra Tempes, Magdalena Blazejczyk, Jacek Jaworski, David J. Kwiatkowski, Sergiusz Jozwiak, Katarzyna Kotulska, Krzysztof Sadowski, Julita Borkowska, Paolo Curatolo, James D. Mills, Eleonora Aronica
Summary: This study used RNA sequencing analysis to define the expression patterns of miRNAs and isomiRs in the serum of patients with TSC, and identified potential circulating molecular biomarkers using ROC curve analysis to discriminate the development of neuropsychiatric comorbidity in TSC patients.
Article
Clinical Neurology
Dominique Frances Leitner, Sasha Devore, Juliana Laze, Daniel Friedman, James D. Mills, Yan Liu, Michael Janitz, Jasper J. Anink, Johannes C. Baayen, Sander Idema, Erwin Alexander van Vliet, Beate Diehl, Catherine Scott, Roland Thijs, Maromi Nei, Manor Askenazi, Shobi Sivathamboo, Terence O'Brien, Thomas Wisniewski, Maria Thom, Eleonora Aronica, Maura Boldrini, Orrin Devinsky
Summary: This study aimed to explore the molecular mechanisms of prolonged postictal generalized electroencephalographic suppression (PGES) in patients with epilepsy. It was found that higher hippocampal 5HT2A receptor protein and potassium channel transcripts may be associated with PGES. Further studies with larger cohorts are needed to elucidate the underlying mechanisms of PGES and SUDEP risk.
Review
Biochemistry & Molecular Biology
Jody M. de Jong, Diede W. M. Broekaart, Anika Bongaarts, Angelika Muhlebner, James D. Mills, Erwin A. van Vliet, Eleonora Aronica
Summary: Seizures are a common symptom of brain tumors, especially in paediatric-type tumors. The extracellular matrix plays a role in epileptogenesis and tumorigenesis. Understanding the epileptogenic properties of brain tumors is crucial for improving health outcomes and developing novel therapies.
Article
Biochemistry & Molecular Biology
Diede W. M. Broekaart, Till S. Zimmer, Sophie T. Cohen, Rianne Tessers, Jasper J. Anink, Helga E. de Vries, Jan A. Gorter, Roger Prades, Eleonora Aronica, Erwin A. van Vliet
Summary: The gelatinase inhibitor ACT-03 has shown disease-modifying effects in epilepsy models by reducing neuroinflammation and preserving blood-brain barrier integrity. Further evaluation of its effects in clinical trials is warranted.
Article
Biology
Gabriele Ruffolo, Alessandro Gaeta, Beatrice Cannata, Camilla Pinzaglia, Eleonora Aronica, Alessandra Morano, Pierangelo Cifelli, Eleonora Palma
Summary: The potential use of phytocannabinoids (pCBs), specifically cannabidiol (CBD), to treat pathological conditions has gained attention in the scientific community. CBD has shown the ability to modulate GABAergic neurotransmission and may be effective in treating pharmaco-resistant epilepsy.
Article
Clinical Neurology
Laura Bindila, Tore Eid, James D. Mills, Michael S. Hildebrand, Gary P. Brennan, Susan A. Masino, Vicky Whittemore, Piero Perucca, Christopher A. Reid, Manisha Patel, Kevin K. Wang, Erwin A. van Vliet
Summary: The International League Against Epilepsy/American Epilepsy Society established the TASK3 working groups to create common data elements for preclinical epilepsy research. This paper discusses the important elements for proteomics, lipidomics, and metabolomics methodologies and provides a rationale for documenting parameters.
Article
Biochemistry & Molecular Biology
Mette Heiskanen, Shalini Das Gupta, James D. Mills, Erwin A. van Vliet, Eppu Manninen, Robert Ciszek, Pedro Andrade, Noora Puhakka, Eleonora Aronica, Asla Pitkanen
Summary: Traumatic brain injury (TBI) is responsible for a significant percentage of structural and all epilepsies, but there is currently a lack of prognostic biomarkers for post-traumatic epilepsy (PTE). This study investigated the potential of plasma microRNAs (miRNAs) as biomarkers for brain damage severity and the development of PTE. The results showed that acutely altered plasma miRNA levels could reflect the extent of cortical injury, but they were not able to predict PTE development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Tessa N. A. Slagboom, Dirk Jan Stenvers, Elsmarieke van de Giessen, Stefan D. D. Roosendaal, Maartje M. L. de Win, Joseph C. J. Bot, Eleonora Aronica, Rene Post, Jantien Hoogmoed, Madeleine L. L. Drent, Alberto M. M. Pereira
Summary: The study provides a structured analysis of the diagnostic accuracy and clinical use of molecular imaging in patients with ACTH-dependent Cushing's syndrome, as well as the role of multidisciplinary counseling in decision making. It proposes a complementary diagnostic algorithm for both de novo and recurrent or persistent Cushing's disease. The use of molecular imaging modalities is of added and complementary value in the detection of pituitary microadenoma in ACTH-dependent Cushing's syndrome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Valentina La Cognata, Agata Grazia D'Amico, Grazia Maugeri, Giovanna Morello, Maria Guarnaccia, Benedetta Magri, Eleonora Aronica, Velia D'Agata, Sebastiano Cavallaro
Summary: Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron (MN) depletion. CXCR2 has been implicated in ALS pathology and its expression is increased in cortical neurons of sporadic ALS patients. Inhibition of CXCR2 prevents MN degeneration in vitro and improves neuromuscular function in SOD1-G93A mice.
Article
Education & Educational Research
Damien S. Fleur, Max Marshall, Miguel Pieters, Natasa Brouwer, Gerrit Oomens, Angelos Konstantinidis, Koos Winnips, Sylvia Moes, Wouter van den Bos, Bert Bredeweg, Erwin A. van Vliet
Summary: Personalized peer-comparison feedback can be used to improve self-regulated learning and academic achievement. Providing meaningful feedback and peer comparison through a learning analytics dashboard offers a solution.
JOURNAL OF LEARNING ANALYTICS
(2023)
Article
Clinical Neurology
Erwin A. van Vliet, Riikka Immonen, Ofer Prager, Alon Friedman, Jens P. Bankstahl, David K. Wright, Terence J. O'Brien, Heidrun Potschka, Olli Grohn, Neil G. Harris
Summary: This article discusses the common data elements (CDEs) for neuroimaging data collected in rodent models of epilepsy, specifically focusing on adult rats and mice. Detailed CDE tables and case report forms (CRFs) are provided, along with a companion manuscript discussing the methodologies and parameters for several imaging modalities.
Article
Behavioral Sciences
Thomas Johnstone, Maria Isabel Barros Guinle, Gerald A. Grant, Brenda E. Porter
Summary: The study aimed to evaluate the safety and impact of Dexmedetomidine Hydrochloride (DH) administration during pediatric invasive intracranial electroencephalography (IEEG). The results showed that DH administration was not associated with adverse events and did not significantly affect the frequency of seizures captured on the IEEG and the duration of hospitalization.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Sabra Zaraa, H. Steve White, Andy Stergachis, Edward Novotny Jr, Chris Protos, Grant Simic, Jennifer L. Bacci
Summary: This study used design thinking to develop a community pharmacist-led intervention for people living with epilepsy. Four features - pharmacist-patient consultations, care plan development, regular check-ins, and care coordination with other health care providers - were identified as desirable, feasible, and viable for the intervention. The study highlights the importance of involving pharmacists in epilepsy care and provides evidence-based features for such interventions.
EPILEPSY & BEHAVIOR
(2024)
Article
Behavioral Sciences
Bofei Tan, Qiang Liu, Yameng Qin, Qiuyan Chen, Rong Chen, Yanzi Jin, Mengyun Li, Xiaodan Jia, Xianrui Xu, Qing Zhang
Summary: The purpose of this study was to identify factors associated with insomnia in patients with epilepsy. The results showed that nocturnal seizures and anxiety were independently associated with insomnia in these patients. Patients with epilepsy and insomnia were more likely to experience depression and excessive daytime sleepiness.
EPILEPSY & BEHAVIOR
(2024)
