Journal
EPILEPSIA
Volume 57, Issue 2, Pages E45-E50Publisher
WILEY
DOI: 10.1111/epi.13274
Keywords
Cytokines; Electrical status epilepticus during sleep; ESES; Continuous spikes and waves during sleep; CSWS; Landau-Kleffner syndrome
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Funding
- Dutch Epilepsy Fund
- Wilhelmina Children's Hospital Research Fund
- ReumaFonds [LLP-10] Funding Source: researchfish
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We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)-1, IL-6, IL-10, chemokine (C-C motif) ligand (CCL)2 and chemokine (C-X-C motif) ligand (CXCL)8/IL-8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow-up analyses in five patients revealed a significant decrease of IL-6 levels after immunomodulating treatment. IL-6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL-6 correlates with disease activity and immunomodulating treatment efficacy.
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