Article
Clinical Neurology
Brian Ervin, Jason Buroker, Anna W. Byars, Leonid Rozhkov, James L. Leach, Paul S. Horn, Craig Scholle, Francesco T. Mangano, Hansel M. Greiner, Katherine D. Holland, Tracy A. Glauser, Ravindra Arya
Summary: The study investigated the cerebral spatiotemporal dynamics of visual naming in epilepsy patients using stereo-electroencephalography monitoring. The results showed sequential yet temporally overlapping high-gamma modulations in neuroanatomic parcels during visual naming, supporting a model with six cognitive subcomponents of visual naming.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Agnes Trebuchon, Renata Racila, Francesco Cardinale, Stanislas Lagarde, Aileen McGonigal, Giorgio Lo Russo, Didier Scavarda, Romain Carron, Roberto Mai, Patrick Chauvel, Fabrice Bartolomei, Stefano Francione
Summary: A retrospective analysis of 346 patients with drug-resistant focal epilepsy who underwent surgery revealed that MRI findings, specific etiologies, and seizures induced by electrical stimulation were significantly correlated with seizure outcomes. Further research indicated that seizure induction by low frequency electrical stimulation could serve as a positive predictive factor for favorable seizure outcomes post-surgery.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Neurosciences
Brent M. Roeder, Mitchell R. Riley, Xiwei She, Alexander S. Dakos, Brian S. Robinson, Bryan J. Moore, Daniel E. Couture, Adrian W. Laxton, Gautam Popli, Heidi M. Clary, Maria Sam, Christi Heck, George Nune, Brian Lee, Charles Liu, Susan Shaw, Hui Gong, Vasilis Z. Marmarelis, Theodore W. Berger, Sam A. Deadwyler, Dong Song, Robert E. Hampson
Summary: This study demonstrates that deep brain stimulation (DBS) can enhance memory in patients who have previously suffered a brain injury, using epilepsy patients as a model. The results show an increased memory retention in response to hippocampal stimulation, especially in patients with pre-existing memory impairments.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jimmy C. Yang, Katie L. Bullinger, Faical Isbaine, Abdulrahman Alwaki, Enrico Opri, Jon T. Willie, Robert E. Gross
Summary: CM deep brain stimulation (DBS) shows promise in treating drug-resistant generalized epilepsy and bifrontal epilepsy, with a significant reduction in seizure frequency observed in patients. Further studies are needed to explore the optimal use of CM DBS in different types of epilepsy and its impact on treatment outcomes.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Abhijeet Gummadavelli, Dario J. Englot, Jason M. Schwalb, Chengyuan Wu, Jorge Gonzalez-Martinez, Joseph Niemat, Jason L. Gerrard
Summary: Neuromodulation has provided additional surgical treatment options for patients with medically refractory epilepsy, especially for those who are not candidates for resective surgery. DBS of the bilateral anterior nucleus of the thalamus has been proven to be a safe and effective treatment option for refractory focal epilepsy.
Article
Clinical Neurology
Birgit Frauscher, Fabrice Bartolomei, Maxime O. Baud, Rachel J. Smith, Greg Worrell, Brian N. Lundstrom
Summary: Direct cortical stimulation has a long history in epilepsy treatment and is currently experiencing a resurgence due to its potential to probe and manipulate the human brain. It has been found to have diagnostic and therapeutic benefits for drug-resistant epilepsy patients, but choosing the right stimulation parameters is challenging due to the complex nature of epilepsy.
Review
Biochemistry & Molecular Biology
Thomas J. Foutz, Michael Wong
Summary: This review discusses the clinical use and mechanisms of action of Responsive Neural Stimulation and Deep Brain Stimulation in the treatment of epilepsy, as well as recent advances and challenges. It also presents a rational approach to device selection based on current mechanistic understanding, clinical evidence, and device features.
BIOMEDICAL JOURNAL
(2022)
Article
Neurosciences
Pandeng Xie, Siqi Liu, Qi Huang, Zhonghua Xiong, Jiahui Deng, Chongyang Tang, Ke Xu, Bo Zhang, Baijian He, Xiongfei Wang, Zhao Liu, Jing Wang, Jian Zhou, Yugang Guan, Guoming Luan, Tianfu Li, Feng Zhai
Summary: Deep brain stimulation (DBS) can reduce spontaneous recurrent seizures (SRS) in epileptic rats by inhibiting ADK and activating A(1) receptors (A(1)Rs).
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Heming Cheng, Yingbei Qi, Nanxi Lai, Lin Yang, Cenglin Xu, Shuang Wang, Yi Guo, Zhong Chen, Yi Wang
Summary: Inhibition of hyperactivity of DR 5-HTergic neuron may present promising anti-seizure effect, and DR may be a potential DBS target for the therapy of TLE.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Erik H. Middlebrooks, Ayushi Jain, Lela Okromelidze, Chen Lin, Erin M. Westerhold, Chad A. O'Steen, Anthony L. Ritaccio, Alfredo Quinones-Hinojosa, William O. Tatum, Sanjeet S. Grewal
Summary: The study showed that high-frequency stimulation (HFS) and low-frequency stimulation (LFS) in deep brain stimulation (DBS) for epilepsy treatment produce significant differences in local and downstream network effects, particularly displaying opposing effects within the limbic network and default mode network (DMN).
Article
Clinical Neurology
Cristina V. Torres Diaz, Gabriel Gonzalez-Escamilla, Dumitru Ciolac, Marta Navas Garcia, Paloma Pulido Rivas, Rafael G. Sola, Antonio Barbosa, Jesus Pastor, Lorena Vega-Zelaya, Sergiu Groppa
Summary: Deep brain stimulation (DBS), particularly thalamic DBS, has shown promising results in reducing seizure severity and frequency in pharmacoresistant epilepsies. This study revealed that the clinical outcome of CM-DBS in generalized pharmacoresistant epilepsy is highly dependent on individual connectivity profiles and involves cerebello-thalamo-cortical circuits, offering potential implications for personalized neuromodulation and refining stereotactic implantation in the future.
Review
Clinical Neurology
Katie L. Bullinger, Abdulrahman Alwaki, Robert E. Gross
Summary: The surgical treatments for drug-resistant generalized epilepsy include VNS, DBS, and CC. Neurostimulation with VNS and/or DBS has been found effective in reducing seizure frequency in patients. DBS primarily targets the centromedian (CM) nucleus in the thalamus, but closed-loop stimulation and other targets are also being explored. CC can be performed using traditional surgical techniques or less invasive methods such as laser ablation and radiosurgery.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Review
Behavioral Sciences
Matthieu Faillot, Antoine Chaillet, Stephane Palfi, Suhan Senova
Summary: This passage discusses the potential use of deep brain stimulation for treating memory disorders in patients with stroke or traumatic brain injury, highlighting the need for proof of concept studies in animal models before clinical translation. The focus is on a comprehensive review of rodent models for traumatic brain injury and stroke, identifying the most relevant models for translational research through systematic evaluation of histological, behavioral, and electrophysiological features.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Yuichi Takeuchi, Mark Harangozo, Lizeth Pedraza, Tamas Foldi, Gabor Kozak, Qun Li, Antal Berenyi
Summary: The study demonstrates that closed-loop electrical stimulation of the medial septum can effectively terminate intrahippocampal seizures and suppress secondary generalization, emphasizing the importance of internally driven stimulus timing. By precisely activating medial septum GABAergic neurons, successful intervention in pathological oscillations was achieved, providing a new avenue for future clinical translation in other neurological and psychiatric disorders.
Review
Neurosciences
Sara Simula, Maeva Daoud, Giulio Ruffini, Maria Chiara Biagi, Christian-G Benar, Pascal Benquet, Fabrice Wendling, Fabrice Bartolomei
Summary: Transcranial electrical current stimulation (tES) has been proposed as a non-invasive therapy for pharmacoresistant epilepsy. This systematic review summarizes the clinical and fundamental effects of tES in epilepsy patients. The review shows that both direct current (tDCS) and alternating current (tACS) stimulation are safe and clinically relevant techniques for epilepsy. Further research is needed to understand the specific effects of tES on epileptic brain activity and to optimize stimulation parameters for personalized therapy.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Lauren N. Ratcliffe, Taylor McDonald, Brittany Robinson, John R. Sass, David W. Loring, Kelsey C. Hewitt
Summary: The study found that when using a cutoff score of <=26/30, White participants were classified more accurately than Black participants, leading to the suggestion of applying cutoff scores of <=25/30 for White individuals and <=22/30 for Black individuals. The research also emphasized the necessity of racially stratified population-based norms for Black participants with high misclassification rates.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Editorial Material
Clinical Neurology
Julie Werenberg Dreier, Kimford J. J. Meador, Jakob Christensen
Summary: Antiseizure medications (ASMs) are commonly used by pregnant women for various conditions, but there is limited evidence on the cognitive risks of in utero exposure. Healthcare professionals and pregnant women face the challenge of balancing the risks and benefits of different treatments due to the lack of robust safety data. High-quality data on the safety of ASMs used in pregnancy are urgently needed, but randomized clinical trials are not possible in pregnant women. Therefore, evidence must be obtained from observational studies.
Article
Public, Environmental & Occupational Health
Shuang Wang, Kimford J. Meador, Jayne Pawasauskas, Adam K. Lewkowitz, Kristina E. Ward, Todd N. Brothers, Abraham Hartzema, Brian J. Quilliam, Xuerong Wen
Summary: This study aimed to assess the effects of buprenorphine and methadone treatment during early and late pregnancy on perinatal and pregnancy outcomes. The results showed that there were varying risks associated with the two treatments, with buprenorphine potentially being the preferred choice.
Article
Clinical Neurology
Andres M. Kanner, Anita S. Saporta, Dong H. Kim, John J. Barry, Hamada Altalib, Hope Omotola, Nathalie Jette, Terence J. O'Brien, Siddhartha Nadkarni, Melodie R. Winawer, Michael Sperling, Jacqueline A. French, Bassel Abou-Khalil, Brian Alldredge, Martina Bebin, Gregory D. Cascino, Andrew J. Cole, Mark J. Cook, Kamil Detyniecki, Orrin Devinsky, Dennis Dlugos, Edward Faught, David Ficker, Madeline Fields, Barry Gidal, Michael Gelfand, Simon Glynn, Jonathan J. Halford, Sheryl Haut, Manu Hegde, Manisha G. Holmes, Reetta Kalviainen, Joon Kang, Pavel Klein, Robert C. Knowlton, Kaarkuzhali Krishnamurthy, Ruben Kuzniecky, Patrick Kwan, Daniel H. Lowenstein, Lara Marcuse, Kimford J. Meador, Scott Mintzer, Heath R. Pardoe, Kristen Park, Patricia Penovich, Rani K. Singh, Ernest Somerville, Charles A. Szabo, Jerzy P. Szaflarski, K. Liu Lin Thio, Eugen Trinka, Jorge G. Burneo
Summary: This study investigated the prevalence of mood, anxiety disorders, and suicidality in patients with newly diagnosed focal epilepsy. The results showed that 43.5% of patients had a psychiatric diagnosis, with 38.6% meeting the criteria for mood and/or anxiety disorders, and 21.6% reporting suicidal ideation. Major depressive disorders, bipolar disorders, panic disorders, and agoraphobia were associated with suicidality.
Article
Clinical Neurology
Teresa Q. Wu, Neda Kaboodvand, Ryan J. McGinn, Mike Veit, Zachary Davey, Anjali Datta, Kevin D. Graber, Kimford J. Meador, Robert Fisher, Vivek Buch, Josef Parvizi
Summary: In patients with presumed temporal lobe epilepsy, the pulvinar subregion of the thalamus is found to be involved earlier and more prominently than the ANT in the propagation of seizures, according to a study. This research provides evidence for the feasibility and safety of personalized thalamic neuromodulation.
Editorial Material
Clinical Neurology
Randi von Wrede, Juri-Alexander Witt, Stephane Auvin, Anita Devlin, Lieven Lagae, Anthony Marson, Kimford J. Meador, Terence J. O'Brien, Jun Park, Rainer Surges, Eugen Trinka, Samuel Wiebe, Christoph Helmstaedter
Article
Clinical Neurology
Konstantinos Tsamakis, Diane L. Teagarden, Hannah K. Villarreal, Latasha Evans, Matthew L. Morton, Nicholas J. Janocko, Olivia Groover, Kelsey C. Hewitt, Michele E. Price, David W. Loring, Daniel L. Drane, Ioannis Karakis
Summary: This study aimed to evaluate the rates and determinants of depression and anxiety in caregivers of patients with functional seizures. The results showed that 96% of patients and 59% of caregivers had symptoms of anxiety and/or depression. The depression and anxiety levels of caregivers were strongly correlated with those of patients, and this occurrence may be related to factors such as patient gender, depression level, caregiver identity, and burden.
EPILEPTIC DISORDERS
(2023)
Article
Geriatrics & Gerontology
David W. W. Loring, James J. J. Lah, Felicia C. C. Goldstein
Summary: This study investigated potential differences between in-person cognitive testing and video telehealth administration of the Montreal Cognitive Assessment (MoCA). The results showed that there were no significant differences in MoCA scores between the two administration methods. Therefore, video telehealth administration can be confidently used for both clinical and research purposes.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Letter
Clinical Neurology
P. Emanuela Voinescu, Page B. Pennell, Kimford Meador
Article
Pharmacology & Pharmacy
R. L. Bromley, M. Bickle Graz, M. Bluett-Duncan, C. Chambers, P. Damkier, K. Dietrich, H. Dolk, K. Grant, S. Mattson, K. J. Meador, H. Nordeng, T. F. Oberlander, A. Ornoy, A. Revet, J. Richardson, J. Rovet, L. Schuler-Faccini, E. Smearman, V. Simms, C. Vorhees, K. Wide, A. Wood, L. Yates, E. Ystrom, T. A. Supraja, J. Adams
Summary: The study aims to achieve consensus on the core neurodevelopmental outcomes, optimize methodologies, and overcome barriers in conducting pregnancy pharmacovigilance studies with neurodevelopmental outcomes. The vision is to establish a comprehensive understanding of neurodevelopmental outcomes in pregnancy pharmacovigilance through a complementary set of studies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Jacob Pellinen, Heath Pardoe, Stefan Sillau, Sarah Barnard, Jacqueline French, Robert Knowlton, Daniel D. Lowenstein, Gregory Cascino, Simon Glynn, Graeme Jackson, Jerzy Szaflarski, Chris J. Morrison, Kimford Meador, Ruben Kuzniecky, Human Epilepsy Project Investigators
Summary: This study found that people with newly treated focal epilepsy and learning difficulties have lower brain tissue volume to intracranial volume, suggesting that developmental factors are an important marker of neuroanatomical changes in focal epilepsy. There were also independent associations between brain volume, age, and sex in the study population.
Article
Clinical Neurology
Oluwadolapo D. Lawal, Kimford J. Meador, Anne L. Hume, Xuerong Wen
Summary: The study analyzed the pattern of antiseizure medication use in women of childbearing age with different indications, showing an increasing trend in the use of newer-generation ASMs and a decreasing trend in the use of older ASMs. The risk of teratogenicity associated with newer medications is largely unknown, emphasizing the importance of counseling and education in prescribing ASMs for women of childbearing age.
Meeting Abstract
Neurosciences
Rebecca Bromley, Miriam Bickle Graz, Matthew Bluett-Duncan, Christina Chambers, Per Damkier, Kim Dietrich, Helen Dolk, Kimberley Grant, Sarah Mattson, Kim Meador, Hedvig Nordeng, Tim Oberlander, Asher Ornoy, Alexis Revet, Jonathan Richardson, Joanne Rovet, Lavinia Schuler-Faccini, Erica Smearman, Victoria Simms, Charles Vorhees, Katrina Wide, Amanda Wood, Laura Yates, Evinid Ystrom, T. A. Supraja, Jane Adams
NEUROTOXICOLOGY AND TERATOLOGY
(2023)
Article
Clinical Neurology
Ignacio Valencia, Allyson L. Alexander, Danielle M. Andrade, Miguel Arevalo-Astrada, Clio Rubinos, Nancy Auer, Jacquelyn L. Bainbridge, Sallie A. Baxendale, Fabrice Bartolomei, Danielle A. Becker, Anne T. Berg, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt, Shivani Bhatnagar, Ingmar Bluemcke, Hal Blumenfeld, Gordon F. Buchanan, David E. Burdette, Jorge G. Burneo, Robyn M. Busch, Patrick Chauvel, Jeannie Chin, Lisa Clifford, Kelly R. Conner, Mark J. Cook, Jeannine Conway, Ramon Diaz-Arastia, Cornelia Drees, Jacqueline A. French, Taneeta Mindy Ganguly, Michael A. Gelfand, Tracy A. Glauser, Ezequiel Gleichgerrcht, Alica M. Goldman, Jorge Gonzalez-Martinez, Jean Gotman, Zachary Grinspan, Shanna Guilfoyle, Gita Gupta, Michael Hammer, Adam L. Hartman, Katie Hentges, R. Edward Hogan, Linda Huh, Ann Hyslop, Barbara Jobst, Colin B. Josephson, Sarah A. Kelley, Kelly Knupp, Matthias Koepp, Sanjeev Kothare, Esther Krook-Magnuson, Jasmine Kwasa, Maite La Vega-Talbott, Alice D. Lam, Jong Woo Lee, Daniel H. Lowenstein, Sarita Maturu, Luis Carlos Mayor, Carrie McDonald, Heather R. McKee, Guy M. McKhann, Kimford J. Meador, Heather C. Mefford, Elizabeth H. Michael, Mohamad A. Mikati, John J. Millichap, James W. Mitchell, Leah S. Myers, Dean Naritoku, Kerri L. Neville, Jeffrey Noebels, Terence J. O'Brien, Chima O. Oluigbo, Anup D. Patel, Milena K. Pavlova, Jeanne T. Paz, Page B. Pennell, M. Scott Perry, Piero Perucca, Asla Pitkaenen, Madona Plueger, Mary Jo Pugh, Mark Quigg, Shilpa B. Reddy, Christopher Ryan, Tamara S. Reynolds, Martha Sajatovic, Cesar Santana-Gomez, Linsday Schommer, Stephan Schuele, Renee A. Shellhaas, Daniel W. Shrey, Rani K. Singh, Michael R. Sperling, Saher Suleman, Jessica W. Templer, Maria Thom, Eugen Trinka, Sophia M. Varadkar, Naymee Velez-Ruiz, Jana Veliskova, Yuliya Voskobiynyk, Janelle L. Wagner, Jacy L. Wagnon, Claire Waller, Jill Waller, Zhong Irene Wang, Michelle W. Welborn, Elaine Wirrell, Barbara Jobst
Summary: The American Epilepsy Society Meeting 2022 in Nashville attracted over 6000 attendees and felt as busy as before the pandemic. The meeting provided a variety of symposia covering topics such as seizure generation, epilepsy pathophysiology, anti-seizure medications, and new treatment tools. It also included discussions on epilepsy comorbidities, practical issues in epilepsy care, and personal stories from patient advocates. Special lectures and smaller group sessions focused on specific areas of interest, and satellite symposia showcased the latest advancements in pharmaceutical and engineering fields.
Article
Clinical Neurology
Kimford J. Meador, Morris J. Cohen, David W. Loring, Abigail G. Matthews, Carrie Brown, Chelsea P. Robalino, Angela K. Birnbaum, Paula E. Voinescu, Laura A. Kalayjian, Elizabeth E. Gerard, Evan R. Gedzelman, Julie Hanna, Jennifer Cavitt, Maria Sam, Jacqueline A. French, Sean Hwang, Alison M. Pack, Page B. Pennell, MONEAD Invest Grp
Summary: This study aimed to investigate the neurodevelopmental effects of fetal exposure to commonly used antiseizure medications, and found no difference in neurodevelopmental outcomes between children with fetal exposure to newer antiseizure medications compared with unexposed children.